Nucleic acids and polypeptides for controlling food intake and/or body weight

ABSTRACT

An isolated nucleic acid molecule comprising a nucleotide sequence derived from a vertebrate animal, said nucleotide sequence codes for a polypeptide that is capable of at least partially complementing the phenotype of an animal having the anx/anx genotype as described in Maltais et al., J. Hered., 1984, 75:468-472, or a similar genotype and the polypeptide encoded by the nucleotide sequence is useful for controlling food or feed intake or body weight in animals including humans. Antibodies to the polypeptide can be used as diagnostic agents or for therapeutic purposes. Receptors for the polypeptide or antibodies to the receptors and/or polypeptide can be used to block, inhibit or enhance the biological activity of the polypeptide.

FIELD OF INVENTION

[0001] The invention relates to the field of controlling food or feedintake and body weight in vertebrate animals including humans. Inparticular there is provided an isolated nucleic acid molecule thatcomprises a sequence coding for a polypeptide that is capable ofcomplementing the phenotype of an animal having an anx/anx genotype, ora similar genotype. The invention is based on the findings that ananx/anx genotype animal has a phenotype implying that significantalterations occur in the hypothalamic distribution of several substancesthat are directly or indirectly involved (both anorexically andorexically) in feed or food intake regulation including neuropeptide Y(NPY), the agouti gene-related protein (AGRP), pro-opiomelanocortin(POMC) and its products, the cocaine and amphetamine regulatedtranscript (CART) and leptin. The implication of these findings is thatthe gene product(s) of the mutated gene(s) causing the anx/anx phenotypeappear(s) to play a significant and possibly, a central role in theregulation of body weight.

[0002] Having isolated a nucleic acid molecule comprising a sequencecoding for the polypeptide that is capable of complementing thephenotypic expressions of the anx/anx genotype, it becomes possible toprovide for recombinant production of such a polypeptide and to utilisethe polypeptide as such or substances inhibiting or enhancing thebiological activities of the polypeptide as body weight controllingagents. Based on the provision of the isolated nucleic acid and thepolypeptide of the invention and/or substances inhibiting or enhancingits activities, diagnostic means for detecting genetic and physiologicaldisorders become readily accessible.

TECHNICAL BACKGROUND AND PRIOR ART

[0003] Inappropriate or abnormal food intake patterns resulting inclinically recognisable disorders such as anorexia and obesityconstitute an increasing medical health problem, in particular in theWestern world. However, in spite of major research efforts, little isknown about the genetic and biochemical mechanisms that control eatingbehaviour. The regulation of food intake is a complex and poorlyunderstood process. In this connection, an important aspect is theinteractions between the central nervous system (CNS) and food intakeand it is generally believed that appetite, energy balance and bodyweight gain are regulated or modulated by several neurochemical andneuroendocrine signals from different organs in the body and diverseregions in the brain. It is known that the hypothalamus has an importantfunction in these processes, acting through a variety of systems thatinvolve a close interaction between nutrients, amines, neuropeptides andhormones (Leibowitz, Trends in Neurosciences, 1992, 15:491-497).

[0004] One approach to gaining understanding of the regulation of foodintake and energy output is by genetic analysis of animals carryingmutant genes. The first recessive obesity mutation, the obese mutation(ob) was described by Ingall et al, 1950, J. Hered. 41:317-318.Subsequently, several single-gene mutations in mice have been found toproduce an obese phenotype as described by Friedman et al., 1990, Cell69:217-220. The mouse obese gene and its human homologue have beencloned as described by Zhang et al., 1994, Nature 372:425. In WO96/35787 is described the production of an ob polypeptide usingrecombinant DNA technology and pharmaceutical compositions comprising obpolypeptides for the control of obesity. Another approach to regulatingobesity is suggested in WO 97/48806 based upon delivery of an obesityregulating gene, preferably a gene coding for leptin or a leptinreceptor, to a mammal.

[0005] Anorexia (anx) is a spontaneous recessive lethal mutation locatedon mouse Chromosome 2 that causes starvation in mice including mice inthe preweanling period (Maltais et al., 1984, J. Hered. 75:468-472). Itwas first discovered in 1976 at the Jackson Laboratories, U.S.A. in theF2 generation of DW/J × (M. m. poschiavinus × Swiss). These mutantanimals of the anx/anx genotype appear normal at birth but they developsymptoms of growth failure and emaciation as well as head weaving, bodytremors and uncoordinated gait. The animals die prematurely. Noabnormalities in respect of histology and anatomy of thegastrointestinal tract or in respect of biochemical parameters in theblood have been reported. Mutant mice (anx/anx) are characterised bypoor appetite with reduced stomach contents compared to normallittermates as from postnatal day 5 (Maltais et al., 1984).Interestingly, the pattern of food intake, measured as daily changes instomach content, for anx/anx mice is very similar to that observed innormal littermates from birth to 20 days of age (Maltais et al., 1984).These data indicate that anx/anx mice fail to properly regulate theamount of food consumed rather than failing to eat for other reasons.

[0006] The neurological symptoms involved in the phenotype caused by theanx/anx genotype, i.e. head weaving, body tremors and uncoordinated gaitcan be partially suppressed by serotonin antagonists. Increasing theserotonin levels by injecting serotonin agonists produces severeneurological symptoms both in anx/anx mice and healthy litter mates(Maltais et al., 1984). It has been reported that mutant mice showhyperinnervation of serotonergic fibres in several structures in thebrain including the hippocampus, cortex, olfactory bulb and cerebellum(Son et al., 1994, Mol. Brain Res. 25:129-134).

[0007] It is known that the hypothalamus plays an important role inregulation of food intake that is effected by a range of neurochemicalmessenger molecules that stimulate food intake such as neuropeptide Y(NPY), the agouti gene-related protein (AGRP), the melanin concentratinghormone (MCH) and orexin (ORX), and molecules having an inhibitingeffect on food intake such as leptin, the cocaine and amphetamineregulated transcript (CART) and the α-melanocyte stimulating hormone(α-MSH).

[0008] In recent studies, the distribution of several of suchneurochemical messenger molecules (including NPY and its Y1, Y2 and Y5receptors, cholecystokinin, galanin, serotonin, somatotostatin,acetylcholinesterase, AGRP, the pro-opiomelanocortinergic (POMC)peptides and CART), in mice that are homozygous for the anorexiamutation has been studied by using immunohistochemistry and in situhybridisation (Broberger et al., 1997, 1998, 1999 and Johansen et al.,2000). Among the significant findings in these studies are: NPY-likeimmunoreactivity is increased markedly in arcuate nucleus cell bodiesand decreased in terminals of the arcuate nucleus and other hypothalamicregions of anx/anx mice as compared to normal litter mates. Similarobservations were made in respect of AGRP. No differences in mRNAexpression for NPY and AGRP, respectively was found in the arcuatenucleus of the anx/anx mice. However, a decreased number of POMCmRNA-expressing neurons in the anx/anx arcuate nucleus was observed and,in parallel, decreased mRNA levels for the Y1 and Y5 receptors for NPYwhich are expressed in POMC-neurons. Additionally, anx/anx mice werefound to have significantly decreased levels of CART mRNA label andpeptide-immunoreactive cell bodies and fibres in the arcuate nucleus anda lower number of detectable CART-expressing cells in the dorsomedialhypothalamic nucleus/lateral hypothalamic area.

[0009] The results of the above studies clearly indicate that theanx/anx genotype confers phenotypic traits that are directly orindirectly involved in food intake regulation. A primary objective ofthe present invention is to provide the gene product(s) of the gene orgenes which is/are mutated in the anx/anx genotype or similar genotypesconferring phenotypic traits similar to the anx/anx genotype as thebasis for a novel approach to regulating food intake and weight gain.

SUMMARY OF THE INVENTION

[0010] Accordingly, the present invention pertains in a first aspect toan isolated nucleic acid molecule comprising a nucleotide sequencederived from a vertebrate animal, said nucleotide sequence codes for apolypeptide that is capable of at least partially complementing thephenotype of an animal having the anx/anx genotype as described inMaltais et al., J. Hered., 1984, 75:468-472, or a similar genotype.

[0011] In further aspects the invention provides an expression vectorcomprising the nucleic acid molecule as defined above and a host cellcomprising such a vector.

[0012] In a still further aspect the invention relates to a method ofproducing a polypeptide that is capable of at least partiallycomplementing the phenotype of an animal having the anx/anx genotype asdescribed in Maltais et al. (1984), or a similar genotype, the methodcomprising the steps of: (i) providing a nucleic acid molecule asdefined above, (ii) introducing the nucleic acid molecule into a hostcell that is capable of expressing the nucleotide sequence coding forthe phenotype complementing polypeptide, (iii) culturing the host cellunder conditions permitting expression of the nucleotide sequence codingfor the phenotype complementing polypeptide, and (iv) harvesting thepolypeptide.

[0013] In other aspects there is provided a method of inducing, in avertebrate animal, the production of a polypeptide that is capable of atleast partially complementing the phenotype of an animal having theanx/anx genotype as described in Maltais et al. (1984) or a similargenotype, the method comprising administering to the animal the nucleicacid molecule as defined herein; and an isolated polypeptide that iscapable of at least partially complementing the phenotype of an animalhaving the anx/anx genotype as described in Maltais et al. (1984), or asimilar genotype, said polypeptide is obtainable by the above method forproducing the polypeptide.

[0014] In yet further aspects the invention pertains to methods ofregulating food or feed intake or weight gain in a vertebrate animal,the method comprising administering to the animal a food or feed intakeregulating amount of the polypeptide as defined herein.

[0015] There is also provided a method of regulating food or feed intakein a vertebrate animal, the method comprising administering to theanimal an effective amount of a molecule that blocks or inhibits orenhances the biological activity of the polypeptide according to theinvention.

[0016] In still further aspects, the invention relates to apharmaceutical composition comprising a polypeptide that is capable ofat least partially complementing the phenotype of an animal having theanx/anx genotype as described in Maltais et al. (1984), or a similargenotype, or a pharmaceutically active part thereof, and apharmaceutically acceptable carrier and to a pharmaceutical compositioncomprising a molecule that blocks or inhibits or enhances the biologicalactivity of a polypeptide that is capable of at least partiallycomplementing the phenotype of an animal having the anx/anx genotype asdescribed in Maltais et al. (1984), or a similar genotype, said moleculeis selected from the group consisting of an antibody capable of bindingto the polypeptide, a receptor capable of binding to the polypeptide, anantagonist that prevents the polypeptide from binding to its receptorand any other molecule that is capable of binding to the polypeptide ora pharmaceutically active part thereof, and a pharmaceuticallyacceptable carrier.

[0017] In yet another aspect there is provided a method of isolating amolecule that is capable of interacting with a polypeptide that iscapable of at least partially complementing the phenotype of an animalhaving the anx/anx genotype as described in Maltais et al. (1984), or asimilar genotype, the method comprising the steps of: (i) providing thepolypeptide of the invention, (ii) permitting the polypeptide to reactwith cells or fragments or extracts thereof to form a binding pair, and(iii) separating from the binding pair a molecule that binds to thepolypeptide.

[0018] There is also provided an antibody comprising at least onebinding site that is capable of binding to the polypeptide encoded bythe above nucleotide sequence derived from a vertebrate animal, saidnucleotide sequence codes for a polypeptide that is capable of at leastpartially complementing the phenotype of an animal having the anx/anxgenotype as described in Maltais et al. (1984), or a similar genotype,and a method of detecting the presence of a polypeptide that is capableof at least partially complementing the phenotype of an animal havingthe anx/anx genotype as described in Maltais et al. (1984), or a similargenotype, or a homologue of said polypeptide, the method comprisingcontacting an antibody capable of binding to the polypeptide with asample suspected of containing the polypeptide or the homologue thereofto allow formation of a polypeptide/antibody complex and detecting thecomplex.

[0019] In yet another aspect the invention relates to an isolatedmolecule that interacts with a polypeptide that is capable of at leastpartially complementing the phenotype of an animal having the anx/anxgenotype as described in Maltais et al. (1984), or a similar genotype,said isolated molecule is provided by the above method of isolating sucha molecule.

[0020] In another further aspect there is provided a method of producingan antibody to the above isolated molecule that interacts with apolypeptide that is capable of at least partially complementing thephenotype of an animal having the anx/anx genotype as described inMaltais et al. (1984), or a similar genotype, the method comprisingadministering an immunologically effective amount of the molecule to ananimal and collecting from the animal serum containing antibodiesagainst the receptor or spleen cells for the production of monoclonalantibodies against the molecule.

[0021] In a further aspect the invention pertains to a method fordetection of a molecule that is capable of binding to a polypeptidecapable of at least partially complementing the phenotype of an animalhaving the anx/anx genotype as described in Maltais et al. (1984), or asimilar genotype, the method comprising the steps of: (i) providing theantibody produced by the above method of producing an antibody to theabove isolated molecule that interacts with a polypeptide that iscapable of at least partially complementing the phenotype of an animalhaving the anx/anx genotype as described in Maltais et al. (1984), or asimilar genotype, (ii) reacting the antibody with cells or fragments orextracts thereof to form a binding pair, and (iii) detecting thepresence of the binding pair.

[0022] In further aspects the invention provides a kit for detection ofa polypeptide that is capable of at least partially complementing thephenotype of an animal having the anx/anx genotype as described inMaltais et al. (1984), or a similar genotype, said kit comprising anantibody comprising at least one binding site that is capable of bindingto the polypeptide encoded by the above nucleotide sequence derived froma vertebrate animal, said nucleotide sequence codes for a polypeptidethat is capable of at least partially complementing the phenotype of ananimal having the anx/anx genotype as described in Maltais et al.(1984), or a similar genotype; a kit for detection of a receptor for apolypeptide that is capable of at least partially complementing thephenotype of an animal having the anx/anx genotype as described inMaltais et al. (1984), or a similar genotype, said kit comprising saidpolypeptide; and a kit for detection of antibodies to a polypeptide thatis capable of at least partially complementing the phenotype of ananimal having the anx/anx genotype as described in Maltais et al.(1984), or a similar genotype, said kit comprising the polypeptide.

[0023] The invention pertains in a still further aspect to a method ofidentifying in a sample a nucleotide sequence that codes for a putativepolypeptide that is capable of at least partially complementing thephenotype of an animal having the anx/anx genotype as described inMaltais et al. (1984), or a similar genotype. In presently preferredembodiments, the method comprises the steps of: (i) providing the codingnucleotide sequence as defined above or its complementary strand, or apart thereof, (ii) contacting the sample with said sequence or partthereof under hybridising conditions to form a binding pair, and (iii)detecting the presence of the binding pair. In other useful embodiments,the coding sequence is identified by PCR or other similar nucleic acidamplification methods.

[0024] In a still further aspect the invention relates to a method ofcontrolling in an animal the expression of a nucleotide sequence codingfor a polypeptide that is capable of at least partially complementingthe phenotype of an animal having the anx/anx genotype as described inMaltais et al. (1984), or a similar genotype, the method comprising thesteps of: (i) providing a molecule that inhibits the translation of atranscript of the coding sequence, and (ii) administering to the animala translation inhibiting effective amount of said molecule.

DETAILED DISCLOSURE OF THE INVENTION

[0025] It is a primary objective of the present invention to provide anucleic acid molecule that comprises a nucleotide sequence coding for apolypeptide that is capable of at least partially complementing thephenotype of an animal having the anx/anx genotype as dscribed inMaltais et al. (1984), or a similar genotype. In this context, theexpression “nucleic acid molecule” refers to DNA, cDNA or RNA and“coding nucleotide sequence” refers to a DNA or a RNA that encodes aspecific amino sequence, or their complementary strand. As used herein,the expression “capable of at least partially complementing thephenotype of an animal having the anx/anx genotype as described inMaltais et al. (1984), or a similar genotype” implies that thepolypeptide, when it is introduced into or produced in an animal havingthe anx/anx genotype or a similar genotype, is capable of eliminating orreducing at least some of the phenotypic traits associated with thatgenotype. Such phenotypic traits include not only those described inMaltais et al. (1984), which is incorporated herein by reference, butthey include any other traits, whether they have been discovered or willbe discovered in the future, which can be associated with the anx/anxgenotype, or with a similar genotype. Accordingly, the phenotypic traitsinclude any detectable behavioural, biochemical, histological andphysiological changes, relative to an animal not having the genotype,including an animal of the same species such as a litter mate, in ananimal having the anx/anx genotype or the similar genotype such as thosechanges published by Broberger et al. (1997, 1998 and 1999) and Johansenet al. (2000), which publications are also incorporated herein byreference. As used herein, the term “animal” include any species ofvertebrate animals including rodents such as a mouse or a rat,carnivores such as canine and feline animals, ruminants, pigs, horses,birds, fish, and humans.

[0026] Accordingly, the phenotypic traits as referred to above includethe following (as compared to an animal not having the genotype):

[0027] 1. Traits Described in Maltais et al. (1984)

[0028] (i) growth failure and emaciation;

[0029] (ii) blood parameters including total RBC, haematocrits,haemoglobin, mean cell volume within normal ranges;

[0030] (iii) higher serum cholesterol level;

[0031] (iv) lower blood glucose level;

[0032] (v) elevated alkaline phosphatase level;

[0033] (vi) abnormal behaviour including head weaving, body tremors,uncoordinated gait and hyperactivity, which can be diminished byinjection of 5,7-dihydroxytryptamine;

[0034] 2. Traits Described in Broberger et al. (1997, 1998 and 1999) andJohansen et al. (2000)

[0035] (viii) Increased agouti gene-related protein (AGRP)immunoreactivity in arcuate nucleus cell bodies and decreasedimmunoreactivity in hypothalamic terminals, no difference in AGRP mRNAexpression in the arcuate nucleus (Broberger et al., 1998);

[0036] (ix) increase of neuropeptide Y-like immunoreactivity inhypothalamic arcuate cell bodies and decrease of said immunoreactivityin terminals in the arcuate nucleus, but essentially no difference inneuropeptide Y (NPY) mRNA in the arcuate nucleus (Broberger et al.,1997);

[0037] (x) decreased numbers of Pro-Opiomelanocortin (POMC)mRNA-expressing neurons in the arcuate nucleus (Broberger et al., 1999);

[0038] (xi) decreased mRNA levels for NPY Y1 and Y5 receptors in POMCneurons (Broberger et al., 1999);

[0039] (xii) decreased immunoreactivities in the hypothalamus foradrenocorticotropic hormone (marker for POMC cell bodies),α-melanocyte-stimulating hormone (marker for axonal projections) and NPYY1 receptor (marker for dendritic arborisations) (Broberger et al.,1999);

[0040] (xiii) cocaine and amphetamine regulated transcript (CART) in thearcuate nucleus and serum leptin levels are reduced and a decreasednumber of CART expressing cells in the dorsomedial and lateralhypothalamic areas.

[0041] 3. Further, unpublished phenotypic traits

[0042] (xiv) the Na⁺, K⁺-ATPase activity is upregulated in the striatumand striatal dopamine—and dopamine metabolite levels are lower;

[0043] (xv) the insulin content in pancreatic β-cells is increased at astatistically significant level and insulin is not secreted.

[0044] As used herein, the expression “similar genotype” refers to agenetic disorder in a vertebrate animal that confers one or more of theabove phenotypic traits such as e.g. having at least half of the traits(i) to (vi), optionally combined with at least one of the above traits(vii) to (xv) such as at least two of these traits including at leastthree, four, five or six of such traits (vii) to (xv).

[0045] It will be appreciated that in the present context “a geneticdisorder” in an anx/anx genotype or in a similar genotype can be amutation in a coding sequence resulting in the expression of a geneproduct having, relative to the wildtype product, a reduced biologicalactivity, a mutation in a coding sequence that results in a reducedexpression or even no expression of a biologically active polypeptide ora mutation in a nucleic acid sequence that codes for a gene producthaving a regulatory effect on the expression of a coding sequence e.g.causing a down regulation of the expression of a biologically activepolypeptide such as the Tyro 3 gene product. When the genetic disorderis one that results in lower or higher expression level, relative to awildtype individual, of a gene product, it can e.g. be detected bycomparing the level of mRNA species in total mRNA determined in vitro orin vivo in anx/anx genotype animals and wildtype litter mates andidentifying mRNA polymorphisms. An example of such an approach isdescribed in Example 3 below. The genetic disorder may also be one thatresults in a changed activity of the gene product.

[0046] As a matter of clarification, it should be noted that theexpression “capable of at least partially complementing the phenotype ofan animal having the anx/anx genotype as described in Maltais et al.(1984), or a similar genotype” as defined above is used herein tocharacterise the effects and functionalities of the polypeptideexpressed by the nucleotide sequence and this use does not imply anylimitations in respect of the use of the polypeptide as can beappreciated from the following description of the invention.

[0047] The nucleic acid molecule comprising the nucleotide sequence thatcodes for a polypeptide as defined herein can be derived from anyvertebrate animals. One preferred approach to providing the nucleic acidmolecule is to derive it from an animal having the anx/anx genotype or asimilar genotype as defined above by isolating a nucleic acid moleculefrom such an animal comprising one or more mutations as defined abovethat confer(s) the phenotype as defined above and isolating andcharacterising the coding sequence(s) or the regulatory sequence(s)containing the mutation or mutations. The coding sequence for theputative polypeptide as defined above can then be derived syntheticallye.g. by modifying the mutant gene to its wild type sequence, or theisolated mutant sequence or a part hereof can be used as a hybridisationprobe to identify the corresponding wildtype sequence in any vertebratespecies or such a wild type sequence can alternatively be identified bycomparing the mutant sequence with published gene sequence data.

[0048] It will be appreciated that the expression “nucleic acid moleculethat comprises a nucleotide sequence coding for a polypeptide” includesa nucleic acid molecule that consists only of the nucleotide sequencecoding for a polypeptide as defined herein. However, the nucleic acidmay also comprise further nucleotides including nucleotide sequencesthat have a regulatory effect on the expression of the polypeptide andmay be of a size which is typically in the range of 1 kilobase (kb) to 1megabase, such as in the range of 10 kb to 0.75 megabase including therange of 50 kb to 0.5 megabase.

[0049] The nucleic acid molecule of the invention can, as it ismentioned above, comprise a regulatory nucleotide sequence thatregulates the expression of the nucleotide sequence coding for thephenotype complementing polypeptide. As used herein, the expression“regulatory nucleotide sequence” includes any expression controlsequence, i.e. a sequence that is conventionally used to affectexpression of a nucleotide sequence or a gene that encodes a polypeptideand includes one or more components that affect(s) expression, includingtranscription and translation signals. Such a sequence includes e.g. oneor more of the following: a promoter sequence, an enhancer sequence, anupstream activation sequence, a downstream termination sequence, apolyadenylation sequence, an optimal 5′ leader sequence to optimiseinitiation of translation in mammalian host cells, a secretion leadersequence that provides for secretion of the phenotype complementingpolypeptide upon expression of the nucleotide sequence coding for thepolypeptide and a Shine-Delgarno sequence. Appropriate regulatorynucleotide sequences differ depending on the host system in which thepolypeptide is to be expressed. E.g. in prokaryotes, such a regulatorysequence can include one or more of a promoter sequence, a ribosomalbinding site and a transcription termination sequence. In eukaryotessuch a sequence can include a promoter sequence and a transcriptiontermination sequence. In accordance with the present invention, anyappropriate regulatory nucleotide sequence can be a sequence that isnaturally associated with the sequence coding for the polypeptide asdefined herein, but it is also contemplated to use such sequences thatare not naturally associated with the nucleotide sequence coding for thephenotype complementing polypeptide. Use of viral promoters to regulatethe expression of the polypeptide of the invention is also contemplated.

[0050] As used herein the term “polypeptide” includes any polypeptidethat is capable of at least partially complementing the phenotype of ananimal having the anx/anx genotype as described in Maltais et al.(1984), or a similar genotype. Accordingly, the term includes theputative polypeptide(s) encoded by the wild type of the gene or genescarrying the anx mutation in a mouse such as is described in the abovereference and any phenotype complementing functional homologue of such apolypeptide, including both a mature polypeptide and a polypeptideprovided with a signal peptide sequence and any truncations, variants,alleles, analogues and derivatives thereof. In this context, theexpression “phenotype complementing functional homologue” indicates apolypeptide that is capable of complementing at least one of thephenotypic traits conferred by the anx/anx genotype in mice, or asimilar genotype.

[0051] The term “polypeptide” is not limited to a specific length of theproduct of the coding sequence. Thus, polypeptides that are identical orare at least 60%, preferably at least 70% such as at least 80% includingat least 90% identical to the polypeptide encoded by the mutated gene inan anx/anx genotype animal or to its wild type, irrespective of thehuman or non-human source from which it is derived, are included withinthe definition of the polypeptide of the invention. Also included aretherefore alleles and variants of the product of the gene carrying theanx mutation that contain amino acid substitutions, deletions orinsertions. The amino acid substitutions can be conservative amino acidsubstitutions or substitutions to eliminate non-essential amino acidresidues such as to alter a glycosylation site, a phosphorylation site,an acetylation site, or to alter the folding pattern by altering theposition of cysteine residues that are not necessary for function.Conservative amino acid substitutions are those that preserve thegeneral charge, hydrophobicity/hydrophilicity and/or steric bulk of theamino acid substituted, e.g. substitutions between the members of thefollowing groups are conservative substitutions: Gly/Ala, Val/Ile/Leu,Asp/Glu, Lys/Arg, Asn/Gln and Phe/Trp/Tyr. Furthermore, the term“polypeptide” as used herein does not exclude post-expressionmodifications of the polypeptide such as e.g. glycosylations,acetylations and/or phosphorylations. It will be appreciated that apolypeptide as defined herein can be a component of a fusion proteinwhere it is combined with one or more polypeptides or part(s) hereof.

[0052] In one useful embodiment, the nucleic acid molecule of theinvention is derived from a rodent such as a mouse, including a mousehaving the genotype anx/anx, e.g. as it is described in Maltais et al.(1984). The molecule may consist only of the gene which carries theanx-associated mutation(s) or it may comprise further nucleotides and beof a size as it is defined above. In a specific embodiment, the nucleicacid molecule is a molecule which is derived from a fragment of themouse Chromosome 2 that is delimited by:

[0053] (i) the locus D2Mit133 that is published in:

[0054]http://carbon.wi.mit.edu:8000/cgi-bin/mouse/sequence_info?database=&sts=D2Mit133,

[0055] and by

[0056] (ii) the locus D2Jojo5 (see FIG. 1). The size of this fragment isabout 0.2 centiMorgan or 400 kilobase. This fragment, which is furtherdescribed in the following examples, is further characterised in that itcomprises a nucleotide sequence selected from the group consisting ofthe sequences D2Dcr14 (accession No. G36398), D2Mit104 published in:

[0057] http://carbon.wi.mit.edu:8000/cgi-bin/mouse/sequenceinfo?database=&sts=D2Mit104,

[0058] D2Mit395 published in

[0059] http://carbon.wi.mit.edu:8000/cgi-bin/mouse/sequence_info?database=&sts=D2M it395,

[0060] Ltk (accession Nos. Mus.musculus: X52621;×07984), Tyro 3A(accession No. Mus.musculus: U18342), Tyro 3B (accession No.Mus.musculus: U18343) and Tyro3 (accession Nos. Mus.musculus: X78103;AH006738; U23718; U 23719; U 23720; U23721).

[0061] The sequence of the above nucleic acid molecule and any othernucleic acid molecule as defined herein that codes for the phenotypecomplementing polypeptide according to the invention can e.g. beobtained by determining the nucleotide sequence of the molecule andsubsequently searching for ORFs against known genes in databases or byusing computer software that predicts genes in novel sequences. Examplesof useful databases include Genscan(http://CCR-081.mit.edu/GENSCAN.htmi) and FGENE(http://dot.imgen.bcm.tmc.edu:9331/gene-finder/gf.html).

[0062] In a further aspect, the invention provides an expression vectorcomprising the nucleic acid molecule as described above. Such vectorscan be provided by ligating the nucleic acid molecule of the inventionto an appropriate plasmid vector containing an appropriate promoter forexpression in the selected host expression system. Depending on theexpression system, the promoter is preferably a prokaryotic cellpromoter, a eukaryotic cell promoter or a viral promoter. Expressionplasmids with various promoters are currently available commercially.One example of a suitable plasmid is plasmid pET23 that can be purchasedfrom Novagen (Madison, Wis.). This plasmid utilises a T7 promotersequence for expression in bacterial cells. Commercially availablemammalian expression plasmids can also be used for the present purposes.Accordingly, the expression vector of the invention includes a vectorfurther comprising a regulatory nucleotide sequence as definedhereinbefore that regulates the expression of the nucleotide sequencecoding for the phenotype complementing polypeptide of the invention.Such a regulatory nucleotide sequence can be one that is naturallyassociated with the nucleotide sequence coding for the phenotypecomplementing polypeptide, but is preferably a nucleotide sequence thatis not naturally associated with said sequence. As it is generallypreferred that the phenotype complementing polypeptide, when producedindustrially, is secreted into the growth medium for the host cellcomprising the expression vector, the vector is preferably one thatfurther comprises a nucleotide sequence encoding a secretion leadersequence that provides for secretion of the phenotype complementingpolypeptide upon expression of the nucleotide sequence coding for thepolypeptide.

[0063] In accordance with the above description of the nucleic acid ofthe invention, the expression vector is in one embodiment a vectorwherein the nucleotide sequence expressing a polypeptide that is capableof at least partially complementing the phenotype of an animal havingthe anx/anx genotype as described in Maltais et al. (1984), or a similargenotype, is derived from a vertebrate animal including mammals such asrodents, e.g. a mouse including a mouse having the genotype anx/anx, orhumans, fish or birds. In one specific embodiment, the expression vectorcomprises a nucleotide sequence expressing a polypeptide that is capableof at least partially complementing the phenotype of an animal havingthe anx/anx genotype as described in Maltais et al. (1984), or a similargenotype, which is derived from a fragment of the murine Chromosome 2that is delimited by locus D2Mit133 and by locus D2Jojo5 and whichoptionally comprises a nucleotide sequence selected from D2Dcr14,D2Mit104, D2Mit395, Tyro 3A, Tyro 3B and Tyro 3, as defined above andany of the further genes within the fragment delimited by locus D2Mit133and by locus D2Jojo5 as described in the following. If appropriate, theexpression vector may further comprise a nucleotide sequence coding fora selective marker.

[0064] In another aspect, the invention relates to a host cellcomprising the above vector, i.e. to an expression system for thephenotype complementing polypeptide. The host is preferably selectedfrom a prokaryotic cell and a eukaryotic cell. In preferred embodiments,the host cell expression system is a bacterial expression system.Control elements for use in bacterial host cells include promoters,optionally containing operator sequences, and ribosome binding sites.Useful promoters include sequences derived from sugar metabolisingenzymes such as galactose, lactose (lac) and maltose metabolisingenzymes. Further examples include promoter sequences derived frombiosynthetic enzymes such as the trp, the β-lactamase (bla) promotersystems, bacteriophage λPL and T7 promoters. In addition, syntheticpromoters such as the tac promoter can be used.

[0065] Useful host cells can be selected from gram negative bacteria andgram positive bacteria. Examples of gram negative host cells include E.coli, Pseudomonas spp., Salmonella spp. and Serratia spp and examples ofgram positive bacteria that may be used in the invention includeBacillus spp., Streptomyces spp and lactic acid bacterial species suchas Streptococcus spp. and Lactococcus spp. Methods for introducingexogenous DNA into such host cells typically include the use of CaCl₂ orother agents such as divalent cations and DMSO. DNA can also beintroduced into bacterial cells by electroporation, nuclear injection orprotoplast fusion as described generally in Sambrook et al. (1989).Preferably, the host cell should secret minimal amounts of proteolyticenzymes. Alternatively, in vitro methods of cloning, e.g. PCR or othernucleic acid polymerase reactions are suitable. Prokaryotic cells usedto produce the phenotype complementing polypeptide of the invention arecultured in suitable media as described generally in Sambrook et al.,supra.

[0066] Suitable eukaryotic host cells can also be selected from fungalcells including yeast cells, mammalian cells and insect cells.

[0067] Expression vectors and transformation vectors, eitherextrachromosomal replicons or integrating vectors, have been developedfor transformation into yeast species including Saccharomycescerevisiae, Candida albicans, Candida maltosa, Hansenula polymorpha,Kluyveromyces lactis, Pichia pastoris and Schizosaccharomyces pombe, andinto species of filamentous fungi such as Aspergillus spp., Trichodermaspp., Neurospora spp. or Penicillium spp.

[0068] Control sequences for yeast vectors include as examples promoterregions from genes such as alcohol dehydrogenase (ADH), endolase,glucokinase, glucose-6-phosphate isomerase and pyruvate kinase.Inducible yeast promoters having the additional advantage oftranscription controlled by growth conditions are available. Yeastenhancers are also advantageously used with yeast promoters. E.g. canupstream activating sequences (UAS) of one yeast promoter be joined withthe transcription activation regions of another yeast promoter to createa synthetic hybrid promoter. Furthermore, a yeast promoter may includenaturally occurring promoters of non-yeast origin having the ability tobind yeast RNA polymerase and initiate transcription. Other controlelements that may be included in yeast expression vectors areterminators and leader sequences which encode signal sequences forsecretion such as e.g. the leader sequence derived form the yeastinvertase gene and the α-factor gene.

[0069] Methods of introducing exogenous DNA into yeast hosts are wellknown in the art and typically include transformation of spheroplasts orintact yeast cells treated with alkali cations. The introduction can becarried out by transformation, nuclear injection, electroporation orprotoplast fusion as described generally in Sambrook et al., supra.

[0070] For yeast secretion of the polypeptide of the invention, thenative signal sequence can be substituted by another leader such as theyeast invertase, a-factor or acid phosphatase leaders. For intracellularproduction of the polypeptide in yeast, a sequence encoding a yeastprotein can be linked to the coding sequence for the phenotypecomplementing polypeptide to produce a fusion protein that can becleaved intracellularly upon expression.

[0071] Particularly useful insect cell expression systems are based uponbaculovirus expression vectors (BEVs), recombinant insect viruses inwhich the coding sequence for a foreign gene is inserted behind abaculovirus promoter in place of a viral gene, e.g. polyhedrin such asit is described in U.S. Pat. No. 4,745,051. A typical useful insect cellexpression vector includes a DNA vector useful as an intermediate forthe infection or transformation of an insect cell system, the vectorgenerally containing DNA coding for a baculovirus transcriptionalpromoter, followed downstream by an insect signal DNA sequence capableof directing secretion of a desired polypeptide, and a site forinsertion of the foreign gene encoding the foreign polypeptide and theforeign gene placed under transcriptional control of a baculoviruspromoter, the foreign gene herein being the nucleotide sequence codingfor the phenotype complementing polypeptide of the invention. Usefulpromoters for an insect cell expression system can be derived from anybaculovirus infecting cells such as e.g. a baculovirus immediate-earlygene IEI or IEN promoter or a strong polyhedrin promoter of baculovirus.The insect expression vector for use herein may also include thepolyhedrin polyadenylation signal and a selective marker. DNA encodingsuitable signal sequences may also be included such as e.g. the signalsequence of the baculovirus polyhedrin gene or mammalian signalsequences.

[0072] The phenotype complementing polypeptide of the invention may alsobe expressed in mammalian cells such as e.g. adipocytes, using promotersand enhancers that are functional in such cells. Typical promoters formammalian cell expression include as examples, the SV40 early promoter,the CMV promoter, the mouse mammary tumour virus LTR promoter, theadenovirus late promoter and the herpes simplex virus promoter.Mammalian expression may be either constitutive or regulated(inducible).

[0073] Mammalian cell lines available as hosts for expression are alsoknown and include many immortalised cell lines available from the ATCC,including Chinese hamster ovary (CHO) cells, HeLa cells, baby hamsterkidney (BHK) cells, monkey kidney (COS) cells, human hepatocellularcarcinoma cells, human embryonic kidney cells, human lung cells andhuman liver cells.

[0074] It is another objective of the invention to provide a method ofproducing a polypeptide that is capable of at least partiallycomplementing the phenotype of an animal having the anx/anx genotype asdescribed in Maltais et al. (1984), or a similar genotype. The methodcomprises as a first step that a nucleic acid molecule as describedherein is provided, followed by introducing the nucleic acid moleculeinto a host cell that is capable of expressing the phenotypecomplementing polypeptide and culturing the host cell under conditionspermitting expression of the nucleotide sequence coding for thephenotype complementing polypeptide, and harvesting the polypeptide. Themethod of introducing the nucleic acid molecule into the host cell will,as those of skill in the art will readily recognise, depend on theselected host cell system and the expression vector used as it isdescribed hereinbefore,

[0075] Likewise, the method of culturing the host cells including thecomposition of the cultivation medium and temperature conditions, andthe harvesting processes, will depend on the host cell type and can bedetermined by those of skill in the art.

[0076] Whereas the polypeptide of the invention can be used as such forpharmaceutical purposes as the active component of pharmaceuticalcompositions, its therapeutic use by genetic therapy is alsocontemplated. Accordingly, the invention relates in one aspect to amethod of inducing, in a vertebrate animal, the production of apolypeptide that is capable of at least partially complementing thephenotype of an animal having the anx/anx genotype as described inMaltais et al. (1984), or a similar genotype, the method comprisingadministering to the animal the nucleic acid molecule or at least thesequence coding for the complementing polypeptide as described herein.

[0077] Accordingly, the nucleic acid molecule that comprises thesequence coding for the phenotype complementing polypeptide, with orwithout a signal sequence, can be used for regulation of food or feedintake and/or for regulating body weight, such as for treatment ofobesity, by administration thereof via gene therapy. Gene therapystrategies for delivery of the nucleic acid molecule construct canutilise viral or non-viral vectors in in vivo or ex vivo modality.Expression of the coding sequence can be induced using endogenousmammalian or heterologous promoters. Expression of the coding sequencein vivo can be either constitutive or inducible.

[0078] For delivery of the nucleic acid molecule comprising the codingsequence using viral vectors, any of a number of viral vectors may beused including those described in Jolly, Cancer Gene Therapy, 1994,1:51-64. The coding sequence can be inserted into plasmids designed forexpression in retroviral vectors, adenoviral vectors, adeno-associatedviral vectors or sindbis vectors. Promoters that are suitable for usewith these vectors include as examples the Moloney retroviral LTR, CMVpromoter and the mouse albumin promoter. Replication competent freevirus can be produced and injected directly into the animal or human orby transduction of an autologous cell ex vivo, followed by injection invivo.

[0079] The coding sequence can also be inserted into a non-viraldelivery system, such as a plasmid, for expression of the polypeptide invivo or ex vivo. For in vivo administration the coding sequence can bedelivered by direct injection or by intravenous infusion. Promoterssuitable for use in this manner include endogenous and heterologouspromoters such as e.g. CMV. The coding sequence can be injected in aformulation comprising buffers or other agents that can stabilise thecoding sequence and facilitate transduction thereof into cells and/orprovide targeting.

[0080] After it has been expressed and harvested according to methoddescribed hereinabove, the phenotype complementing polypeptide can bepurified to provide an isolated polypeptide that is capable of at leastpartially complementing the phenotype of an animal having the anx/anxgenotype as described in Maltais et al. (1984), or a similar genotype.The purification and, optionally, folding of the polypeptide can becarried out using conventional methods of isolating and purifyingproteins including, but not limited to, precipitation, chromatography,filtration, ultrafiltration and reverse osmosis procedures. If required,the purification of the polypeptide may imply a degree of purity wherethe polypeptide preparation is essentially free of other polypeptides.

[0081] The isolated polypeptide can be used in a variety of ways as itwill be described in the following. For example, the polypeptide,optionally in conjunction with suitable carriers, can be administered toanimals and humans intravenously, subcutaneously or orally in atherapeutically or prophylactically effective amount in methods ofregulating food or feed intake or body weight including weight gaininhibition, in a vertebrate animal, the method comprising administeringa food or feed intake regulating amount of the polypeptide according tothe invention. The specific amount to be administered depends on thecondition to be treated.

[0082] The expression “therapeutically or prophylactically effectiveamount” is generically the amount of the polypeptide that will provide adesired therapeutic or prophylactic result either in respect ofregulating food or feed intake or in respect of a desired control ofbody weight, i.e. weight gain inhibition or, optionally weight gainenhancement. The precise inhibitory amount varies depending on thehealth and physical conditions of the individual to be treated, thecapacity of the individual's ability to adjust to the change inregulation of food intake and metabolism and body size, the formulationand other relevant factors.

[0083] As an alternative to administering the polypeptide of theinvention as described above, it is also contemplated that food or feedintake in a vertebrate animal can be regulated by administering to theanimal an effective amount of a molecule that blocks or inhibits orenhances the biological activity of the phenotype complementingpolypeptide of the invention. Such a blocking, inhibiting or enhancingmolecule can be selected from an antibody capable of binding to thepolypeptide, a receptor capable of binding to polypeptide, an antagonistthat prevents the polypeptide from binding to its receptor, an agonistsubstance that enhances the biological activity of the polypeptide, andany other molecule that blocks, inhibits or enhances the biologicalactivity of the polypeptide. In the present context, the term “receptor”indicates a structure, generally a protein, located on or in a cell,e.g. in the membrane, that specifically recognises a sequence of aminoacids of the phenotype complementing polypeptide so as to bind to itwith a higher affinity than to a random polypeptide. Such an interactionbetween the polypeptide and the receptor is generally expected totrigger an intracellular response.

[0084] As it is mentioned above, the polypeptide of the invention can beused in a pharmaceutical composition comprising the polypeptide asdefined herein, and a pharmaceutically acceptable carrier. Theexpression “pharmaceutically acceptable carrier” refers to a carrier foradministration of a therapeutic or prophylactic agent, such as thepolypeptide of the invention or antibodies, and refers to anypharmaceutical carrier that does not in itself induce the production ofantibodies harmful to the individual receiving the composition, andwhich can be administered without undue toxicity effects. Suitablecarriers may be large, slowly metabolised macromolecules such asproteins, polysaccharides, polylactic acids, polyglycolic acids,polymeric amino acids, amino acid copolymers, and inactive virusparticles. Such carriers are well known to those of ordinary skill inthe art. The carrier may be a pharmaceutically acceptable salt such ase.g. mineral acid salts such as hydrochlorides, hydrobromides,phosphates, sulphates and the like, and the salt of organic acids suchas acetates, propionates, malonates, benzoates and the like. Adiscussion of pharmaceutically acceptable excipients can be found inRemington's Pharmaceutical Sciences (Mack Publ. Co., N.J. 1991).Pharmaceutically acceptable carriers in therapeutic compositions maycontain liquids such as water, saline, glycerol and ethanol. Inaddition, auxiliary substances such as wetting or emulsifying agents, pHbuffering substances and the like, may be present in such vehicles.Typically, the therapeutic compositions of the invention are provided asinjectables, either as liquid solutions or suspensions, solid formssuitable for solution in, or suspension in, liquid vehicles prior toinjection may also be used.

[0085] The pharmaceutically acceptable carrier as defined above can alsobe used in pharmaceutical compositions that comprise a molecule thatblocks, inhibits or enhances the biological activity of the polypeptideaccording to the invention where the molecule is selected from the groupconsisting of an antibody capable of binding to the polypeptide, areceptor capable of binding to the polypeptide, an antagonist thatprevents the polypeptide from binding to its receptor, an agonistmolecule that enhances the biological activity of the polypeptide, andany other molecule that is capable of binding to the polypeptide or apharmaceutically active part thereof and which blocks, inhibits orenhances its biological activity.

[0086] In a further aspect, the invention provides a method of isolatinga molecule that is capable of interacting with the phenotypecomplementing polypeptide as defined herein. This method comprises asthe first step that the polypeptide is provided as described abovefollowed by permitting the polypeptide to react with cells or fragmentsor extracts thereof to form a binding pair, and separating from thebinding pair the molecule member that binds to the polypeptide. As usedherein, the term “binding pair” refers to a pair of molecules such ase.g. a protein/protein pair, a protein/RNA pair or a protein/DNA pair inwhich the components of the pair bind specifically to each other with ahigher affinity than to a random molecule such that upon binding, e.g.in case of a ligand/receptor interaction. Specific binding indicates abinding interaction having a low dissociation constant, whichdistinguishes specific binding from non-specific, background binding.The molecules which can be isolated using the method include an antibodycapable of binding to the polypeptide or a fragment hereof, a receptorcapable of binding to the polypeptide or to a fragment of thepolypeptide, an antagonist that prevents the polypeptide from binding toits receptor, e.g. an antibody to the receptor, an agonist molecule thatenhances the biological activity of the polypeptide, and any othermolecule that is capable of binding to the polypeptide.

[0087] The phenotype complementing polypeptide of the invention can beused to generate monoclonal or polyclonal antibodies. Accordingly, theinvention provides in a further aspect a monoclonal or a polyclonalantibody comprising at least one binding site that is capable of bindingto the polypeptide encoded by the nucleotide sequence as defined above.Such antibodies to the polypeptide can be prepared by conventionalmethods, e.g. by immunising a suitable animal such as a mouse, rat,rabbit or goat. Immunisation is generally performed by mixing oremulsifying the polypeptide in saline, preferably in combination with anadjuvant such as Freund's complete adjuvant, and injecting the mixtureor emulsion. The immunisation may be boosted 2-6 weeks with one or moreinjections.

[0088] Like any other antibodies, the resulting antibodies, whetherpolyclonal or monoclonal, can be labelled using conventional techniques.Suitable labels include chromophores, fluorophores, radioactive labels,electron-dense reagents, enzymes and ligands having specific bindingpartners. In this context, “specific binding partner” refers to aprotein capable of binding a ligand molecule with high specificity suchas in the case of an antigen and an antibody specific herefor. Otherspecific binding partners include biotin, avidin or streptavidin, IgGand protein A.

[0089] The antibodies generated in this manner can be used in anyconventional applications including for diagnostic and therapeuticpurposes. E.g., as a diagnostic, they can be used in an immunoassay foridentification or detection of a polypeptide of the invention or ahomologue thereof in a sample suspected of containing the polypeptide.For this purpose, the antibodies can be labelled with a suitable marker,such as a radioactive label, and allowed to react with the sample. Afteran appropriate reaction time, the sample is examined for the presence ofspecific binding pairs. Presence of specific binding suggests that apolypeptide of the invention is present in the sample. The antibodies,when used for diagnostic purposes, can be a part of kits for detectionof the phenotype complementing polypeptide of the invention.

[0090] Additionally, the antibodies to the polypeptide can be used fortherapeutic purposes for blocking the in vivo biological activity of thepolypeptide. When used as therapeutics, the antibodies are preferablycompatible with the host subjected to such treatment. E.g. when used forhumans, the antibodies can be human antibodies or humanised antibodies,as this term is generally known in the art. The humanised antibodies canbe made by any conventional methods for that purpose. e.g. bycomplementary determining region grafting, veneering, phage librarydisplay or by use of xeno-mice.

[0091] As mentioned above, the invention pertains in one aspect to amethod of detecting the presence of a polypeptide as defined herein, ora homologue of said polypeptide, the method comprising contacting anantibody capable of binding to the polypeptide with a sample suspectedof containing the polypeptide or the homologue thereof to allowformation of a polypeptide/antibody complex, i.e. a binding pair asdefined hereinbefore, and detecting the complex. The immunoassays whichcan be used for that purpose can be designed to meet specificrequirements, e.g. determined by the nature of the sample to be assayed.Generally, protocols for the immunoassay can e.g. be based oncompetition, direct reactions for sandwich type assays. Protocols mayalso include the use of solid supports or they may be byimmunoprecipitation. The assays which can be used in accordance with theinvention may involve the use of labelled antibodies to the polypeptideor labelled target polypeptides. Useful labels include fluorescent,chemiluminescent, radioactive or dye molecules. Assays which amplify thesignals from the probe can also be used. Examples hereof include assayswhich utilise biotin or avidin and enzyme labelled and mediatedimmunoassays such as ELISA assay. The immunoassays can, if desired, bedesigned so as to determine the amount of polypeptide antigen that ispresent in a sample.

[0092] An immunoassay utilising the antibodies to the phenotypecomplementing polypeptide can be used for any biological sample, such asa blood sample, a serum sample, a tissue sample including as examples asample of brain tissue or a sample of pancreas tissue.

[0093] In yet another aspect the invention relates to an isolatedmolecule that interacts with a polypeptide according to the inventionincluding such a polypeptide that is produced by the above method ofproducing the polypeptide. Such a molecule includes a monoclonal or apolyclonal antibody as described above, and a receptor molecule as alsodefined above.

[0094] A receptor molecule can e.g. be identified and isolated byreacting cells, cell membranes or extracts with a suitably labelledpolypeptide of the invention. The mixture is then examined for presenceof specific binding to the labelled polypeptide and the binding pairsformed can be separated by conventional techniques, such as by use ofsolvents or denaturing reagents for by passage through a column thatselectively binds one member of the binding pair, and eluting theopposite member, i.e. the receptor molecule, with an appropriatesolvent. The receptor molecule can be purified by conventionaltechniques and the amino acid sequence thereof can then be determined.Based on the amino acid sequence identified, an oligonucleotide probecan be made to probe a cDNA or genomic library and clones that hybridiseto the probe can be amplified and sequenced. A cDNA clone that encodes afull length receptor can be used for recombinant production of largequantities of the receptor, useful for further studies into themechanism of regulation of food intake and/or body weight and to obtainagonists and antagonists thereto.

[0095] In a useful aspect of the present invention there is provided amethod of producing an antibody to the above molecule that is capable ofinteracting with the polypeptide of the invention, including an antibodyor a receptor molecule. Such an antibody can be produced by anyconventional method as it is described above including that animmunologically effective amount of the molecule is administered to ananimal and that sera containing antibodies against the receptor orspleen cells for the production of monoclonal antibodies against themolecule are collected from the immunised animals.

[0096] Such antibodies, whether monoclonal or polyclonal can be used inimmunoassays, such as it is described above, for detecting moleculesthat are capable of binding to the polypeptide of the invention.Generally, an immunoassay for such purposes involves that the aboveantibody is reacted with cells or fragments or extracts thereof to forma binding pair, and detecting the presence of the binding pair.

[0097] A particularly interesting use of antibodies to a receptor forthe polypeptide of the invention is to block, reduce or inhibit thebiological activity of the polypeptide in vivo. Accordingly, suchantibodies can be used as therapeutic agents and be provided informulations or pharmaceutical compositions that are suitable for thatpurpose.

[0098] The polypeptide of the invention, optionally in a form where itis provided with a detectable label including those mentioned above, canbe provided as a part of a kit for detection of a receptor for thepolypeptide or for detection of antibodies to the polypeptide.

[0099] It is a further objective of the invention the provide a methodof identifying in a sample a target nucleotide sequence that codes for aputative phenotype complementing polypeptide as defined herein. For thatpurpose any DNA- or RNA-containing sample can be collected from ananimal of interest including a human. The method involves that anucleotide sequence as defined hereinbefore or a complementary strandhereof, or a part or fragment thereof, which is preferably provided witha detectable label, e.g. a radioactive label, is contacted with thesample to be tested under hybridising conditions to form a binding pairand subsequently detecting the presence of the binding pair. The membersof the binding pair can then be separated e.g. by a denaturingtreatment. The isolated target member can be used as the starting pointfor a recombinant production of a polypeptide according to theinvention.

[0100] It is also, as mentioned above, an objective of the invention toprovide a method of controlling in an animal the expression of anucleotide sequence coding for a phenotype complementing polypeptide ofthe invention. This method comprises as a first step that a moleculethat inhibits the translation of a transcript of the coding sequence isprovided, followed by administering to the animal a translationinhibiting effective amount of said molecule. In accordance with theinvention, presently preferred translation inhibiting molecules includeantisense RNA and PNA.

[0101] The invention is further described in the following examples andthe drawings wherein:

[0102]FIG. 1 illustrates genetic linkage maps of the anx interval ofmouse Chromosome 2. The percentage recombination ±1 SE is indicated foreach genetic interval. Centromere at the top (filled circle) andtelomere at the bottom;

[0103]FIG. 2 is a physical map spanning the anx interval on mouseChromosome 2 as described and defined in Example 1. The map is not drawnto scale. The relative positions of genes and markers, shown above themap, were deduced form the genetic linkage map and their presence andabsence in clones. Chromosome centromere to the left and telomere to theright. Clones are identified by type of clone and number. Open boxindicates internal deletion within the clone. ^(A)Chartier et al. (1990)Nature Genet. 1, 132;^(B)http://carbon.wi.mit.edu:8000/cgi-in/mouse/yac_info?yac=281_H_(—)8&database=mouserelease;^(C)P1library derived from E14 (129/Ola) ES cells; ^(D)BAC library RPCI-23,segment two (BACPAC Resources, Oakland, Calfi.); ^(E)PAC library RPCI-21(BACPAC Resources, Oakland, Calif.). Genes identified: lp3k (clone IDP1-Ltk); EMBL No. baa92641 (clone ID P1 Ltk); DII4, EMBL No. aaf76428(clone ID 356H20); Vps18, EMBL No. baa95999 (clone ID 356H20); Epa6,EMBL No. epab_mouse (clone ID 356H20); EMBL No. mmaa11531 (clone ID356H20); EMBL No. q9ulg1 (clone ID 356H20); EMBL No. q9vci9 (clone ID356H20); Chp, EMBL No. q9z1y0 (clone ID 356H20); S27-1, EMBL No.aad56582 (clone ID 356H20); Fabe, EMBL No. fabe_mouse (clone ID 348L16); Mga, EMBL No. q9qxj5 (clone ID 348 L16); JNK, EMBL No. q9r010(clone ID 348 L16); CPLA2-beta, EMBL No. q9ukv7 (clone ID 348L16); p22,EMBL No. rn39875 (clone ID 365N11);

[0104]FIG. 3 is the sequence of gene S27-1, EMBL No aad56582, exonsequences are indicated with letters in bold (also in the followingfigures);

[0105]FIG. 4 is the sequence of gene DII4, EMBL No. aaf76428;

[0106]FIG. 5 is the sequence of gene Vps18, EMBL No. baa95999;

[0107]FIG. 6 is the sequence of gene Epa6, EMBL No. epab_mouse;

[0108]FIG. 7 is the sequence of gene EMBL No. mmaa1531;

[0109]FIG. 8 is the sequence of gene EMBL No. q9ulg1;

[0110]FIG. 9 is the sequence of gene EMBL No. q9vci9;

[0111]FIG. 10 is the sequence of gene Chp, EMBL No. q9z1y0;

[0112]FIG. 11 is the sequence of gene Fabe, EMBL No. fabe_mouse;

[0113]FIG. 12 is the sequence of gene Mga, EMBL No. q9qxj5;

[0114]FIG. 13 is the sequence of gene JNK, EMBL No. q9r010;

[0115]FIG. 14 is the sequence of gene CPLA2-beta, EMBL No. q9ukv7;

[0116]FIG. 15 is the sequence of gene EMBL No. baa92641;

[0117]FIG. 16 is the sequence of gene Ltk;

[0118]FIG. 17 is the sequence of gene Ip3k; and

[0119]FIG. 18 is the sequence of gene Tyro 3.

EXAMPLE 1 Identifying the anx Interval in Mouse Chromosome 2

[0120] Material and Methods.

[0121] 1. Markers and primers

[0122] All markers were simple sequence length polymorphisms (SSLPs) andwere tested by PCR. The D2Mit markers were obtained from ResearchGenetics, Huntsville, Ala. The markers were chosen based on thechromosomal map position reported in the Chr2:Integrated MIT SSLP andCopeland/Jenkins RLFP Genetic Maps(http://carbon.wi.edu:8000/cgi-bin/mouse/sts_by_chrom). The D2Jojoprimer pairs, with predicted annealing temperatures of 55° C. or higher,were designed around simple repeats located in the clones covering theanx interval.

[0123] The forward primer was labelled with γ-³²P-dATP as follows:

[0124] F primer (6,7 μM), 0.125 μl/sample; 10× PNK buffer,1.6 μl; T4 PNK(10U/μl), 1 μl/16 μl reaction; γ-³²P (6000 Ci), 0.03 μl/sample; H₂O to16 μl final volume.

[0125] 2. PCR protocol

[0126] The PCR was performed according to the following protocol.

[0127] Labelling reaction mixture, 16 μl; R primer (6,7 μM), 0.125μl/sample, dNTPs (5 mM), 0.4 μl/sample; 10× PCR buffer (0.5M KCl, 15 mMMgCl₂, 100 mM Tris, 0.1% gelatin),1 μl/sample; Taq (5U/μl), 0.1μl/sample; DNA, 2 μl; H₂O to 10 μl final volume.

[0128] 95° C., 5 minutes; 95° C., 30 seconds; 50-60° C., 30 seconds(temperature optimised for each marker); 72° C., 30 seconds; 35 cycles;72° C., 10 minutes; 4° C.

[0129] After the PCR had been carried out, the products were separatedon a 6% denaturing polyacrylamide gel, National Diagnostics, Atlanta,GE, at 90V for approximately 1.5 hrs. The gel was then transferred to anX-ray film that was exposed for a period of time in the range of twohours to a couple of days.

[0130] 3. DNA Preparation

[0131] DNA was prepared from 2-5 mm mouse tail snips as follows:

[0132] Add 1 ml of Tail Solubilisation Buffer (TSB) (1×SET [10×SET: 10%SDS, 50 mM EDTA, 100 mM Tris (pH 8.0)], 100 mM NaCl, 200 μg/mlproteinase K) to the tail snip. Incubate for about 4 hrs at 55° C. todigest tail.

[0133] Add 400 μl Tail Salts [4.21M NaCl, 0.63M KCl, 10 mM Tris (pH8.0)] and vortex thoroughly. Incubate overnight at 4° C. to precipitateproteins.

[0134] Centrifuge the tubes for 10 minutes at maximum speed in amicrofuge.

[0135] Remove 100 μl supernatant and precipitate the DNA with 200 μl 95%EtOH for 20 minutes at −70° C. or 4 hrs at −20° C.

[0136] Pellet the DNA in a microfuge at maximum speed for 20 minutes.

[0137] Remove supernatant and resuspend the DNA in 100 μl water or TE.

[0138] 2 μl of DNA suspension was used in a PCR reaction.

[0139] 4. Breeding and Mapping Scheme and Results

[0140] The anx mutation arose at The Jackson Laboratory (TJL), BarHarbor, Me., in 1976 in the F2 generation of a cross between strain DW/Jand an inbred strain derived from a cross of M. m. poschiavinus to aSwiss stock. The anx mutation has since then been kept on a nonagoutihybrid background referred to as B6C3-a/a F1. A general treatise ofmouse genetics can be found in Mouse Genetics, Lee M. Silver, OxfordUniversity Press, New York, 1995.

[0141] When starting a new linkage study in mice, two questions must beaddressed. First, what strains should be used and second, what type ofbreeding scheme is suitable. To map a mutationally defined locus it isrequired to start with one strain that carries the mutation. This strainis then crossed with another strain that should be selected based on thegenetic distance between the two strains—the larger the distance, thebigger chance is there to identify polymorphisms at DNA marker loci. Thechoice of breeding scheme is usually limited to one of two approaches:backcross or intercross. The nature of the phenotype may limit thischoice even further. With both approaches, the first mating will alwaysbe an outcross between the two parental strains. Once F1 hybrid animalshave been generated, it must be decided whether to backcross them to oneof the parental strains or to intercross them with each other. There aredisadvantages and advantages with both breeding scheme approaches. Inthis study it was decided to use the intercross approach to map the anxgene. The intercross has two major advantages over the backcrossapproach. The first is that it can be used to map recessive lethalmutations, such as the anx mutation, since both heterozygous F1 parentswill be normal. The second advantage is that informative meiotic eventswill occur in both parents leading to twice as much information on a“per animal” basis as compared to the backcrossing.

[0142] anx breeding mice (B6C3-a/a-a +/+anx) were obtained from TJL. Theanx gene had already been mapped to Chromosome 2 and two intercrosseswere set up to narrow the anx interval further. Cross 1 comprises 2050F2 progeny (4100 meioses) of an (B6C3Fe-anx A/+a×B6C3H Fl) intercross.Cross 2 was set up between B6C3Fe-anx A/+a and CAST/Ei and 372 F2progeny (744 meioses) from this cross were analysed.

[0143] The mapping project was initiated by identifying polymorphicmarkers in the area to which the anx locus had been mapped,approximately 20cM proximal of the agouti locus on mouse Chromosome 2(Maltais et al., 1984). Approximately 100 markers from ResearchGenetics, Huntsville, Ala., were tested and about 20% of these turnedout to be polymorphic. The polymorphic markers were tested on the F2progeny from both of the above crosses. As all of the anorexic mice hadto have the genotype anx/anx at the mutation site, it was possible towork out how closely linked to the mutation the markers were, based onhow many anorexic mice were recombined (showed an anx/+or +/+genotype)at those specific loci. A marker whose variant co-segregates with theanorexic phenotype is close to the gene controlling the phenotype. Theorder of the markers closest to the mutation is shown in FIG. 1. Threeanimals showed recombination between markers D2Jojo5 and anx (FIG. 1)thus defining D2Jojo5 as the distal flanking marker.

[0144] One F2 progeny from cross 2 identified D2Mit133 as the proximalflanking marker. The anx mutation was found to co-segregate with themarkers D2Mit104, D2Mit395 and D2Jojo8. Recombination frequencies andstandard errors were calculated as described by Green (1981). Geneticdistances are shown in FIG. 1 as percentage recombination ±1 SE.

[0145] These results are backed up by a large number of recombinationson either side of the interval. All markers within the interval arenon-recombinant and closely linked to the mutation.

EXAMPLE 2

[0146] Establishing a Contig Covering the Identified anx Interval.

[0147] The distal end of the anx interval was covered by a YeastArtificial Chromosome (YAC) spanning from Capn3 (distal to D2Jojo5) toD2Mit395, including Ltk and Tyro3 (Aamir Zuberi, The Jackson Laboratory,personal communication). When searching the Whitehead database(http://carbon.wi.mit.edu:8000/cgi-bin/mouse/index) for YACs containingthe other loci known to map within or close to the anx interval, one YACwas identified that not only spans the proximal end of the anx interval,but also overlaps with the distal YAC (FIG. 2).

[0148] In order to further characterise the interval, three libraries (aP1 library derived from E14 (129/Ola) ES cells, PAC-RPCI-21 andBAC-RPCI-23) were screened for clones spanning the anx interval. The P1library was screened by successive rounds of PCR with primers specificfor D2Mit133, D2Mit104, D2Mit395 and Ltk. Four P1 clones were recovered(one for each locus). These clones were partially sequenced to obtainSTS markers to be used as probes in the screening of the twoRPCI-libraries. The clones were assembled in the order established fromthe genetic linkage map. The clones were linked together with STSmarkers generated from the ends of the clone inserts. In some cases thelibraries were rescreened to find overlapping clones. FIG. 2 shows therelative order of markers, STS loci and the clones that span theinterval between D2Mit133 and Capn3. Total DNA was isolated from clonesusing a CsCl gradient ultra-centrifugation or a modified Qiagenmidi-prep protocol (Sambrook et al., 1989; Pinkel et al., 1998).

[0149] Materials and methods.

[0150] 1. Partial sequencing of clone inserts

[0151] Partial sequences from the clones were generated usingappropriate primers using the following reaction mixture: 2 μg DNA; 8 μlBIG Dye (Amersham); 20 pmol primer; H₂O to 20 μl final volume.

[0152] The sequencing reaction was performed during 100 cycles oframping at temperatures in the range of 50° C. to 96° C. as follows:$\left. {\begin{matrix}{{96^{\circ}\quad {C.}},{30\quad {seconds}}} \\{1^{\circ}\quad {C.\text{/}}\sec \quad {to}\quad 50^{\circ \quad}{C.}} \\{{50^{\circ}\quad {C.}},{5\quad {seconds}}} \\{1^{\circ}\quad {C.\text{/}}\sec \quad {to}\quad 60^{\circ \quad}{C.}}\end{matrix}} \right\} 100x$

[0153] 60° C., 4 minutes

[0154] 4° C

[0155] 2. Purification of Samples

[0156] The samples were then purified according to the below protocolusing Sephadex G50 microtiter filter plates (Millipore). Sephadex G50(Pharmacia Biotech), 10 g/l 30 ml.

[0157] Fill the wells with Sephadex. Place a collection microtiter plateunder the filter plate.

[0158] Centrifuge at 1500 rpm for 2 minutes. Empty the collection plate.

[0159] Fill the wells again and repeat centrifugation.

[0160] Add the sequencing reactions. Place a clean collection plateunder the filter plate.

[0161] Centrifuge as above.

[0162] Vacuum dry the samples collected and store at −20° C. untilneeded.

[0163] Add loading dye and load the samples onto the ABI gel.

[0164] 3. Providing labelled probes

[0165] The STS loci generated were PCR amplified and used as probes whenscreening the PAC-RPCI-21 and BAC-RPCI-23 libraries (BACPAC Resources,Oakland, Calif.). The probes were labelled using a standard RandomPriming protocol (Current Protocols in Molecular Biology, 3.5.9-3.5.10).Finally, the probes were purified using QiaQuick Nucleotide removal kit(Qiagen, Venlo, the Netherlands).

[0166] 4. Hybridization

[0167] The following hybridisation conditions were used:

[0168] The filters containing the libraries were pre-hybridised inhybridisation solution at 42° C. for 2 hrs. Then new hybridisationsolution including labelled probes (denatured at 95° C., 5 minutes) wasadded and the filters were left to hybridise overnight. The filters werewashed once for 15 minutes at room temperature (2× SSC, 0.1% SDS)followed by another wash for 15 minutes (0.1× SSC, 0.1% SDS). If thefilters were still very hot the last wash was repeated.

[0169] Hybridisation solution: 2% SDS, 5× SSC, 10× Denhardt's solution,50 mM P-buffer (pH 6.5), 50% formamide, salmon sperm DNA.

[0170] The filters were wrapped in saran wrap and applied onto an X-rayfilm that was exposed overnight and optionally for several days. Thepositive clones were obtained from Roswell Park, Buffalo, N.Y. Whichclone had which marker was determined as follows:

[0171] Each clone was inoculated on a Nylon N⁺ membrane on top of aLB+50 μl/ml kanamycin plate. The clones were allowed to grow at 37° C.overnight. Then the membrane was treated as follows:

[0172] 1. 0.5M NaOH, 1.5 M NaCl for 15 minutes, then dry.

[0173] 2. 0.5M Tris pH 7.5, 1.5M NaCl for 10 minutes, then dry.

[0174] 3. 0.5M Tris pH 7.5,1.5M NaCl, 50 μg/ml proteinase K for 30minutes, then dry.

[0175] 4. 2× SSC for 10 minutes, scrape off the colonies, then dry.

[0176] 5. Stratalink.

[0177] The filters were then hybridised (conditions see above) with eachof the probes separately to determine which clone corresponded with thedifferent probes. The other markers within the interval were tested onthe new PACs by PCR. The results are summarised in FIG. 2.

EXAMPLE 3 Showing that Tyro3 is Down Regulated in anx/anx Mice

[0178] 3.1. Summary

[0179] A differential display analysis was performed on total RNAextracted from whole brain from newborn anx/anx (n=2) and +/+ (n=3)mice, and three weeks old anx/anx (n=3) and +/+ (n=3) mice. The analysiswas done by Lark Technologies, Inc. using the Hieroglyph mRNA ProfileKit (Beckman Coulter, Inc., Fullerton, Calif.) and the genomyx LR System(Beckman Coulter, Inc., Fullerton, Calif.) to generate and display largeamplified fragments. Differently expressed bands were excised from thegel, reamplified and, when necessary, subcloned prior to sequencing byLark Technologies, Inc.

[0180] The differential display analysis identified 102 bands differingin expression levels between anx/anx and +/+ mice of one or both ages.When analyzing the bands it was discovered that one band that wasmissing in anx/anx mice of both ages was identical to the 3′UTR ofTyro3. To confirm this, a Northern blot and mRNA in situ hybridizationwas performed on brain tissue from both anx/anx and +/+ mice. Theseexperiments confirmed a down regulation of Tyro3 mRNA in cerebellum ofanx/anx mice.

[0181] 3.2. Materials and Methods

[0182] 1. Northern blotting

[0183] The Northern blot was performed using the following protocols:

[0184] (i) Providing a total RNA preparation

[0185] Total RNA was isolated from whole brain using Trizol (LifeTechnologies) according to the manufacturer's protocol.

[0186] (ii) Northern Blotting Gel

[0187] In the Northern blotting a 1,5% agarose gel was used. 200 ml ofthe gel was prepared by adding 3 g agarose to 150 ml DEPC-treated waterfollowed by boiling to dissolve the agarose. To the solution 40 ml 5×MOPS (see below) was added and when cooled to 50° C., 10.8 mlformaldehyde was added. Prior to blotting the RNA, the gel was treatedby rinsing in DEPC-treated water at least two times, in 50 mM NaOH for20 minutes followed by rinsing in DEPC-treated water and in 20× SSC for45 minutes.

[0188] (iii) Northern Blotting Procedure

[0189] The gel was prerun for 5 minutes at 100V in 1× MOPS. Total RNAsamples were prepared by adding 10-12 μg of total RNA in 5 μl transferbuffer and vacuum dried if necessary, followed by adding 10 μl loadingbuffer. The resulting sample mixtures were denatured at 65° C. for 3-5minutes.

[0190] The samples and an RNA ladder (3 μg) were loaded on the sideleaving at least two empty lanes between ladder and samples and the gelswere run at 40-50V. The BPB band was permitted to run approximately 10cm. After running, the ladder was cut off, washed in 1× MOPS followed bystaining with EtBr for 20-30 minutes and destaining in 0.2M NH40ac for2×30 minutes.

[0191] Prior to blotting the RNA, the gel was treated by rinsing inDEPC-treated water at least twice in 50 mM NaOH for 20 minutes followedby rinsing in DEPC-treated water and in 20× SSC for 45 minutes.

[0192] Set up the blot (see Maniatis). Use 7,5 mM NaOH as transferbuffer and Hybond N+ membrane. Let it sit for at least 4,5 hours.

[0193] Rinse the membrane in 2× SSC, 0.1% SDS.

[0194] Stratalink.

[0195] (iv) Reagents Used

[0196] 5× MOPS buffer:

[0197] The buffer contains 0.1 M MOPS (pH 7.0), 40 mM NaOAc, 5 mM EDTA(pH 8.0) and is prepared as follows: For 1 liter 20,6 g MOPS is added to800 ml DEPC-treated NaOAc. pH is adjusted to 7.0 with 2M NaOH. 10 mlDEPC-treated EDTA is added. Bring to 1 liter with DEPC-treated water.Filter sterilise (Nalgene 0.2 μm) and store at room temperatureprotected from light.

[0198] Loading buffer:

[0199] The loading buffer used had the following composition: 7.2 mldeionized formamide, 3.2 ml 5× MOPS, 2.6 ml 37% formaldehyde, 1 ml 80%glycerol, 800 μl saturated bromphenol blue, 200 μl water.

[0200] 2. Northern Hybridization

[0201] (i) Preparation of probe

[0202] The probe was labelled using a standard Random Priming protocol(Current Protocols in Molecular Biology, 3.5.9-3.5.10). Finally, theprobe was purified using OiaQuick Nucleotide removal kit (Qiagen, Venlo,the Netherlands).

[0203] (ii) Hybridization Procedure

[0204] The hybridisation solution used contained per 100 ml: 8 ml 25%SDS, 20 ml 25× SSC, 10 ml 100× Denhardt solution, 5 ml 1 M phosphatebuffer (pH 6,5), 50 ml formamide, 50% 1 ml ssDNA (denatured) and 6 mlwater.

[0205] Pre-hybridisation of the sample was carried out for at least 1hour at 42° C. (6 hours if the membrane has never been used before). Usea Tupperware container and just enough solution to cover the membrane.The hybridisation solution was replaced and the probe previouslydenatured at 95° C. for 5 minutes was added. Hybridisation was doneovernight. Following hybridisation, the membranes were rinsed in 2× SSC,0,1% SDS followed by washing in 2× SSC, 0,1% SDS for 15 minutes at roomtemperature and in 0,1× SSC, 0,1% SDS for 15 minutes at roomtemperature. If the membrane is still very hot a further was in 0,1×SSC, 0,1% SDS at 65° C. for 5-15 minutes may be carried out.

[0206] After a final wash in 2× SSC for 10-30 minutes, the membrane iswrapped in saran wrap and an autoradiography film exposed overnight withthe membrane.

[0207] 3. mRNA in Situ Hybridization

[0208] Brains to be tested were collected on postnatal day 20-22. Bothmale and female mice were analyzed. For in situ hybridization, thebrains were rapidly dissected from decapitated mice and immersed inphosphate-buffered saline (PBS). Brains were mounted on chucks andrapidly frozen at −70° C.

[0209] A 45-mer antisense oligonucleotide, complementary to nucleotides2411-2455 of Tyro 3 (Acc.no. U18343) was used. The oligonucleotide wassubsequently labeled with ³⁵S-dATP (NEG 034H, NEN DuPont, Zaventem,Belgium) at the 3′ end using terminal deoxydinucleotidyl transferase toa specific activity of 2×10⁹ cpm/μg and purified using QIAquickNucleotide Removal Kit (Qiagen, Venlo, the Netherlands).

[0210] The frozen brains were cut in 14 μm serial sections at −17° C. ina cryostat (Jung CM 3000, Leica Instruments GmbH, Nussloch, Germany).The sections were thaw-mounted onto ProbeOn slides (Fisher Biotech,Springfield, N.J.), and processed for in situ hybridization as describedelsewhere (Schalling et al., 1988). In brief, the sections wereincubated at 42° C. for 15-18 hr with 10⁶ cpm of labeled probe per 100μl of a solution containing 50% formamide, 4× SSC (1× SSC: 0.15 M NaCl,0.015 M sodium citrate), 1× Denhardt's solution (0.02% polyvinylpyrrolidone, 0.02% bovine serum albumin and 0.02% Ficoll), 1% sarcosyl,0.02 M sodium phosphate (pH 7.0), 10% dextran sulfate, 500 μg/mlsonicated salmon sperm DNA and 200 mM dithiothreitol. The sections weresubsequently rinsed in 1× SSC at 55° C. for one hour with five changesof buffer, following which they were dried and exposed to Hyperfilmβ-max X-ray film (Amersham International, Little Chalfront, UK) forseven days before development and fixation. Some of the sections weresubsequently dipped in NTB 2 nuclear track emulsion (Kodak, Rochester,N.Y.), followed by two weeks of exposure, developed in Kodak D19, fixedin Kodak 3000A and analyzed using a microscope equipped for darkfieldillumination (Axiophot, Carl Zeiss, Oberkochen, Germany). Pictures fromthese emulsion radiographs were taken using T-MAX 100 film (Kodak).

[0211] 4. Mutation Analysis

[0212] Mutation analysis was performed by exon sequencing of genomicDNA. In short: each exon was PCR amplified and cycle-sequenced using anABI 377 equipment. No mutations could be found in any of the exons. Thepromoter sequence was also searched for mutations but without success.

[0213] 5. Conclusions

[0214] Tyro3 is down regulated in anx/anx mice compared to normal littermates. While no mutations were found in this gene it is still possiblethat its down regulation contributes to the phenotype of anx/anx mice.

REFERENCES

[0215] 1. Broberger, C., J. Johansen, M. Schalling and T. Hökfelt(1997). Hypothalamic Neurohistochemistry of the Murine anorexia(anx/anx) Mutation: Altered Processing of Neuropeptide Y in the ArcuateNucleus, J. Comp. Neurol. 387:124-135.

[0216] 2. Broberger, C., J. Johansen, C. Johansson, M. Schalling and T.Hökfelt (1998). The neuropeptide Y/agouti gene-related protein (AGRP)brain circuitry in normal, anorectic, and monosodium glutamate-treatedmice, Proc. Natl. Acad. Sci. USA 95:15043-15048.

[0217] 3. Broberger, C., J. Johansen, H. Brismar, C. Johansson, M.Schalling and T. Hökfelt (1999). Changes in Neuropeptide Y Receptors andPro-Opiomelanocortin in the Anorexia (anx/anx) Mouse Hypothalamus, J.Neurosci 19:7130-7139.

[0218] 4. Green, M. C. (1981). Gene mapping, In “The mouse in BiomedicalResearch” (H. L. Foster, J. D. Small and J. D. Fox, Eds.), pp. 105-117,Academic Press, New York.

[0219] 5. Johansen J. E., C. Broberger, C. Lavebratt, C. Johansson, M.J. Kuhar, T. Hökfelt, M. Schalling (2000). Hypothalamic CART and serumleptin levels are reduced in the anorectic (anx/anx) mouse. Mol. BrainRes. 84:97-105.

[0220] 6. Pinkel, D., R. Segraves, D. Sudar, S. Clark, I. Poole, D.Kowbel, C. Collins, W. L. Kuo, C. Chen, Y. Zhai, S. H. Dairkee, B. M.Ljung, J. W. Gray, D. G. Albertson (1998). High resolution analysis ofDNA copy number variation using comparative genomic hybridization tomicroarrays. Nature Genet. 20:207-211.

[0221] 7. Sambrook, J., E. F. Fritsch, T. Maniatis. Molecular cloning; alaboratory manual. Cold Spring Harbor Laboratory Press, Cold SpringHarbor, N.Y.

[0222] 8. Schalling, M., K. Seroogy, T. Hökfelt, S -Y. Chai, H. Hallman,H. Persson, D. Larhammar, A. Ericsson, L. Terenius, J. Graffi, J.Massoulié and M. Goldstein (1988). Neuropeptide tyrosine in the ratadrenal gland—Immunohistochemical and in situ hybridization studies,Neuroscience, 24:337-349.

1 206 1 1318 DNA Rattus sp. 1 tgagttgggt ccctggaacc acacagtggaaagagaactg tctgccacaa gttgtcctct 60 gtcctccaca cgcacagtga cacatgccctcattcacccc agtgtgcacg gcatcaataa 120 atgtaattgc ttttttagat gtatttacttttgatgtgta tgagtatttg cctggatgaa 180 agtatgtgca cagactttag atgcccctggaaccagagtt acagatagtt gtgaaccacc 240 atgctagtgc caggaaccaa acccaatttctgtaagagtg ctcttgcttg cttagccttc 300 tcaccagccc tctagtttaa attaaagcaacaaacaaaca aacaagtgat gaagaattgc 360 atgaaggaaa agtaaactta agaaaataatagccggttgt ggtggtacac gctggtagga 420 tttgctgaaa gaggcagagg caggaggattgtgagtttga ggccagccta ggctacacat 480 tagcctttct ggtggtgaca acctccctaagagagcaggc ctcgaaaagg atctctttca 540 tccctctact gaggagaaga ggaaatgcaagaaaaatcgc ctggtgcaga gccctaattc 600 ctactttata gatgtgaaat gcccaggatgctataaaatc accatggtct ctagccatgc 660 acaaatggta gtcttgtgtg ttggctgctccactgtcctg tcagcctaca ggtgggaaag 720 caaggctgac agaaagacgc tccttcaggaggaagcagca ctgaaagccc ctgactcaag 780 atgagtggga accttcccaa taaacacattttgaatataa gaaaaaagaa aataataaca 840 atgtctaagg attagccttg tagctcaggcctgctgtcct agcattcagg aggcaagaga 900 gtagaatggt catgaggctt gttttgggggtacagagtaa ggcttggtct caaacaacaa 960 cagcaataac aaactggaca tggtagtacgagttatgtca tagttctcag gagaagcatc 1020 aggaattcaa agtcatcttc acggatacctggtaagttca aggctatcct gggccacata 1080 gtgagttcta agtctgcttg ggacacataagaccctgtcc caaaaagcaa aatatataaa 1140 gcgtatatat atttttaaaa gatttatttattgtatataa gtacactgta gctgtcttta 1200 aacataccag aaaagggcac cagatctcattacagatggt tgtgagccat catatggttg 1260 ctgggaattg acctcaggac ctctggaagagcagtcagtg ctcttaaccg ctgagcca 1318 2 1378 DNA Mus musculus 2 tctggaaaggaaagggagat ccaaatcccc tggtcctgct ttttgctttc ctagtttaag 60 ctttccccacctgctagagg actgtaggta tctaatgcct ggatcaggtg caccgcctac 120 ggggaccccttagagtttcc accccctgga ccattcggga accacctcac ctcccgccgc 180 atcactgggctaccctccta tcctctggtg gcgagggtct cagcctttaa gcagacgatc 240 tctaaggactgctcgccggg cacgcgcaga gctggaagcc cagaagttgg aagaggggcg 300 gggacctgcgccctactggc tggctgacag ggggagcggc gggggcggag gccccctccg 360 gtgggtgctgggactgtagc cactagaggc ctggagggga ggggagagtg accgtgagtc 420 tgtctgactgacaggctgcg aagagcagcc aatatatata agaaaggctc tggagcaagc 480 aggtttcagtagcggcgctg ctcgcaggct aggaacccga ggccaagagc tgcagccaaa 540 gtcacttgggtgcagtgtac tccctcacta gcccgctcga gaccctagga tttgctccag 600 gacacgtacttagagcagcc accgcccagt cgccctcacc tggattacct accgaggcat 660 cgagcagcggagtttttgag aaggcgacaa gggagcagcg tcccgagggg aatcagcttt 720 tcaggaactcggctggcaga cgggacttgc gggagagcga catccctaac aagcagattc 780 ggagtcccggagtggagagg acaccccaag ggatgacgcc tgcgtcccgg agcgcctgtc 840 gctgggcgctactgctgctg gcggtactgc cgcagtgggt aatgtctcac gtcctctccg 900 ccccctcccgcagcgctccg ggcttgcgcc ccggccccgg ctgagcctga ccgctctcct 960 ccctccttctctcggtccct gtgcagcagc gcgctgcggg ctccggcatc ttccagctgc 1020 ggctgcaggagttcgtcaac cagcgcggta tgctggccaa tgggcagtcc tgcgaaccgg 1080 gctgccggactttcttccgc atctgcctta agcacttcca ggcaaccttc tccgagggac 1140 cctgcacctttggcaatgtc tccacgccgg tattgggcac caactccttc gtcgtcaggg 1200 acaagaatagcggcagtggt cgcaaccctc tgcagttgcc cttcaatttc acctggccgg 1260 taagcacaacttaaatgcac cgggagataa ccgaagggaa agaagggagc gccgggacac 1320 cagagctcctttccaaagcg ctctctggag agccccaagg gctctttctc ttctgccc 1378 3 1273 DNA Musmusculus 3 cagtagcggc gctgctcgca ggctaggaac ccgaggccaa gagctgcagccaaagtcact 60 tgggtgcagt gtactccctc actagcccgc tcgagaccct aggatttgctccaggacacg 120 tacttagagc agccaccgcc cagtcgccct cacctggatt acctaccgaggcatcgagca 180 gcggagtttt tgagaaggcg acaagggagc agcgtcccga ggggaatcagcttttcagga 240 actcggctgg cagacgggac ttgcgggaga gcgacatccc taacaagcagattcggagtc 300 ccggagtgga gaggacaccc caagggatga cgcctgcgtc ccggagcgcctgtcgctggg 360 cgctactgct gctggcggta ctgtggccgc aggtaatgtc tcacgtcctctccgccccct 420 cccgcagcgc tccgggcttg cgccccggcc ccggctgagc ctgaccgctctcctccctcc 480 ttctctcggt ccctgtgcag cagcgcgctg cgggctccgg catcttccagctgcggctgc 540 aggagttcgt caaccagcgc ggtatgctgg ccaatgggca gtcctgcgaaccgggctgcc 600 ggactttctt ccgcatctgc cttaagcact tccaggcaac cttctccgagggaccctgca 660 cctttggcaa tgtctccacg ccggtattgg gcaccaactc cttcgtcgtcagggacaaga 720 atagcggcag tggtcgcaac cctctgcagt tgcccttcaa tttcacctggccggtaagca 780 caacttaaat gcaccgggag ataaccgaag ggaaagaagg gagcgccgggacaccagagc 840 tcctttccaa agcgctctct ggagagcccc aagggctctt tctcttctgcccccgccccc 900 ctgttctctc ataggatcat cccggagagg ctttggttag tctttcctcccagtttcttc 960 cctttccttc tccccaattc ttgggatacg aatttcatta ccaaacccccaacgcggcgc 1020 cgcccgccca ccccccggct ctcacttaca ctcccgcatc cctcatccctcccctgcctt 1080 ctcagctcgc gcgcagcgct gcgcgaacac cagttatgtt gagccgagctccgtaactat 1140 atcctgcaat tagattaatt aaacaggctg ctgcgaggca ccccctcctttccctccctg 1200 ctgatatcgc tatctctaat gtcccccacc cccccttttg cttcccagggaaccttctca 1260 ctcaacatcc aag 1273 4 1058 DNA Mus musculus 4 gttgcccttcaatttcacct ggccggtaag cacaacttaa atgcaccggg agataaccga 60 agggaaagaagggagcgccg ggacaccaga gctcctttcc aaagcgctct ctggagagcc 120 ccaagggctctttctcttct gcccccgccc ccctgttctc tcataggatc atcccggaga 180 ggctttggttagtctttcct cccagtttct tccctttcct tctccccaat tcttgggata 240 cgaatttcattaccaaaccc ccaacgcggc gccgcccgcc caccccccgg ctctcactta 300 cactcccgcatccctcatcc ctcccctgcc ttctcagctc gcgcgcagcg ctgcgcgaac 360 accagttatgttgagccgag ctccgtaact atatcctgca attagattaa ttaaacaggc 420 tgctgcgaggcaccccctcc tttccctccc tgctgatatc gctatctcta atgtccccca 480 cccccccttttgcttcccag ggaaccttct cactcaacat ccaagcttgg cacacaccgg 540 gagacgacctgcggccaggt gagtatctaa cttctcggcc acaggggggc gacatcacac 600 agcgccgaaagagttaacca gttataggcg ggggtggggg ttggggacgc aggcttgggg 660 ggtgggggccaggacgctta gcttggccgg agctgcgccc cgcgctggac gctcggattc 720 cgctcgctgcctggactcag agcacaattg cgtttcctgc gggttatttt tggcgtggga 780 acgcggggagcacggcggtg agaaaggccg aggctgccag cgccgctgac gggcctcttc 840 ctgtattttacaccttttgc gaattccgct cctttggaaa gggaataatg gctttgggat 900 gttgttctgacacagaggaa aaggatattt caccagcaca acaattctca ctttgaaaag 960 gaaaaagaaaaaccattacc tacgtctaga acagaacccc ttgctcccag ttctcgaacc 1020 agaaaacttccccctttaaa ttttttcttt ttttccat 1058 5 1264 DNA Mus musculus 5 cgctcctttggaaagggaat aatggctttg ggatgttgtt ctgacacaga ggaaaaggat 60 atttcaccagcacaacaatt ctcactttga aaaggaaaaa gaaaaaccat tacctacgtc 120 tagaacagaaccccttgctc ccagttctcg aaccagaaaa cttccccctt taaatttttt 180 ctttttttccattttgacct cttttcctct ttcccctccg tatctgcctc cacaacccta 240 ggatatcttaacatccgtcc attgtaccct tttttgaatg ctatcaagcc ccctgcacat 300 gcacacacccagggagacta agtagcaaga ttctgggacc ctctggcctg tgcttacttg 360 caggtagagttaatctagat aattagagtg tgaactgacc accatagtca caactaaaga 420 gagagttggcagcagtcaac tctctctgaa tcaggttggc tttctgaatc aggttctctg 480 accaaagcctctttctgcag agacttcgcc aggaaactct ctcatcagcc aaatcatcat 540 ccaaggctctcttgctgtgg gtaagatttg gcgaacagac gagcaaaatg acaccctcac 600 cagactgagctactcttacc gggtcatctg cagtgacaac tactatggag agagctgttc 660 tcgcctatgcaagaagcgcg atgaccactt cggacattat gagtgccagc cagatggcag 720 cctgtcctgcctgccgggct ggactgggaa gtactgtgac cagcgtaagt agccaggccc 780 cctgtgagaatagaagggat gggattttcc caagaaagca ctcagaatgg gtctgtgctg 840 ggtctcaggaccagctgggg atgctgtact gtacccttag tctcagagcc tcctccgcag 900 tgcttaagcctacagggtcc ttattcttca tcccatgcag tgtgatgttc tcccaccccc 960 tcgtcccctggtccccttta agataaccat ggctcctctt ggaggccaag agcaggaagt 1020 gagcccaggggagcaggaga ggaggttgaa gcttcagagt ccatggtacc acaacctcat 1080 ccagcccaatttcttttcct tagctatatg tctttctggc tgtcatgagc agaatggtta 1140 ctgcagcaagccagatgagt gcatgtaagt ggggacagga aacgggagta ggggggctct 1200 cccttgtgagcaggtctccc atcttacact gggctcccct cttgtcttaa cagctgccgt 1260 ccag 1264 61061 DNA Mus musculus 6 actgagctac tcttaccggg tcatctgcag tgacaactactatggagaga gctgttctcg 60 cctatgcaag aagcgcgatg accacttcgg acattatgagtgccagccag atggcagcct 120 gtcctgcctg ccgggctgga ctgggaagta ctgtgaccagcgtaagtagc caggccccct 180 gtgagaatag aagggatggg attttcccaa gaaagcactcagaatgggtc tgtgctgggt 240 ctcaggacca gctggggatg ctgtactgta cccttagtctcagagcctcc tccgcagtgc 300 ttaagcctac agggtcctta ttcttcatcc catgcagtgtgatgttctcc caccccctcg 360 tcccctggtc ccctttaaga taaccatggc tcctcttggaggccaagagc aggaagtgag 420 cccaggggag caggagagga ggttgaagct tcagagtccatggtaccaca acctcatcca 480 gcccaatttc ttttccttag ctatatgtct ttctggctgtcatgagcaga atggttactg 540 cagcaagcca gatgagtgca tgtaagtggg gacaggaaacgggagtaggg gggctctccc 600 ttgtgagcag gtctcccatc ttacactggg ctcccctcttgtcttaacag ctgccgtcca 660 ggttggcagg gtcgcctgtg caatgaatgt atcccccacaatggctgtcg tcatggcacc 720 tgcagcatcc cctggcagtg tgcctgcgat gagggatggggaggtctgtt ttgtgaccaa 780 ggtgagtaag ggaaggagag atggggtggc agggcctgaaactagagatg gtgactggac 840 acctttcttg gtggtcagta actgactttc ctattattctattattgttc aaggacaagt 900 ctcaggactt gtctatgtgc acatgtgtgt gtgtggtgtgtgtgtgtgtg tgtgaggtat 960 taggaatgga actcagggtc tctaacatac taggcaagcactccacctgt gagctctacc 1020 ccagtccact cactgctttt aaaggctctt tacaactgac c1061 7 1131 DNA Mus musculus 7 ctgtgaccag cgtaagtagc caggccccctgtgagaatag aagggatggg attttcccaa 60 gaaagcactc agaatgggtc tgtgctgggtctcaggacca gctggggatg ctgtactgta 120 cccttagtct cagagcctcc tccgcagtgcttaagcctac agggtcctta ttcttcatcc 180 catgcagtgt gatgttctcc caccccctcgtcccctggtc ccctttaaga taaccatggc 240 tcctcttgga ggccaagagc aggaagtgagcccaggggag caggagagga ggttgaagct 300 tcagagtcca tggtaccaca acctcatccagcccaatttc ttttccttag ctatatgtct 360 ttctggctgt catgagcaga atggttactgcagcaagcca gatgagtgca tgtaagtggg 420 gacaggaaac gggagtaggg gggctctcccttgtgagcag gtctcccatc ttacactggg 480 ctcccctctt gtcttaacag ctgccgtccaggttggcagg gtcgcctgtg caatgaatgt 540 atcccccaca atggctgtcg tcatggcacctgcagcatcc cctggcagtg tgcctgcgat 600 gagggatggg gaggtctgtt ttgtgaccaaggtgagtaag ggaaggagag atggggtggc 660 agggcctgaa actagagatg gtgactggacacctttcttg gtggtcagta actgactttc 720 ctattattct attattgttc aaggacaagtctcaggactt gtctatgtgc acatgtgtgt 780 gtgtggtgtg tgtgtgtgtg tgtgaggtattaggaatgga actcagggtc tctaacatac 840 taggcaagca ctccacctgt gagctctaccccagtccact cactgctttt aaaggctctt 900 tacaactgac ctaaaatggg atggtgggacattcttctcc acatcctaaa gagccaggat 960 gactaaagag gccaggggta acagcttggcagcctgcagc tcatactcat aaattctagc 1020 aagactaaag agaaagggaa ggttagcgctgttcctcttt ctgccttgta gttacctatt 1080 aaccccctga gtgtttgctc accttccaaggctctcccct aaacagctgt c 1131 8 1170 DNA Mus musculus 8 tgctttgtctggctctccct ccttgttctt ctccaacaag aaaacaaata gctatcattc 60 aaaatacactttcaacacct cctttagaag atgccggtcc tgcctgtagt ggctcttatg 120 ccccctcactctttccacct gttgaatttt tactcttcct tctagtcctt ccaggcatgc 180 acctcctctatgaagccttt cctgacttcc tcattggcta agggcctctt cttcatcttg 240 ctctggctggaaatgtttgt gagcataccc agcaggatgc tggccaattg tgctttgtct 300 cccacttttggtatacgtat acagtttaga tgtagtttca ggcgagtgaa tgctcaggat 360 ttcacaggcagagaaaggag ggatgcctgg gcctggaaaa cttatgagtt taaacttctt 420 tgggccaaatacagggtgat cttgagtgga ggtgggagag ttcctggtcc cactcagctg 480 gttttttcctgtctccacag atctcaacta ctgtactcac cactctccgt gcaagaatgg 540 atcaacgtgttccaacagtg ggccaaaggg ttatacctgc acctgtctcc caggctacac 600 tggtgagcactgtgagctgg gactcagcaa gtgtgccagc aacccctgtc gaaatggtgg 660 cagctgtaaggtgagaccca catcagctca ggaaggcaca ggtctaacca ggtagcatcc 720 agtcagtgtggttgtatatg catgcatgga tgggcactct ggacaagtag aggctaggca 780 ccaacctcatacatccttgt cccatccccc gggcccaact ttagcctgtt tatattctct 840 ctccaggaccaggagaatag ctaccactgc ctgtgtcccc caggctacta tggccagcac 900 tgtgagcatagtaccttgac ctgcgcggac tcaccctgct tcaatggggg ctcttgccgg 960 gagcgcaaccaggggtccag ttatgcctgc gaatgccccc ccaactttac cggctctaac 1020 tgtgagaagaaagtagacag gtgtaccagc aacccgtgtg ccaatggtaa gctcttctgt 1080 caccttaccaacctgctgaa gtggccccgg ggccagagag cctgagaaaa tcgtgaggag 1140 agagacctgtctgctattgt ggtcaggctg 1170 9 1220 DNA Mus musculus 9 tgaatgctcaggatttcaca ggcagagaaa ggagggatgc ctgggcctgg aaaacttatg 60 agtttaaacttctttgggcc aaatacaggg tgatcttgag tggaggtggg agagttcctg 120 gtcccactcagctggttttt tcctgtctcc acagatctca actactgtac tcaccactct 180 ccgtgcaagaatggatcaac gtgttccaac agtgggccaa agggttatac ctgcacctgt 240 ctcccaggctacactggtga gcactgtgag ctgggactca gcaagtgtgc cagcaacccc 300 tgtcgaaatggtggcagctg taaggtgaga cccacatcag ctcaggaagg cacaggtcta 360 accaggtagcatccagtcag tgtggttgta tatgcatgca tggatgggca ctctggacaa 420 gtagaggctaggcaccaacc tcatacatcc ttgtcccatc ccccgggccc aactttagcc 480 tgtttatattctctctccag gaccaggaga atagctacca ctgcctgtgt cccccaggct 540 actatggccagcactgtgag catagtacct tgacctgcgc ggactcaccc tgcttcaatg 600 ggggctcttgccgggagcgc aaccaggggt ccagttatgc ctgcgaatgc ccccccaact 660 ttaccggctctaactgtgag aagaaagtag acaggtgtac cagcaacccg tgtgccaatg 720 gtaagctcttctgtcacctt accaacctgc tgaagtggcc ccggggccag agagcctgag 780 aaaatcgtgaggagagagac ctgtctgcta ttgtggtcag gctgactgaa acaggctcct 840 ctttggtttggagggtgaag aactttatgc attatggaga gtagggcttt ggagaagaag 900 gtcatcgataggctgtaggt gagggtagtg cccatctgta tgacctctgt tcttattcca 960 tgggtgagcctctgcctgac aaggctagct tgtgccctcc tcaggaagcc ttgaattaga 1020 aaaaaggatgttggaggctt cacattccct tttcaaggga ggctggtgat agagctctgt 1080 accttgaagcctcatcttcc ccgacattca cctagaacaa gtgtagcaca aagaatctgg 1140 aatacccagtgctttttgat acacagaaca cgttggtagg tgatggtcta agaggcaggc 1200 aggcaggcaggcaaccattc 1220 10 1703 DNA Mus musculus 10 gatggtctaa gaggcaggcaggcaggcagg caaccattca ggagctgaca aggccctggg 60 agtggcaatg tgatctattcgcactctcct gtgcgtggtc tatactattc taccttgcgt 120 cttccctact gatcctcagggctacctgtg aaaggatcaa attctccagt ttagcaggtg 180 aggaaaccaa gactaagggatcaggtgaag ctacaggtgt cagatcccct gccagagaga 240 tcaagccaag catatctgtctgaccctaaa ttctggaaga cgccagtaac tattatccaa 300 tagcccactg tggcatagagaaccaggatt accccagagg ccaggacttt ggagtctttg 360 tacagttctc tgtagagagctctctgtcca cgcaggctga acacacggtg gtagaagagc 420 ttaagctcgt gggggagacctcattccctt cacccgggaa tccacaggct attgctgatg 480 cgggtcctgt gcccttacaggaggccagtg ccagaacaga ggtccaagcc gaacctgccg 540 ctgccggcct ggattcacaggcacccactg tgaactgcac atcagcgatt gtgcccgaag 600 tccctgtgcc cacgggggcacttgccacga tctggagaat gggcctgtgt gcacctgccc 660 cgctggcttc tctggaaggcgctgcgaggt gcggataacc cacgatgcct gtgcctccgg 720 accctgcttc aatggggccacctgctacac tggcctctcc ccaaacaact tcgtctgcaa 780 ctgtccttat ggctttgtgggcagccgctg cgagtttccc gtgggcttgc cacccagctt 840 cccctgggta gctgtctcgctgggcgtggg gctagtggta ctgctggtgc tcctggtcat 900 ggtggtagtg gctgtgcggcagctgcggct tcggaggccc gatgacgaga gcagggaagc 960 catgaacaat ctgtcagacttccagaagga caacctaatc cctgccgccc agctcaaaaa 1020 cacaaaccag aagaaggagctggaagtgga ctgtggtctg gacaagtcca attgtggcaa 1080 actgcagaac cacacattggactacaatct agccccggga ctcctaggac ggggcggcat 1140 gcctgggaag tatcctcacagtgacaagag cttaggagag aaggtgccac ttcggttaca 1200 caggtaagcc acacctggaagcccatagct tggtcacaga cccttccata gtttgacagg 1260 atctcctagg ctgagtgggaggctggcatc aggccttggc aacttttaat caagtaagat 1320 tgtagtactg acaagaagacactctagtta catttatttt tttttgtggg gggtggggtg 1380 gggttttttg agacaaagtttctctgtgta gccctagctg tcctggaact cactttgtag 1440 accaggctgg cctccaactcagaaattcac ctgcctctgc ctcccgagtg ctgggattaa 1500 aggcgtgcgt caccacgccaggcttctagt tacatttcta tagggaccca ggcacagtgg 1560 cacagacttt gtagccctacctacttaggc taagacagga ggattgctag tttgatgcta 1620 gcctgggtaa catagcagcagatcatgtct caaaaacatt gagatggctc agagagtaaa 1680 ggcacctgct gccaagcctggtg 1703 11 1109 DNA Mus musculus 11 ttctgagttc gaggccagcc tggtctacaaagtgaattcc aggacagcca gggctacaca 60 gagaaaccct gtttcaaaaa accaaaaaaccaaaaaaaaa aaaaaaaaaa agaattctgc 120 taggaatctt ttactaggga agtccctctcattcattcat tcattcattc attcattcat 180 tcattcagtc ttaactccca aataccaagtgtccacagta tatctctcgt ggtttccatc 240 ttcccacagt agggcttgtc tctagtggcaatactggctt ttttctggtt tggtcggctc 300 ctgtagctcc cttagaggcc tattctaaccccctgcccct gaaggccagc actgagcatc 360 ctccccgatg ccctccccga acccctccggacccctgcag cacataccct aaaggggatc 420 tctgggatct agactgacag ctccttgcttgtcccctccc tattccttcc ttcttacctc 480 cctgtcttct gttccttcag tgagaagccagagtgtcgaa tatcagccat ttgctctccc 540 agggactcta tgtaccaatc agtgtgtttgatatcagaag agaggaacga gtgtgtgatt 600 gccacagagg tgagttcttc cctctaagcatgtcccctcc tgctttgtgt ggtgggaaaa 660 aaatgtcctg ttcactagca atctcattcctgaaggggtg ggtcagagat ctcttctttg 720 gtgtgtagtg gctcttgggt gccctgctggccccattgcc acagagggag tgatactgga 780 gccaggtggt atgcctgact tggcagctgtgccagggaaa gggacatagt caaggagcag 840 gagaaggctc aggcagagct ttcaggaactatttcccact tgcctttggg tgaagacaca 900 gggttacctg tgtctgcttc ctccattgaactcctcttgt gtgtcttaga gcaggaggct 960 gagggtacta actccctcag tggtgtctcctagagaggtc cagagcacct ctggatcatt 1020 gcataccgcc cccccccacc cccggtataaccattttccc attttgtatg tgatccccag 1080 gtataaggca ggagcctact cagacaccc1109 12 2029 DNA Mus musculus 12 agaggaacga gtgtgtgatt gccacagaggtgagttcttc cctctaagca tgtcccctcc 60 tgctttgtgt ggtgggaaaa aaatgtcctgttcactagca atctcattcc tgaaggggtg 120 ggtcagagat ctcttctttg gtgtgtagtggctcttgggt gccctgctgg ccccattgcc 180 acagagggag tgatactgga gccaggtggtatgcctgact tggcagctgt gccagggaaa 240 gggacatagt caaggagcag gagaaggctcaggcagagct ttcaggaact atttcccact 300 tgcctttggg tgaagacaca gggttacctgtgtctgcttc ctccattgaa ctcctcttgt 360 gtgtcttaga gcaggaggct gagggtactaactccctcag tggtgtctcc tagagaggtc 420 cagagcacct ctggatcatt gcataccgcccccccccacc cccggtataa ccattttccc 480 attttgtatg tgatccccag gtataaggcaggagcctact cagacaccca gctccggccc 540 agcagctggg ccttccttct gcattgtttacattgcatcc tgtatgggac atctttagta 600 tgcacagtgc tgctctgcgg aggaggaggaaatggcatga actgaacaga ctgtgaaccc 660 gccaagagtc gcaccggctc tgcacacctccaggagtctg cctggcttca gatgggcagc 720 cccgccaagg gaacagagtt gaggagttagaggagcatca gttgagctga tatctaaggt 780 gcctctcgaa cttggacttg ctctgccaacagtggtcatc atggagctct tgactgttct 840 ccagagagtg gcagtggccc tagtgggtcttggcgctgct gtagctcctg tgggcatctg 900 tatttccaaa gtgcctttgc ccagactccatcctcacagc tgggcccaaa tgagaaagca 960 gagaggaggc ttgcaaagga taggcctcccgcaggcagaa cagccttgga gtttggcatt 1020 aagcaggagc tactctgcag gtgaggaaagcccgaggagg ggacacgtgt gactcctgcc 1080 tccaacccca gtaggtggag tgccacctgtagcctctagg caagagttgg tccttcccct 1140 ggtcctggtg cctctgggct catgtgaacagatgggctta gggcacgccc cttttgccag 1200 ccaggggtac aggcctcact ggggagctcagggccttcat gctaaactcc caataaggga 1260 gatgggggga agggggctgt ggcctaggcccttccctccc tcacacccat ttctgggccc 1320 ttgagcctgg gctccaccag tgcccactgctgccccgaga ccaaccttga agccgatctt 1380 caaaaatcaa taatatgagg ttttgttttgtagtttattt tggaatctag tattttgata 1440 atttaagaat cagaagcact ggcctttctacattttataa cattattttg tatataatgt 1500 gtatttataa tatgaaacag atgtgtacaggaatttatta cttcttgggt cctatctgtg 1560 taatagcaga gtggggatct ttttcctgcctccctatccc aaattcaaag ccccttatct 1620 tctcactgtg gagtggctct gcgggaaccccagggcctgt gtatgcttgg gtttgccatg 1680 ttgtgtagaa gggtggtctt tgggtagcctggccttggcc tcctgtgcct ggtgacttta 1740 agcctgggtg ttcctactcc actttaagttccatggggct attttcccct gccttgattt 1800 tctcccattg aggaagagcc tctcattacttattcaaaag tgctctttta ttagatcatg 1860 agtgtcgtcc cctcgggtac ttcctcctgccactggggca tttgggttgt actggcacct 1920 gcacttctgg tactagtgtg gaactggtctgggttgagga aggggagggg atctgcccta 1980 gatttatctt tttcgaagtt gggcagagctgaagggatgg ctgaggcta 2029 13 1368 DNA Homo sapiens 13 gaaaaaaaaaaaaaatccag gtcttatacc cgctgggcaa ggtgcttatg caccactgag 60 ccacacttgtgacccattca gctacttcct ctggaagcta gggggccctg gggtgaaaga 120 agggacactcagactgttct gcctgtgcct gtgaaggtgg actgaggcag caattcgatt 180 gaggaacaggaggtagtgtg acagatggag gagcaccgcc ggcctttcag tgacagtctg 240 agggagtgaagtctgagctg cggaagccta ggatccgcgc aagcctgtta ctggacgccg 300 ctgggaaatcccgggctgcc tcctagcgcc aacatgagga actgcagcag cagggtggcc 360 cgcaagcgctcctcccccgc cgcgccgagt ctccgacaac gcctccttgt ggaggctcag 420 gtgcccaggactccagttaa cactcgcggc tgaaaaaccc ggaagcacgt cataagcacg 480 cgtcacgggggcgggagtca gctgagctgc ctgggcgagg ttgtgattac ctgggatctg 540 ctaaggggagcctataatct cttgggactg gagctggggt gcaaagctgc gccatggact 600 agttggggctcctcgatcgt ctcgtccttc acagagaaag cgaaaagggc cccagaattt 660 ttaaaaggttctcaggatct gtcagacgct ggggaagcac aacttgcaaa tccaggacga 720 ccggggtcccagttgtgacc cccagccccc agatcagaga tccagaactt gattgccatg 780 gcgtccatcctggatgagta cgaggactca ttgtcccgct cggccgtctt gcagactggt 840 tgccctagcgtgggcatccc ccattctggt aagttagaag aggccgcctc tgcccctttc 900 tgttatggtagcatttacgg gggagagaag ctctagagct tgcagcgtgt gtttaggatc 960 taagccccaggcctttcttg tcttgcccag cttgtcattg gtcgaagttt gaaagagcca 1020 caggaacagcctcgtgatct aggccttaac tcaaaggtcc ttcaaaagag ggaacttggg 1080 ctcagataaggaagtacttg ttacttttgt ctataggctg cagttgggag aactgaatat 1140 aggttccaggcttctgtgtc ttgttctatg gatttttttt aaagcttttg gagtctgtgt 1200 atgtgttcgttcccaccaga cttcatcttg aggtagcaga ggaggcagaa tgagcactga 1260 acttggtggaacgtgaatgt tataagtgaa ggagggtcga tccaaaaggg aattttgtta 1320 ctgaacaggaacaatggaga tgattgtccc ggggtaaagc tggctgca 1368 14 1142 DNA Homo sapiens14 gcagggttac ccacactatg atgatattgc agcggactat cgagaaagca actgtagcct 60atgaactgga ctgataggac tgggttccca gaactctcta catacaatgg agactcactg 120aaccatactg tgtggacagc aaggaaggga ctttagtttc tcttggccaa agaccataag 180ggagaatgcc aaaaccatcc tccctgtact gtctcccccc acccccgtta ccactgggaa 240cgtgcatatc atgatacaac ctcatctcag gcacagagaa ccaatccctt actactgtca 300caagtgtggg aagagcccag gacccttcca ataaagacaa ccagaaaact atttcatgtt 360gaactcttta tgaaccaaga ccctgtgggt aggaatatac ttgggaagca gaagtatcag 420ctaacactgg ggtttctctg ggtttctggg tgcctcaccc ccctctggac gcctttttct 480cttgtcttcc ccacctatag ggtatgtaag tgcccacctg gagaaggagg tgcccatctt 540caccaagcag cgggttgact tcaccccctc ggagcggatc actagcctcg tggtctcctg 600caatcagctc tgcatgagcc tgggcaagga tacactgctc cggtagtatc tttggagact 660tttagctgac tagggtcttt ttccatactt agcaaatgac acaatagctt ttcaggagat 720gcactattcc ttcccaaaga gaaccagtgt ggtggctgaa gatcagagag aactatgttc 780agattccacc catgctgttg aacgagtcag ctaatcattc tggtctttca acagggggaa 840aggtgctctc agcctcccag agttagccac acagatcatt gggacagtct ggaatcctga 900agtatgtccg ctatttgcca aaagtgttga cagcgttgtt tatcatttgg gataagccat 960ctggaataag acagttagac ctctgtccca caaggatgaa tcccagcacg aatagttatt 1020agaacaacgg gtgttgggat tgtggcccag tgatagagta cctggcattc ctgaggcctt 1080gggtttgatt cccggcactg caaatgaaat gctgtagata agtgaggctg gagttctgtt 1140gg 1142 15 865 DNA Homo sapiens 15 aaaaaaaaag gaagaaagac aagaaaaaagttagcatagt aataataaaa tgctttagtt 60 gtttatctga accaagacgt ttagtctcactaggaaagca ctcccatgcg tatacatctg 120 catcacagat atcttgtgtt gtgttttgttttggagacag ggtctcctgt agctcaaggc 180 tgtgactccc taaccagccg tctaccccactcaagtgcta gagctacaaa tgttcaaatc 240 tagtagtaaa cagcgctggc aaaggtacagggaagaggac tgccacgcct ggcacactga 300 gggcctagtg cccacatggc agccaacaactccagttcta gggggaccca gcaccttcct 360 ctgacttcca tgggttcctg cacacatgatacgcttacat gcattcatga acaacatgta 420 cacattaagt aaattaatta attaatattttaagaagggg gacttctctt gagagtgaca 480 actaactctt gcccttacag cattgacttgggcaaggcaa gtgagcccaa ccgtgtggaa 540 ctggggcgca aggacgacgc caaagtccacaagatgttcc tggaccatac tggtgagtgg 600 cgctggagat ctgaggaggc ttcctgtgagagttcactga tgatgggcgg gatctgaacg 660 ggggtggggt ggggatgggg ggactcgaggtccactcagt gctgttttcc atccgcccca 720 ggctctcatc tgctggttgc gctgagtagcaccgaggtcc tttacatgaa ccgcaatgga 780 cagaaggccc ggcccctggc tcgctggaagggacagctgg tggagagtgt gggatggaac 840 aaggccatgg gcaacgagag cagca 865 161152 DNA Homo sapiens modified_base (644)..(844) a, t, c, g, other orunknown 16 agctacaaat gttcaaatct agtagtaaac agcgctggca aaggtacagggaagaggact 60 gccacgcctg gcacactgag ggcctagtgc ccacatggca gccaacaactccagttctag 120 ggggacccag caccttcctc tgacttccat gggttcctgc acacatgatacgcttacatg 180 cattcatgaa caacatgtac acattaagta aattaattaa ttaatattttaagaaggggg 240 acttctcttg agagtgacaa ctaactcttg cccttacagc attgacttgggcaaggcaag 300 tgagcccaac cgtgtggaac tggggcgcaa ggacgacgcc aaagtccacaagatgttcct 360 ggaccatact ggtgagtggc gctggagatc tgaggaggct tcctgtgagagttcactgat 420 gatgggcggg atctgaacgg gggtggggtg gggatggggg gactcgaggtccactcagtg 480 ctgttttcca tccgccccag gctctcatct gctggttgcg ctgagtagcaccgaggtcct 540 ttacatgaac cgcaatggac agaaggcccg gcccctggct cgctggaagggacagctggt 600 ggagagtgtg ggatggaaca aggccatggg caacgagagc agcannnnnnnnnnnnnnnn 660 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnnnnnnnnnnnn 720 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnnnnnnnnnnnn 780 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnnnnnnnnnnnn 840 nnnncgagct cggtaccctg gtcggcacag ctcaaggaca gatctttgaagcagagctct 900 cagctagcga gggtggcctc tttggccctg ccccagatct ctacttccgtccactgtatg 960 tgttaaatga agaagggggt ccagcccctg tgtgctccct cgaggctgagcgtggccccg 1020 atggccgagg ctttgtcatt gccaccactc ggcagcgcct cttccagttcataggccgag 1080 ctgtggaaga tactgaagcc cagggcttcg caggactctt tgctgcctatacagaccacc 1140 cgcccccatt cc 1152 17 2719 DNA Homo sapiensmodified_base (291)..(490) a, t, c, g, other or unknown 17 gttcctggaccatactggtg agtggcgctg gagatctgag gaggcttcct gtgagagttc 60 actgatgatgggcgggatct gaacgggggt ggggtgggga tggggggact cgaggtccac 120 tcagtgctgttttccatccg ccccaggctc tcatctgctg gttgcgctga gtagcaccga 180 ggtcctttacatgaaccgca atggacagaa ggcccggccc ctggctcgct ggaagggaca 240 gctggtggagagtgtgggat ggaacaaggc catgggcaac gagagcagca nnnnnnnnnn 300 nnnnnnnnnnnnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 360 nnnnnnnnnnnnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 420 nnnnnnnnnnnnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 480 nnnnnnnnnncgagctcggt accctggtcg gcacagctca aggacagatc tttgaagcag 540 agctctcagctagcgagggt ggcctctttg gccctgcccc agatctctac ttccgtccac 600 tgtatgtgttaaatgaagaa gggggtccag cccctgtgtg ctccctcgag gctgagcgtg 660 gccccgatggccgaggcttt gtcattgcca ccactcggca gcgcctcttc cagttcatag 720 gccgagctgtggaagatact gaagcccagg gcttcgcagg actctttgct gcctatacag 780 accacccgcccccattccgt gagtttccta gcaatttggg gtatagtgag ttggctttct 840 atacccctaagttacgctcg gcacctcgcg cctttgcctg gatgatggga gatggagtgc 900 tgtatggctcactggactgc gggcgtcctg actcgctgct gagtgaggag cgagtgtggg 960 aatacccagcgggggttggt cctggggcca atccaccctt agccatcgtc ctgacccagt 1020 tccatttcctactgctgctg gccgaccggg tggaggctgt gtgcacgcta acagggcagg 1080 tggtgctacgggatcacttc ctggagaagt ttggaccact gaggcacatg gtgaaggact 1140 catccacaggccacctatgg gcctacactg agcgtgcggt cttccgctac catgtgcaac 1200 gtgaggcacgggatgtctgg cgcacctact tggacatgaa ccgctttgac ctggccaaag 1260 agtattgtagagagcggcct gattgcctgg acacggtcct ggcccgagag gctgatttct 1320 gttttcgtcagcatcgctac ctggagagcg cccgctgcta cgcgctgacc cagagctatt 1380 ttgaggagattgccctcaag ttcttggagg cccggcaaga ggaggcgctg gccgagtttc 1440 ttcagcggaaactggccggc ttgaagccga cggagcgtac ccaggccaca ctgctgacca 1500 cttggctgacagagctctac ctgagccgcc tgggtgctct gcagggtgac ccagatgctc 1560 tgactctctaccgggacaca cgggagtgtt tccgtacttt tctcagtagc cctcggcaca 1620 aagagtggctctttgccagc cgggcctcta tccacgagct gctcgccagt cacggagaca 1680 cagagcacatggtgtatttt gcagtgatca tgcaggacta tgaacgggtg gtcgcatacc 1740 actgccagcatgaggcttac gaggaggccc tggctgtgct tgcccgccac cgggaccccc 1800 agctcttctacaaattctcc cccattctca tccgccacat cccccgccag ctcgtagacg 1860 cctggattgagatgggcagc cggctggatg ctcggcagct catccctgcc ctggtgaact 1920 acagccagggcggtgaggcc cagcaggtga gccaggccat ccgctacatg gaattctgcg 1980 tgaatgtgctcggtgagacg gagcaggcca ttcacaacta cctgctgtcc ctgtatgccc 2040 gtggccagccagcctcactt ctggcatacc tggaacaagc tggggccagc ccgcaccgtg 2100 tacattatgatctcaaatat gcacttcgac tttgtgctga gcacggccac caccgcgcct 2160 gcgtccatgtctataaggtg ttggagctat atgaggaggc tgtggacctg gccctgcagg 2220 taagtcttacctttatccag aagagggacc tggagaaaga gcctgagagg ttgggggagg 2280 tgtggctggcgcttgctggc ttctcatgaa gagaagtgct gtgaggcaga ggctgaaact 2340 cagactcagctgagttggtg gtgcaagctc gttgccggta atccctgcac ttgggtgctt 2400 aaggcagaaagagcacagtt taggcaacac cgtgagtccc cgtctttaaa aacaaaaaac 2460 aaaacaaagttagcaggaaa ggaagagggg aaaaaaagaa cacgaattaa ataaaacttt 2520 ggggtttgcattctggcttt gccagcttgc tgtgtgattt ggggctggtt tctatacctc 2580 tctgtgccttagattatcca ttaaatggtg gtaatgagcc agcgagatgg ctcggtaggt 2640 agaagcacttgtacaagcct gacaagctaa gttctgtccc cagagctgat ggtagaagga 2700 gaaaactgactgccgcaaa 2719 18 1916 DNA Homo sapiens 18 tgaacttgcc agcattcctgcttccccctc ctgggtgctg tgctttcagc attaccagct 60 gatctttttt tttttttaatatttatttat ttattattta tttattatta tatgtaagta 120 cactgtagct gtcttcagacactccagaag ggggagtcag atctcattac agatggttgt 180 gagccaccat gtggttgctgggatttgaac tctggacctt cggaagagca gtcgggtgct 240 cttacctgct gagccatctcaccagccccc cagctgatct ttttatatcc actaaaattg 300 cctgccacca aaatagccttccggtagctg tgacagggca gaccaatgca ggttcctgtt 360 gtgcctcttg ctacccggagtgcggagaat cctgcttggg ccctctcctg gggcccagat 420 ttctgtggcc atctgtctttccagtagtct gatgctgggt ggagcgtggc ttgcccctga 480 caccggtggt ttccccacaggtggatgtgg acctggccaa gcagtgtgca gacttgccgg 540 aggaggatga ggaacttcgcaagaaactat ggctcaagat cgcccggcac gtggtgcagg 600 aggaagaaga cgtccagacagccatggcct gcttggccag ctgccccttg ctcaagatcg 660 aggatgtgct gcccttcttccctgactttg tcaccatcga ccacttcaag gaggcaatct 720 gtagttccct gaaggcctacaaccaccaca tccaggagct gcagcgcgag atggaagaag 780 ccacagccag tgcccagcgcatccgacgag acttgcagga gctccgaggc cgctatggca 840 ccgtggagcc ccaggacaaatgctccacct gtgactttcc tttgctcaac cgaccctttt 900 acctgtttct ctgtggccacatgtttcacg ctgactgtct cctacaggct gtgcggcccg 960 gcctccctgc ctacaagcaggccagacttg aggaactgca gcgcaagctt ggggcggcgc 1020 ctcctccgac caaaggctccgtgaaggcca aggaggcaga agctggggct gcagcggtgg 1080 ggcccagtcg ggagcagctcaaggctgacc tggatgagct ggtggctgct gagtgtgtgt 1140 actgtgggga gctgatgattcggtctatcg accggccctt cattgatccg cagcgctatg 1200 aggaggagca cctcagctggctataggaag ttcccccgcg tgggtggaca gacatggatc 1260 cagctgccag accctcctgcgaaagccagg ccctggttgg tgttcggtcc ttgagcttgc 1320 cgggtctgcg attgtgagggggttgcagcc aagcttcagc cgggaggttt tcaggtgcga 1380 acgccgagct gtgcttcagacctgtcttag agctgcccgt cccaggcagc ccgagctggt 1440 gagatcagcc gtgatccttttaaccactac atctaacagt tcctctgttc tcgtcagcat 1500 gttcacctgg actgagtggcccgctgtcct tccttcctcc gtccttccac agcctctgga 1560 cctccagctc gccctcttctgcctcaacta ggtgacccag gagcaagcag gcagacccta 1620 ggcacttgtg gggagagtgggcatgtggag atgctaatgt gacctggggc tccagtgtcg 1680 ggtgccctga ggctgagggcacacctggga caaggggaaa tagggagagt attaaatcac 1740 gctacaatgg tggccctggacttgatggct ttgtgttgat gctgaagcta acaggatatg 1800 atcccaagaa aggatggaatgccacaagaa ggctgcctgc accaagtgtg gaatagaaca 1860 ggtcaggtca cggccagcctagtcgacata ataagttcta ggccagcaaa ggctag 1916 19 1736 DNA Mus Musculus 19cacagatgaa atttgagatt atgataagtg aaaaaagcta ggggttttaa aggcatattg 60tatgactcca attgtataag tattcaaaat tatagagtac tgctgtgctt ttagggaagg 120tagggagagg tttaatgggt atgatatttc agctttgtga ggtgaaaaga attctaggaa 180tggatagtgg tgattgcata atggtatgat tgcactttgt gccccaaact agtcccataa 240ggaaaattaa agccaggcac agaggtgtgc gcctaagtcc cagcactcag gagataaagg 300cattaagatt gtgaaactga gagcagcctg ggctacacat aaagaccctc tctcgaaaaa 360caaagtttta tgtcctttga attttaccac aataaaaaca attagagctt ctggtgtcca 420tccgtgccgg gagctgatcc tgtgccacag caatccacac ccaaatactg ccgggagaga 480gcttgtttcc caggagtgct gacaagcctg tgagcacaga atcccctggt gatgttcccg 540aacatccatt gtttatcaca gtgggtgact gactggattc tataaagacg ggcaatgcaa 600gagtaacttc ctagcagtgg gttttacaac gtttgatctg atttcaagaa tgagcataga 660tgacattagg ggagttcaga gtcacactta tcagacatca gagacaaata gcatcataca 720aactctgcat ttacatatga tgcacataca ggagaaaggg tttcatgtat gtaagtacta 780taaacaacgg catcttgtgc ctcagtattt ctacgaagaa agatgttccc tcctcggctc 840gttcttctga ttctccagcc ttcccttcac cacccaccgt ctcttgttga gactgaggct 900gcgcacctta cgattacgct tccaccctgg acttcagtgt catgctgcac aggtcctctc 960tgaatagcat gcaagcaaaa ctctggccca cggcagatca tcactgcacg ataatactca 1020tataagcaac agcatggatg tgtaactttg tagagaaatg attgggaagt gttcctggac 1080ttaacctaaa ggaatttgtc cttaagtgtg tcatcttcaa agatgtatgt ggagtttgat 1140gatagataag aaggagatag cagaccattc gttcatgttt tgtgatcaag tagcttccaa 1200tgtcacatac ttctttttca atagttttac tcagctgtat aggttttttt ttgttggttt 1260tttttgtttt tgttttttca gatttattta ttttacttat atgagtacac tgtaactgtc 1320ttcagacaca ccagaagagg acatcagatc ccattacaga tggttgtgag ccatcatgtg 1380gttgctggga attgaattca ggacttctac ttttttagac cctgcttgct ccagctccgc 1440tcactctggc ccaaagattt atttattatt atatgtaagt ataataatat actgtagctg 1500tctttagaca caccagaaga gggcgtcaga tctcattaca gatggttgtg agccaccatg 1560tggttgctgg gatttgaact caggaccttt ggaagtgcag tcagtgccct tacatgctga 1620gccatctctc cagcccccag ctctacaggt tttgttgttg ttttatttta aatgacttaa 1680ctgttggtgc ctgatgttgt tacaatgatt tgcagagata attaatgatt ccatgt 1736 201081 DNA Mus Musculus 20 gatagataag aaggagatag cagaccattc gttcatgttttgtgatcaag tagcttccaa 60 tgtcacatac ttctttttca atagttttac tcagctgtataggttttttt ttgttggttt 120 tttttgtttt tgttttttca gatttattta ttttacttatatgagtacac tgtaactgtc 180 ttcagacaca ccagaagagg acatcagatc ccattacagatggttgtgag ccatcatgtg 240 gttgctggga attgaattca ggacttctac ttttttagaccctgcttgct ccagctccgc 300 tcactctggc ccaaagattt atttattatt atatgtaagtataataatat actgtagctg 360 tctttagaca caccagaaga gggcgtcaga tctcattacagatggttgtg agccaccatg 420 tggttgctgg gatttgaact caggaccttt ggaagtgcagtcagtgccct tacatgctga 480 gccatctctc cagcccccag ctctacaggt tttgttgttgttttatttta aatgacttaa 540 ctgttggtgc ctgatgttgt tacaatgatt tgcagagataattaatgatt ccatgtactg 600 caattgtatc cggtgtgact acagtatgaa gggcattgttggggagggag atggacaaaa 660 atactgtgct tttaaatctt cttcttcttc ttttttctttaagatttatt tatttacttt 720 atgtatgtga gtacactgta gctgtacaga tggttgtgagccaccatgtg gttgctggga 780 cctgaactca ggactcagaa gagcagtcag tgctcctacccactgagcca tcttgccagc 840 ccttaaatct tctcaaacaa acaaacaaac acacaaacaaaaaactggaa aggtaagcag 900 gtacatttga atagaggcta tattacagga gaacatgccacaaggagaga gtcagaggga 960 agaggcaaaa ctgagtcaga tggtcaagat aacctgtgcaaagggcacag aagctatggt 1020 atgagggccg gccgaaggtt gcccactggc agcctgcaatagtactgtca ccaaacagtt 1080 a 1081 21 1045 DNA Unknown OrganismDescription of Unknown Organism EMBL No. mmaa11531 21 tgattcccctcgggacgctg ctcccttgtc gccttctcaa aaactccgct gctcgatgcc 60 tcggtaggtaatccaggtga gggcgactgg gcggtggctg ctctaagtac gtgtcctgga 120 gcaaatcctagggtctcgag cgggctagtg agggagtaca ctgcacccaa gtgactttgg 180 ctgcagctcttggcctcggg ttcctagcct gcgagcagcg ccgctactga aacctgcttg 240 ctccagagcctttcttatat atattggctg ctcttcgcag cctgtcagtc agacagactc 300 acggtcactctcccctcccc tccaggcctc tagtggctac agtcccagca cccaccggag 360 ggggcctccgcccccgccgc tccccctgtc agccagccag tagggcgcag gtccccgccc 420 ctcttccaacttctgggctt ccagctctgc gcgtgcccgg cgagcagtcc ttagagatcg 480 tctgcttaaaggctgagacc ctcgccacca gaggatagga gggtagccca gtgatgcggc 540 gggaggtgaggtggttcccg aatggtccag ggggtggaaa ctctaagggg tccccgtagg 600 cggtgcacctgatccaggca ttagatacct acagtcctct agcaggtggg gaaagcttaa 660 actaggaaagcaaaaagcag gaccagggga tttggatctc cctttccttt ccagacttta 720 ggtagctcctgcctcgctgg cctccagcct atgtgtgccc accctccacg cgtccccagc 780 accgcagggaagccatccga cgccttaacc tttccctggc tattccaagc aaggcaaagg 840 gccaagcgtctaggactctg gtcttctctg cacctggtag gcgtgtcacc tcaagcagca 900 gggcgtgcccagcgcgtgcc ttctctcttt gtcccccacc cccactccct cctggctcgt 960 gctagagccaggactagagg ttcgaaagag aggtgggggg cgtggttctc gaagtggggg 1020 gggggtcctcagctgtatgg taatg 1045 22 1162 DNA Unknown Organism Description ofUnknown Organism EMBL No. mmaa11531 22 gcagcgccgc tactgaaacc tgcttgctccagagcctttc ttatatatat tggctgctct 60 tcgcagcctg tcagtcagac agactcacggtcactctccc ctcccctcca ggcctctagt 120 ggctacagtc ccagcaccca ccggagggggcctccgcccc cgccgctccc cctgtcagcc 180 agccagtagg gcgcaggtcc ccgcccctcttccaacttct gggcttccag ctctgcgcgt 240 gcccggcgag cagtccttag agatcgtctgcttaaaggct gagaccctcg ccaccagagg 300 ataggagggt agcccagtga tgcggcgggaggtgaggtgg ttcccgaatg gtccaggggg 360 tggaaactct aaggggtccc cgtaggcggtgcacctgatc caggcattag atacctacag 420 tcctctagca ggtggggaaa gcttaaactaggaaagcaaa aagcaggacc aggggatttg 480 gatctccctt tcctttccag actttaggtagctcctgcct cgctggcctc cagcctatgt 540 gtgcccaccc tccacgcgtc cccagcaccgcagggaagcc atccgacgcc ttaacctttc 600 cctggctatt ccaagcaagg caaagggccaagcgtctagg actctggtct tctctgcacc 660 tggtaggcgt gtcacctcaa gcagcagggcgtgcccagcg cgtgccttct ctctttgtcc 720 cccaccccca ctccctcctg gctcgtgctagagccaggac tagaggttcg aaagagaggt 780 ggggggcgtg gttctcgaag tggggggggggtcctcagct gtatggtaat gaggttctag 840 tcttttccct cagtgcctat ctcacctgggtcgcgcttgg tctccatatc ctcatcctgg 900 cccccacccg cgtcccctag ctccgctggagtagggagga aactttctta attccagaat 960 ttccttgggc cacttgagag gcaaggtgagagagcttgag gctgatcagg tctagatctc 1020 tctgcatagg gcaggatgta gggtggaactggaggcgcat agagttgttt gagtttcggg 1080 tggtttcacc catgtcacac gcgcgcctctcccgggtggc ctccgagcgc aaaccctgca 1140 gctgctttcc cagaacccgt cg 1162 231132 DNA Unknown Organism Description of Unknown Organism EMBL No.mmaa11531 23 cagggggtgg aaactctaag gggtccccgt aggcggtgca cctgatccaggcattagata 60 cctacagtcc tctagcaggt ggggaaagct taaactagga aagcaaaaagcaggaccagg 120 ggatttggat ctccctttcc tttccagact ttaggtagct cctgcctcgctggcctccag 180 cctatgtgtg cccaccctcc acgcgtcccc agcaccgcag ggaagccatccgacgcctta 240 acctttccct ggctattcca agcaaggcaa agggccaagc gtctaggactctggtcttct 300 ctgcacctgg taggcgtgtc acctcaagca gcagggcgtg cccagcgcgtgccttctctc 360 tttgtccccc acccccactc cctcctggct cgtgctagag ccaggactagaggttcgaaa 420 gagaggtggg gggcgtggtt ctcgaagtgg ggggggggtc ctcagctgtatggtaatgag 480 gttctagtct tttccctcag tgcctatctc acctgggtcg cgcttggtctccatatcctc 540 atcctggccc ccacccgcgt cccctagctc cgctggagta gggaggaaactttcttaatt 600 ccagaatttc cttgggccac ttgagaggca aggtgagaga gcttgaggctgatcaggtct 660 agatctctct gcatagggca ggatgtaggg tggaactgga ggcgcatagagttgtttgag 720 tttcgggtgg tttcacccat gtcacacgcg cgcctctccc gggtggcctccgagcgcaaa 780 ccctgcagct gctttcccag aacccgtcgt gctcccccga ggctgcagaccggggagggc 840 tggcttctcc cagttttggg gggtgctaga tttctctctc tctctctctctctctctctc 900 tctctctctc tctctctctc tctctctctc tctctctctc tctctctctctctctctctc 960 tctctctctc ctacagtgag agcggtgggg gccctgtggc ttcagctgtcagccctcccg 1020 cgtggtgatt gctggctatg gtcggacgat aagatcagtg cgggcgggggttgaggggag 1080 cagggacgcg gctccagccc cagggaggcc gtggtagggg gaagtggaaccc 1132 24 1112 DNA Unknown Organism Description of Unknown OrganismEMBL No. mmaa11531 24 cccgcttagc aagcagcgcc ccgcggcgcg gcgcacttttccctactgcc ccttggagaa 60 actgcgtact tggagttttt gcccggggtc agagtggattccccagagaa taggcctgag 120 gctgagggag gagagaggaa gatgatgact tagcattggcctcgaggact ggctgggggg 180 cttcaaggaa ggaacaggat gcaggaactg atgataaaatcccagggcta ggagagaaga 240 ggggcatggt gttgtaagtc acaatgggtt ctgaggattgaagaggaggc ccgagcactg 300 aggtggcctg gggtctcacc ccattctccc cttagtctggtgaatgagta tgactcggat 360 ttggccaaga aacgtaacca cggctctaca tctgttctttcatccctgca aagtgataat 420 aatagcgatc tgggagactg tattggacta tccattttgcaagattcaaa gaataattta 480 gttcctttct ttccctctag gcaacatgaa gacaaccagaggccacctcg ggggcggggc 540 acaaatgaaa ttcacgggta gaggaaaaga cagaggacacactcctaagg gaagaggcaa 600 taggagcaga acggaggagg ggaaagagca gagcgtgaaaagtcaaggtt tcggggcctt 660 ttttggtagg aggcctgtga taaggttctt gactgaacaacctggcctag agaaaacctt 720 cccactgaga caactctcct gctggagggt agtctttcagagcagcggcc tgcagaaagg 780 aagagatgtc atccttgaat ggatctaatc agagagggtgctggcctcag agagaggggg 840 ggcgcggggg cgcgctcggc ttttcctcat acctctgagagaccctactt cctgggttca 900 ctgtccactg tctggttgct catgcctgat gactcaacatatgccaaata aaggataccc 960 aagtgggcag gattactggg cacggcagag aactgcttgggtttctccta aggcctggaa 1020 ggcctcccac ctcctttccc ggggtcccag gcacagtgtctggagtagtt tcatactgtt 1080 tccttggctt tccagaacac agagcctggc ac 1112 251188 DNA Unknown Organism Description of Unknown Organism EMBL No.q9ulg1 25 aaggtattct tcctgggagt ctttcgactc tggggaagtt tataattttccttaatctat 60 gatccatctg ctttaaaaaa acaaaaataa aatctttaat tccagttctgaggagagatt 120 ttgtagaata ctctgatata tatatatatt ctggtagata ggattcttcaaacttatgga 180 tgaatgaaat tgttgggaac aagcactgtc ctcagcactt cacttcgttaattgtaattc 240 attcttgtta ttagtggagg acaaatagga agtgagtata acgtctcagggttctttgag 300 aaagtgcttt ataaatgata gtgtttctat actttgccct tgcagtaggaggcagtgtct 360 aatgaacttt ctgtagtctg ttattgtcac agtgtcttgt gtttgagagggcctgattcc 420 tgtttgtact gaaggcaagc atgcaggaga aggagaagag gaataatcttggattttttt 480 ttaacttatc tccattttgc agctgtgcag ttggaggtcc tcgtgcatgaagacaaattt 540 gttctatggc ctcggagttg ggtgccgggg acgatggcag cagcactgagctggcaaagc 600 ccctttatct tcagtacctg gagagagcct tgcggttgga ccactttctgcgacaaacat 660 cagccatctt caacaggaat atttctaggt gtgttatttt atctcttgacagtgttttat 720 tacatttctg atttctgtct ttaggattta aggttaaact tgtatggtttttacttttag 780 tattttcttc ctcttttttt cacataaatc aactttttca aagctatttgttctttacgt 840 tttcatttat agtaacctta atcacttaat tattgttttc cttttcttctttccttcctc 900 cctcctttcc ttccttcctt atttcctctt tcttcctttt tttttttttttgagacaggg 960 tttttctgtg tatccctggc tgtcctggaa ctcactctag accaggctggcctagaactc 1020 agaaatccgc ctgtcaccaa aaaaaaaaaa aaaaaaaaag agccgggcatggtggtgcgc 1080 ctttaatccc agcacttggg aggcagaggc aggtggattt ctgagtttgatgccagcctg 1140 gtctacagag tgagttctag gacagccagt accggttcgt tctttctt1188 26 1170 DNA Unknown Organism Description of Unknown Organism EMBLNo. q9ulg1 26 ctctctctct ctctctctct ctctctcttt ctttctttct ttctttctttctttcattct 60 ttctttcttt ctttctttct ttctttcttt attgtttttt gagacagagtttctctgtgt 120 agctctggct gtcttggagc tcattttgga gaccaggctg gcttcaaactcagaaatctg 180 cctgcctctg cctcccaagt gctgggatta aaggtgtgcg ccaccactgcccagcttctt 240 tctttctttt ttgctcaata tgtagcccag actgtcctag aactcacagatctcctgcct 300 ctacccctgg agcactgtaa aggtttaaag gtatgtgtgc catcttgcctgactccttag 360 attatgtaca cacatatatg tacataatcc tcttgtctcc tgtctccaccaggtttatag 420 gcatatgcta tcacactcgg ctcaaaatgt gttttgttgg ataacctttaattatggact 480 tactgttctt ccatttatag tgatgacagt gaagatggac tggatgacaataatccctta 540 ttgcctgagt ctggggatcc cttaatacaa gtaaaagaag agcctccaaattcattgctt 600 ggcgaaacct ctggagcaag cagttctggg ttgttgaacc catattcactgaacggcgtt 660 ctgcagtcag gtcagtgtgg agtgggagcc ctttgcagct gcagttctcttgggggcagt 720 cagcgtttca tttttttttg tttttgtttt ttgttttttt ttttttactctttatgtttc 780 tttatccaga atcaaaatct gacaagggga atttatataa cttctctaagttgaagaaaa 840 gcagaaagtg gctaaaggta agagataaga cagaacattt ccagtccaaataacctacta 900 agattacagt tagaagggaa gttatccaac cattctggaa tattgacagttttctagaca 960 aagttattct atactgggat ttgttttatg aagaaagttc aacaaagtaattttttagta 1020 ggctttttat taaatatggg acactgagaa aagaggagat aaatggatcagataagatcc 1080 tcccttcatt ggcttatctt gtaatcagga atgttaattt aggttttcatgagtttttga 1140 gtacttcatt caacaaatgc tcagaatgca 1170 27 1068 DNAUnknown Organism Description of Unknown Organism EMBL No. q9ulg1 27atctcctgcc tctacccctg gagcactgta aaggtttaaa ggtatgtgtg ccatcttgcc 60tgactcctta gattatgtac acacatatat gtacataatc ctcttgtctc ctgtctccac 120caggtttata ggcatatgct atcacactcg gctcaaaatg tgttttgttg gataaccttt 180aattatggac ttactgttct tccatttata gtgatgacag tgaagatgga ctggatgaca 240ataatccctt attgcctgag tctggggatc ccttaataca agtaaaagaa gagcctccaa 300attcattgct tggcgaaacc tctggagcaa gcagttctgg gttgttgaac ccatattcac 360tgaacggcgt tctgcagtca ggtcagtgtg gagtgggagc cctttgcagc tgcagttctc 420ttgggggcag tcagcgtttc attttttttt gtttttgttt tttgtttttt tttttttact 480ctttatgttt ctttatccag aatcaaaatc tgacaagggg aatttatata acttctctaa 540gttgaagaaa agcagaaagt ggctaaaggt aagagataag acagaacatt tccagtccaa 600ataacctact aagattacag ttagaaggga agttatccaa ccattctgga atattgacag 660ttttctagac aaagttattc tatactggga tttgttttat gaagaaagtt caacaaagta 720attttttagt aggcttttta ttaaatatgg gacactgaga aaagaggaga taaatggatc 780agataagatc ctcccttcat tggcttatct tgtaatcagg aatgttaatt taggttttca 840tgagtttttg agtacttcat tcaacaaatg ctcagaatgc atccatgtgc catgtactat 900tattgtaggt agacaaggct gctctgtatc atttatattc taaatgaggg aggtagtgag 960taagagtgta aatacttgtt taaatacaac ttgaaaatag catttttgta cagtgttctc 1020agtgatcaga gtgagccatg tgaatgccaa gggtaagagc ctttgagc 1068 28 1162 DNAUnknown Organism Description of Unknown Organism EMBL No. q9ulg1 28cctgctggct actaatctta tttcctctcc attaatttgc ccattctgga catttcatat 60aaattaaatc gtagtatgtg ggctttcgtg gctggctttc tcacttggta tactgctttg 120aggtctctta tggtgtggta tatattagta cttcatttct tcttggggct agtcatctgc 180attttattta tccagtcatg agctactgga tatttgaggt tttttctccc actttggcca 240tcacaccttg ttttgtgctt gttcccttat atgctatatt ctttttccta ttgatatact 300ctaatttttt gtttgccttg tatatttaac atttagggtt ttttagttaa attaaaatta 360gtaaagatta gtgtaagaat cagaaatgac tatactctga ctgttttggc cattgttgta 420gcatctggga aaaaataatt ggattgtaaa agaaattgct tcacagcaaa agttatattc 480cattttcacc ccttttctag agcattcttt taagtgatga gtccagtgag gcagattctc 540agagtgaaga caatgatgat gaagaagaag aactcagtct cagcagagaa gaacttcaca 600acatgcttcg attacacaaa tataagaaac ttcaccaaaa taaatatagt aaagataagg 660aggtgagagt ttcaagagaa cactcacaac cacactattt taacttatgt gaaataataa 720atgttaagag ctttattgtg ataggattca cataacataa atccagcttt tggaagtagg 780taactgaatt ttttctgagt ttattcgtcg tgcatgtttt cgtcatcact gtctcagttc 840tagaacactt tcctcacttc agaaagaaac ctttgtgcca tggcttctgc ctcattctgt 900tctttgtgcc aggcacccac cagtttactt tctttcttga tacttatttt tattttacgt 960atttattctt ggtcttgtat aatagggtga ccttgaactc cgtgttctcc catctccatc 1020ttccaagtgc tggcatgtgt cgccgcgtgc agatgtgtgc cactatgtgc agctctgatt 1080gttgtttggt ttttggatgg tgttagagat tgagtccagg gcctcatgca tgtgcgtttc 1140ttataaatgt gttcattctg ga 1162 29 1121 DNA Unknown Organism Descriptionof Unknown Organism EMBL No. q9ulg1 29 ctttgttttc tgttttattt atgataaggccttatttagc tcaggttggc ctagaattcc 60 ttacctccac ttcccgaatg ttgaaattacctgtaagaaa tgaatttcat accaaatgtg 120 tatctgctgt gtgtagtggt acatattttgcatttctagt atttgaagtg tggaggcaga 180 agtatcagga gttcaagtca gcctgggctacatgaacttg tgttgaagaa tatagaaaag 240 aaaagatgtg atagaagttc agattctgaaggatttcctt ccaaattcct ttctagcagt 300 ttgtcttgtg catagcagtt gatcctgttttacttctgag ttaaaggaat tatctttgat 360 gtactaattt cttattggtc tctgtgggaaactatttcag agctatggtt ttctctggct 420 tagctttttt taagttaaga tgacttcaaggctgcgttgt ggaacgcagg cagacccatc 480 acagtgtttg cctgcttcag ttgcagcagtaccagtacta cagtgcaggc ctgctctcta 540 catacgaccc tttctatgag caacagcgccacttgcttgg acccaaaaag aagaaattca 600 aggaagacaa gaagcttaaa ggtaagtatatttattcttt cttaatttca gaactgtgtg 660 tggtacattt taacttttgg tagaaaattacttttatctg taaaagtata gtctctttcc 720 taattaccga cattattgac cttatttacatttgttgtgt ggtcttttat agacatagat 780 agacttaacg aactataggt tgcaagcacgtggactgtga tcctagcgct tggtaggtag 840 gagtaggagt ctgtggagca aagttcttgttggctacata gaggctgagt ctaccttggg 900 ctgcctgaga ccttgtttta ccgcctcctccttctcttct aacccaagaa acaaagaaaa 960 ctatagctgt aggttgctac acaaaggtttaggcaaaata gtttccttcc ttttatcttg 1020 tacactctgc catcgatgag agtattctgaggtgagaagc agttggttaa gttactccag 1080 atgagcctct gtagcttctg cagtggttaccaggatgcag a 1121 30 1215 DNA Unknown Organism Description of UnknownOrganism EMBL No. q9ulg1 30 tcaaaaaaca tcttttctag ccttcccttc tttctccataccctcctttt cttgtcttcc 60 agtctccctc tcaatgtaaa taatttgtgc catttggtttttttcctcaa aaattttatt 120 gacctctcaa ttgatgcaat ttttcctttt attttctttagttgccttgc atttccacca 180 agtggaagta ggtttccatc ctgtacctgt cacttgaggccagtgactct tcagctttat 240 aaacaattct acagtgttga gttcacgtca tttgatttttaggttttagt ttcagttttt 300 catgtcaaca aaaggaacgt cagtgtccag tgttctttttgagttagtga gatcctcctc 360 ttcgacgatt cattggcctg atagaaggaa gaaactctgcctgcctctag tagaatgaac 420 agagctcctg gatgtcttct caaatgatga gggtgctcgctggttctgta cagccttgtc 480 agcatctctt tcctttgcag ccaagttgaa aaaagtgaagaaaaaaagaa gacgtgatga 540 agagttttcc tctgaagaat ctccacgtca ccaccatcaccagaccaaag tctttgctaa 600 gttttctcat gatgcacctc cccctggcac caagaagaaacacttatcca ttgagcagct 660 taatgcccgc cgcaggaaag tgtggctgag catcgtgaaaaaggaactac caaaggtgag 720 tggatgggtg ggtaagggag ggagggaaag ggagagatgggaacgaggta gcaggaatgg 780 ggacaggacc aacttgtaga cattcagtga tgttgtgatgtcttttacag ccacaagaag 840 taagccaagt cattaacact gaccagcatg agggtgaatagagatattag agatgaggag 900 aggaaggcca gatgttgtag aaacaagtca aacatgtatttgcctatgtt atgtaacacc 960 gtcagttttt agaggtagag gccaagtggg tgtctccatgatttttatac tcagagtttg 1020 taaaaaatgg aaaacaatgt attatataaa actaaagaccaaacaaactc tacaggagtt 1080 caggtagagt gggtagaact ccccagcaag cctgccatcctcagtttgat ctatgtgtga 1140 tctgttctta gttggaatgt taagggaaga aatatgtatgccttggtgtc tgaggaagtt 1200 tcagatgatg ccctt 1215 31 1054 DNA UnknownOrganism Description of Unknown Organism EMBL No. q9ulg1 31 caatagcataagaatctaag atctagttcc cagcacccac gtaaaaagcc aagcattgtg 60 gtatgtacctataaatatgg tacattggag gctgagacag gaagatctgt gtagtttatt 120 ggccactcagtcttgctgaa tttgagttcc aggtttattg agaccctgtc tgaaaaaata 180 agtagcaaagtgatagagca aagtacccag cgtctaatgc tacgctctac acatgtgcac 240 atgtacatgtgctcatacat ttaaacgtat atacacgcag gtaccataca tgtggaagta 300 aaactaaaataagattaatg gcaccttcaa cagtagcttc ttgttcctgg tattttagta 360 gttttatggtatgccagaca atgttttaaa agtaatttgt cttgtatgta cttgacattt 420 ttcagtccttcaggaactaa ataaaagcta tgtaatctta cttagaaatg aatcttaaat 480 attactttcaaatgttttag gccaacaagc agaagtcttc agctcgaaac ttatttctta 540 ccaatagccgaaaggtaaca tttttccgtt ttctattttg tctattgtgt gttctctagg 600 cttattcttactactctctt atgttgtgat ctgaattgga taatatgtaa agaaccatct 660 aagtagtctcattctgttta ataagtaaaa ttgttcttct tcatatttct cttattttct 720 gtgtcaaattaatctctgat tctttaagat tcgtgctcag tttttccact taagaagtga 780 tgggggtcacagggatggct tggtgggtaa aggcactttc tggcaagctt gacagcctga 840 gttcagtccctggaaccact gatggaagga aagaactgac tgcccacagt tgcccttcaa 900 catccttacgtataccttgg tgcatgtgcg cctgtacaca caactctccc ctcccccaac 960 aataatggtaacaataatag aaatgtggat gtgaaaaaac ttctgagaga aaaacaataa 1020 cttgttataagggttggatg aggtaacagt ttag 1054 32 1204 DNA Unknown Organism Descriptionof Unknown Organism EMBL No. q9ulg1 32 tgccattgtt gcatgacttt ttctgtggaattgtgaagaa atatgttcat cccatttagg 60 gtaccgagga ctggagcaat ggggtctattgcacactgcc tagggagcca catcagtgac 120 tgcctcttcc ctcatgcatg tgtttgctgccttgaaatct cttcctacct ttcacagagg 180 aacaggtcac aagggttcag tcttgtgagggtctcaagct aataaatata gtaaagggaa 240 tttcatgtat aatgtacaga ataagtatactttgtttcat ctaaagtgat cgatgtggat 300 aggcatctta attagagtat tttacctcaggggtctgagt cttactcagg ggcattaatt 360 aaagcaggag agagagatat aatcacctctttagtagaat tgtaggtact aaaaagattg 420 agggacactg gtttaaagtc caggcagaactgttcttgga attgtgtcct tctctgttgc 480 tataatgatg ctgtttgcag cttgcccatcaatgcatgaa ggaggtgcgt cgagctgctt 540 tgcaagcaca gaaaaactgt aaggagactctgcctcgagc ccggcgccta acaaaagaga 600 tgcttctgta ctggaagaag tatgagaaggtggagaagga gcaccgcaag cgagcagaga 660 aggaagctct ggagcagcgc aagttggatgaggaaatgcg ggaggtgggg caaaagcata 720 cattttgttt tggtctggtt tggtttttcttttctttctt tttttttttt tttttttttt 780 tttttccttt gggttgttgg agacagggcttttctgtatt gtcctggctt tcctggaact 840 cactctgtag accaggctgg cctcgaactcagaaatctat ttgcctcttc atcccaagtg 900 ctgggattaa aggcgtgcac caccactgcccggttttggt tttgcttttc gagaccaggt 960 ttttaatgtg tagtccagct atcctggaactcattcaata gaccaggaaa gactgccttt 1020 gcctcctgag tgctgggact aaaggcatgtgccaccactg ccaggcacaa gcatacaaat 1080 tctaaaacct ctatttagta ccaaagcactaaggatttag tttgttgctt tgaacctttg 1140 agatagtagc tctggctttc ctggaactggtgacatatac cagattatcc tcaaactcaa 1200 aggt 1204 33 1196 DNA UnknownOrganism Description of Unknown Organism EMBL No. q9ulg1 33 taatttagttttctgagacc tatcctcttt ttcatctacc atttttaagc ttgtagccat 60 tatattgatgaatgtgatgt ctctcaactg atctaggcgt tgtatgtcta gtaatagaga 120 ataagtaattgtttgacatt ggtaaaacag ttgggaagaa aggtaggttc agaaaagaga 180 gtcgggattagatgatgtgg ttttcagatg tgaccagcat cgttctcggt ggagttttga 240 agcctcttcctgacacttaa tcatcctttt cttttctctt tcactctttc ttctcatcct 300 tccttctcttcccttttctt tcttttgtat ttatattttt atgtgtttat gtgttgttta 360 ttagcagtagttgccttttt aaaagtaaaa aggttttgaa ggacttatac acaggctttt 420 attaagatttgctaaattct gttgactaca tataatttat gacttggata ttcttacctt 480 caatttccaccctactttag gccaagaggc aacaacgaaa actcaacttc ttaatcactc 540 agacagaattgtatgctcat tttatgagtc gaaaacgtga tatgggtcat gatggaatcc 600 aggaagaaatcttaaggaaa ctagaagata gttctaccca gagacaaatt gacattggtg 660 gaggagtggtggttaacatc acccaagaag actatggtaa gtcctgagtc aggaagtagt 720 ggaagtaggtagccttcttt tttcacatca aggttgtgta tgttaaaatt cttacaggtt 780 ttgtcctaattcgtgcataa tactgctcag aaatgggaga tttaatgcac tggatcaaga 840 aaatacgtgtatttctgcaa aggaagccta taaaataact taagaatttt cagtagaggc 900 ctgggaagagagaatgtttg cctagctgca cgaatccctg gacttgatac ctagcatcac 960 ataaaccaggtggtagtgat ctcacacttc agaaggttag gcaagaggat cagaagttgg 1020 aggtcatcttcagttacatg gttagagtat tttcatagtg tagtaattaa gatcgtgttg 1080 acctagaaatgcagaatgga aatatttcag agtatcttga gtattaacac atgtatagat 1140 ttcaattgctttctccccac ataaatataa ttttgaatct gcatgttggt cttgcc 1196 34 1068 DNAUnknown Organism Description of Unknown Organism EMBL No. q9ulg1 34caattgcttt ctccccacat aaatataatt ttgaatctgc atgttggtct tgcctatcct 60ggtaattgat atcaatttat aaagaaacca taggactgag agattgtaga tcttaactcc 120cagttgggtt ttgtgtgctg tctttcactc ttggagacaa gagacagccg cagctacttt 180atacgtctag gttctgttgt ttgtttattt ttgttgtagt ttttttgaga tagtgtctca 240ctctggctgt cctgaaactc actgtgtaga ccagagtggc gtggaacaca cagaaaccta 300cttgcctctt cctactaagt gctggcatta aagttgtgtg tcaccatgcc ttacttgttt 360ctaggttttt gcccactcct tgtcctttgt taatcttggg ataaatacag tgggaaactg 420ggaatccact tatgtgtggg ataaatcttt gaagacgtga taattctaag tgcaataatc 480tacgtgtttt ctcttttcag atagtaacca ttttaaagcc caggccctga agaatgctga 540aaatgcttat catattcacc aagctcgagt aagtctttaa gtcaaaaggc aggctgggca 600tggtgaccac acctttgatc ccagcactca ggaaggtaga gtcagatgga gctccatgag 660tgtgaggcta gcttggtgga caatatcagt tctagaccag ccaaggatac atagtgagac 720ccgtcccaaa aaaaggggag ggggaggcaa aggtatattg tagttatcct aggaaatgtg 780ccagtttctt actttatttt attctttgtt cattgttttc agtttaacac actggttagt 840gtgtgtgtgg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg 900tgtgtgtgtg tgtatatcta tgtatgtgta tgtgtttgtg agactcagac tgtatatagg 960gtgaaggctt tccttacttc agttacagat ggttcttgcc accatgtggg tactgggact 1020tgaactggaa gatcagccag tgcttttatt tagtgagcca tccctcag 1068 35 1210 DNAUnknown Organism Description of Unknown Organism EMBL No. q9ulg1 35taaaagtttt tattttttta tttttttatt ttttttttat tttttttggt ttttcgagac 60agggtttctc tgtgtagccc tggctgtcct ggaactcact tgtagaccag gctagcctcg 120aactcagaaa tccgcctgcc tctgcctccc gagtgctggg attaaaggcg tgcgccacca 180tgcccggctt tttggtcctt tttttttttt tttttttttt tttttttttt ggtaaaagtt 240tttattcaag tagatcatgt actttcatta tggttaacat agtctcctat gtacccaaac 300tcttatatca gaacttggaa caaatagttt taattagtga gcaacatagc ttagtatggt 360aataaaaaca ttttaatata attgttacat taactcagta agatattaga aacattatta 420gcatagtgta aaaatgttga taaattttat gttaatttaa aaaattctta tatatttttc 480ttgacatttt tattttccag acaaggtcat ttgatgaaga tgcaaaagaa agtcgggcag 540ctgcccttag ggcagcagac aagtctggct ctgggtttgg ggagagttat agcttagcaa 600atccatctat ccgggccggt gaggatattc cgcaacccac tattttcaat ggcaagttga 660aaggttacca gctgaaaggc atgaactggt tagcaaattt atatgaacag gtaaatttag 720aactctattg agcctattct ttttacttta acatctgttt ttcttttgat taatgtaatt 780atgaagtgag tttaccttta gcttttattt atttattttt taaagattta cttgttttta 840ttatgtctgt aagaatgttt gcctgtattg tatgtaacta caccataggc atgcagtctg 900catggagatc aaaagagggc atcagattcc tagaaccgga gttagagctg ggtgtgagcc 960atgtgggcaa tagaaactga acttgaatcc tttgcaaaag cagcggtgct cttaaccact 1020gagcaatttc tccattttca aaacttcact atcatgttag agtcagaaag gtatcagtat 1080ttctaacttg gatattctgt gtgtatccag tgtatatagt atgtcttaga tggtcttggt 1140aaactgcatt gtttgcttaa tatgtgctac attaggtaaa gaactggcct tagtcttggt 1200ctaatatatc 1210 36 1081 DNA Unknown Organism Description of UnknownOrganism EMBL No. q9ulg1 36 gcatggagat caaaagaggg catcagattc ctagaaccggagttagagct gggtgtgagc 60 catgtgggca atagaaactg aacttgaatc ctttgcaaaagcagcggtgc tcttaaccac 120 tgagcaattt ctccattttc aaaacttcac tatcatgttagagtcagaaa ggtatcagta 180 tttctaactt ggatattctg tgtgtatcca gtgtatatagtatgtcttag atggtcttgg 240 taaactgcat tgtttgctta atatgtgcta cattaggtaaagaactggcc ttagtcttgg 300 tctaatatat catgaatcac acatatatct ctagtgttgctaaaagaaac tattgcagta 360 gtgatttaat agtcttggta ctgagtatct ctccaatcaatctttgctgt cttttgagct 420 cttttggcat taagtgaaat gaattctaat gggtgcaatcaggtgttgat catgtgtctc 480 ttactctctc tgtctctcag ggtattaatg gaattcttgctgatgaaatg ggtcttggta 540 aaactgtaca gagcattgcc ctcctggccc atctggctgaggtgagtaga tggaattgtc 600 aatcttgttt tccttaactt aggcctcccc tcccctttcctcccctccct ctcatccccc 660 ctacttccct ctcctcccca cttctccctc cacccttcaaaacagggttt ctctgtatag 720 ccttggctat cctagacctc actgtacaga tatggctggcgtccaaccca gagatctgcc 780 tgccttttct cccaagtact ggaattaaag acctgcatcaccgtcgacaa tgagccactt 840 aaaagcagtg ttactcttgg tagtatatga aaatagccgaatttgttgct atacctgaag 900 acttttttgt tgttgttgtt gttttttcga gacagggtttctctgtatag ccctggctgt 960 cctcgaactc actttgtaga ccaggctggc ctggaactcagaaatctgcc tgcctttgcc 1020 tcctgagtgc tgggattaaa ggcgtgtgcc accaccgcccagctcaagac gtttttaaaa 1080 t 1081 37 1096 DNA Unknown OrganismDescription of Unknown Organism EMBL No. q9ulg1 37 acagtgaaat tgtgataacatcgtagaaca aataaaagtg aattagtatg ttacacacac 60 atttttttaa aagatttatttattttatgt atatgagtac accgttgcta tcagacacta 120 gaagaggcca ttggattctattacagatgg ttgtgcgcca ccatgtgatt gctgggaatt 180 gaactcagga cctcttgaagagcaatcagt gctcttaacc attgagccat ttctccagct 240 ccatgtcatg cacatgttatgaatgaaatt aagacccaaa agtcacgagt gtcactgctt 300 agtactttac ctccttagtgtgtcattttt atactaacat tgcttttcat tgaaagatat 360 gtgtagacac ttgggagataggcacagttt ctcttgttac agtaatatct atttttaaac 420 ttctcttgtc atgggttgattatttaggat taaataactt cagttttcct acagcaggct 480 aacctcattt tctgttgcagagagaaaaca tttggggacc tttcttaata atttcacctg 540 cttctacact taataattggcaccaggagt ttacaagatt tgttcctaaa tttaaggtaa 600 agatcctctt gttctttaagataagctttc tgacccttgt ttactgctgt ctaattgtct 660 tagacttctg tgctgtagtaaacactgtaa ccgaaagcag cacagaagac agggttcatt 720 ttagttcaca gctttatatttcatcatcct ttaaggaatt ctgagcagga gctcaagcaa 780 tcgggaacct ggaggcaggtattgaagcag aggccttaga actagtgtgc tgcttactgg 840 tttgttctca tagtttgctcagcctgcctt tttcatcagt catctatgaa ggtgtggccc 900 cgcccgctgc aggataggaccttccacatc tatcacttac agacttgctt agaggctaat 960 cttggttttg tttctttttctttttctttt tttttttttt tttttttgct tttttgtttt 1020 gttttgtttg tttatttgtttgagacaggg tctctatatg caaccttgtc tatcttgaaa 1080 ctctctatat agacca 109638 1060 DNA Unknown Organism Description of Unknown Organism EMBL No.q9ulg1 38 caactttttt gtttgtttgt ttgtttgttt tttcacaggg tttctctgtgtagcccgggc 60 tgtcctggaa ctcactctgt agaccaggct ggccttgaac tcagaaatctgcctgcctct 120 gcctcccgag tgctggggtt aaaggtgtgc accaccacag cccggctccttacaacttct 180 ttatttttct cataaaatgt gatttgccaa ggttttttgt ttgcttttgttttgattttt 240 tttttgtttg tttgtctttg ttttttcgag acagggtttc tctgtatagttctggctgtc 300 ctggaactta ctctgtagac taggctggcc tggaactcag aaatccacctgcctttggct 360 cccaagtgct gggattaaag gcctggacaa ccactgcctg gcctcttaatagtttcttac 420 taagtaattc agaataacat tattgataat gcttttagtt tattttcaaaaacaaaataa 480 ggtaatgatc tgttttccag gtgctaccat attggggaaa tcctcatgatagaaaagtta 540 tccggagatt ctggagtcag gtaacttcag tttctttctc tctctctctctctctctctc 600 tctctctctc tctctttcgc tctctctcgc tctcttgctc tcctgtcctcttgctctgtc 660 attctctttg gcctgagtaa atcctcatgt atacaaaatc tataatatgtttctgaatat 720 gggtcaaata tgtttttatt atttgaataa aatgtttttc ttctacaggcaatcatttgg 780 actttaaaaa gagacttttt aaaaaaagat ttatttttaa aaaattgtatttgtacaaca 840 aatatatgta gaattctttt tttttttaaa gatttattta ttattatatgttaagtacac 900 tgtagctgtt ttcagacaca ccagaagagg gcatcacatc tcgttatgtatggttgtgag 960 ccaccatgtg gttgctggga ttcgaactca gaacctttgg aagaacagtcagtgttctcc 1020 accgctgagc catctctcca gcccatatgt aggattctta 1060 39 1143DNA Unknown Organism Description of Unknown Organism EMBL No. q9ulg1 39atttattatt atatgttaag tacactgtag ctgttttcag acacaccaga agagggcatc 60acatctcgtt atgtatggtt gtgagccacc atgtggttgc tgggattcga actcagaacc 120tttggaagaa cagtcagtgt tctccaccgc tgagccatct ctccagccca tatgtaggat 180tcttaagagg ctagagagga gggcatcaga tcctcttgag ctagagttac aagtgattct 240gagccaccat acacactcca agtggtctaa ctactgagct gtctgttcag tcacaccttc 300aagctgagca aggttaataa ttaatgtgca tttaatccct agaaccaata gtggaaggag 360agaaccagct ctggaaaatt gcccttttta tcaccacatc tatatgctta ctcatattta 420cacatacata tacatcaaaa aaacgtttct tataaagtgt gacataatgt ttttccacat 480ttttcttatt acttttgtag aagaccttat atactcagga tgcccccttt catgtggtca 540tcactagcta ccagctggtg gttcaggatg tcaagtactt ccagcgggtc aagtggcaat 600acatggtact ggatgaagct caggcactga agagcagttc caggtaatat gagtaataga 660aactagcctt gtgggtggaa atctatccat agaatccgca aaggccagaa atttcagaat 720gtcacatagc ataggctatg tatgcctcag ctacttgcct gaccagaatg gagaaattct 780tatttatact tttctttgaa attcgaaaat catgcttaga atatattgat ttttcttcaa 840tattaatctc ctcagttaat ggttataatt tttgttgttg ttgctgttgt ttcctcttct 900tcttccttct tctcctcttc cttcttcctc ctcttcctac tccttcttct ctttcctttt 960cctttttaaa ggtaagaaca gtaggaaact gtaaggccag aaaggtctct cactttacct 1020atttgtggat tttttttccc ctaagccata ataccattgg tattgatgat tctcacagtt 1080ctgttttttt ttaatttctt tctttttgtt taaagattta tttattatta tatctaaata 1140cac 1143 40 1085 DNA Unknown Organism Description of Unknown OrganismEMBL No. q9ulg1 40 tttttgattg tgtgcatgaa acagtatatg atttttttaaagtttattta ttttatgtat 60 gtgagtacat gtagttctct tcatacacac cagaagagggcaccagatca tattacagat 120 ggttatgagc taccatgtgg ttggtggaaa atgaactcgggacctctgga agagcagtca 180 agtgctcttg gggcgggggt ggggtggggt gggggtgttttgagacaggg tttctctgtg 240 tagccctggc tgtcctggaa cttactatgt agaccaggctggtctcaaac ttagaaaccc 300 acctgcctct gcctcccaag tgctgggatt aaaggcatgtgccaccactg ccaggccaat 360 caagtgctct taaccactct ccagccccag tatatgattcttaagtatta tttggaaagc 420 aattttagaa tttgggtctt agtataatta cagaaagacatattgccaac ttataatttg 480 taactcattt tcttgaacag tgttcgttgg aagattctcttacaattcca gtgtcgaaat 540 cgacttttgt taactggaac ccccattcag aataccatggcagaggtagg cactagtcaa 600 ggtaatggag tatatcttcg tgagacacct atacctacgctggactccag tcattctgta 660 caaattatat ttaccactgt acaagaatta gattgtagcttcctaagtgt cttgtaggca 720 gtattcttac tttcttacta tttattaatt ataatgttccttttgtttcc ttaatattga 780 gtacattagg aaatgttgcc catctaataa aggtaactttttactctaga attggaaaat 840 ctctaacatc gagggcctca atttttttgt ttagaattcatcataatagg ggtcagaaaa 900 ctttcggtaa aagaggaaat agtattttac atttcatagacagtacattt cactgttaac 960 aactgcttgt ttttgcttat gcagtatgga agcagtcataagtagcgtat aaatgaatgg 1020 ctatggctat gttcccatag aactttattc atgaaaacatatgaccagcc gaatagcgtc 1080 atggc 1085 41 1118 DNA Unknown OrganismDescription of Unknown Organism EMBL No. q9ulg1 41 taaaagagga aatagtattttacatttcat agacagtaca tttcactgtt aacaactgct 60 tgtttttgct tatgcagtatggaagcagtc ataagtagcg tataaatgaa tggctatggc 120 tatgttccca tagaactttattcatgaaaa catatgacca gccgaatagc gtcatggctg 180 taattgtcta gccctggctgagggctatta gcagctatta cactactata aactgtgttc 240 agttgtggaa ccagctgtggggttgtcatt tgtaaaactt attacactac aaaagctgag 300 caggctttgt acttctaaatttgtagttag caattaattg agaaatcatc attttttgtt 360 atgtattagg gttcactgagcaagattgtg tttggattca tttattcttt ctgtctcata 420 aacactcatt tcttaatatatagtcacaca gtatcatttt atggcaccat atctgtttca 480 tatttttcct ttgttttaagctctgggctc tgctacattt cattatgcca acattatttg 540 attcgcatga agaatttaatgaatggtttt ccaaagacat tgaaagtcat gctgaaaaca 600 aatctgctat tgatgagagtaagtactgct gtggctttcc tctttttgtg tagagtttaa 660 gactctgtaa cccaagtctcacattgcagc ctagaatggc ctgggattct ctatgtagtg 720 tggcctcaaa cagatatttccaggttcaat ttcccaagtg ctgggattat aggtggctct 780 gaattttatt ttcaatctattagtatgggc aactatgcac agtttttttc tgtgtgaaga 840 atttctcttt cattatacctacaagagtta agggtaaaac tgttataaat tagttaatat 900 aatgttaata aagtagctaaattctctgag ttaaaaagaa tagaacacta ctctagacaa 960 tctaagcaag atgtataaacttaataaaat attacatttt ggtttgtagg cattctgtct 1020 taggtagggt ttccattgctgtgaacagac atcatgacca aggcatctct tataaaggaa 1080 aacatttaat tggggctggcttaccatttc agaagtgt 1118 42 1086 DNA Unknown Organism Description ofUnknown Organism EMBL No. q9ulg1 42 gtaattcaga aaatggagcc acgtgttgtgatgtatgttt ttaatctcac cacttaggag 60 gcagaggcat gtggatctct ggatttgaggccaacctgat ccatagagtg agttctagga 120 tagccagagc tacatagtga gaccctgtcttgaaagaaaa gaaaatattc ccacagtcca 180 gtcttgatgg gaaagaattc ctcagttggagttctctatc cccagggaat gctactttgt 240 gtcaggttga taagaattac atagcacactctggaagtcc cttttagctt tgagtcgatt 300 tttatacagt ctcccaaata ggctctgaaagtgtgttcta atgtaaacag tcggtataag 360 atgcttgcct tggaacaagt tcattttttagagaatcctt gatctcagtg gcattttcag 420 ggtgtaggag aggggaaggt gtttattttgattgtcttaa gtcagtatat ggtaaattat 480 ttgtggactt cctgtttcag atcaactctctcgtttacac atgatcttga aaccatttat 540 gctgagaaga atcaaaaaag atgtagaaaatgaattgtct gacaaggtaa gaaataaaat 600 cttaatgagt ttgaacctta gtagataccaatttatggtt cttcacagat atttccttga 660 tatatattat aaggataatt agtttgattaggaagatctt tgtacttgaa tagtcatagg 720 ggacctaacg aaggcaaagt aaccttctttccctttggtt actaatcctc ctccagttgg 780 ttttgtttta tctttatagg gtcttaacactgtaagctgg gccagcctgg aactcatgta 840 tgtaggtgac caaactctga acagtcttcctgcctttgag atcataggca tgagccatca 900 tgcctgaagt gtaaaacatt acaaaaatagaataatgtaa taactccact cgtgcccatg 960 atagagcata agtagttatc aacacatggccatccctaac tgtacatgta ttatgaaact 1020 aatagtttca tgcagatctc tcgattttcctttgaaacaa tgtctcactg ggtagaccag 1080 gctgag 1086 43 1168 DNA UnknownOrganism Description of Unknown Organism EMBL No. q9ulg1 43 agttccagaacagacagaga gagctacaca ggcaaacctt gtcttagatg aggggaaaaa 60 ataaaagaagtggaaaatat tattcaggga gaacatctag tgtgtgattg ttcacaacat 120 aggataggattatagaaata gttaattctg gtaagtattg tttctttagt cataatctgg 180 tttgtatgtcttctgtttta agttttactg ttttttttgt ttggttggtt tttttttgtt 240 tgtttttttttttttggtct tttgagacag ggcttctctg tgtagccctg gctgttctgg 300 aactcactctgtagaccagg ctggccttga actcagtaat cgcctgcctc tccctcccaa 360 gtgctagaattaaaggcgtt tgtcaccatt gccccctcct cctttttttc cttcacatat 420 acaagcatataaaaaatttt tagtttttta caaacatata taaaaatgtt tagtttcaaa 480 tttttcttttttttttttag attgagattc taacgtactg ccaattgacc agtcgacaaa 540 aactcttatatcaggcacta aagaataaaa tttccattga ggacttactg cagtcttcaa 600 tgggctccacacaacaagca cagaacacca ccagcagcct catgaattta gtcatgcaat 660 tcaggaaggtaagacttggg tcatttgttt tgatgttttt attgacctgc ttcacggaga 720 ggactttaatcttgatgcca gatagagcaa tagagatgaa aattgggagg taaatattca 780 gggagcttaaccctcagcag tgatgtccac aagggacagt aatgactgac catttctttt 840 cttaggtgtgtaatcaccca gagttattcg aacggcaaga aacgtggtct ccatttcata 900 tttctctaaagccatatgaa atttcgaagt ttatttatcg tcatggacag atcagggtct 960 tcaaccactcacgagatagg tgagcaaata gtttacattt ggtgatgctg tgtgcttttg 1020 taatttggcacattgatttt ttagtagtgc taggtattga actcaaggtc tcatgcttat 1080 taagtgaatgatatgtgaat gtccaataaa gagatgttta aacaagtggt gaacagctat 1140 tgcgggtgcttatgggggga gttggagc 1168 44 1134 DNA Unknown Organism Description ofUnknown Organism EMBL No. q9ulg1 44 gcctctccct cccaagtgct agaattaaaggcgtttgtca ccattgcccc ctcctccttt 60 ttttccttca catatacaag catataaaaaatttttagtt ttttacaaac atatataaaa 120 atgtttagtt tcaaattttt cttttttttttttagattga gattctaacg tactgccaat 180 tgaccagtcg acaaaaactc ttatatcaggcactaaagaa taaaatttcc attgaggact 240 tactgcagtc ttcaatgggc tccacacaacaagcacagaa caccaccagc agcctcatga 300 atttagtcat gcaattcagg aaggtaagacttgggtcatt tgttttgatg tttttattga 360 cctgcttcac ggagaggact ttaatcttgatgccagatag agcaatagag atgaaaattg 420 ggaggtaaat attcagggag cttaaccctcagcagtgatg tccacaaggg acagtaatga 480 ctgaccattt cttttcttag gtgtgtaatcacccagagtt attcgaacgg caagaaacgt 540 ggtctccatt tcatatttct ctaaagccatatgaaatttc gaagtttatt tatcgtcatg 600 gacagatcag ggtcttcaac cactcacgagataggtgagc aaatagttta catttggtga 660 tgctgtgtgc ttttgtaatt tggcacattgattttttagt agtgctaggt attgaactca 720 aggtctcatg cttattaagt gaatgatatgtgaatgtcca ataaagagat gtttaaacaa 780 gtggtgaaca gctattgcgg gtgcttatggggggagttgg agcattatta aggctcccat 840 tagatggcct taagaacctt agccattttttattatctac ctgttacggg tatgtatttg 900 caccagaagt caacagttaa aatactaaaatgccttggta tgcttaaagt gacttagagt 960 tgcacttact gcagcactga gtctattactttttggttaa atttactctc ttgatagtgt 1020 ctgcatttaa aaagttgaaa tagtcactaagctaatctgc tagagatcat attcataaag 1080 tggtgtatgg ttcattgtat atctgtaagttagataattc tggattccag actt 1134 45 1068 DNA Unknown Organism Descriptionof Unknown Organism EMBL No. q9ulg1 45 gacttagagt tgcacttact gcagcactgagtctattact ttttggttaa atttactctc 60 ttgatagtgt ctgcatttaa aaagttgaaatagtcactaa gctaatctgc tagagatcat 120 attcataaag tggtgtatgg ttcattgtatatctgtaagt tagataattc tggattccag 180 actttctatt gtgctcttaa gtgaatatctgcatgccagc ttttgagagc tatggacttt 240 gacagggttt ctttgtgtag ccctggctgtcctgaaactc actctgtaga ccaggctggc 300 ctcgaactca gaaatccgcc ggcctctacctcctgagtgc tgggattaaa ggcgtgcgcc 360 atcacgccca gcctggcaaa gaactttcttatgtgtagaa atagtctaaa aagatttttc 420 ttattttgaa ccctccagtt taattatctttccaattctt ttatttccct tgagagttac 480 tgtaattact tgctttccag gtggttgaaggttcttctct ctccgtttgc accagattat 540 atccagcagt ctctcttcca taggaaaggtaggcattttg atctttggaa ggaagtgtat 600 ttgggattta ccagggtgtt cttaattttgcctgtggaca aattttgttt tgaaatagta 660 atggtttggg cttttatttt tattaaaaataagactgttc aattagtgtc tagggaggtg 720 acttagaatg gagcattagc atttgctgcactagtgtgag aactggagtt cagatctctg 780 caaccctggt gaatgctgcc tgtgtagccctcctgtcatc ggaattgggt gttggaaaca 840 ggttgtgcta catgaaactt cctgcacgtggttgcagaaa caggatccct aagggtcagg 900 attgttcttt gattttccag gtattaatgaaggaagctgt ttttctttcc ttcgatttat 960 tgatgtctcg ccagcagaaa tggcaaacctcatgcttcag ggacttttgg ccaggtgaga 1020 agtttgctta ctgtttgatg gaagagcattgggaataggc agggacaa 1068 46 1094 DNA Unknown Organism Description ofUnknown Organism EMBL No. q9ulg1 46 ttattttgaa ccctccagtt taattatctttccaattctt ttatttccct tgagagttac 60 tgtaattact tgctttccag gtggttgaaggttcttctct ctccgtttgc accagattat 120 atccagcagt ctctcttcca taggaaaggtaggcattttg atctttggaa ggaagtgtat 180 ttgggattta ccagggtgtt cttaattttgcctgtggaca aattttgttt tgaaatagta 240 atggtttggg cttttatttt tattaaaaataagactgttc aattagtgtc tagggaggtg 300 acttagaatg gagcattagc atttgctgcactagtgtgag aactggagtt cagatctctg 360 caaccctggt gaatgctgcc tgtgtagccctcctgtcatc ggaattgggt gttggaaaca 420 ggttgtgcta catgaaactt cctgcacgtggttgcagaaa caggatccct aagggtcagg 480 attgttcttt gattttccag gtattaatgaaggaagctgt ttttctttcc ttcgatttat 540 tgatgtctcg ccagcagaaa tggcaaacctcatgcttcag ggacttttgg ccaggtgaga 600 agtttgctta ctgtttgatg gaagagcattgggaataggc agggacaaca tgtaataatg 660 tgaagtgaaa tatttagtat tacaccgtctggaccccccg ccccccacac ctccattagt 720 aatttttttt ttatgaccta ggaatgatacatacctgtaa tcttgggagg ctgaggcagg 780 ggaattgggt gttggaaaca tgttatgctacatgaaacct catcccaccc accaataaaa 840 aaggattatg ggctggagag atggcttagcaggtaagagc aatgactgct cttccaaagg 900 tcctgagttc aattcccagc acccacatggtggcttacaa gatataatag gatctgatgc 960 cttcttctag tgtgtctgaa gacagaaacagtgtagtcat atacattaaa taaataaata 1020 ataaacatcc tttttattta aagaattacttttatttttc tttaataatt tttttaaaaa 1080 tgtatgtgag taca 1094 47 1172 DNAUnknown Organism Description of Unknown Organism EMBL No. q9ulg1 47actgatttta ttacattatt gaatttattt ataacttttt aaaaaatgtt gattggtgtt 60ttgcctgcat gtatgtctgt gtgagggtgt tatagacagg tgtgaactgt catgaagctg 120cgagaaattg aacttgggtc tccaaataag cagtcagtgc ttactcttaa ctgctgagcc 180ttctctccag tccctgttac agtgtttcta atgtactaga tagctcattg ggaattattg 240tctccccgat aagatggttt ttatgctaag agcttttaca gtagagataa atgcttttga 300atatttttgt atttgtttac tttttgttgt ggttttatag aacagcaaaa gtatgaaatt 360gctttatctg aatgtttgaa ggaattgttt ccaaaatgct caagatctac aaaggatgta 420tggtaatgag atagatcctt gttgtgaact cccaaagttc ctaggagcac tgagtgtgca 480catttctctg tttgtttcag gtggttagct cttttcctat ctctgaaagc ctcctacagg 540ctccaccagc tgcgctcttg ggcagagccg gatgggacaa gccatcagag ctatctgaga 600aacaaggatt ttcttctcgg agttgatttc ccactttcct tccctaacct ttgcagctgc 660cctttgttaa aggtaagcca ctgtctgtgc agtgtctgct tactttcctt ctctttgcat 720tattcaaaat gttaaatgat gtcaagtacc cagtgttctc aggagctcgt actgtgtatt 780gagttagaac atatcatgtg taagtttaaa tcctctgtat ataataactt cattgtcgtg 840aacaactgct tggcttgctt tctctaaatg tttcctttat ttttatcgtc tatgttagta 900gttttgcctg catgtgtctg gagttgattt cccactttac acccacatta caaacaactt 960ctcccacgaa atctggatct gcctcacaca tctaccagaa ggaagaggaa tgaaaaggag 1020agggacaaga ggactatgag ttcagagtca gcttgggaaa tttagtgaga cccagtctac 1080aaaataaaaa taacaatagg cccgcagctg ttgtagtagt ttgccatttg ctcatgttaa 1140atttttctta ggaattattt gcttgaggct cc 1172 48 1141 DNA Unknown OrganismDescription of Unknown Organism EMBL No. q9ulg1 48 tcccagcact cagaaagcagcagcaggtgg ttctctgtga cttgaagact agcctgttct 60 acataaagaa ttctgggccatcaaagggta cactgtctca aaaaggatca tctttgctag 120 aactacatga tgctgttagcacctgatttt atattaagag aaaatttaga tgaacatagt 180 cttaatcatc atggcttgagtttacatctg tagttataac aaactactta gtacacgtag 240 tattttgtct gaaatacctcttctgaaagt agaattagaa atgacatttg tttctgtata 300 ctaataaaac tgcattttgaaattaatgtg ggcctaaact acgtactgta tgtttggttc 360 taatttgtgg ttgtttagatataatagtat tggccaagaa aaaaagttct ttaagttgaa 420 tagtatatga ctcattaacagtaattgtcc ttacactaat tttggtttgt tttttttgtt 480 ttttgttttg ttttttttagtctcttgttt tcagcagcca ctgtaaagca gtgagtggct 540 actcagacca tgttgtccatcagcggagat cagctacctc ctcacttcgt tgctgcctcc 600 tcactgagct gccgtcttttttgtgtgtgg ccagtccacg agtaagtgcc acaggagaga 660 aggaatgaaa ccaattatcctgtaagaatg agctagtact caagggacag tttctaagct 720 gttcagtctt agtttgtaagaagagaagtg ctgggcgtgg ttattcactt ttgatcctaa 780 gacatgggaa tcttgtgagttcaaggcaag actgaattac atagtaaaac cccatgccaa 840 agaacattaa aaatggagaatatccatgat cctgaccttc ctaagacagt acttctcacc 900 ttgaaatgtg cagatttgcaaattattata tggtacatgg ttgctacttt tgattaagcc 960 agagactgta aactgtaatgaaacaagggg cttgttgagt acatcattcc ttagcaggat 1020 cagagaaaag gaaggaagccattgtcacct gctttgatgt tttattaagg tcataggatt 1080 ctggctcaat tatttgaagattctctctgg ccttatctca atacagtcca ggatcaggca 1140 a 1141 49 1230 DNAUnknown Organism Description of Unknown Organism EMBL No. q9ulg1 49gcttcctttc tgacatcact gtcataagtg gccatagcac ttgtaataag tgggtggtaa 60atgtatattg agagtagata tccagactag aatcttactt tatctacatg caccttttta 120tatcttttga ttgcaggttc atgtgattag cgattaccag tttgcccaga gaagctctca 180aattgagtta gtctttgcct tcatcttact atgctagagg atgaaatata aagccaccag 240tctgaggtta ttcacattga tctgatttca gagttgtggg cctagggata gagctcagca 300ttcacaagcc tgaaacttgc tataaccccc actgggtagg tgaaaggact actcaggtgg 360cttcttgaga atttggaggc cagcctgagc tatatgagat cctatctcag aaggaaaaaa 420agttgatttc cctcaaaggc ttgatgtgtg tgacaaatgg cagaagagcc attttattgt 480ctgcgaattt taccctgcag gtcaccgcag tgccgttgga ttcttactgt aatgacagaa 540gtgcagagta tgagagagga gttctgaagg aaggagggag tctggctgcc aagcagtgtt 600tgttgaatgg ggctcctgag ctggctacgg attggctgag tcgcagatcc cagttcttcc 660cagagccagc tggagggctg ctgagcatta gaccccagaa cggctggtct ttcatcagaa 720ttccaggtga gttttctgct ctttggagca tgtttccagc tttgacaaga ggagaaaggg 780ggagaaagcc catgtgatag tttttgttgt ttggtatttg gagttcctga ggtttctaac 840tctcctaacc tgtaacttat aggtaaaaat atgagtactt tgtgtcttga gtggaaagat 900gatgattgaa atgtttctag atttgttcgt gagtactctc ctttgataag aagagtgtaa 960tgtcactttt ttaaatggga gaaggttggg gtgctcatgg gtagagtgct tatctagtat 1020gcacaaggcc ctcaccagat gaccccccac acacacacac cccaaaaccc cacaaagttt 1080aggaaagact tcaggtcgaa tgagtgcagt tgttttgtgc cattgccagt ggaatgaatg 1140agaatgtcgt cactcccaca gagcctagtt aagtagcata aacagtgtcc tgcacaaggt 1200ctagagatct aaatgatagc aagaggaaaa 1230 50 1286 DNA Unknown OrganismDescription of Unknown Organism EMBL No. q9ulg1 50 taactcccag catgcaaacagaggcaggga aacctttttg aatccaaagc caacctggtc 60 tacatagcaa attccagactagccattgct acaaagttag aaccttgtct caagagaaat 120 gaggagaaga ggaagagcagttaacagcta agaggtatta ccaggcttcg cagtgtctct 180 gtaatctgag cacttggatgatggaagcca gaggaccaaa aactcagggt catcctcagc 240 tacatactaa gttctagagtagccaaagat agaaggaagt atctcaaaag aggggagaaa 300 ggctattggg ctgaaatcgtagctcagagg tagagtgctt gccaaatgtg ttcacattcc 360 taggtttggt gctctggagtaccgcaagaa aggcaaaaca aacaatatac atgtaatgtt 420 gtatagctga aggtctgtttctataatgac atatttttct gtaatatctg ttccatgttt 480 ctacttttat tggttatcagtcagatatta gtatggcagc aaaagcttat gtacagatta 540 caaggtgact gccatcatttgagttttaaa gaaagaacac ctttgcacag tagtacaaac 600 ctcaagatag catccactctctagccctag attgtaattg tagagattcc tgtctatttc 660 cacattgaat ctttccttttcctcctaaca tgtcttcctc ccctcttctt taggaacgac 720 atctttgtgt ttctgttaagcacgcgagct ggaggactgg gtatcaatct cacagctgca 780 gacacagtaa gtgatgaggtctctactata aatagttcat tcgttgcacg ttttactttt 840 cccttttgtt ttttcattcactttgaatga ttttatacat taatttaata aaatgcttac 900 tatgtgtcaa gtattttcctaacagttaag atatagcatg ataataagtg aacaggagat 960 ggctgctaac caggcagtccaattggtttt gtctgaggag ctataactaa acaaataaaa 1020 aagagttgtt ttcttattagtgcctgattt cattacttga gaaggtaatg gtagaagttg 1080 tggtctaaat gtcaagagctgtttggatag tgatgaataa ttaaataaaa taaagtaaat 1140 tatattcttg caattttttgtccattcata ccaagtctcc tgataagact actttagcct 1200 ctgaaaggaa aaagaaattttcttttgaat cttagcatta ttccatggat tcagatgtat 1260 ttagtagcag tcatagtaacatttag 1286 51 1159 DNA Unknown Organism Description of Unknown OrganismEMBL No. q9ulg1 51 aacctggtct tgatagtgat cctttcgtgt gagcttcctaagtatcagtg actttaggca 60 catacaagca ctcctgtcta attgttacca ccaacccctcccccttaaat gtattttatt 120 tttaattgtg tatgtgcaat gccgtgaaag ctagatatgtcagattccct agaactgggg 180 gtacagaaga ctatcagcct cctgtcccag gtactggaaataaaacccag gccctcatcg 240 cttagccatc tgtctgtcta gttcatagtt ggatcttttcagtgaaaact ggaaagacgg 300 ggggcatgcc tagttttcca gagcaacaca catatagcttggtcttttaa ggagtttctt 360 tttcatcatt acaccataga aagaaattgg acatgactaacactagtttt gtagacagat 420 aagtggctat actgctctca gaatttctgt cctgcactcagaacatccat ttttgttgta 480 tccttttctt gtctatgcag gtgattttct acgacagtgactggaacccc actgtagacc 540 agcaggccat ggatagggcc caccgcttgg ggcaaacaaaacaggtcact gtgtaccggc 600 ttatctgtaa aggcacaatt gaggagcgta ttctgcagagagccaaggaa aagagtgagg 660 tgagcacggg gaaggaaggg tgatcgtgct ggagggacagaaagcagtca gtactgtacc 720 gaaattattt aagacttata tttcattagg cagacaaactagtgttcttg gtaagcattg 780 gagcctgtac cttacttagt cttactagct cctgtgtacactgataccag gaagggtgac 840 atttcagagt tcaccttggt ttgtccccaa aaaaatcttcaaattgtcct ttctttggga 900 caaataatgt agaggagcca ggtcagtgaa caagaactagtgagccaaag cctccctttg 960 gagctgattt cacagggctg ctgctgctgc tgctgtatgggaaagaacac atgcagatga 1020 cattttaatc cactttgttt agattcagcg catggtgatttctggtggga acttcaaacc 1080 agataccttg aaacccaaag aggtggttag ccttcttctagatgacgaag aactggaaaa 1140 gaaacgtatg tactttggc 1159 52 1103 DNA UnknownOrganism Description of Unknown Organism EMBL No. q9ulg1 52 caggccatggatagggccca ccgcttgggg caaacaaaac aggtcactgt gtaccggctt 60 atctgtaaaggcacaattga ggagcgtatt ctgcagagag ccaaggaaaa gagtgaggtg 120 agcacggggaaggaagggtg atcgtgctgg agggacagaa agcagtcagt actgtaccga 180 aattatttaagacttatatt tcattaggca gacaaactag tgttcttggt aagcattgga 240 gcctgtaccttacttagtct tactagctcc tgtgtacact gataccagga agggtgacat 300 ttcagagttcaccttggttt gtccccaaaa aaatcttcaa attgtccttt ctttgggaca 360 aataatgtagaggagccagg tcagtgaaca agaactagtg agccaaagcc tccctttgga 420 gctgatttcacagggctgct gctgctgctg ctgtatggga aagaacacat gcagatgaca 480 ttttaatccactttgtttag attcagcgca tggtgatttc tggtgggaac ttcaaaccag 540 ataccttgaaacccaaagag gtggttagcc ttcttctaga tgacgaagaa ctggaaaaga 600 aacgtatgtactttggcaac cgaagttctg cccttgccag atttacagaa tgagataagc 660 attgcatatgccaaggctag agtgagtgtg tgtgtgcagt gtgtatgagt gtgtgtgcag 720 tgtgtatgagtgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg 780 agattgtggttaccttccac tatatgagtt ccaggttcaa attctcattg tcaggcttgg 840 tagcaaatacctttacctag tgagtcatct cactggccca gaaaaatatt ttacacataa 900 tttcaacagcaagcttctat aactataaag accctttgca tagagttgta tattctgaga 960 atattgagtttcagatttac cctgagttcc tgtgagtact tcctcacctc tacatctaaa 1020 ctaaactcttttcaagaaga aaagacaagg aagcaacata attgagtaga atccaggttt 1080 gaacctaaaagctgttgaga tac 1103 53 1089 DNA Unknown Organism Description of UnknownOrganism EMBL No. q9ulg1 53 atattgagtt tcagatttac cctgagttcc tgtgagtacttcctcacctc tacatctaaa 60 ctaaactctt ttcaagaaga aaagacaagg aagcaacataattgagtaga atccaggttt 120 gaacctaaaa gctgttgaga taccaataac tattgttccttatttaggaa aacgatattt 180 tctcttgttt tggcttttgt tttgttgttg ttgttgttgtttgtttgttt gggttttgct 240 ttgttttgtt tttttctgaa acagaatttc tttatgtatccttccttagc tgttctggaa 300 ctagctctgt agaccaggct ggccttgaac ttatgaaatctgcctagctt tgcctcttga 360 tccctgggat tgaaagcata tgcccagacc aaaataaaagtttttcttaa acaaaaatta 420 caccttggga accaaccaca agaggatatg gccctaagtttcagaggata acagttatga 480 ctcctacatt ttcttgatag tgagactgcg gcaggaagagaaacggcagc aggaggaaag 540 caaccgagtg aaagaacgca aacgcaagcg ggagaagtacgcagaaaagg tatctccaga 600 tggcttgtgg gggggccagg ccctgggata agttttagaagcacaaaagg cctttgggtg 660 ccatacatgc atgtatgggc gggcgcctac acacatatttgttttacgta gtaaaccaca 720 gcttgcatca gtttttcctt ctcacgcatg ctcgtgttggtcccagttgg actggacaat 780 cagtgataac tgtgatagct aaggggataa tgctacgtacataattagct tttatagaac 840 ttagtttatg tggtttgcgt cagggtcttt ctacttatccctgctgccct ggaacgcagt 900 gggtagacca ggctggcctg gaactcaaaa tatcctcctgtctctgactc aggagtgtct 960 gacttctttc atagactctt ttaaaaggac ctgggcaagcatgatgagaa ccacctttaa 1020 tcccagcaac tgggagacag aatcaggcag atctctgagttccagaccag tcatggctac 1080 ataatgaga 1089 54 1156 DNA Unknown OrganismDescription of Unknown Organism EMBL No. q9ulg1 54 gtgcagtgca tgcatatgcacacatacagt cagtcagtca gtcaatgagc gagccagact 60 agaaatgggc tgtcaggaaagggtatgcct tcctcctcct ctgcgagttt tcacttcctt 120 caagattcag ggcttgagaagtggctcagt ggtggagcac tttccctgag tgtgagaggc 180 ctttagttca gtcctcagtacacacataac ctatacacac gaaaaattaa ttgagcctgc 240 atagtcatgc tgtcaggaagatggagaaaa tttgaggtca gcctaagcta tagagcaaga 300 ccctgtctca agtcagtgtagggtgtgtgc tcatggctta gacaggacaa tgaggccaca 360 acaggaactg taacaagtgccaggctagtc agagccatat accaagactc tgcctataat 420 tgttttattt gttaatctcgcttttctctt tggggcaaat actcatgttt ttatgtattt 480 tctgaccttt gtattcccagaagaaaaagg aagatgagtt ggatgggaag aggaggaaag 540 agggtgtgaa cctcgtgatcccgtttgttc cctctgctga caactccaac ctctccgctg 600 atggggatga ttccttcatcagtgtcgact cagccatgcc cagccctttc agtgaggtga 660 gcctcttcct gcgttctacatcacagcagt gggactgcac tctgaccttg tggcagggac 720 atggtgggca gtgttcacttccagccttgt aggaagggtt gtataaggac aggctgactc 780 tcagagccaa aggcagatgggagggagaaa tgctacatgt cccccagagc atgttctcac 840 ttgagtgtga gggctgtagccattgaagtt attagtaagc tcagcccttc tgcttccaga 900 tctcaatcag cagtgaactgcacactggct ctattccccc tgatgagagc agcagtgaca 960 tgttagtcat cgtggatgacccagcctcct cagcacctca gtcgagagcc accaactctc 1020 ctgcttccat aacaggctctgtgtcagaca ctgtgaatgg taagtgatgc tactctttca 1080 tacagcgtca gcctgctccactgctcagtg ggaagcattc ctctgggggt aagtgagctc 1140 tgcttccttt taggat 115655 1160 DNA Unknown Organism Description of Unknown Organism EMBL No.q9ulg1 55 taccaagact ctgcctataa ttgttttatt tgttaatctc gcttttctctttggggcaaa 60 tactcatgtt tttatgtatt ttctgacctt tgtattccca gaagaaaaaggaagatgagt 120 tggatgggaa gaggaggaaa gagggtgtga acctcgtgat cccgtttgttccctctgctg 180 acaactccaa cctctccgct gatggggatg attccttcat cagtgtcgactcagccatgc 240 ccagcccttt cagtgaggtg agcctcttcc tgcgttctac atcacagcagtgggactgca 300 ctctgacctt gtggcaggga catggtgggc agtgttcact tccagccttgtaggaagggt 360 tgtataagga caggctgact ctcagagcca aaggcagatg ggagggagaaatgctacatg 420 tcccccagag catgttctca cttgagtgtg agggctgtag ccattgaagttattagtaag 480 ctcagccctt ctgcttccag atctcaatca gcagtgaact gcacactggctctattcccc 540 ctgatgagag cagcagtgac atgttagtca tcgtggatga cccagcctcctcagcacctc 600 agtcgagagc caccaactct cctgcttcca taacaggctc tgtgtcagacactgtgaatg 660 gtaagtgatg ctactctttc atacagcgtc agcctgctcc actgctcagtgggaagcatt 720 cctctggggg taagtgagct ctgcttcctt ttaggataca ggattttattgttgttgttg 780 ttgttgttgt tgttgttatt aacttttttg ttctgttttg gatgtttttgttgttggttg 840 gttggttggt tggttggttt ttttaagaca gggtctctca catagtgctggcatttgcta 900 tgtagaccag gttgtccttg aacttaataa gagatccacc tgcttctgatttccacatcc 960 tgggattaaa agcatatact accacatctg gcacattttt atttattgtgtgtgtgtgtg 1020 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtatg tgtgtgtatacacaacgtgg 1080 aggtcaaagg acagaataca aggattggtt ctctccttcc accactgtggtcccagggat 1140 tgaatcagcc tctcaggctc 1160 56 1216 DNA Unknown OrganismDescription of Unknown Organism EMBL No. q9ulg1 56 gcttgtctag cgtgcactaatccaagacct gggctcagtg cccagaaggt tgttttgttt 60 tgttttgttt tgttttgttttgttttaaat agagatagaa gttggttgtt gaaggcggga 120 acactttagt ttttgaaggaagtcttggag ttcatttagt gatgggctag aataaaaagt 180 aataaccatg gtggagccactccttagaag ggacaacagt aggaaaatca tagctatgtt 240 aaaagacatc cccaaatgtcctcagatctc agtgagtcag gcaccatatc ctgtgtctat 300 ggtctcagaa ctcagaatatcagtctgaga ttggaggatt acttgagatc gggggtttta 360 aaaaggtcag cctgaataacattaggaaac cttgtctcaa acaaaagagg accccttgag 420 agccagtatt ccctatcaggggtatttgtt agcattttaa gagatttatt tttttccctc 480 ttggctattc gttcccacaggaatttccat tcaggaagtg ccagctgcag gacgtggtca 540 ctcagctcga agccgaggccgccccaaggg ttcaggaagc acagccaaag gagcaggcaa 600 aggccgaagc cgcaagtccactgcaggcag tgctgctgcg atggcaggag ccaaagcagg 660 ggctgcagca gcttctgcagctgcttatgc tgcatacggg tacaatgtgt ctaaaggttg 720 gtgcagattg tgatcaaggactgtctgaga atccatttaa catagagtgt gcaggatatt 780 ccaagccaaa acccggagaccatcttagga ctgagcagtt ctgactcacc cttgcactcc 840 tgacaaatag ctgtctgtgaagtagaagta gctgtggtca gagtgaactg aaggaggagc 900 tgcacttgaa acatccagtttttctgcccc tcccctttaa ttctggttgg ttattgtttg 960 cttgtttgtt tgtttttctgggacatttat tttccagtaa tccaaacaag ggtagttaac 1020 atttatccag ctacctgggccattgcctca ggcagtgcac acctaagagt gcataggggt 1080 agagctggta gagcatgcatgtgcccttga atggaacaag ccagaagaga agcacgttgt 1140 ggagtggttt ataagcagtatacagataat ggaaggaaag aggcaagctt acttgtgatt 1200 acaggtcaaa agctgg 121657 1949 DNA Unknown Organism Description of Unknown Organism EMBL No.q9ulg1 57 tacctttaat cccagcactc aggaggcaag acagtcagat ccttgtgagttcaggaccag 60 cctggtctac agaatgaatt ccaggatagt catctctatg aaaagatgatactatctcaa 120 caaacaaaca aaaagcaact gaattcaggt gttttccaga agacaagacagcattagtgc 180 ctggtgagct acagctctca ttgtgcaacc aggccttcca tgtcagacatgtgccctctc 240 cagagcctga agagtatgtc ttccactctg gatggggtaa tataggtgggacttagtgtt 300 tgttgttctc tctcaacaat gtagacatct taccaaaagg caattaacaggaaaaatagg 360 caacatcaga gatgttggca aggagcaaca gacagagggg ttcccacccctttcctccag 420 cccagactta gcctaatact tcagactcca aggctgacag ctggtgctgagggtcattgt 480 ggttctctcc atccctacag gaatctccgc aagcagtcct ctgcagacatccattgtccg 540 acctgctggc cttgcagact ttggaccttc aagcgcctct tctcccttaagttcccctct 600 gaacaaagga aataatattc ctgggactcc taaaagcctc cacatgaccagcagcctagc 660 ctcagactcc ttgatccgga aacagggcaa aggcaccaac ccctctggaggacggtaacc 720 atggtaacca tctctgccct ctagcttcct tcaaccaaac caggggctacagtcctgagc 780 cataggtggt ctttggatgg cttgcctagt gtggcatctt gcatcctatttggagagtgg 840 aaaggaccag ttgtagcagg agagaacagg caggtggttg gtgtgagcacttttatcacc 900 tgtttccaaa ggaatatcct gggttcggcc ccacagcatc ttagatgtactctgcagccg 960 tactcttaac ctctttctgg ggacgggcct gacacagaac ccttttatagatgctcaggc 1020 acactgtctc catccccatc ctactcttca gctctgacca tgtccctcatgaaagctcca 1080 tgggtgctgt gaagagcctt ccatagtgga gacttgtcta aaggttatggtttcctgcag 1140 gactagggag gaagtggttc cctggcatcc atagtctggg accgctcctgggtctctaaa 1200 ccctgtttgc cacagtgtca tcactgaaga acagaacaca gtgaatgccagagaagatgg 1260 tggctgtaag gatgagaggc tggagcaagc agagccacag gcagttatcccagcatttcc 1320 tcctgtccag cacagttcac accagggaag ctttaggtcc caccagcaacagtagcagca 1380 gctcccactc aagggacttc ccagaagcca gtaaagagac caggaaccacctcaatcagc 1440 aggacatcct caccaccctc ttgcagatgc ccctttgccc atcctgaatgcacagcctcc 1500 ccggctttgc ccttcagccc ctgcttggct gtatgcactg tctgtattgcactgagaaag 1560 aagggacagc aggagtgaga tggggaggga gctggctcag caccacccctcccagccctg 1620 ccccactcgc ctgagcttgc tgccctctga gaggggaaaa gggcggctgggagggctttc 1680 cacctgatgt ccctggtgga acaggtgctt ctgggcgggc cagcctctaatttgcacacc 1740 tgaaatcgcg gaattgagtt tagatagatt gattttttaa acactttttttttttttgga 1800 gtaggtgtag gggaatcatt taatttaaat cataaagatt cccctacccaaaccctgact 1860 cctgtgtaca gatgctcttt agagggaatc agaaaaatgc caagcctttttttctctttg 1920 aatgtgctgt ctatttttat aactgaact 1949 58 1369 DNA UnknownOrganism Description of Unknown Organism EMBL No. q9ulg1 58 tccctggcatccatagtctg ggaccgctcc tgggtctcta aaccctgttt gccacagtgt 60 catcactgaagaacagaaca cagtgaatgc cagagaagat ggtggctgta aggatgagag 120 gctggagcaagcagagccac aggcagttat cccagcattt cctcctgtcc agcacagttc 180 acaccagggaagctttaggt cccaccagca acagtagcag cagctcccac tcaagggact 240 tcccagaagccagtaaagag accaggaacc acctcaatca gcaggacatc ctcaccaccc 300 tcttgcagatgcccctttgc ccatcctgaa tgcacagcct ccccggcttt gcccttcagc 360 ccctgcttggctgtatgcac tgtctgtatt gcactgagaa agaagggaca gcaggagtga 420 gatggggagggagctggctc agcaccaccc ctcccagccc tgccccactc gcctgagctt 480 gctgccctctgagaggggaa aagggcggct gggagggctt tccacctgat gtccctggtg 540 gaacaggtgcttctgggcgg gccagcctct aatttgcaca cctgaaatcg cggaattgag 600 tttagatagattgatttttt aaacactttt tttttttttg gagtaggtgt aggggaatca 660 tttaatttaaatcataaaga ttcccctacc caaaccctga ctcctgtgta cagatgctct 720 ttagagggaatcagaaaaat gccaagcctt tttttctctt tgaatgtgct gtctattttt 780 ataactgaacttgtacatat gtataaagag agacacatct ttcttttact aactggataa 840 aaaaaatcttaaataaaatg gagtgagata attttatgta aatcaaagtg tctgtggtct 900 ttgcagctgcctttgtactt tgcagtacaa agttgcgccc ttggagattt gacagcgtca 960 aaacaatccagagccctaat ttctgtgacc aaagaggacc atagtgggac aaggagtgtg 1020 cggtgtgtgtgtgctcaggg ggacaaggag tgagctgggg agggggtgct caggtgcagt 1080 gttaatggaacttgcggatt tgtctccacc tttcaaaaga agattgacca agtccctgcc 1140 atgcagaatgggccctgggg atgagggttc cttatggttc agtcctagta gaactggcct 1200 ggagcaggcaaagttagata gtggtaacct gaatacttgt aagaaacatg aaaggaaact 1260 gtgagtgagtccctaaggat tccagatgtt cttagttttg acagcttgac tggtcggttg 1320 aggaaaggtaccagcctaga ctggcagtca ctgttctgtg attgaactt 1369 59 1408 DNA UnknownOrganism Description of Unknown Organism EMBL No. q9vci9 59 ccagagtggaatgcggaggg tgtccaaaac agcttctctg cagtgcgtgc ttttaggcgg 60 ggccccaaaggcaagaattc gtgccgccca aagtattcct actggtcgtg ccctgcactg 120 gccactgctttgggcggcaa tgattctgcc aggtgcaccg gctggactgc agggatgaca 180 ccgtttagaccactgagagg gccttcccgg gagacggcgg gtgcccgcgc ccattctaag 240 gcccgttcccggtgccagca gcctgacgca atctgactcg cccttgctgc atgccagttc 300 tggggaaaccttccctgccg ttgcatcact cctgccaggt ctgccacggg aggaggagcc 360 gaaccaatcagcacgcgcgt tggccctggg gcgggctgct ctggtaccca ctcggagggc 420 ggcgcggttaaccgagaagc aaaatctaaa ggtgattggc cagaaagaga tttgccccgc 480 cccaatcatagggacagctg gaggcagtct gagggccttc ctggccggag ggtttaaaga 540 gcgcctctggagggaccact cagctggaac gaccgatcgg tgccaggcca ggtgtacgcg 600 tccgtcggtccttccgtgcc cgtgccggag accagtctcg gaggccaccc gggtccgtcc 660 ctgcgcccggcaccatgaag caggagtccg catcccagag cactccgcct ccttcactgt 720 cccctgcaccatcatccgcg cagccttcct ggggggatgg cgacccccaa gccctgtgga 780 ttttcgggtacggctcccta gtgtggaagc cggactttgc ctatagtgac agccgtgtgg 840 gcttcgttcgtggctatagc cgacggttct ggcagggaga caccttccat aggggcagcg 900 acaagatggtgagcatcctt ctgtgcccag aggagtggag tggggttggc aggagagtgg 960 gcactcgtatcctggagtgg cagggaccct gggctaacta agagaaaatt gtaaacctgg 1020 tttgtggtttaaatttgtgt gcctggaaat caggttggtg attgcacctg tggattcttg 1080 tgctggttactaatctgggc cgctcgttgt ttgtctcttc cacatctgcc catcactcca 1140 tgtcactcgatgaaaggtcc tctcccaggc ttggggctta ggctggcact ctttcctcct 1200 cttccttctcttcctcttct tcctttccct cttcctcctc ttcctcttct cttcctctcc 1260 ctcttcctccttgttcttct cttcctcttc ctcctcctcc tccttttcct cctcctcttc 1320 tcccccctctttttccccct cctccatctt acctatttct tgctatgtgg cctcaaactt 1380 gtgacaaatctctctctctg gtgctgaa 1408 60 1036 DNA Unknown Organism Description ofUnknown Organism EMBL No. q9vci9 60 cccatcactc catgtcactc gatgaaaggtcctctcccag gcttggggct taggctggca 60 ctctttcctc ctcttccttc tcttcctcttcttcctttcc ctcttcctcc tcttcctctt 120 ctcttcctct ccctcttcct ccttgttcttctcttcctct tcctcctcct cctccttttc 180 ctcctcctct tctcccccct ctttttccccctcctccatc ttacctattt cttgctatgt 240 ggcctcaaac ttgtgacaaa tctctctctctggtgctgaa gtgctggaac tacaggttca 300 agtcacaaca ggactaaagg tgtgtgtgtgtgtgtgtgtg tgtgtgtgtg tgtgtgtgtg 360 tgtgtgtgtg ttgctggaga ttgaatctaaggtcttgtgc atgacaggca agccccccat 420 gtcaataagg ttcattcata gtcctttcggaagtgctaat atctaatttg tctttttcaa 480 aacctttctt ccctgtctag cctggccgagtggtgaccct ccttgaagac cgtgaggtaa 540 gtgtgcagtc aagaagagaa tcctggggtctgatgtatca gggtgcagag ggtcagagct 600 cttgtgtggg gagagtggaa gtgtagctagcttactccat gcttcttgga gaatcacttg 660 agggagggtc ttattaagat ggatttctgtgagttcagag ttattcttgg ttacataatg 720 aatcctgggt cagacaccct gtactatatgagacgtctca aaataaacaa aactcaaggg 780 aaatagggtg aagggtattg cttctgggtggctcagcagc cagtcaaaca cgttagtttt 840 tttttaaagc ttcatggaga aatggctcaggagtcagaag caccttctgc ttctccaaag 900 ggcctggatt tgatacccag cacccacacagtaactcaca atctgtagct ccagttccag 960 ggaatcagac tcttctgact gaccaccaagatcacaggtc gccaggcaca cacgtccata 1020 cacataaaac ttcaaa 1036 61 1450 DNAUnknown Organism Description of Unknown Organism EMBL No. q9vci9 61ttagtttttt tttaaagctt catggagaaa tggctcagga gtcagaagca ccttctgctt 60ctccaaaggg cctggatttg atacccagca cccacacagt aactcacaat ctgtagctcc 120agttccaggg aatcagactc ttctgactga ccaccaagat cacaggtcgc caggcacaca 180cgtccataca cataaaactt caaaattaca tctatttgta catgcacgca tgtgcacacg 240ctgtaggtca gatgtggaag caagacgaca agatggaagt cgattctttc ctccgaccat 300tcatgtccca gggattggac ttaggttatc tgatcatcag gcatggtagc aactacctct 360atcccttgag acgtctcccc accccctcca cctcttttat agaacatagg tgtggaatgt 420gtctagggga acattctaga atgaacacag gaccagcatc aagctctgtg actgactgga 480gtgtctctgt ttttccctag ggctgcactt ggggtgtggc ataccaagtt cgaggggagc 540aggtgaacga ggccctgaag tacctgaatg tgagggaagc cgtgcttggt ggctatgaca 600ctaaggaagt caccttttat cctcaagaca cccctgacca acccctcaca gcactggcct 660atgtggccac cccacagaac cctggctacc tgggccctgc tcctgaagag gtcattgcca 720cacagatcct tgcttgccga ggcttctctg gtcacaacct tgagtactta ttgcgtttgg 780cagacttcat gcagctctgt gggcctcagg cacaagatga gcacctggaa gccattgtgg 840acgccgtagg aaccctgcta ccctgctctt acctacctga gcagcctctg gcactgacct 900gaggagccaa gctcctgcaa gaagtgtctg agtggtactg gtggacatca gtatgcagta 960cttgagatag acttgatgga gcaagagaga gttgagaagg catgctgggt ggccaggggc 1020tttgtgtctt atgccccgcc tgtctgctag ccttcagctc ttccttcatt gacccttact 1080cactacttga acctttattt attgcaccat gttggtgtgg tgggcagggc aggtggggga 1140cctgccctgg atgtgggccc tgcagtgcgg tggctctgcc ctagtcctct ggtatgtaac 1200cagaatcccc ccattgctgc tgccaattcc acaccaccca ggcctccgta gccccaggga 1260ccctccaaga tcgttgctcc tctgtccacc cagactaccc cagccgtggt agtatcacct 1320gcccatgttc cgggccttct ggatgaggga cagcagagaa ggaggcgaag tagctcttca 1380agggccaagg gtcagcatcc ctcttcattg acgggcccgg ggcagagccg gatcctatgc 1440acagacacag 1450 62 1301 DNA Unknown Organism Description of UnknownOrganism Chp, EMBL No. q9z1y0 62 ctttatatgc taggcaagca ctctgagctacattctcagc ttcaatctca gtatattaac 60 aaaatagttt attagtaaaa ttactattctgatgtttagt acttgtacat atatatatat 120 atatatatat atatatgtat atatatacatatatatatat gtgtgtgtgt gtgtgtgtgt 180 gttactaact tagaagagat gaatgtgatgtgtttaattt gaacatgcag tattatggat 240 tctgtagctg catcttccta ctaacaataaattgtggatt taccaaaata tcatatgccc 300 ggtctttgtc cttgtacctt cgtggagcctggttttcata ttcctttctt ttctggatgc 360 ttggtttttt ttctgggtgt tctgcagagggaggctccag gtcggtgggc ggggtccggg 420 gcactaggga catgcagatg aggtgggcgggacccaactt atataccttc tgtcagcctc 480 tagcgggcgt gcccagcttg gacagattgtcagcgtccgg ctgcggaacc tgcttccccg 540 agtgccgcgg agcctggtcc gggctggcccctctgctacc ccaggagcgg accatgccgc 600 cgcgggagct aagcgaggcc gagccaccgcctctcccggc ctcgacccct cctccgcggc 660 ggcgcagcgc ccctccggag ctgggcatcaaatgcgtgct ggtgggcgat ggcgcggtgg 720 gcaagagcag cctcatcgtc agctacacctgcaatgggta ccccgcgcgc tatcggccta 780 cagcactaga caccttctcc ggtatgttctatagccccgg ggcccctgag gatgggaagg 840 gttgtgcatt cagtagcctg ctggcgggagggtacggaag accccgggag caggcccgga 900 ggtggcgctg gtgaggcctg caggagggacgaggatgctg tgcctaagtc atgctttccc 960 ctccccacct ctgcagtgca agtcctggtcgatggagccc ctgtgcgaat cgagctttgg 1020 gacaccgcag ggcaggtgag aacctgggtgtagccttcct tgggcaaggg gttggagagg 1080 gttggaggct gggaggatcc ctgcgtggagtgggaatgga ataggctttg ggctttagca 1140 cttttaggtc tccaccccca agggagaagcagattctggt tccaatgtgg agggaatgat 1200 gttgctaaca actagccttg ccaccccaggaggactttga ccggcttcgt tctctctgct 1260 acccggacac cgatgtcttt ctggcttgcttcagcgtggt g 1301 63 1059 DNA Unknown Organism Description of UnknownOrganism Chp, EMBL No. q9z1y0 63 cctctagcgg gcgtgcccag cttggacagattgtcagcgt ccggctgcgg aacctgcttc 60 cccgagtgcc gcggagcctg gtccgggctggcccctctgc taccccagga gcggaccatg 120 ccgccgcggg agctaagcga ggccgagccaccgcctctcc cggcctcgac ccctcctccg 180 cggcggcgca gcgcccctcc ggagctgggcatcaaatgcg tgctggtggg cgatggcgcg 240 gtgggcaaga gcagcctcat cgtcagctacacctgcaatg ggtaccccgc gcgctatcgg 300 cctacagcac tagacacctt ctccggtatgttctatagcc ccggggcccc tgaggatggg 360 aagggttgtg cattcagtag cctgctggcgggagggtacg gaagaccccg ggagcaggcc 420 cggaggtggc gctggtgagg cctgcaggagggacgaggat gctgtgccta agtcatgctt 480 tcccctcccc acctctgcag tgcaagtcctggtcgatgga gcccctgtgc gaatcgagct 540 ttgggacacc gcagggcagg tgagaacctgggtgtagcct tccttgggca aggggttgga 600 gagggttgga ggctgggagg atccctgcgtggagtgggaa tggaataggc tttgggcttt 660 agcactttta ggtctccacc cccaagggagaagcagattc tggttccaat gtggagggaa 720 tgatgttgct aacaactagc cttgccaccccaggaggact ttgaccggct tcgttctctc 780 tgctacccgg acaccgatgt ctttctggcttgcttcagcg tggtgcagcc cagctccttc 840 caaaacataa cagaaaaatg gctgcctgagatccgcactc acaaccccca agcacccgtg 900 ttgctggtgg gcactcaggc tgacctaagggacgatgtca atgtactaat tcagttggac 960 caaggaggcc gggagggccc agtaccacaaccccaagccc agggtctggc tgagaagatc 1020 cgcgcctgct gctaccttga gtgctcggccttgacgcag 1059 64 1845 DNA Unknown Organism Description of UnknownOrganism Chp, EMBL No. q9z1y0 64 gcctcatcgt cagctacacc tgcaatgggtaccccgcgcg ctatcggcct acagcactag 60 acaccttctc cggtatgttc tatagccccggggcccctga ggatgggaag ggttgtgcat 120 tcagtagcct gctggcggga gggtacggaagaccccggga gcaggcccgg aggtggcgct 180 ggtgaggcct gcaggaggga cgaggatgctgtgcctaagt catgctttcc cctccccacc 240 tctgcagtgc aagtcctggt cgatggagcccctgtgcgaa tcgagctttg ggacaccgca 300 gggcaggtga gaacctgggt gtagccttccttgggcaagg ggttggagag ggttggaggc 360 tgggaggatc cctgcgtgga gtgggaatggaataggcttt gggctttagc acttttaggt 420 ctccaccccc aagggagaag cagattctggttccaatgtg gagggaatga tgttgctaac 480 aactagcctt gccaccccag gaggactttgaccggcttcg ttctctctgc tacccggaca 540 ccgatgtctt tctggcttgc ttcagcgtggtgcagcccag ctccttccaa aacataacag 600 aaaaatggct gcctgagatc cgcactcacaacccccaagc acccgtgttg ctggtgggca 660 ctcaggctga cctaagggac gatgtcaatgtactaattca gttggaccaa ggaggccggg 720 agggcccagt accacaaccc caagcccagggtctggctga gaagatccgc gcctgctgct 780 accttgagtg ctcggccttg acgcagaagaacttgaagga ggtgttcgac tcggccattc 840 tcagtgcgat tgagcacaaa gcccgtctggagaagaaact gaacgcaaaa ggtgtgcgca 900 cgctgtctcg ctgtcgctgg aagaagttcttctgctttgt gtgagcagct atggcaagag 960 ataggcgggt ggcctgagac ttctggaccccgagacatcg ggtactggca gggcctggcc 1020 aacccctgga actcagttct ctattgaacacagggcacat gggcctcaaa gctgtacacc 1080 ctggtgagcc agggtgagct ctgtctgtgcaggggctgcc ccatttggat ttctttggtc 1140 aagactcaca ggaaaatccc agcactttgattttcatggg atagcgccat cagcgtcagt 1200 gctgctgagc agcttgggat gtaattctcagtttcttatc ctggggccac aggtcagttt 1260 ggctgaatgc aggcccctcg gggtcatccccctctcctag cacagtgcga ggatcaagga 1320 gaacagtggg gcatcttgca gggctggcggatggtcagct tgatttggag acgtttgaga 1380 tggggtatga agaagagggc agtgagagattgagagggaa aacagaaagt gaggcgagtg 1440 gtggacagga ggcagattag aggcctgggcctggaaggag gaagacagga agggagaagg 1500 gtggacagct gtggagaagg ccgacacctgggctgccctc gagccccaag gccagggagg 1560 acaggactgc tccctgggaa gaactgggtctcagggttcc ccaggcactg gccaaactgg 1620 ctgggctagc agaggggcag gaagtgagagttcaggccca gcaaagggag gggaggagct 1680 gcaggtagga gcctgaagga ggaaggggcagggaccgtcc ctttccccaa ggtcatagct 1740 tagaaggtga gctatacagt ctgcaaataaaaccttccat ttctcaagct gctgtctgtg 1800 gtctcctgga gtggtcagcc caatgccccttcataacctt tgcca 1845 65 1623 DNA Mus Musculus 65 gatttctgag ttcgaggccagcctggtcta cagagtgagt tccaggacag ccagggctat 60 acagagaaac ccttgtctcaaaaattaaaa aaattaaaaa atttgggggc tgttgagata 120 tctggctaag tgggtaagagtacccaaatg ctcttccgaa ggtcctgagt tcaaatccca 180 gcaaccacat ggtgactcacaaccatccct aatgagatct gactccctct cttctggagt 240 gtctgaagac agctacaactcacatataat aaataaataa atcttaaaaa acaaaacaaa 300 acaaaaaaac tgaaaaaacaaacaaaaaaa caaacaaaca aaaaaacagg tgtagtagta 360 cacgtctgta atcccaacatttggaaggca gagacaagag aattatgatc tcaaggccag 420 cctcaactaa atgaaacctgtgtcaaaaaa aaaaaaaaaa aagacttcaa agatgcatta 480 tcttgagcgc cctcgccaccgcatctcttc tgcttttgtg ctctcccgcc tgccatggcc 540 aaccttaagg atctcaaagggaagtggtgc ctgatggaaa gccacggctt tgaggagtac 600 acgaaagagc taggagtaggactggctctt aggaagatgg ctgccatggc caagccagac 660 tgtatcatta cttgtgatggcaacaacatc accgtcaaaa ccgtgagcac agtgaagacg 720 accctgttct cttgtaccctgggagagaag tttgatgaaa ctacagctga tggcagaaaa 780 actgagacgg tctgcaccttcaaagacggt gcctggtcca gcaccagcaa cgggaaggga 840 aggagaacat gataatgagaaaactgaagg atgattgtgg tgcactcggg tctatgagaa 900 ggtgcaatga gggcttcctcgtcatcctgg acaggagtta gctgtaggag tgaatatgct 960 caattcaatt agtggtcataaacagcaaac cgtttcactt ctttggtttt atttttcatg 1020 actgttgagt tctctttatcacaaacactt tacatggaac ttcatgtcaa acttggttta 1080 cccaggatca tccctttggttagtaaataa acgtgtttgt gcttaaaaaa aaaaaaaaaa 1140 aaaagcatta tcttgaggctggaaatcttg ttcaatgatc atagatgatc cccggcatac 1200 acgtgctgac tcacaaccattcataactcc agttccaggg gaatataaca ccttcttttg 1260 acctctgaga gcaccaggcacatacattca gacaaagcag tcaatacaca cattttaaaa 1320 ataaaccaca ccgagcggtggtggcacatg cctttaatcc cagcacttgg gtagcagagg 1380 caggtggatt ttcaaggccagcctggtcta tagagtgagt tccaggacag ccagggctac 1440 acagagaaac cctgtctcgaaaaaccaaag taaataaata aataaaccaa aataagaaga 1500 ggggagggga ggaaacagcaagaaggaaga aagcaaagga ggaagaaagg aaggaaggaa 1560 agagaagaga aactggagaggaagaggaag aacaggagga agaggaaaag gagagcagca 1620 gca 1623 66 2002 DNAUnknown Organism Description of Unknown Organism Mga, EMBL No. q9qxj5 66ttcacttttt tgtaaggttc agggattgaa cttggatcaa ctggcttgcc tgatctgctg 60acccatctct ctgacctcta ctaagtttaa gtagggttgc ttgcataagc atgggtaggt 120gattatttac tggaacatgg gcaagtttat ctgtgcctgt accactgact ggctttgaac 180ttgtgctctt tctccatctc ccaagtgtgt agagtacagg tctgtgccac tactcctggt 240atacgcaggg ctggaaatac ccagggcttt atgtgtgcta ggcaaatctc taccagatga 300gttacagttg tatttttgtt agaaaaattc tgagttgact aaagttctgt tttttgttcg 360tttgtttgtt ttttaggatg aaaaagcatt tgtaactatg aattgactac agttttctta 420ctactgaatt tctcactgga atcatggaag agaaacagca aatcatattg gccaatcaag 480atggagggac agtgacagga ggagcaccta ccttctttgt catcctaaag cagccaggaa 540atggcaaaac tgatcaagga attttagtta ctaatcgaga tgcccgtgct ttgttgagta 600gggagtcatc accaggaaaa tctaaagaga aaatttgcct tccggctgat tgtactgtgg 660gaaaaatcac ggttaccctt gataacaata gtatgtggaa tgagttccat aatcgaagca 720cagagatgat tctgaccaaa cagggaagac gcatgtttcc ttattgtcga tattggataa 780caggcttaga ttcaaattta aagtatatcc ttgtaatgga catatctcct gtggatagtc 840atcggtataa gtggaatggt cgttggtggg aacccagtgg gaaggctgaa ccccatattt 900tggggagagt tttcattcat ccagaatctc cttctacagg tcattattgg atgcatcaac 960cagtgtcttt ctataaactc aaacttacta acaatacact ggaccaggaa ggacatatta 1020tcttgcactc tatgcatcgt tatctgccaa ggcttcattt ggtgccagca gaaaaggcta 1080cagaagtgat acagttaaat ggccccggtg ttcatacttt tactttcccc cagactgaat 1140tctttgcagt aacagcttat cagaacattc agattactca gttgaaaata gattacaatc 1200cttttgccaa aggctttcgg gatgatgggt tgagcagtaa gcctcagaga gaaggaaaac 1260agaggaatag ctccgatcaa gaagggaata gtgtttctag ttctcctgct catcgtgttc 1320gtcttacaga aggtgaaggg tcagagatac attcaggtga ttttgatcct gtgttaaggg 1380gtcatgaagc atcaagctta agtttagaga aggctcccca taatgtaaaa caagactttc 1440ttggatttat gaatactgat tcgacacatg aagttcctca gttgaaacat gagnnnnnnn 1500nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1560nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1620nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1680nnnnnnnnnn nnnctgtatt gctcattctc ctgatagttg aatagttgaa tagtttctgt 1740agattccttt gacaattgct gcatagtttt attttgtttg ataaggaaaa aataatgagg 1800ttaaaaaatt gttaagatat gtgtatgctc taaaatgtga tcttttgagg aagtttcata 1860tgtatttctg agctattagg tggaatattc acatatatgt attaaattca tttctttgtg 1920gtagtttaag tttcttaatt gtttgtttgg attacattta ctggtgagac tgcagtactt 1980tagtttttac tcatcatcat tg 2002 67 1853 DNA Unknown Organism Descriptionof Unknown Organism Mga, EMBL No. q9qxj5 67 ctttttttcc ctcttattagcatttgatga tgcataagtt ttaagacttt gatttttttt 60 ggttggttat agctgacttttagtttggag ttctttatat gtgatcaata tctaaagaca 120 aacacatttt ataaggcactctgcattttg atttaatgat aagggtaaac tattcttttc 180 ctgcatttta tttatacaagtggggttagt ttatgtagtg ttagagattg aatttaggac 240 ttttgtgttc taggcaagcagtatatcagt tgagctacat gcccagccct gaaacttggc 300 tcttgaattg tatttttttgtgtgtgaaac attgataaac atgtgatgtt gataatttac 360 ttttgagcac tttgttaagctataattttt aagtaatgac tcatgaaatc tgatggatat 420 attgatttta agaactgtttttccttctct gagtcttgtt gatagatagt tctgtacttt 480 ttattgtttt ctacctttctagtcgtattg tgaacagttt tgaagatgat tcccagattt 540 cctcaccatc aaacccgaatggaaacttta atgtcgtcat taaagaagag cctctagatg 600 attatgatta tgaacttggtgaatgcccag aagggataac agtgaaacaa gaagagacag 660 atgaggaaac ggatgtatactcaaacagcg atgacgatcc tatactagag aaacaactaa 720 agaggcacaa taaagttgataatttagaag ctgannnnnn nnnnnnnnnn nnnnnnnnnn 780 nnnnnnnnnn nnnnnnnnnnnnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 840 nnnnnnnnnn nnnnnnnnnnnnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 900 nnnnnnnnnn nnnnnnnnnnnnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnattgta 960 caaaaatata cttaacttaaagagcctaat tggaaatacc cggacatact tgacaacagt 1020 agcacgaaaa gaatacatgacagttccaaa ggatcaactg cagagtcatt ttcaggaaaa 1080 gaggacttag gcaaaaagcgaacaacaatg cttaaaatgg caataccatc aaagactgtg 1140 actgctagtc atagtgcctctccaaatact cctgggaaaa gaggaagacc gagaaagttg 1200 agactctcta aggcagggcgaccacctaaa aacacaggga aatctttaac tgctgccaag 1260 aatattcctg taggccctggaagcaccttt catgatgtga aacctgatct agaagatgtg 1320 gatggggtgc tctttgtttcctttgaatca aaggtatggt tgtaatgatc agctttcttt 1380 ttaaggtctg ctaatcagttttgaattgaa aattggctta aaatttagga cctactttta 1440 ttaatgtatc tatttgtgagtatgtttggg gctattgagt gagtgttaaa catttggttt 1500 aattaacagt aatcatctcttaagatactt gctttgaaat agactttaaa gaaatgtacc 1560 tttgtgtaga tctcattctataatttgttc aatgtttatc tgattaaaaa agatttatgt 1620 gtgtctatgt atgtgagtgcaggtgccagt ggaggccaga ggtgtcaggt tgtcctggag 1680 ctactagagt tgaagctacttgtgaactat aaataacatc agtgttagaa aattgagctt 1740 gagggctggt gagatggccccgttgagagc actggctgtt cttccagagg tcatgagatc 1800 agttcccagc aaccacatggtgactcacaa ccatttgtag ggatatctga tgc 1853 68 1079 DNA Unknown OrganismDescription of Unknown Organism Mga, EMBL No. q9qxj5 68 actcctattctgtgaatttg gagcaattgc taaaacatgg tattttatac tcttactcct 60 atattattaatttaaaaata ttctttatat gagtggcaga tgtatgcata tccttgggtg 120 tcagtgtgtatacctatgtg agtgtgtgca gaggctagag attggaactt ccttctttgt 180 tcactcagtctaattctttg agacagggta tcttcactga acttggagct cactgattgc 240 ttaggctaaccagtggattt cagagagtct cctccttcat cctaaccacc accaggagtt 300 acagaaaagtgatacgatac ctagctttta catggatact ggggataaac cagcttctca 360 tgatcagacagcatgccctg tagctactga gcatgctctc cagccactcg tcattgtcat 420 cctttttttttcttttaaaa attgaatttc ctttgaaaat tttagaagca acataactgg 480 gttttatttttaatgtatag gaggctcttg atattcatgc agttgatggg acaacagaag 540 aaccttctagtcttcagacc acaaccacaa atgattcagg tattgtctaa cagtataaat 600 ttagatgtatttgctgttgg gcctatatag catggaatat cctctctgat gtacattatt 660 ttatttcatcactgttttgt gagtaggttg cagaacaaga atttcccagt tggaaaagga 720 attaatagaagatttgaagt ctttgaggca taagcaggtg atacatcctg ctcttcaaga 780 aggtactagtttcaaaatgt ggaaaagccc atttgtcttt tgtacatttt gtcttcccct 840 tttctttcctacctcttttt gcttatttct ccctttattt tctctttcaa ttagcagttt 900 tttattttttccacttctaa agttcttttc aattttaaaa acacatctag gtcttttttt 960 gtttgcttttcgagacagac agggtttcga cagctgtagc cctggtcatt ctgtacacca 1020 ggctggtggcctcgaactca gaaatctgcc tgcctctgcc tcccacgcac tgggattaa 1079 69 1096 DNAUnknown Organism Description of Unknown Organism Mga, EMBL No. q9qxj5 69agtctaattc tttgagacag ggtatcttca ctgaacttgg agctcactga ttgcttaggc 60taaccagtgg atttcagaga gtctcctcct tcatcctaac caccaccagg agttacagaa 120aagtgatacg atacctagct tttacatgga tactggggat aaaccagctt ctcatgatca 180gacagcatgc cctgtagcta ctgagcatgc tctccagcca ctcgtcattg tcatcctttt 240tttttctttt aaaaattgaa tttcctttga aaattttaga agcaacataa ctgggtttta 300tttttaatgt ataggaggct cttgatattc atgcagttga tgggacaaca gaagaacctt 360ctagtcttca gaccacaacc acaaatgatt caggtattgt ctaacagtat aaatttagat 420gtatttgctg ttgggcctat atagcatgga atatcctctc tgatgtacat tattttattt 480catcactgtt ttgtgagtag gttgcagaac aagaatttcc cagttggaaa aggaattaat 540agaagatttg aagtctttga ggcataagca ggtgatacat cctgctcttc aagaaggtac 600tagtttcaaa atgtggaaaa gcccatttgt cttttgtaca ttttgtcttc cccttttctt 660tcctacctct ttttgcttat ttctcccttt attttctctt tcaattagca gttttttatt 720ttttccactt ctaaagttct tttcaatttt aaaaacacat ctaggtcttt ttttgtttgc 780ttttcgagac agacagggtt tcgacagctg tagccctggt cattctgtac accaggctgg 840tggcctcgaa ctcagaaatc tgcctgcctc tgcctcccac gcactgggat taaaggtgtg 900caccaccaaa taatatattt aaggatacac acacttttct tggggctgaa gagatggctt 960agtagatgaa gtttgcttga tgtgaagtat atgagtatct tactttgatc cccagcacac 1020ataaaaatgc taggtagagc agtacatgcc tgcagtcttg gtgcttggaa aaaccaaatt 1080aggatgttct aggttc 1096 70 1132 DNA Unknown Organism Description ofUnknown Organism Mga, EMBL No. q9qxj5 70 ctcatgccga ctttaggagatgcccgttat tgtttttagt ggtaacctag tacagtatta 60 ctctatataa cgtctaagctgtctttgctc acctccccct ttaatccagt gaaatatttt 120 cccaaaatgt tgtctcttaatttataagta atttcatttt aggttcattg ataataactg 180 gagaatataa tcaggtcagaaactccacct gtggcttttn nnnnnnnnnn nnnnnnnnnn 240 nnnnnnnnnn nnnnnnnnnnnnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 300 nnnnnnnnnn nnnnnnnnnnnnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 360 nnnnnnnnnn nnnnnnnnnnnnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnna 420 aaaaactgag ttttttgtttgttttgcttt ttgaagaagg aaggggggaa aatatgaatt 480 gtggtccttt tttcttgtagtgggcttaaa actgaattca gtggatccaa cagtgagcat 540 tgatcttaaa tacttgggagtacaattgcc tttggctcca gccaccagct ttcccctatg 600 gaatgttaca ggtaccaaccctgcctcacc tggtgagtat gtagatagca tttgtataag 660 tgaacattat ttttcttctttaagtttagg ttatttgtag tacaaatttt aaaacattac 720 ttttatgttc caatttagggtatttagaga ataaatcttt catctcttgg catagaatta 780 atacatggat gtattcatagtagagaaaga gtaatttgac atatattggt tggctagaac 840 tttggcaatt tctttttctttttcttttat agatgctggg tttccttttg tttctaggac 900 ggggaagacc aatgactttaccaaaatcaa gggatggaga ggaaaatttc aaaatgcttc 960 tgcatctagg aatgaaggtagctagatgtt tggtttttga ttgtcttttt gttttttgtt 1020 ttgttagtac cacagattcagagtagttca aacagctttt ccagcacttt cctattcacc 1080 tcaagcccaa ctccttttctgtttaaaatg cagtttcatt gagtgtagaa tg 1132 71 1045 DNA Unknown OrganismDescription of Unknown Organism Mga, EMBL No. q9qxj5 71 ttttgtttgttttgcttttt gaagaaggaa ggggggaaaa tatgaattgt ggtccttttt 60 tcttgtagtgggcttaaaac tgaattcagt ggatccaaca gtgagcattg atcttaaata 120 cttgggagtacaattgcctt tggctccagc caccagcttt cccctatgga atgttacagg 180 taccaaccctgcctcacctg gtgagtatgt agatagcatt tgtataagtg aacattattt 240 ttcttctttaagtttaggtt atttgtagta caaattttaa aacattactt ttatgttcca 300 atttagggtatttagagaat aaatctttca tctcttggca tagaattaat acatggatgt 360 attcatagtagagaaagagt aatttgacat atattggttg gctagaactt tggcaatttc 420 tttttctttttcttttatag atgctgggtt tccttttgtt tctaggacgg ggaagaccaa 480 tgactttaccaaaatcaagg gatggagagg aaaatttcaa aatgcttctg catctaggaa 540 tgaaggtagctagatgtttg gtttttgatt gtctttttgt tttttgtttt gttagtacca 600 cagattcagagtagttcaaa cagcttttcc agcactttcc tattcacctc aagcccaact 660 ccttttctgtttaaaatgca gtttcattga gtgtagaatg ctggccttga gtttccagtt 720 ctcctgctcagccttccaag tgttggaatt acaggcatat gccaccaaag cctggctggt 780 cactagtgtttgttttgctt ttaaagtcta tgtatgtttt gaaaaatgta ttcttggcct 840 ggggtagtagcacacttgcc ttttatctca acactttgga ggcagaggca ggtatatttc 900 tgtgagtttgagtccattct gagtacatag caagttccag gccagccagg gttacatagt 960 gaggtgagaccctctttgaa atcaagttag tctcattgaa acacttaccc ttttcatctc 1020 tctaaactgaactaaaaaca gtgta 1045 72 1659 DNA Unknown Organism Description ofUnknown Organism Mga, EMBL No. q9qxj5 72 ccattctagt tcattcacttgggaggcaaa cagagacaaa taaaggagaa ttgtaagtct 60 ggcctagttc ctacagagctgaatcgccag attcaagaca tctagggcta cttagtgaga 120 acttgtttca aaacaaaaccagataaatga aaatccttaa aggttgtgct ctccttttta 180 tggcttcctc tctttccttgtatcatgttt cagactctag ggactcaagt ctcttaaata 240 accccttggc attttgttgatttttttttt tttttctttt tccctggctg ttagtttttg 300 ctcatcactg tttactatagttaggtgaaa aggtctgaag gcttgtatct gagacactgt 360 ctcattttgt tttggctttctgtttttttt cttctttttg agtaggaaca gtttagagaa 420 gcttcagtag gatatagctcagttcttaga gagctaagac ccttcaaggt ttaaatgttt 480 tgtatctcct tattttctaggtggaaattc agaggcttca ctgaaaaacc gttctgcttt 540 ctgtagtgat aagctagatgagtacttgga aaatgaaggc aaattgatgg aaacaaacat 600 aggtttctct tcaaatgctcccacatctcc agtagtgtac cagctaccca ccaagagtac 660 cagctatgtt cgaactcttgatagtgtact aaagaagcaa tctaccattt ccccttctac 720 ctctcactct gtgaagcctcagtctgtaac cactgcctct cgaaaaacaa aggctcagaa 780 caaacagaca acactcagtggccgaactaa atcatcttat aagtctattt taccataccc 840 tgtttcacca aagcagaaaaactctcatgt gagccaagga gataaaatta ccaagaattc 900 cttgagttcg acctcagataatcaggtgac taacttggtt gtgccatctg tagatgaaaa 960 tgcatttcca aagcagattagtttgcggca ggcccagcaa cagcaccttc agcagcaagg 1020 aactcgccct ccaggcttgtcgaaatctca agtaaagctt atggacctgg aagactgtgc 1080 actctgggaa ggaaaaccaaggacctatat tactgaagag cgagcagatg tctccttgac 1140 aactctgctt actgctcaggtaaatattgc tattttctgt aaacattggt gcttagctac 1200 aaattagaca ttggtactttggtaagtgga taagttagag tttagcattt ttttaagatt 1260 tatttattat atataagtacactgtagctg tctttagaca taccagtaga gggtgtcaga 1320 tctcattaca gatggttgtgagctatcttg tggttgctgg gatttgaact caggaccttt 1380 ggaagagcag tcaatgctcttaaccgctga gccatctctc cagccccagg gtttagcatt 1440 ttaattaact aggtaacaattaaggggatg tcttcagcaa tgagctaatc ttttgagtct 1500 agctttcttc tgccagtaaagggagactga ctgactgact gaatgaatga atgaatgaat 1560 gaatgaatga atgaaaaattctttactgaa ttgcttgcta tctaagcatg ggaacttgaa 1620 tttagattta tagcactgacatacaaacca ggtgagatg 1659 73 1339 DNA Unknown Organism Description ofUnknown Organism Mga, EMBL No. q9qxj5 73 cctgtactgt attttctagtcattataaag attcaagcat gtatgattct cttattttta 60 ttgtttactt aggacattttgtgtaaaata gtagtaatta ttttgcattt tgcggaccat 120 atatgctatc agagagttattactaggatg ttctattcta ggcagtatga gcttgcttgt 180 gcttcaggaa aatcgtatgagacattgttt gacctatgta ccttagactc atcagtccct 240 acagaagaac attatatgtggtttctattg agtgaagaga atatttggtg tttttgctct 300 taataagact cctttgctaatgcattagag tggcagcttc tttacgcaga gccctcatta 360 tatgtgtttg acttttgaattctgtgttag tcttgtgtta ttagtactag taatcagaag 420 gtagatgagt atgtgactcttaagttggtg gtagtattgg gatgatttag taaaatttta 480 atgttctcct ttaactttaggcatctctca aaactaaacc tatccacaca atcataagga 540 aacgagctcc tccatgcaacaatgacttct gtcgcctggg ttgtgtgtgc tctagtctag 600 ctttggaaaa gcgccaacctgctcactgcc gtcgaccaga ctgcatgttt ggttgcactt 660 gtttgaaaag aaaagttgtgttggttaaag ggggatctaa aacaaagcat ttccataaga 720 aggctgctaa tcgagatccattattttatg atacgctggg agaggaannn nnnnnnnnnn 780 nnnnnnnnnn nnnnnnnnnnnnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 840 nnnnnnnnnn nnnnnnnnnnnnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 900 nnnnnnnnnn nnnnnnnnnnnnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 960 nnnnnnncaa ttccatgctgataattggac aattcaaatg acaacagtcc aattcattgg 1020 gagacatgta actcatagcaatagaagaac cgatgggaac agttgtgtat gccattaatc 1080 ctggcactca gtagctaaggttgaatatct agagttcaag gccagtatgg gctacatagt 1140 gagactcaac cctaccgcagaaaactataa tttcaacttg ctaaagaatt atgctaataa 1200 caaaagcacc tgtaataatcatcaggggtt gcatgaaata gtaaaaaaag aactagcacg 1260 ttcctgcact agtgtgggcaactggagggc cacagagctc ctgccagctg acctcactgg 1320 gatgttcctc tgcagtgat1339 74 1228 DNA Unknown Organism Description of Unknown Organism Mga,EMBL No. q9qxj5 74 atgtataagc aacagacagt tgaaagttga aataaaaattctcatttaaa ataacatgta 60 aggattggtg gaattgttta gccagtaaag tttgatccctggagttcaca tgatagcgag 120 aacctactct taaaagttgt cctctgactt acatacatgttctgttatac acaggtgtgc 180 cccaccccaa tttaaaatat tagctaacga gatgaggcatgataaattta acaaaaatat 240 ctaagatata tgtacgtatg tatacatgca catactttgttttattctta gctattctct 300 tggttggaga ataggtactc aacaaatatt tgattaatagatgaataaat taatgcatct 360 gaagacaact aaaggtcttt tagggatcac ctgattattacaaattactc tctttgtgag 420 ggaacatacc ttgttttagc attgctcagt gctgaacttatattgccaaa aacaccttaa 480 atcttggcct tttcttttgt taagctgtat gtgaagcagaacctgagcag ccggttcgac 540 attacccact gtgggtgaag gtagaaggtg aagtagatccagagccggtt tatattccaa 600 ctccttctgt cattgaacct ataaaaccat tggtgttgcctcagccggat ttatcttcta 660 ctacgaaggg caaactaacc cctggaatta aaccagcacgaacatatact cccaagccca 720 atcctgtggt aagcctgttt gttgttgttt ttattgtaagttcataagcc atttgtaaag 780 gtgataggtt tcaagtagag cttttgttaa tattctgtcaagattttaga cagtgtattt 840 ttaagacctt tcctctctga ctcagtttat ttgctctcactttaacaatg tgataaaagt 900 gaagatgcag agtaataatt gaagatagcc aagtttttcttcaagttcat agaaagtgaa 960 ctttttcata atttgtttat atttgtgtat gtgtgtttgcctctgtctat gtaaatgccc 1020 tcagagttca gatgtggttg tgggatcccc tggagcttgagtcagacaca gttgggaggc 1080 agagacagag gtgaatctct gagttcaaga ggtctagcctagcctactat tgggagttcc 1140 aggatagcaa gggttataca gagagatcct atattgaaaaacaaaatgaa aacacatctt 1200 ttgtaataga aacaaattaa attcttcc 1228 75 1183DNA Unknown Organism Description of Unknown Organism Mga, EMBL No.q9qxj5 75 gagcttttgt taatattctg tcaagatttt agacagtgta tttttaagacctttcctctc 60 tgactcagtt tatttgctct cactttaaca atgtgataaa agtgaagatgcagagtaata 120 attgaagata gccaagtttt tcttcaagtt catagaaagt gaactttttcataatttgtt 180 tatatttgtg tatgtgtgtt tgcctctgtc tatgtaaatg ccctcagagttcagatgtgg 240 ttgtgggatc ccctggagct tgagtcagac acagttggga ggcagagacagaggtgaatc 300 tctgagttca agaggtctag cctagcctac tattgggagt tccaggatagcaagggttat 360 acagagagat cctatattga aaaacaaaat gaaaacacat cttttgtaatagaaacaaat 420 taaattcttc ctttggattc caggataagt tttttccttc tatcattataatggtctgtt 480 ttgttatttg aaacttacag atacgagaag aggacaaaga tccagtctatttgtactttg 540 aaagtatgat gacttgtgcc cgagttcgag tatatgaacg aaagaaagaggaacagagac 600 aactgtctcc acccctgtct ccatcctcat catttcagca gcagagttcctgttactcta 660 gtcctgagaa ccgtgttaca aaggttaatt gcttgtttca taataaccttctaatttcca 720 gttccccgtg tctggtatta gaatttttat tactatcacc gtaatcatctttgtgtttcc 780 tataatgtat aaaaaaaacc atttctccac atatttaagt aatctatcagtgtttgttac 840 taaaatcctg ataaaatgta tcatgtaaat tattttctaa gtaactcagtcatttaagaa 900 cgttgaaggt aagaagacta cattttattt atctactttt gggggcacagggttgtataa 960 tattaataca actggacaga tataaagttg tagataattt tactaatttatgtcctctgt 1020 agataataaa tactttttta attaatttct gtattgcttc cttctttaggaacttgattc 1080 tgaacagacc ttaaagcagc tcatttgtga cttggaggat gattctgataaatcacaagg 1140 tcagaataaa aacagataat aacagttgat agtagctatt atg 1183 761070 DNA Unknown Organism Description of Unknown Organism Mga, EMBL No.q9qxj5 76 gtatatgaac gaaagaaaga ggaacagaga caactgtctc cacccctgtctccatcctca 60 tcatttcagc agcagagttc ctgttactct agtcctgaga accgtgttacaaaggttaat 120 tgcttgtttc ataataacct tctaatttcc agttccccgt gtctggtattagaattttta 180 ttactatcac cgtaatcatc tttgtgtttc ctataatgta taaaaaaaaccatttctcca 240 catatttaag taatctatca gtgtttgtta ctaaaatcct gataaaatgtatcatgtaaa 300 ttattttcta agtaactcag tcatttaaga acgttgaagg taagaagactacattttatt 360 tatctacttt tgggggcaca gggttgtata atattaatac aactggacagatataaagtt 420 gtagataatt ttactaattt atgtcctctg tagataataa atacttttttaattaatttc 480 tgtattgctt ccttctttag gaacttgatt ctgaacagac cttaaagcagctcatttgtg 540 acttggagga tgattctgat aaatcacaag gtcagaataa aaacagataataacagttga 600 tagtagctat tatgtaattc tgattttttt ttttcttttt tctttttttttggtttttca 660 agacagggtt tctctgtata gccctggctg tcctggtact cacttgtagaccaggctggc 720 ctcgatctca gaaatccccc tgcctctgcc tcccgagtgc tgggatcaaaggcctgcgcc 780 accatgcccg gcttaattct gaattattta gtggcaaaaa atttaaaccgctgatccata 840 attgacactg tgtattttct aacctctgca aaaaatggag cgagcagaagcattttctta 900 tcatttgctt taatatccat aggtctgcct gttttgatca ggtatttcatttcagacaac 960 ataagaatca tctcagcaaa aaagttttct cttttcaaga ctcaaggataattatttatt 1020 aaaatttaac cttaagtctt ccatagccac cacaatctcc aaatttcttt1070 77 1518 DNA Unknown Organism Description of Unknown Organism Mga,EMBL No. q9qxj5 77 tgttgagcca tctctccagc ccagaacaat aacttctgtcaagtaaaatt tatcatagtt 60 ataggtcaca ctttgcaagg cagtactttt taatgtttttgagagaagta ctaaggaaat 120 ttccttttta tgacataatt tagtctgtgg gatagtgaagacaagtgtct agttctgtga 180 attttttttc ctagaaaact ctagaatgtt gagtttgcacactaatttaa cactgaaatg 240 agacaatgag aaccttgggt ttctttcaaa gttcagtagcatgcctttaa tcccagtact 300 tgggaggcag aggtaagtgg ttctctgtga ttttgaggccagcctgattt acatagttcc 360 aagacagcca gggcttttat tcagagaacc cctgttttgagaaaaagaaa gaaagaaaag 420 accccccccc ccatcaaagt ttagtacaga aagtctgtgatctgtgatgt agtgggtctt 480 tctatttatt ttttaaacag aaaagagctg gaaatcctcctgcaatgaag gagagtcctc 540 ttctacctcg tatgtacatc agaggtcacc tggtggtcctaccaaattga tagagatcat 600 ctcagactgc aactgggaag aagatcgaaa caagatcttgagcattttat ctcagcacat 660 caatagcaac atgccacagt cacttaaggt gggcagcttcatcattgagt tggcttctca 720 gcggaagtgt cggggtgaga agacccctcc tgtttattcttctcgtgtga aaatctctat 780 gccatcaagt caagaccaag atgatatggc tgagaaatctggatcagaga ctcctgatgg 840 tccattgtcc cctgggaaaa tggatgatat ctctcctgtgcagacagatg ccctggattc 900 agtgagggag agattacatg gaggcaaagg tctacctttttatgcagggc tttctccttc 960 ggggaagctt gtggcctata aacgtaaacc cagttcaactacatctgggc ttatccaggt 1020 gagaattata tttaatctgg gcatagtacc tttttatacttagctaacat tgtgattttt 1080 tttaattatt tttatttttt attaaacact caagcccctttgttgacctt aggtcatttc 1140 tttttttttt tttttttttg agaactgggt aataaaaaaccatcggtaat tcttattatg 1200 ataaatgtag gttaggtgaa tacagaaggc aaactactgttacatcaaca gagatatgga 1260 gccttacatt agcttatggt tttctttcta ttcttttcagaaagttcctt tttataagct 1320 ttactgcacg ggctctagtg atcctaagta agcaaaaataggcatttaat ttgggtctta 1380 gaatatctta ctagcataaa aatttcaaaa caaatatatagactactagg tgtagtagag 1440 ataaattgtc tttataggtc agtgccttta atcccagcacttgagagcag aggcaggtgg 1500 atcttttgag ttcaggac 1518 78 1148 DNA UnknownOrganism Description of Unknown Organism Mga, EMBL No. q9qxj5 78atggttatcc tttttgctgg tgattcatta ataaccacag ttgcttatta aagtaaaaca 60attagatgaa ttgttggatc cagttatgtc ttttacatat ctataatgca gaaatgagtt 120tagtttctaa gattatctat ttccagacta taaatgaagt tcaagttagt tcagatatca 180gatgatacca tccagttatt gagattatcc tgattagaaa gtcttcactt ttcccctttt 240acatctaaag catagacttt aaaacacctt ataaaaatga aacccctgtc aagggagaga 300agttagcaag agaattttat ctttacagaa tttctctttg ccacttgttt caggttaatg 360gtaagagtta cccgcaggct aagttgctat tgggacagat gggggcattg catccagcca 420ataggctagc tgcttatatc acaggcaggt tgcgaccctc agtcctggac ctctcaaccc 480tcagtactgt catctccaag gtagcatcca atgccaaggt ggctgcatcc aggaaaccac 540gcaccctgtt gccttcaaca tccaattcca aaatggcatc ctctggccca gcaacaaatc 600gctctgggaa gaatctgaag gcatttgttc cagcaaaaag gccaattggt aagtaagaga 660atgcatatgg tttggaaagg cctgtaattt aatgttggcc agtgaataca atatgaaagt 720tataaaagtg gcaaaataga tttttgtgtt attattaatg ccctttctta aatattctaa 780aaataattct tctgatgacc tatgatatct gatgaattga aattaagttt tacagtcaaa 840agactttgag actgtattaa catattaaaa ccaaggtttt attttaaaat gtttccttta 900cttttcctat gatgattgag gtttttcata ccaatcataa gcatattcct tgtacttaac 960aaatctgaga cactaacaag agctagtaga atgggttagt ataggttaaa aataaaaagc 1020tcttgtaaaa caaaaacttt tagtatattt ctgtcttgtg tatgaaaact tcttttgcct 1080aacactttac agtctatatt aaattgcctt cttgaaacat tgttttagtt gaaagttata 1140cagttagt 1148 79 1624 DNA Unknown Organism Description of UnknownOrganism Mga, EMBL No. q9qxj5 79 cagtttgagg gcagcctggc ttaccaagtgagttccaggc caaccaggtt tatagagaga 60 ccctgtgtcg gaaaacaaaa accaaacaatcgaaaagtag aattttaaaa ctttgctttg 120 ggtggaggac agtgtttgag ttattttgtgtgtgtgtgtg tgtgtgtgtg tgtgtgtgtg 180 tgtgtgtgtg tagcaattgg tacttataggtggattgtac ctttaagaaa ttgacccagg 240 agccgtggat taaagtgcca cctttaatcctagcacttgg gggtcagagg caggcagatt 300 tctgagtttg aggccagcct ggtctacagaagtgagttcc aggacagcca gggctataca 360 gagaaaccct gtctcgaacc ccccctcacccctcaaagaa attaacccag tgggcacaac 420 taatgctata agcacaatca tttagtaggagggcacagtg agagaatgaa gattttttac 480 ctgcaaattt ttatttgcag cagcgcggccctctcctggt ggtgtgttca cacagtttgt 540 gatgagcaaa gttggtgcct tacagcagaagatacccgga gttcgcacac ctcaacccct 600 tacagggcca cagaagttca gtatcaggccttctccagta atggtcgtca cacctgtggt 660 ttcttctgag caagttcagg tgtgcagcactgtagctgct gctgtcacta cttcccctca 720 agtgtttcta gaaaatgtta ctgctgtgccatctctgact gctaattctg atatgggagc 780 taaagaagct acatattctt ctagtgcctccactgctggg gttgttgaga tctctgaaac 840 taataacact acccttgtaa catctacccagtctacagcc actgtgaacc ttaccaaaac 900 tactgggata actactagcc ctgtggcttcagtttcattt gctaaaccat tggtagcatc 960 tccaaccata actcttcctg ttgcttccactgcctccacc tccatagtca tggtgaccac 1020 agctgcatct tcctccgtgg tgaccacacctacttcatca ctgagttctg tacctattat 1080 actctcagga attaatggaa gtccacccgtgagccagaga ccaggtaagg actagttctt 1140 ttcagctgct ttattataaa taaagctccttaattaaatt ttacagttgt aataaaatta 1200 ggagtttcta gtttagacat tgtcatctgtaaatgcattg ggctgcattc atagctatct 1260 tgagatgtat gtaggccaca atttatagatatgcctgaat acattttaga gtttcagcca 1320 tagtatgaca tgttaacatt cctaaatctttaaaattcta caaaactgaa ccctaaaaat 1380 aacagcttat ggctagttgc aagattaggaatgaccactg tctatacagt tctgaagcca 1440 gattccagag tacagggatc agctgtcttcaagagattat ctgattgata gattaatagg 1500 actaaagttg aatccaagga atactaaaactcgaaaacaa agtggaaatg atcgctgaag 1560 gacactaaat gatgtaaata ggaccagacctctgagcatt agaacagcca ttaaagtggc 1620 atgg 1624 80 1076 DNA UnknownOrganism Description of Unknown Organism Mga, EMBL No. q9qxj5 80cctttgattc atatacgcat aagatacaca caaaaataaa tgtattgtga tttgtttgtt 60tgttgagaca gggtttctct gtataggcct ggctatgcta aaagttgcat tgtagaccag 120actagcctct aaactcatag atttgcccat cttgcctccc atattctggg attaaaagtg 180tggatcacca ttggcaaatg tgatgacaac aataatgagc caaggcattt tctttttagt 240ttgaagccaa cctcttttcc atagcgagtt ctaggatagt cagggctcta taaagagatc 300ttgtctcaaa aaataaagca aattatagat tattcttagc tatgaatagt atatactata 360aagggaaagt gtttcattaa ctttataaat tcaagtaaga cgttacttgc agcattatta 420ggtcttatgt catattattt ttacccatgt acttttaaag ataaattctc atagtagctt 480ctcatttttc tgttttccag aaaatgcccc tcaaattcca gtgactactc cacagatctc 540ttctaacaac gtgaaacgta ctggacctcg attgttgttg attccagtgc agcagggttc 600tcctacgctt agaccaatcc aaaacccaca gcttcaggga cagcggatgg tcttgcaacc 660tgttaggggt ccaagtggaa tgaacctatt caggcacccc aatgggcaga ttgtccaact 720cctaccttta catcagattc gaggctctaa tgcccagccc agcttacagc ctgtggtatt 780tcggaaccca ggtataaagt tagagatctt tctgatgagt tttttttttt ttaaagattt 840acatatcttg taactacact gtagctgtct ttagacactc cagaagaggg cgccagattt 900cgttatggat ggttgtgagc taccatgtgg ttgtgggatt tgaactcagg acctctggaa 960gagcagttag tgctcttaac cgctgagcca tctctccagc ccctctgatg agttttgttg 1020ttaaatcact tgactatgtg atttgtttga tatgccagaa tttttttttc agtctc 1076 811098 DNA Unknown Organism Description of Unknown Organism Mga, EMBL No.q9qxj5 81 gcaaatgtga tgacaacaat aatgagccaa ggcattttct ttttagtttgaagccaacct 60 cttttccata gcgagttcta ggatagtcag ggctctataa agagatcttgtctcaaaaaa 120 taaagcaaat tatagattat tcttagctat gaatagtata tactataaagggaaagtgtt 180 tcattaactt tataaattca agtaagacgt tacttgcagc attattaggtcttatgtcat 240 attattttta cccatgtact tttaaagata aattctcata gtagcttctcatttttctgt 300 tttccagaaa atgcccctca aattccagtg actactccac agatctcttctaacaacgtg 360 aaacgtactg gacctcgatt gttgttgatt ccagtgcagc agggttctcctacgcttaga 420 ccaatccaaa acccacagct tcagggacag cggatggtct tgcaacctgttaggggtcca 480 agtggaatga acctattcag gcaccccaat gggcagattg tccaactcctacctttacat 540 cagattcgag gctctaatgc ccagcccagc ttacagcctg tggtatttcggaacccaggt 600 ataaagttag agatctttct gatgagtttt ttttttttta aagatttacatatcttgtaa 660 ctacactgta gctgtcttta gacactccag aagagggcgc cagatttcgttatggatggt 720 tgtgagctac catgtggttg tgggatttga actcaggacc tctggaagagcagttagtgc 780 tcttaaccgc tgagccatct ctccagcccc tctgatgagt tttgttgttaaatcacttga 840 ctatgtgatt tgtttgatat gccagaattt ttttttcagt ctcctaaagtgggagacata 900 ccttgaaaag acttgatggt atgaacagta gtgatttaag ctcttcctttttctttccag 960 gatctatggt gggaatccga ctaccagctc cttgcaaatc ttcagagactccatcatctt 1020 ctgcttcatc ctctgccttc tctgtcatga gtcctgtgat tcaggctgttgggtcttctc 1080 caacagtaaa tgtcattt 1098 82 2488 DNA Unknown OrganismDescription of Unknown Organism Mga, EMBL No. q9qxj5 82 tgcaacctgttaggggtcca agtggaatga acctattcag gcaccccaat gggcagattg 60 tccaactcctacctttacat cagattcgag gctctaatgc ccagcccagc ttacagcctg 120 tggtatttcggaacccaggt ataaagttag agatctttct gatgagtttt ttttttttta 180 aagatttacatatcttgtaa ctacactgta gctgtcttta gacactccag aagagggcgc 240 cagatttcgttatggatggt tgtgagctac catgtggttg tgggatttga actcaggacc 300 tctggaagagcagttagtgc tcttaaccgc tgagccatct ctccagcccc tctgatgagt 360 tttgttgttaaatcacttga ctatgtgatt tgtttgatat gccagaattt ttttttcagt 420 ctcctaaagtgggagacata ccttgaaaag acttgatggt atgaacagta gtgatttaag 480 ctcttcctttttctttccag gatctatggt gggaatccga ctaccagctc cttgcaaatc 540 ttcagagactccatcatctt ctgcttcatc ctctgccttc tctgtcatga gtcctgtgat 600 tcaggctgttgggtcttctc caacagtaaa tgtcatttct caggcacctt cactgctttc 660 ctctggatctagttttgtct ctcaggctgg tacactgact ctgaggatct ctcctcctga 720 aactcaaaaccttgcaagta aaacaggctc tgaaagcaaa ataacaccca gcactggagg 780 acagcctgtaggcactgcta gcctcattcc tctgcagtca ggtagttttg ccttgttgca 840 gctcccaggacaaaagccta tccctagctc tgttcttcag catgttgctt cccttcaaat 900 aaaaaaggaatctcagagta cagaccagaa agatgaaaca aactctatca aaagagagga 960 ggaaactaagaaagctctac catcaaaaga taaagctcta gactctgagg ctaatataat 1020 gaagcaaaactcaaggaatt attgcctcag aaaatacctc gaataattca ttggatgatg 1080 ggggtgatcttttggatgaa gaaaccctta gggaagatgc cagaccttat gaatactctt 1140 atagcactgggtctcataca gatgaagaca aagatggtga tgaggactct gggaacaaga 1200 atcagaacagtccaaaagaa aaacaaactg ttccagaagt tagagctggc tctaaaaaca 1260 ttgatattatggcactccaa agcatcagaa gtatacggcc tcaaaagtgt gttaaggtga 1320 aggttgaaccgcaggaggga tcagacaatc cagagaaccc agatgacttt ctagtccttt 1380 ctaaggacagtaaatttgaa ttatcgggga accaagttaa ggaacagcaa tctaactcac 1440 aggcagaggccaagaaggat tgtgaagatt ctctggggaa ggacagtctt agagagagat 1500 ggagaaaacacctaaagggc cccttaactc agaagtacat tggaatttcg cagagcttta 1560 gcaaagaggcgaacgttcag ttctttacag aaatgaagcc atgtcaagag aattctgacc 1620 aggatatctctgaattactt ggannnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1680 nnnnnnnnnnnnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1740 nnnnnnnnnnnnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1800 nnnnnnnnnnnnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnaaaggat gggagaagca 1860 gtgctgctgacttcacagtt ttggatctgt aagatgagga tgaggaagat gagaaaactg 1920 atgattctcttgatgagatt gtggatgttg tctctggcta ccagagtgag gaggttgatg 1980 tagaaaaggtggtgagcccg ttttttgttg ttgactgaaa ccttgtggat ttaaatgatt 2040 agagctagcttttctagaga atcactaaaa cctaatgtat ttacttgggt gcctaggttt 2100 agatcattattaaatgacta atgtttaagg aaacactttg tgtcttactc attactcttg 2160 taaaggttgcttcatccttt ggaatataga tgctgtaaag tgcctactaa gttgaatttt 2220 taaggatacctacaatcatt tgatcatagt ggtttctgtc acattgtctg tgatgtgatt 2280 gacacttaacctgatacact taaacactga aaatatgctt ttaaaaagta gaggagaaag 2340 agtttgtctgcatttagagg gaaatttttc ctcttgggaa aaactgcaaa attccaccta 2400 atatttttgtttaattttac ctgaaagttg ctttgtatct ttcagtattg tgttggaact 2460 aaaaattctatattttttct atacttca 2488 83 1162 DNA Unknown Organism Description ofUnknown Organism Mga, EMBL No. q9qxj5 83 ccagaactgg agaggttaaagcaagaggat cattaactag ttccaggcca gccagggcta 60 catagtgatt gatacttttgaaatgattac aaccatgtat acatttctca tataatatag 120 ctaacaaact gcagagcctgaagaaaatta tattgagaga catgggaaaa ttcagtaagt 180 ggatgcacca tattattaggttaggataat ggataataaa agagccaaga ataactacta 240 tatacaaact ataaaagagcagaaattaaa tttaaaggca gaaacaggca gatctgagtt 300 tgaggccaga acagccatgctttcacaatg acgccctgcc tatgaatgaa tgaatgaatg 360 aatgaatgaa tgaatgaatgaatgaatgaa tgaatgaatg aatgaatgaa tgaaatttta 420 attttagtaa ctatttgaacactataggta aagtgtactg tttaataaat tgtgaccatc 480 tagtatacct tggagaaaagaaactaattt aggaagtttg ggatgatgta gtttcataat 540 ttgtgaaatg aaattgatctgatattgaat ttcagtaaaa tattaaaact acttttattt 600 ttaaatctag gtgtcatagccatatctctg cagatgaaaa agcttctgaa aagagtcgaa 660 aggtatttag aatgtatctaataaaattat ttaataaaat tggtgacatt tatgcttaaa 720 aacaataaga tctatttactagtttattaa gggcttttgt ttagatcatt ttatttgtcc 780 tctctttaca aatatactacttggttttgc gagtatgtgt nnnnnnnnnn nnnnnnnnnn 840 nnnnnnnnnn nnnnnnnnnnnnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 900 nnnnnnnnnn nnnnnnnnnnnnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 960 nnnnnnnnnn nnnnnnnnnnnnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1020 taaaagaagt tgcccattgaatccctgagt atgtatcagt ggtaaggtgt ataaatttga 1080 gttttccaaa ttctactcagtgagacatat tcgttgactt taggattact ttcagaagat 1140 aatgaagttt gtttatacaaag 1162 84 1192 DNA Unknown Organism Description of Unknown OrganismMga, EMBL No. q9qxj5 84 actctttttg taacttatga catgtttagt tgatatccttgggaagcctg ttttgttttg 60 tttcttaaag ggaaactgag gaggagtgga ggtaggagggaagggtggga gcaggggaaa 120 atgtagtcag aatgtaatgt atgtaaagag tgaaaatttaaaaaatagag accttttttt 180 taaaaagaaa accaaaagat tgtggatttt tgttgttgttatgtcctgaa aactcatttt 240 aacaataaat tagattttaa aagctattcc agatctttccttcctgaagc tccagatggt 300 ccctcattcg agctggaaag taatatgatt atatagtatatattagaatt tatactgttg 360 gtattgttga aataaggaaa gatagactgg gaagatagcatctgagaagc cttgataaaa 420 gtccagacaa ggtgtatctg atttcgaaca gtatgatttgggatggagga agatgctgag 480 gaaatactct ttttggacag gtttcattaa tttcttcaaaattgaaagat gggtacnnnn 540 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnnnnnnnnnnnn nnnnnnnnnn 600 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnnnnnnnnnnnn nnnnnnnnnn 660 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnnnnnnnnnnnn nnnnnnnnnn 720 nnnnnnnnnn nnnnnnagca cctgaaaggc tgaactggaagattgccatg agttcaaggc 780 agcttgagct atagagtaat gcagcatcac aaacaggactagtaaggaag cagtaaatat 840 tcaggggaaa aatcattaag tcaaaataac tttatgttgattgttaagaa caggagagag 900 agagagagag agagaaagag agagaggggg ggtgctggtgtgcaaggaag cacatgagcc 960 tatgggtaca tgcttgcttc tatgagtgtg tatgcaggaatcaggaggat gttgggcgtt 1020 ttctttttta ttactttgag acaggctctc tcgtgaaactggcacgttgc ctttatggct 1080 aggctgggtg gccatccagc tcttggaatc tgtctgccttattccaatgc tagtattacc 1140 atactcagct ttttacgtga gtgctgggga ttcaaactcgggccctcatg ct 1192 85 1127 DNA Unknown Organism Description of UnknownOrganism Mga, EMBL No. q9qxj5 85 taattttaac tctgcacaca ggctaggccatcaaaggtaa catcatttca ttacttttaa 60 gtagacgttg gggatataca tctggcattcatatttcgct attgaaataa acaggttgta 120 aacattttaa aatttgatta aaatgtaaacagaacatgag tattttatat ttttccttgt 180 agtagtggaa aagctgttta acactcatctttggaaataa tcattcttta cattccataa 240 aaatataagc tagaaaacaa tttaataaatactgttggat tggggatata gcccagagac 300 agactcttgc tttgcatgca caaggccctgaggttctttg ccagcaccag aatcagtggc 360 tcaatgtatt attcaatttc tgaaacatgattagttgttt tataatgttc tctaaaatac 420 taccttaaaa tactttcatt aaagaaattgtgtaggcccc tgtacttttt ggagtacagg 480 tgaatgctcc attgatatta ctatttttattctaggcatt cagtgaaatt caaggactaa 540 cagaccaggc agataaattg atagggcagaaaaatctcct gagtcgaaaa cgaagtattt 600 taatacggaa ggtatcgtct ctttcaggtaagctctttaa gcgtctctga gaaagagaga 660 gcatagtgcc agcattagca cggactccaagcctttcaga gtctgtggag gtaaaggatt 720 ggcatctcag gcttgcacca gggtaactttgactgagcac atcatatttt ctgaatcata 780 ataatcacat ttgcctctca gagttctagggaatatagtt aaatcagtta gataacagct 840 gtttctcatt gttatatggt atcatgcacagagtgatgct ttactgccta tttaccttca 900 gggaagacag aagaagtggt cctgaagaagctagagtata tttatgcaaa acaacaagca 960 ctagaagcac aaaaaagaaa aaagaagctggggtcagatg agttttgtgt gtcccccaga 1020 attggcacac agctggaggg atcttctgcatcatctgtag atcttggaca gatgctcatg 1080 aataacagga gggggaaacc tttgattctttccagaaaaa gagacca 1127 86 1234 DNA Unknown Organism Description ofUnknown Organism Mga, EMBL No. q9qxj5 86 ataatgttct ctaaaatactaccttaaaat actttcatta aagaaattgt gtaggcccct 60 gtactttttg gagtacaggtgaatgctcca ttgatattac tatttttatt ctaggcattc 120 agtgaaattc aaggactaacagaccaggca gataaattga tagggcagaa aaatctcctg 180 agtcgaaaac gaagtattttaatacggaag gtatcgtctc tttcaggtaa gctctttaag 240 cgtctctgag aaagagagagcatagtgcca gcattagcac ggactccaag cctttcagag 300 tctgtggagg taaaggattggcatctcagg cttgcaccag ggtaactttg actgagcaca 360 tcatattttc tgaatcataataatcacatt tgcctctcag agttctaggg aatatagtta 420 aatcagttag ataacagctgtttctcattg ttatatggta tcatgcacag agtgatgctt 480 tactgcctat ttaccttcagggaagacaga agaagtggtc ctgaagaagc tagagtatat 540 ttatgcaaaa caacaagcactagaagcaca aaaaagaaaa aagaagctgg ggtcagatga 600 gttttgtgtg tcccccagaattggcacaca gctggaggga tcttctgcat catctgtaga 660 tcttggacag atgctcatgaataacaggag ggggaaacct ttgattcttt ccagaaaaag 720 agaccaggct acaggtaggaggggcttttt tttttttggt agataaacat caatttattt 780 tagtggactg aacatcttctcttggctgta gttctaatta aatgaattgg gatgattttt 840 aagaaaaata actttaaatagtacttttca acgtttggct ttatacaata aataacttta 900 agagcttagt attctattgtataaatccta cttctgatag cagtctactt gtaacatgtt 960 tttagtaagt acataactgctactatatgt gaatcctcca ttttttttaa tctattatgg 1020 gttgaaaaat aaattggaactttttaaact tacgcttaag gctcagaatt gagttcaatc 1080 taggtaacac aatgagactgttgttttctt aaaaagttta atttctttga actagtccat 1140 ttttcattgt ctttattaaggaacaaagtt aattggttta gttgtttctt accttgtttt 1200 tggaagtagc tacactgatttaatgttact tggt 1234 87 1177 DNA Unknown Organism Description of UnknownOrganism Mga, EMBL No. q9qxj5 87 attgagttca atctaggtaa cacaatgagactgttgtttt cttaaaaagt ttaatttctt 60 tgaactagtc catttttcat tgtctttattaaggaacaaa gttaattggt ttagttgttt 120 cttaccttgt ttttggaagt agctacactgatttaatgtt acttggtaaa ctcatgtctt 180 agagaaaggt gtgttctttt ttattcttcagacagttcag tgtatggacc agaaaaatct 240 gacttatcag ttcacgttga ttctaaaacaagaattagtt ctaacattac agaatagaat 300 aaataactcg tactcacaag cggaatgaaactgtggtcga gatatatgaa ggactttgtt 360 aggagtgtat aagatagaaa gcctgtgaatagtgtatgcc ctcatgtaaa cttacattgt 420 accttttaag tcagcctctc tttagagtacactgacatta actggacatt tgttttacta 480 atttttcact ttctttgcag aaaatgcctcaccttctgac actccgcact cttctgccaa 540 cctggtaatg actccacaag ggcagttgcttaccctaaaa ggccccttat tctcaggacc 600 agtggtagcg gtttctcctg ctctcttagaaggtggtctg aagcctcaag ttgcaagcag 660 tactatgtct cagtctggta tgtggtggtattctatggtt tgtaaatata tactatggtt 720 ggtaaagaat ggtccattga tagaggacgtctttaaatct gatctgtagt tacctagagc 780 tgttcttttg gcatttgcct tgttaaaaaatggtccttct agctggccag tagtggcaca 840 cgcctttaat cccagcattt gggaggcagaagcaggtgga tttctgagtt caaggacagc 900 cagggctaca cagacaaacc ctgccttggaaaaaagaaaa gaaaagaaaa aaaaaaaaga 960 aagaaatagt cctcctagct tgatttgattggtggttaac ctggagttgg aaactgtttt 1020 gttaataact ctagtgacat ttctaagcaggggaagaatt aaaatggtgt tcaagtgaaa 1080 tgatgatgta gaagggtcaa tatttaagttcttggtgttg atcgttgttt tgggttgtat 1140 ttggaatgga ggcactccca tgttaccaatccagtga 1177 88 2275 DNA Unknown Organism Description of UnknownOrganism Mga, EMBL No. q9qxj5 88 ttgtataggc aagttcctgg gttcagtctcctccactgct ctcccagtcc aaaaaaagaa 60 aagagttatt ttgtagagat tttctaaaaatgtaattaag tggaactatt gctaataatg 120 aaatacctaa gtgtcttgac tagattttacttgacttatt gctatttcag ctgttattct 180 gttattttgt cctttttttc tttttccctccctcccttcc ttccttcctt ccttccttcc 240 ttccttcctt ccttccttcc ttccttccttccttcctttc tttctttctt tctttctttc 300 tttttttttt ttttccagag ctgaggaccaaacccagggc cttgcgcttg caggcaagag 360 ctctaccact gagctatagc cccaacccctcagctgttat tctgacaaaa gtggactaag 420 atagactggg aaggagagag agaaaaagagattttcatta ctgcatctaa tgaactctct 480 ctttaatttt tgattttcag agaatgatgacttatttatg atgccacgaa ttgtcaatgt 540 gacatcattg gctgcagagg aagatttgggaggtatgagt ggcaacaaat accgtcacga 600 agttcctgat ggcaagccac ttgaccacctgagagacatt gctgggagtg aagccagctc 660 cttaaaagat acagagagaa tctcttccagaggaaaccat cgagatagca gaaaggcact 720 gggtccaaca caggtgcttt tggcaaataaagattctggg tttccacatg tagctgatgt 780 ttccactatg caggcagcac aggaatttatacctaaaaat atgtctggtg atgtgagagg 840 gcatcggtat aaatggaagg agtgtgagttgagaggagag agactaaagt caaaggagtc 900 tcagtttcat aaattaaaga tgaaagatctgaaggactca agcatagaga tggaactgag 960 gaaagtagcc tcggctatcg aggaagcagccctccatccc agtgagctgc tgactaacat 1020 ggaagatgag gatgacactg atgagactctgacttcactg ctcaatgaaa ttgcttttct 1080 taatcaacag ctaaatgatg actctggcctagctgaactg tcaggttcta tggatacaga 1140 attctcagga gatgctcagc gagcttttatcagtaaactt gctcctggga acagatcagc 1200 tttccaagtt ggacacttgg gagcaggtgtgaaagagttg cctgatgtcc aagaggagag 1260 tgaatccatc agccccctcc tcttgcacttggaagatgat gacttttctg agaatgaaaa 1320 acagcttggg gacacagcct ctgagccagatgtccttaag attgttattg accctgaaat 1380 aaaggattct cttgtttccc ataggaaatctagtgatgga gggcagagta cttctggtct 1440 ccccgcagag cctgaaagtg tatcttcacctcccatctta cacatgaaga ctggcccgga 1500 gaacagcaac acagatactt tgtggaggcctatgccaaag ttggccccat taggtttaaa 1560 agtagctaat ccccccagtg atgccgatggtcagagtctt caaggtgatg cctgccttgg 1620 cacctatagc tgccaaagtt gggtccattggacccaaaat gaatttagca ggaattgacc 1680 aggaaggccg ggggagcaag gtgatgcctacattggcacc tgttgtacct aaattgggca 1740 actctggagc tccatcaagt tcatcagggaaatgagcttg ttcatcctca tacaaaagcc 1800 aggctgtgag gggaaatgaa tttcacctcctttctctgta ggcgtctgtt tgtttgtatt 1860 atggaactat tatccttgac ttaattatgtgtgaatattg atggagaaag gaggtgtagg 1920 gtgctggtcc tggtgtttga aattctgatcatgttaaaaa tgtgttacct tacttgtggt 1980 gctgggtccc ctcatcttct ctaagaaggtgtgattccct cttgcccaag gaattcataa 2040 caagattctg gctccatcaa ctaccttattattttcccct gagaaaatgc ttgagacttg 2100 gaattactat agactaaagt ataagtcatagttgttggct ccaaaatctg agaattatga 2160 tacagttgtg tgggaaaaaa aaaaaaaaagaacttttagt tactatttca atagtagggc 2220 atggtaggac tgggcatggt agtgcacacttgtaattcca gcacttagaa gacta 2275 89 1266 DNA Rattus sp. 89 gccgctggtgccaccatagc tactgctgcg gctgcggcag cagagctgaa gccgtcgatc 60 gcgatgccggagggcgctgt gagctgggcc ccagcgaacg ggggcgctga cgagtagtag 120 ggtttctgaagtaggcagtg ggtgtggggg gctaaaacgg agctcccaag actcgggtgc 180 gggagggagcttctcgcatc ggctcgggcc agcgtgagcc cggcggccag ctcggtgctt 240 cggccccttgcccagtggct tcggaggcct cctcccttgg acacctcagt taccatggga 300 acacttgggctgtaaccggc gcccgactgg tcactagttc atccgattct tcagttaaac 360 gcctctggcaggtgtgggcc tgacatttct tcactccagg ggtcgtcctc cccttgtaaa 420 aaaaaatctagcaggctagg gtggggatgg ggagtgggaa agcgcagggc aatgcccaga 480 gtaagagttggtgacaagca gaagacacct actgtgatga taaggttgct tctgccatct 540 caggccagtgaaagtgcata tccgaaggct gtgttgaacg agaaggcagt accgctgttg 600 agacaagtccaaaggctagg ccagggactg tccttagggg ctcctcgtta tgatggctgg 660 agaagggtcaaccattacta gccgtatcaa gaacttgctg aggtctccat ccatcaaatt 720 acgcagaagtaaagcaggaa accggagaga ggacctcagc tccaaggtga gtcctgttgg 780 gagccacctcttacctactc tgtcctctcc tgcacttcgt tccttttttt tacctttctc 840 tttcttgaggggcaggaagg gggtggaaga atgaaatttc tctgttggct ttaaaagatc 900 atatacgcttatctttgacg acctgatttg aagttggaag aacagcaggc gtgggtgggc 960 atgctgagacgcagccatgg cttgaagaag ggcataggaa ggcaaactgg gtttaacagg 1020 gcctcagtttaaactaagtg tgtgcttggg aaacaagttg acattttatg actcagtttc 1080 tcttcttagaagagtacagt gagatcacat attctgtaaa ggacctagct gtgactaatg 1140 tattagtgtaacagttgggg ttataatgcc agactgtaca acagaaagaa tatactaata 1200 cacttcatctaagagagcaa aacaattttt tgacaagctt agtgatgcat gcctgtaatc 1260 ccagca 126690 1092 DNA Rattus sp. 90 cttttaactg gcagacacgg gaggtggagt cctttgatgggacgcaaaga tcaaggatgt 60 ccgagttacc taattgatac ctaacgttct tctggctctcggtagagaga tcacagtggc 120 ctttgaaggt ttgaaggcca gtgacctctt gtcaatctcatagaccccag gtcctagcct 180 acagttagtg ccttctcaca tcggaaggat tcttgttcctctttggtcat aaacctgtac 240 tttaacccat gttttctttc ccatggtaac agcaggtggagcgtgattaa tgcaggtgac 300 acttattact ggcattttct cgtatggcca agaggattttgatcagaaca aagtctgaaa 360 aagacccaga ctgaataagg ttgtagggaa atagtgcgtcagaggctggg ttgtaggagc 420 ctttagcacc cacctcgaac cctactgtga ctgtcatcctatggtctgta aggagtcact 480 tctctgtctt gctctaacag gtaaccttgg agaaggtcctgggagtaaca gtatctggag 540 gaagaggact tgcttgtgac ccccgatctg gcttagttgcctacccagca gggtaagtta 600 agtgcctttc agggcatctt gctacatgaa agtgtattttttatttctta ctaacatgtt 660 attcattgag aatttcatac aatatacttt ggtcctatttactcccttcc cctactattc 720 ccacatccac tcccccttcc tacccatttt acttggtgctctctccctct tctctccccc 780 cccacctttt taaagaccca tcaagtcata tttgtgttgcccaactactc tcaggtgtgg 840 ggcttatcct tggatgtggt caccctccca ggggggtcacaccattaaag aaagctggct 900 ttccctcttc cagcagttgc caggtgccaa cagcttctgggttagatgtg ggacttttgc 960 ccactcacca cttctaccca ctccccagtc cacccatgttaggattttga ctggcttgag 1020 ctcactgaga tcctatgaat gcagtcacaa ctgcagtgagttcttaggtg caattgtcat 1080 gctgtatcca ga 1092 91 1063 DNA Rattus sp. 91tggaagcttt gtagccttcc caagtcattc ccaaggtcct cccaagctat ctctgctccc 60tccacctcca gcttaggcct ccttgcagtt ctagccccta gcatagcccg tgtgttcttt 120cttactcagt aggtagaagc ataccatctc taacagtgat taagacatgt ggctccaagc 180ctgagaacca gttgcaagct gaggcctgag ctgatcaaat cacattaact cttccatctt 240ccattcattc cttgggatat gttcaaaggc tgggggaagg ccctgtctct gctgtccttt 300aggagtatga tcagagatgg gactgacagt cagggtcctg gtgactaggc ttctggtgga 360gagcctttct attatgggaa tctgataata gacccttttg ggtggagact ccgacctgtt 420ccctctgctg ggtgaccaga agtctcagtg ggctcctgag gaagctatgg ttcagtgtga 480catctcactc atctcctcag gtgtgtggtc gtcctcttca atccccggaa gcacaaacag 540caccacatcc tcaacagctc caggtgtgtg ggcctggcct caggggctgg gggtgaccgt 600ggccgggggc ctgaggccct gtggccagat agggacgcgc atatacactc ttgagtttgt 660tggccttgcc tttgggaaat atgcatgaag gatggaggaa gggaggttgg ggaagggggc 720acagtctagg gtcaaccaaa cctgccccgt ctcttgtagg aaaaccatta ctgcccttgc 780cttctcccct gatggcaagt acttggtcac tggagaggta agtgaagaac agggtggcaa 840tattgtagct tatggacacc ctgccttcaa ccaaagccac cgtcctgtgt tccagctagg 900gtgctgtcac tttggcttca gggattgata ccctggttcc tgctttgacc agatagctgt 960tcttaagctt tagtgtgatc aggctccctg ggagggcttt tcaaagtgct cacagctagg 1020ctcctactcc aaagttgttt gattctataa ccttctttta aaa 1063 92 1058 DNA Rattussp. 92 tgttcaaagg ctgggggaag gccctgtctc tgctgtcctt taggagtatg atcagagatg60 ggactgacag tcagggtcct ggtgactagg cttctggtgg agagcctttc tattatggga 120atctgataat agaccctttt gggtggagac tccgacctgt tccctctgct gggtgaccag 180aagtctcagt gggctcctga ggaagctatg gttcagtgtg acatctcact catctcctca 240ggtgtgtggt cgtcctcttc aatccccgga agcacaaaca gcaccacatc ctcaacagct 300ccaggtgtgt gggcctggcc tcaggggctg ggggtgaccg tggccggggg cctgaggccc 360tgtggccaga tagggacgcg catatacact cttgagtttg ttggccttgc ctttgggaaa 420tatgcatgaa ggatggagga agggaggttg gggaaggggg cacagtctag ggtcaaccaa 480acctgccccg tctcttgtag gaaaaccatt actgcccttg ccttctcccc tgatggcaag 540tacttggtca ctggagaggt aagtgaagaa cagggtggca atattgtagc ttatggacac 600cctgccttca accaaagcca ccgtcctgtg ttccagctag ggtgctgtca ctttggcttc 660agggattgat accctggttc ctgctttgac cagatagctg ttcttaagct ttagtgtgat 720caggctccct gggagggctt ttcaaagtgc tcacagctag gctcctactc caaagttgtt 780tgattctata accttctttt aaaagtaaaa ccaagcccgg gtggtggcgc acgcctttaa 840tcccagcact tgggaggcag agccaggtgg atttctgagt tcgaggccag cctggtctac 900aacgtgagtt ccaggacagc cagggctaca cagagaaacc ctatctcaaa aaacaaaaca 960acaacaaaaa agtaaaacca aaacaagaaa tattaattaa tttctttatg tgggggaggg 1020gtcatgaagg ttatgtcaaa tgctttacac gctgaagt 1058 93 1171 DNA Rattus sp. 93agagaaaccc tatctcaaaa aacaaaacaa caacaaaaaa gtaaaaccaa aacaagaaat 60attaattaat ttctttatgt gggggagggg tcatgaaggt tatgtcaaat gctttacacg 120ctgaagtcat ctcttgcctc ctttccccca gagcttctaa caatgtgggg tagttaagga 180cacatttatc ctaaaatatt cctatcttca gatgccccct gctgggcaca tgaggaacat 240ggcccttggt tttacaagga ggcagtcagg gtagatgcct gctgctgctt gctagaacca 300ttcaaggagc tttgaccaga cagaggcaag ggctaacctc tgctgacact ggtgtcctca 360gatccttttt ctatgccttt atcttgctct cccttgttga acactggagg gacagtgttt 420aaagctgggg aggtgagaga ctaaggaggc tacacataac accttccaca gttctcacgt 480gcggttttgc ctccctgcag agtgggcaca tgcctgccgt gcgggtttgg gatgtggctg 540aacgtagcca ggtggcagag ctacaggagc ataagtatgg tgtggcttgt gtggctttct 600ccccaagtgc caagtacatt gtgtctgtgg gctaccagca tgacatgatt gtcaacgtgt 660gggcctggaa ggtgagtagg ctggtgacag ccttagcggc ctcatgaggg ttcccatggg 720ggtggagggg gaactgctga cccaagcaac ctcatttcct tcactgtctc cagctcttcc 780ttgaacagta tttgaagtac aaaatagcac ctgaggagca agggtgtttc tagaggcttt 840tcctacacat ctaaggaatt aaacctttga attcctttag aaaagaggtt gggtttttgt 900tgttattgtt ttgttttctg accattaaat accagaaagg aagagttttg tttttcctct 960ctttctgttg ttgttttgtt tgtttgtttg tatttgtttt tattttgggg tttttttttg 1020tttttgaagt agaaattatt gctagctctt gtccattctc agataccttc ttaccccagt 1080aggaagagct tgtctgttct cggatacctt cttatcccca acaggcagaa ctttgattct 1140tcctctggct tcccctccag aaaaacattg t 1171 94 1138 DNA Rattus sp. 94gggcctggaa ggtgagtagg ctggtgacag ccttagcggc ctcatgaggg ttcccatggg 60ggtggagggg gaactgctga cccaagcaac ctcatttcct tcactgtctc cagctcttcc 120ttgaacagta tttgaagtac aaaatagcac ctgaggagca agggtgtttc tagaggcttt 180tcctacacat ctaaggaatt aaacctttga attcctttag aaaagaggtt gggtttttgt 240tgttattgtt ttgttttctg accattaaat accagaaagg aagagttttg tttttcctct 300ctttctgttg ttgttttgtt tgtttgtttg tatttgtttt tattttgggg tttttttttg 360tttttgaagt agaaattatt gctagctctt gtccattctc agataccttc ttaccccagt 420aggaagagct tgtctgttct cggatacctt cttatcccca acaggcagaa ctttgattct 480tcctctggct tcccctccag aaaaacattg tagtggcctc caacaaagta tccagtcggg 540taaccgcagt gtccttttct gaagactgca gctactttgt cactgcaggc aaccggcaca 600tcaaattctg gtacctggat gacagtaaga cctcaaaggt gagggctgag atgaccaacc 660ctgaacagca ctccagctgt tgcctttggc ttgtttaaca gtcacaggtt cttcatggac 720ctgacctgcc tgggctgagg cgtctcaaag aacacatgct tgccctctct ctgaggccct 780catttccaag gctagatggc tgtagtggtg tctccacagg tgaacgccac tgtgcccctg 840ctgggccgct cggggctgct gggggagctg aggaacaacc tgttcactga tgtggcctgt 900ggccgagggg aaaaggctga tagcactttc tgtatcacgt cgtcggggct gctgtgcgag 960ttcagcgatc gcaggcttct ggacaaatgg gtggagctaa gggtaagtaa ctctggctcc 1020agaacagggt ctggccttat ctcaaatcag gggagaactg gccttggggc tgtagagcca 1080ggctgggcct ttgtgcatgc tgaaggggac tgcaggagaa gactcagggc gctcgctc 1138 951183 DNA Rattus sp. 95 ttgtttgttt gtatttgttt ttattttggg gtttttttttgtttttgaag tagaaattat 60 tgctagctct tgtccattct cagatacctt cttaccccagtaggaagagc ttgtctgttc 120 tcggatacct tcttatcccc aacaggcaga actttgattcttcctctggc ttcccctcca 180 gaaaaacatt gtagtggcct ccaacaaagt atccagtcgggtaaccgcag tgtccttttc 240 tgaagactgc agctactttg tcactgcagg caaccggcacatcaaattct ggtacctgga 300 tgacagtaag acctcaaagg tgagggctga gatgaccaaccctgaacagc actccagctg 360 ttgcctttgg cttgtttaac agtcacaggt tcttcatggacctgacctgc ctgggctgag 420 gcgtctcaaa gaacacatgc ttgccctctc tctgaggccctcatttccaa ggctagatgg 480 ctgtagtggt gtctccacag gtgaacgcca ctgtgcccctgctgggccgc tcggggctgc 540 tgggggagct gaggaacaac ctgttcactg atgtggcctgtggccgaggg gaaaaggctg 600 atagcacttt ctgtatcacg tcgtcggggc tgctgtgcgagttcagcgat cgcaggcttc 660 tggacaaatg ggtggagcta agggtaagta actctggctccagaacaggg tctggcctta 720 tctcaaatca ggggagaact ggccttgggg ctgtagagccaggctgggcc tttgtgcatg 780 ctgaagggga ctgcaggaga agactcaggg cgctcgctcgcagtgatctg cataaccagc 840 tcctcttgct ctttctcgcc tctcttccct gctttcctcttctgctcaga acacagacag 900 cttcacagta agtgcttcta ggccttctct tctcaagctgttgctttctc cttgttgggg 960 tttttctacc ttccaatctt ggtccctctg atggccttgatttctacccc acctcccaag 1020 tctgcagggc tacaggccct ctgaccatat gctgctggagggagggcatt tctagatgac 1080 acctgagggg ttggcccgac tttggcctgg ctctcctttgtgagcgagtg ttgctgaggg 1140 cttgggaagg attaagccaa gctaaatggg aagatggccctta 1183 96 1018 DNA Rattus sp. 96 ttcttcatgg acctgacctg cctgggctgaggcgtctcaa agaacacatg cttgccctct 60 ctctgaggcc ctcatttcca aggctagatggctgtagtgg tgtctccaca ggtgaacgcc 120 actgtgcccc tgctgggccg ctcggggctgctgggggagc tgaggaacaa cctgttcact 180 gatgtggcct gtggccgagg ggaaaaggctgatagcactt tctgtatcac gtcgtcgggg 240 ctgctgtgcg agttcagcga tcgcaggcttctggacaaat gggtggagct aagggtaagt 300 aactctggct ccagaacagg gtctggccttatctcaaatc aggggagaac tggccttggg 360 gctgtagagc caggctgggc ctttgtgcatgctgaagggg actgcaggag aagactcagg 420 gcgctcgctc gcagtgatct gcataaccagctcctcttgc tctttctcgc ctctcttccc 480 tgctttcctc ttctgctcag aacacagacagcttcacagt aagtgcttct aggccttctc 540 ttctcaagct gttgctttct ccttgttggggtttttctac cttccaatct tggtccctct 600 gatggccttg atttctaccc cacctcccaagtctgcaggg ctacaggccc tctgaccata 660 tgctgctgga gggagggcat ttctagatgacacctgaggg gttggcccga ctttggcctg 720 gctctccttt gtgagcgagt gttgctgagggcttgggaag gattaagcca agctaaatgg 780 gaagatggcc cttacttact gagctgctctgcccacagac cactgtggcc cactgcatct 840 ctgtcaccca agaatacatc ttctgtggctgtgctgatgg cacggtgcgc cttttcaatc 900 cttccaacct gcacttcctc agtaccctacctagacccca tgctcttgga acagacattg 960 ccagcatcac tgaggccagg tgagctatatggggcccact gtccattcaa agctttag 1018 97 1161 DNA Rattus sp. 97 gggtctggccttatctcaaa tcaggggaga actggccttg gggctgtaga gccaggctgg 60 gcctttgtgcatgctgaagg ggactgcagg agaagactca gggcgctcgc tcgcagtgat 120 ctgcataaccagctcctctt gctctttctc gcctctcttc cctgctttcc tcttctgctc 180 agaacacagacagcttcaca gtaagtgctt ctaggccttc tcttctcaag ctgttgcttt 240 ctccttgttggggtttttct accttccaat cttggtccct ctgatggcct tgatttctac 300 cccacctcccaagtctgcag ggctacaggc cctctgacca tatgctgctg gagggagggc 360 atttctagatgacacctgag gggttggccc gactttggcc tggctctcct ttgtgagcga 420 gtgttgctgagggcttggga aggattaagc caagctaaat gggaagatgg cccttactta 480 ctgagctgctctgcccacag accactgtgg cccactgcat ctctgtcacc caagaataca 540 tcttctgtggctgtgctgat ggcacggtgc gccttttcaa tccttccaac ctgcacttcc 600 tcagtaccctacctagaccc catgctcttg gaacagacat tgccagcatc actgaggcca 660 ggtgagctatatggggccca ctgtccattc aaagctttag tcactacttc atggagcaga 720 atggagagtgcgcaatgccc aaagatcccc tttgtagaca gaaacctggg tttcttggta 780 gttgtcagaatcggggagat taaatagcac agaggaccat ggactgtctc acctgggtgc 840 atcttaggtgattttaagaa tgactcaagg gattggagtc ttccttctgg ttggcctctt 900 gataagctgtcagcaccaga aagaaagtat gctgtggtaa agacacagaa agacaaagtc 960 accaatcatgctaggaggaa aagggtgatg tgtggtcatt tttatggttt ggcaagtgtc 1020 ctcagtaaaagatgaggagg gggaagagga ggaagaagaa gaagaggggg aggggaggaa 1080 gaggaggaagaagaggaaga agagaaagag gaggaggaga ttttgaggtg ctggagatag 1140 taccaagagccttgcttgtt a 1161 98 1190 DNA Rattus sp. 98 tggtttggca agtgtcctcagtaaaagatg aggaggggga agaggaggaa gaagaagaag 60 agggggaggg gaggaagaggaggaagaaga ggaagaagag aaagaggagg aggagatttt 120 gaggtgctgg agatagtaccaagagccttg cttgttagat aagtgctcta ccactgagct 180 atatcacaaa ccctatttttgtggtatgta gtatagtctt gttttgatct ctgtgcagaa 240 atactcatag aaccatgtagattttgttgt gctccattgt aaccacagaa ttgccttgtc 300 tggtattggt gatctatgaatttgttagca tttctctgga aaacactctg cccagtagct 360 gtggttgggt gagctcctggattggatctc taggcactgc ttttgaattc tcagttctac 420 ttccaaatct gtaggactggagacagtgtc ctgtgctcca ttccttcctt tgtggtaact 480 tcctgtcctc tctcccacagtcgcctcttt tctggagggg tcaatgcaag gtacccagac 540 accattgcct tgaccttcgatccaactaat cagtggctat cttgtgtata caacgaccac 600 agcatatatg tttgggatgtgagggacccc aagaaagtgg ggaaggtgta ctccgctctg 660 tatcactcct cctgtgtctggagtgtggag gtacgtggga tgggtttgca gtaattccac 720 tgtgagaata gaaagcagagaacaccaagc acggccctag ggtcctgccc ctcggctctc 780 agtggcttcc ctgctgtagctctagagctt ctagagctcc agtgtgaacg ttggtgccca 840 tgcacctcag ccttcttgtgtgtctctgcc tagcctgagt ctttgcctta tcctcggctc 900 aggaatcttg gataagttactaaaccagac taagcttcag atcccttaac tgtaaaatga 960 tgtatcagat tttcccaattgttctaacaa tgaaatgaca taacgtaatt gagagattat 1020 ggcacacagg aggagctgggatcgcgggct tttccttact gggtgcatat ataacagtaa 1080 tgtctccttt ccttactaaatgtcagacaa tagctaagtc ttagcactct gccttggatg 1140 ccataaccct ttccttcttcctgagtagac aaaaatgccc cccaaagcgg 1190 99 1147 DNA Rattus sp. 99tgtgagaata gaaagcagag aacaccaagc acggccctag ggtcctgccc ctcggctctc 60agtggcttcc ctgctgtagc tctagagctt ctagagctcc agtgtgaacg ttggtgccca 120tgcacctcag ccttcttgtg tgtctctgcc tagcctgagt ctttgcctta tcctcggctc 180aggaatcttg gataagttac taaaccagac taagcttcag atcccttaac tgtaaaatga 240tgtatcagat tttcccaatt gttctaacaa tgaaatgaca taacgtaatt gagagattat 300ggcacacagg aggagctggg atcgcgggct tttccttact gggtgcatat ataacagtaa 360tgtctccttt ccttactaaa tgtcagacaa tagctaagtc ttagcactct gccttggatg 420ccataaccct ttccttcttc ctgagtagac aaaaatgccc cccaaagcgg aagtctaatt 480ctctccctct gtcccttcag gtctaccctg agatcaagga cagtcaccag gcctgtcttc 540cccccagttc ctttattact tgctcctcag acaacaccat ccgcctgtgg aacacagaga 600gctctggggt acatggctct accctgcacc gtaacatcct cagcaatgtg agcctcccgt 660ttcatactta tgcccccatg cttatagatt ttgaccttgt tttcaggaac tggctccccg 720aatcttgatc attcagcttt tatttggctg gactctctga gcctagggtt gattttaccc 780agcatccctc tgtgcttgca gccatcctgc tggtactgcc tgagctgtct cctttctcct 840ttcccaccag gatctcatta agatcatcta tgtggatggg aacactcagg ctttgttgga 900cactgagctg cctggaggag acaaagctga tgggtcgctg atggaccccc gagtgggcat 960ccggtccgtg tgtattagcc ccaatggaca gcacctggcc tccggagacc gcatggggac 1020acttaggtaa ggtcaagttc tgagctaggt actgactgcc tctcatggtg actgtggtag 1080ttagatcctc aagagcagcg ctttaggagg gcttgtctcc ccccaaagct tagaaacaag 1140atattta 1147 100 1176 DNA Rattus sp. 100 ataacagtaa tgtctcctttccttactaaa tgtcagacaa tagctaagtc ttagcactct 60 gccttggatg ccataaccctttccttcttc ctgagtagac aaaaatgccc cccaaagcgg 120 aagtctaatt ctctccctctgtcccttcag gtctaccctg agatcaagga cagtcaccag 180 gcctgtcttc cccccagttcctttattact tgctcctcag acaacaccat ccgcctgtgg 240 aacacagaga gctctggggtacatggctct accctgcacc gtaacatcct cagcaatgtg 300 agcctcccgt ttcatacttatgcccccatg cttatagatt ttgaccttgt tttcaggaac 360 tggctccccg aatcttgatcattcagcttt tatttggctg gactctctga gcctagggtt 420 gattttaccc agcatccctctgtgcttgca gccatcctgc tggtactgcc tgagctgtct 480 cctttctcct ttcccaccaggatctcatta agatcatcta tgtggatggg aacactcagg 540 ctttgttgga cactgagctgcctggaggag acaaagctga tgggtcgctg atggaccccc 600 gagtgggcat ccggtccgtgtgtattagcc ccaatggaca gcacctggcc tccggagacc 660 gcatggggac acttaggtaaggtcaagttc tgagctaggt actgactgcc tctcatggtg 720 actgtggtag ttagatcctcaagagcagcg ctttaggagg gcttgtctcc ccccaaagct 780 tagaaacaag atatttattctgtaaaatga aagaatgagc ttacagtggt gagctcagaa 840 aaagccatcg cagacataggcacagctatc agtcacacat ccgcatgagg aagctcaaga 900 taaggggttc taagaaggacataatattgt ttctgtggtg ttctttaaaa aaatgcatat 960 aactcagttc acttgtgagaggctcaaatg aggtacatac aagagagtaa ttgtcagtgt 1020 tcttcaaaag tgtcgaggacatggaaggta aggagggatg gagagactac cacagacttc 1080 aggaaactaa agagcagtgatagctaaatg ccttttacat tctttaagat cctgaatcca 1140 ggacatatgg acaaataatggcatgttaat aatata 1176 101 1092 DNA Rattus sp. 101 taaagagcag tgatagctaaatgcctttta cattctttaa gatcctgaat ccaggacata 60 tggacaaata atggcatgttaataatatac ctacttgggc tggtgagacg gttcagcggt 120 taagagcacc gactgctcttccaaaagtcc tgagttcaaa tcccagcaac cacatggtgg 180 ctcacaacca tccgtaacaaaaatctgatg ccctcttctg gagtgtctga agatagctac 240 agcgtataca catataataaataaattaat taattaaaaa aataataata tacctactta 300 acagtatgta aatgcctggctctgacatgt gctgttgtta tgtatgctag ttaagaactg 360 ggcaagggga tatagaacaccttcagtgtt tgaacttttt cttaaagctt taaaatgttt 420 gtttaaaggt ggggagaggatgtaacagaa gaaggaggcc tttcctctca cagccaggca 480 atgatgtctc ttatttgtaggatacatgaa ctgcagtccc tgagtgagat gctgaaagtg 540 gaggcccacg actctgagatcttgtgcctg gagtactcta agccagacac aggtaaggcc 600 taacccatgc cctagcagggtctagctctg gcacagcccc tcctgtcctg ccagtgccac 660 cttatacctg ccttggcttctgataatctt gggtcctata ttcattcaga tcacttggtg 720 tttgcaggat tgtaagatctctgcccctgt tctgtggttc tgtggcttta gggatatgag 780 gctctgtcta cttggggctctttcccaggc actgataagg gccagcttaa cgtgaactga 840 taagattctt ccaaccccaggtttgaaact gctagcatcg gcaagccggg accgtctgat 900 ccacgtgctg gatgctggccgggaatatag tctacagcag acactggatg agcattcatc 960 ttccatcact gctgtcaagtttgcaggtgg ggactgggca attgaagcta ttcatccctc 1020 tacctaccac ctacatttatgagaagagtt tgctgggaag gattgggagg tacccgggag 1080 tcatgaggct ag 1092 1021126 DNA Rattus sp. 102 ggcaagggga tatagaacac cttcagtgtt tgaactttttcttaaagctt taaaatgttt 60 gtttaaaggt ggggagagga tgtaacagaa gaaggaggcctttcctctca cagccaggca 120 atgatgtctc ttatttgtag gatacatgaa ctgcagtccctgagtgagat gctgaaagtg 180 gaggcccacg actctgagat cttgtgcctg gagtactctaagccagacac aggtaaggcc 240 taacccatgc cctagcaggg tctagctctg gcacagcccctcctgtcctg ccagtgccac 300 cttatacctg ccttggcttc tgataatctt gggtcctatattcattcaga tcacttggtg 360 tttgcaggat tgtaagatct ctgcccctgt tctgtggttctgtggcttta gggatatgag 420 gctctgtcta cttggggctc tttcccaggc actgataagggccagcttaa cgtgaactga 480 taagattctt ccaaccccag gtttgaaact gctagcatcggcaagccggg accgtctgat 540 ccacgtgctg gatgctggcc gggaatatag tctacagcagacactggatg agcattcatc 600 ttccatcact gctgtcaagt ttgcaggtgg ggactgggcaattgaagcta ttcatccctc 660 tacctaccac ctacatttat gagaagagtt tgctgggaaggattgggagg tacccgggag 720 tcatgaggct aggtaggaag gcaggtgaaa tatagactttcagtctaggg gaccctgagc 780 cagactgagg gctgaggagg gggtgcatgg gttttgtgggatgcactctg ttttatttgg 840 ttggtccacc atgtagagta gctccattgg ggaaaataagggaaggcagg agaaaggctg 900 ccttcatatg gtggaagcag ccaggtccct gtcccctacagccagtgatg ggcaagtgcg 960 aatgatcagc tgtggtgcag acaagagcat ttacttccgaactgcacaga aggtaagggc 1020 actgggtgtc cccagcaggg caggggtggg aacagggtttcaggctatgg gaggtgaaga 1080 gagaagtgag ccctgtgagc tgtgatgcat ttgcagtctggagaag 1126 103 1071 DNA Rattus sp. 103 ttcccaggca ctgataaggg ccagcttaacgtgaactgat aagattcttc caaccccagg 60 tttgaaactg ctagcatcgg caagccgggaccgtctgatc cacgtgctgg atgctggccg 120 ggaatatagt ctacagcaga cactggatgagcattcatct tccatcactg ctgtcaagtt 180 tgcaggtggg gactgggcaa ttgaagctattcatccctct acctaccacc tacatttatg 240 agaagagttt gctgggaagg attgggaggtacccgggagt catgaggcta ggtaggaagg 300 caggtgaaat atagactttc agtctaggggaccctgagcc agactgaggg ctgaggaggg 360 ggtgcatggg ttttgtggga tgcactctgttttatttggt tggtccacca tgtagagtag 420 ctccattggg gaaaataagg gaaggcaggagaaaggctgc cttcatatgg tggaagcagc 480 caggtccctg tcccctacag ccagtgatgggcaagtgcga atgatcagct gtggtgcaga 540 caagagcatt tacttccgaa ctgcacagaaggtaagggca ctgggtgtcc ccagcagggc 600 aggggtggga acagggtttc aggctatgggaggtgaagag agaagtgagc cctgtgagct 660 gtgatgcatt tgcagtctgg agaaggagtacagtttacac gaacgcacca cgtggtacgg 720 aagacaactc tctatgacat ggacgtggagcccagctgga agtacacggc catcggctgc 780 caagaccgga atattcggtg ggtgggcgttcccttctcag acttctttac aaattcattt 840 tcactttgtt tattttgtgg gaagaggattgagcccgtgg gggtcagaac tactttcagg 900 agtggtttgt ctcttaccag gacatgggttctggaggtca gacttagcca tcagtccagg 960 cagcaagcgc ctttaccctc tgagctatttttctggcctc ctcttgtcag atttttggac 1020 cacattcctt tgtgcagctc agtctcaaatctgctttttt gtccaggctt t 1071 104 1122 DNA Rattus sp. 104 aagtttgcaggtggggactg ggcaattgaa gctattcatc cctctaccta ccacctacat 60 ttatgagaagagtttgctgg gaaggattgg gaggtacccg ggagtcatga ggctaggtag 120 gaaggcaggtgaaatataga ctttcagtct aggggaccct gagccagact gagggctgag 180 gagggggtgcatgggttttg tgggatgcac tctgttttat ttggttggtc caccatgtag 240 agtagctccattggggaaaa taagggaagg caggagaaag gctgccttca tatggtggaa 300 gcagccaggtccctgtcccc tacagccagt gatgggcaag tgcgaatgat cagctgtggt 360 gcagacaagagcatttactt ccgaactgca cagaaggtaa gggcactggg tgtccccagc 420 agggcaggggtgggaacagg gtttcaggct atgggaggtg aagagagaag tgagccctgt 480 gagctgtgatgcatttgcag tctggagaag gagtacagtt tacacgaacg caccacgtgg 540 tacggaagacaactctctat gacatggacg tggagcccag ctggaagtac acggccatcg 600 gctgccaagaccggaatatt cggtgggtgg gcgttccctt ctcagacttc tttacaaatt 660 cattttcactttgtttattt tgtgggaaga ggattgagcc cgtgggggtc agaactactt 720 tcaggagtggtttgtctctt accaggacat gggttctgga ggtcagactt agccatcagt 780 ccaggcagcaagcgccttta ccctctgagc tatttttctg gcctcctctt gtcagatttt 840 tggaccacattcctttgtgc agctcagtct caaatctgct tttttgtcca ggctttcgag 900 cctctttgaggcagcaaagt actctgcctc acctgagaga gtgcgagcga gttcccagga 960 caaatgggaagtcccatttg ctgccagctt atagcctggg ctctggtcct caggctgctg 1020 tgaacacgtgccttcctttt caggatcttt aacattagca gcggaaagca gaaaaagctg 1080 tttaaagggtcacagggtga agatggcact ctcattaagg tg 1122 105 1076 DNA Rattus sp. 105ggaagacaac tctctatgac atggacgtgg agcccagctg gaagtacacg gccatcggct 60gccaagaccg gaatattcgg tgggtgggcg ttcccttctc agacttcttt acaaattcat 120tttcactttg tttattttgt gggaagagga ttgagcccgt gggggtcaga actactttca 180ggagtggttt gtctcttacc aggacatggg ttctggaggt cagacttagc catcagtcca 240ggcagcaagc gcctttaccc tctgagctat ttttctggcc tcctcttgtc agatttttgg 300accacattcc tttgtgcagc tcagtctcaa atctgctttt ttgtccaggc tttcgagcct 360ctttgaggca gcaaagtact ctgcctcacc tgagagagtg cgagcgagtt cccaggacaa 420atgggaagtc ccatttgctg ccagcttata gcctgggctc tggtcctcag gctgctgtga 480acacgtgcct tccttttcag gatctttaac attagcagcg gaaagcagaa aaagctgttt 540aaagggtcac agggtgaaga tggcactctc attaaggtga gcaccccagt gggactagca 600gagcctgctg cctgccctgc cattgggcag cttggggtcg gtgctaagtg aggaggggtg 660gtgatcccct actcttgctg tgtccccagg tgcagacaga cccctcaggg atctacattg 720ccactagctg ttccgataag aatctctcca tttttgactt ctcctcaggc gagtgtgtgg 780ccaccatgtt tggccactca ggtgagtgag tgagtgtagc agccacctcc ctagttgaaa 840ttgtactttc ttcccttggc tgttgccaca ccacaactct gccctaccct gggaggcatc 900acctgactaa agcaagagta gaaagccctg tggcagaagg ggacagtatg gttggtacct 960ttcccttccc ccatatccag actcagagca caaagtgcct atgtgaggat agaacccgac 1020tctccctctc ctgcagccag tgcccatccc tgcagctgga agaggcagga atttga 1076 1061112 DNA Rattus sp. 106 tgtctcttac caggacatgg gttctggagg tcagacttagccatcagtcc aggcagcaag 60 cgcctttacc ctctgagcta tttttctggc ctcctcttgtcagatttttg gaccacattc 120 ctttgtgcag ctcagtctca aatctgcttt tttgtccaggctttcgagcc tctttgaggc 180 agcaaagtac tctgcctcac ctgagagagt gcgagcgagttcccaggaca aatgggaagt 240 cccatttgct gccagcttat agcctgggct ctggtcctcaggctgctgtg aacacgtgcc 300 ttccttttca ggatctttaa cattagcagc ggaaagcagaaaaagctgtt taaagggtca 360 cagggtgaag atggcactct cattaaggtg agcaccccagtgggactagc agagcctgct 420 gcctgccctg ccattgggca gcttggggtc ggtgctaagtgaggaggggt ggtgatcccc 480 tactcttgct gtgtccccag gtgcagacag acccctcagggatctacatt gccactagct 540 gttccgataa gaatctctcc atttttgact tctcctcaggcgagtgtgtg gccaccatgt 600 ttggccactc aggtgagtga gtgagtgtag cagccacctccctagttgaa attgtacttt 660 cttcccttgg ctgttgccac accacaactc tgccctaccctgggaggcat cacctgacta 720 aagcaagagt agaaagccct gtggcagaag gggacagtatggttggtacc tttcccttcc 780 cccatatcca gactcagagc acaaagtgcc tatgtgaggatagaacccga ctctccctct 840 cctgcagcca gtgcccatcc ctgcagctgg aagaggcaggaatttgatta ggtctttgtg 900 gcagttcata gaccatatac tttacttttt acagagattgtcactggcat gaaatttagt 960 aacgattgca aacatctcat ctctgtgtca ggggacaggtgagcagaagc taacttccct 1020 gagacaattc ttctctgtgc cacctgtccc tcctctcattttctctcctg gtgtctctgg 1080 gaagtaggtc tgaagaggga catttcttgg tg 1112 1071064 DNA Rattus sp. 107 tgggcagctt ggggtcggtg ctaagtgagg aggggtggtgatcccctact cttgctgtgt 60 ccccaggtgc agacagaccc ctcagggatc tacattgccactagctgttc cgataagaat 120 ctctccattt ttgacttctc ctcaggcgag tgtgtggccaccatgtttgg ccactcaggt 180 gagtgagtga gtgtagcagc cacctcccta gttgaaattgtactttcttc ccttggctgt 240 tgccacacca caactctgcc ctaccctggg aggcatcacctgactaaagc aagagtagaa 300 agccctgtgg cagaagggga cagtatggtt ggtacctttcccttccccca tatccagact 360 cagagcacaa agtgcctatg tgaggataga acccgactctccctctcctg cagccagtgc 420 ccatccctgc agctggaaga ggcaggaatt tgattaggtctttgtggcag ttcatagacc 480 atatacttta ctttttacag agattgtcac tggcatgaaatttagtaacg attgcaaaca 540 tctcatctct gtgtcagggg acaggtgagc agaagctaacttccctgaga caattcttct 600 ctgtgccacc tgtccctcct ctcattttct ctcctggtgtctctgggaag taggtctgaa 660 gagggacatt tcttggtggg gcctgacctg gcagtggagggtggcttgga tcgccttgcc 720 aattcgtggg aagtagggat aaacgatact gctacccgcagagtccttcc ctgcccctca 780 ctcagtgctg tggctccacc ctagctgcat ctttgtctggcgtctgagct ctgagatgac 840 catcagcatg aggcagcgct tggctgagct gcggcagcgccagcgaggga tcaagcagca 900 aggaccaacc tctccccaga gggcttctgg agccaagcagtaagtgggcc agagatgggc 960 tctgctcacg gttgtgcaca gggtgtgtgc tctccctgcacctccttgtg tggaacgtac 1020 tgttcagcat ctccggtaat ctcaaggcct tcctttgcatgcac 1064 108 1135 DNA Rattus sp. 108 ctgtggcaga aggggacagt atggttggtacctttccctt cccccatatc cagactcaga 60 gcacaaagtg cctatgtgag gatagaacccgactctccct ctcctgcagc cagtgcccat 120 ccctgcagct ggaagaggca ggaatttgattaggtctttg tggcagttca tagaccatat 180 actttacttt ttacagagat tgtcactggcatgaaattta gtaacgattg caaacatctc 240 atctctgtgt caggggacag gtgagcagaagctaacttcc ctgagacaat tcttctctgt 300 gccacctgtc cctcctctca ttttctctcctggtgtctct gggaagtagg tctgaagagg 360 gacatttctt ggtggggcct gacctggcagtggagggtgg cttggatcgc cttgccaatt 420 cgtgggaagt agggataaac gatactgctacccgcagagt ccttccctgc ccctcactca 480 gtgctgtggc tccaccctag ctgcatctttgtctggcgtc tgagctctga gatgaccatc 540 agcatgaggc agcgcttggc tgagctgcggcagcgccagc gagggatcaa gcagcaagga 600 ccaacctctc cccagagggc ttctggagccaagcagtaag tgggccagag atgggctctg 660 ctcacggttg tgcacagggt gtgtgctctccctgcacctc cttgtgtgga acgtactgtt 720 cagcatctcc ggtaatctca aggccttcctttgcatgcac aagcccatca gtgttgcctt 780 cttgcccagt gagtcttctc ttctgaccttcttgtcttgg actcaggcac catgctccag 840 tggtaccccc ttctggacca gctctttcctcagacagtga caaggaggga gaagatgagg 900 gtactgaaga agaagaactg ccagctctgcccatccttag caagagcacc aagaaagaac 960 taggtttgtg gcagttaggt gtaaagcagacaggcactag ctgctgtggt gactaggtta 1020 gtccatctgg accatgggat aaggaggctgggccatcaca gtgatcacat gggggatggg 1080 gatgttctgg gctcctggtc ccagaggtgggcagggagga aacacacctt ctgac 1135 109 1137 DNA Rattus sp. 109 ctcctggtgtctctgggaag taggtctgaa gagggacatt tcttggtggg gcctgacctg 60 gcagtggagggtggcttgga tcgccttgcc aattcgtggg aagtagggat aaacgatact 120 gctacccgcagagtccttcc ctgcccctca ctcagtgctg tggctccacc ctagctgcat 180 ctttgtctggcgtctgagct ctgagatgac catcagcatg aggcagcgct tggctgagct 240 gcggcagcgccagcgaggga tcaagcagca aggaccaacc tctccccaga gggcttctgg 300 agccaagcagtaagtgggcc agagatgggc tctgctcacg gttgtgcaca gggtgtgtgc 360 tctccctgcacctccttgtg tggaacgtac tgttcagcat ctccggtaat ctcaaggcct 420 tcctttgcatgcacaagccc atcagtgttg ccttcttgcc cagtgagtct tctcttctga 480 ccttcttgtcttggactcag gcaccatgct ccagtggtac ccccttctgg accagctctt 540 tcctcagacagtgacaagga gggagaagat gagggtactg aagaagaaga actgccagct 600 ctgcccatccttagcaagag caccaagaaa gaactaggtt tgtggcagtt aggtgtaaag 660 cagacaggcactagctgctg tggtgactag gttagtccat ctggaccatg ggataaggag 720 gctgggccatcacagtgatc acatggggga tggggatgtt ctgggctcct ggtcccagag 780 gtgggcagggaggaaacaca ccttctgact gcctatttct gtctagcctc aggctctagt 840 ccagccttgctccgaagcct gtcccactgg gaaatgagtc gggtaagttg ccatcactga 900 aatgtgcttctaagattatt agacgtgagg gatgaggcat tgggtaagga cctgcccaca 960 tgcaccattcctgtttccaa ggaaggcctt atcattaagg tcaggcagcg ggtctagtcg 1020 gggataagggagtgagcatc agtttttcct tcttgtatca gatgaggttg cctccactag 1080 aggagggcccacctcctcat ctgccaggag cctgggagaa gtaccattca agagtag 1137 110 1056 DNARattus sp. 110 gggctctgct cacggttgtg cacagggtgt gtgctctccc tgcacctccttgtgtggaac 60 gtactgttca gcatctccgg taatctcaag gccttccttt gcatgcacaagcccatcagt 120 gttgccttct tgcccagtga gtcttctctt ctgaccttct tgtcttggactcaggcacca 180 tgctccagtg gtaccccctt ctggaccagc tctttcctca gacagtgacaaggagggaga 240 agatgagggt actgaagaag aagaactgcc agctctgccc atccttagcaagagcaccaa 300 gaaagaacta ggtttgtggc agttaggtgt aaagcagaca ggcactagctgctgtggtga 360 ctaggttagt ccatctggac catgggataa ggaggctggg ccatcacagtgatcacatgg 420 gggatgggga tgttctgggc tcctggtccc agaggtgggc agggaggaaacacaccttct 480 gactgcctat ttctgtctag cctcaggctc tagtccagcc ttgctccgaagcctgtccca 540 ctgggaaatg agtcgggtaa gttgccatca ctgaaatgtg cttctaagattattagacgt 600 gagggatgag gcattgggta aggacctgcc cacatgcacc attcctgtttccaaggaagg 660 ccttatcatt aaggtcaggc agcgggtcta gtcggggata agggagtgagcatcagtttt 720 tccttcttgt atcagatgag gttgcctcca ctagaggagg gcccacctcctcatctgcca 780 ggagcctggg agaagtacca ttcaagagta gcttggtttt gttttgagtcagagtctcac 840 tgtgcagccc tggctgacct ggaactcagg gagatccaca gggccttagctctgagtgct 900 gagaagaaag gccttgccac cacactgtgc ttaatccaaa ctaaaccacagcagcaacaa 960 agcagcagcg tgcagtgagg agtaatggtg tgagtcacat gttagagcaacagcccaggg 1020 agagcaaggc tccagcaagg agaaacctag ggaact 1056 111 1237DNA Rattus sp. 111 caagttggac ttttgagtct agcactctgt gttgttggtagcagccgcac agagtggcct 60 cgtcagggtc tcagtccctc attgttggtt tggccttagtgctaagatgg gactctgggt 120 tctgttgggt atcttcagag aacagaatta tttaagagtcctagctctag actgtaagac 180 accagataaa ggcagaaact aaagaggttc ctattatgaggtctagaatg cggctccgag 240 tatgcactct atagagctaa ccttgcctgc aggccacttaaggtcccaca tggacgtggg 300 ctagtcacag aaatccactg tgcttctgtt tccctcgtgtgtaagacctg ggataataat 360 gctacctact ctataaaatg actgtaaaga taaaatgagctaatacacag agggtggcgt 420 tcatgccgac aatatgtaca tatgtttgtt tgctgatagtataattctaa ttagtactct 480 ttttttgcca caaccaccag gcacaagaga ccatggagtacctggaccca gctcctgtag 540 ctaacacagg acctaaaaga agagggcgct gggctcagccaggcgtggag ctgagtgttc 600 gctccatgtt ggacctgaga cagatagaga ccttagccccaagccctcga ggccccagcc 660 aggactcact ggctgtgtcc ccagctggtc ctgggaagcatggtccacag ggccctgagc 720 tgtcatgtgt cagtcaggtg agctatcttt ctcccagctctctagaggtc tcaggaagcc 780 tcagccggtc ctgtgctaac agccggggcc tgcgcttaggtacttctgtg cacagaagac 840 acagagacag gaagtctcct ctgaaatgca gttgtagtagaactgactgg gctgtattgt 900 gagtggggtg ggccgagagg tacagggagc tttggggaggattcttggtg ttgagtagca 960 agagcctggc agtccgagtg ccaaaacagc tcttccagaggcttagtatt ccagctgagc 1020 ccagcctggc ctcctgcttc ctgtccccag agctacaacactctgcttcc gcagcactgc 1080 tgttcaccag caccttcttc tcacgccagc aatcctcacaagtacccctt tctttatgtg 1140 cttccagaat gaaagggccc ctcggcttca gacctcccaaccctgctcct gcccccacat 1200 tatccaattg ttgtcacaag aggaaggagt ctttgcc 1237112 1173 DNA Rattus sp. 112 cgaggcccca gccaggactc actggctgtg tccccagctggtcctgggaa gcatggtcca 60 cagggccctg agctgtcatg tgtcagtcag gtgagctatctttctcccag ctctctagag 120 gtctcaggaa gcctcagccg gtcctgtgct aacagccggggcctgcgctt aggtacttct 180 gtgcacagaa gacacagaga caggaagtct cctctgaaatgcagttgtag tagaactgac 240 tgggctgtat tgtgagtggg gtgggccgag aggtacagggagctttgggg aggattcttg 300 gtgttgagta gcaagagcct ggcagtccga gtgccaaaacagctcttcca gaggcttagt 360 attccagctg agcccagcct ggcctcctgc ttcctgtccccagagctaca acactctgct 420 tccgcagcac tgctgttcac cagcaccttc ttctcacgccagcaatcctc acaagtaccc 480 ctttctttat gtgcttccag aatgaaaggg cccctcggcttcagacctcc caaccctgct 540 cctgccccca cattatccaa ttgttgtcac aagaggaaggagtctttgcc caagatctgg 600 agcctgcacc cattgaagat ggtattgtct acccggaacccagtgacagc cctaccatgg 660 ataccaggca agggttgtgc cctggccaga actcatgggctctgcggccc ttacacttcc 720 tttccctctg agttttctta cgtgggcagt ggttggcctccaggccacca cctccctagc 780 agtggtcaca ggcaggagct gagtggagct gctgacccctgctcactgtc tttccttcct 840 ttgctggcct ttccggcagt gcgtttcagg tgcaggctccaaccggagga tccctaggaa 900 gaatgtaccc aggcagcagg ggctcagaaa agcacagtcctgacagtgca tgctctgtgg 960 attacagcag cagccggctt tccagccctg aacaccctaatgaaggtaag gctgtaccat 1020 gaggaaggga caacggggtg aagcagggaa ggcagacctgtgaccgatag gtacagtgtg 1080 atgcctttcc cctccccccc atccagactc tgagagcacagagcccctaa gtgtggatgg 1140 catctcctca gacctggaag agccagccga ggg 1173 1131146 DNA Rattus sp. 113 tattccagct gagcccagcc tggcctcctg cttcctgtccccagagctac aacactctgc 60 ttccgcagca ctgctgttca ccagcacctt cttctcacgccagcaatcct cacaagtacc 120 cctttcttta tgtgcttcca gaatgaaagg gcccctcggcttcagacctc ccaaccctgc 180 tcctgccccc acattatcca attgttgtca caagaggaaggagtctttgc ccaagatctg 240 gagcctgcac ccattgaaga tggtattgtc tacccggaacccagtgacag ccctaccatg 300 gataccaggc aagggttgtg ccctggccag aactcatgggctctgcggcc cttacacttc 360 ctttccctct gagttttctt acgtgggcag tggttggcctccaggccacc acctccctag 420 cagtggtcac aggcaggagc tgagtggagc tgctgacccctgctcactgt ctttccttcc 480 tttgctggcc tttccggcag tgcgtttcag gtgcaggctccaaccggagg atccctagga 540 agaatgtacc caggcagcag gggctcagaa aagcacagtcctgacagtgc atgctctgtg 600 gattacagca gcagccggct ttccagccct gaacaccctaatgaaggtaa ggctgtacca 660 tgaggaaggg acaacggggt gaagcaggga aggcagacctgtgaccgata ggtacagtgt 720 gatgcctttc ccctcccccc catccagact ctgagagcacagagccccta agtgtggatg 780 gcatctcctc agacctggaa gagccagccg agggtgatgaagacgaggaa gaagagggag 840 gcactggcct ctgtgggcta caagaaggcg gccctcataccccagatcag gaacagtttc 900 taaaacagca ctttgagact ctggccaatg ggactgctccaggtgtggtc tgtgggccag 960 ccttcagtca gccacatctg cccttgtccc ctagctgagagggagggtcc agtaggcagt 1020 gccttaggtt gctttgtagg ggctgcaaag acctcgggcaagaactaaac ttctgactca 1080 gttcatggtt tctgtgcctc ctgcaggggg cccagcacgggtgctagaga ggacagagtc 1140 tcagag 1146 114 1195 DNA Rattus sp. 114cacccattga agatggtatt gtctacccgg aacccagtga cagccctacc atggatacca 60ggcaagggtt gtgccctggc cagaactcat gggctctgcg gcccttacac ttcctttccc 120tctgagtttt cttacgtggg cagtggttgg cctccaggcc accacctccc tagcagtggt 180cacaggcagg agctgagtgg agctgctgac ccctgctcac tgtctttcct tcctttgctg 240gcctttccgg cagtgcgttt caggtgcagg ctccaaccgg aggatcccta ggaagaatgt 300acccaggcag caggggctca gaaaagcaca gtcctgacag tgcatgctct gtggattaca 360gcagcagccg gctttccagc cctgaacacc ctaatgaagg taaggctgta ccatgaggaa 420gggacaacgg ggtgaagcag ggaaggcaga cctgtgaccg ataggtacag tgtgatgcct 480ttcccctccc ccccatccag actctgagag cacagagccc ctaagtgtgg atggcatctc 540ctcagacctg gaagagccag ccgagggtga tgaagacgag gaagaagagg gaggcactgg 600cctctgtggg ctacaagaag gcggccctca taccccagat caggaacagt ttctaaaaca 660gcactttgag actctggcca atgggactgc tccaggtgtg gtctgtgggc cagccttcag 720tcagccacat ctgcccttgt cccctagctg agagggaggg tccagtaggc agtgccttag 780gttgctttgt aggggctgca aagacctcgg gcaagaacta aacttctgac tcagttcatg 840gtttctgtgc ctcctgcagg gggcccagca cgggtgctag agaggacaga gtctcagagc 900atctcatcac gattccttct gcaagtgcag acctccccac tcaggtacgg accaccccac 960atggctctgc tcacctggtg ctcctgcacc tggcacagca tgtagccttc ctcatgtctc 1020tccagaaggg gacgttgtac tcctagattt gaagcaggtg gtctcacgca gactctgtct 1080tgctttgtgc ttgtcctctc ctggtgcatc tctgtctgtg agggcatctg gccagctcag 1140ggaggaaagc actgagcctt ctctgggcct tcttctgaac ccattctccc tgtag 1195 1151085 DNA Rattus sp. 115 agcagcagcc ggctttccag ccctgaacac cctaatgaaggtaaggctgt accatgagga 60 agggacaacg gggtgaagca gggaaggcag acctgtgaccgataggtaca gtgtgatgcc 120 tttcccctcc cccccatcca gactctgaga gcacagagcccctaagtgtg gatggcatct 180 cctcagacct ggaagagcca gccgagggtg atgaagacgaggaagaagag ggaggcactg 240 gcctctgtgg gctacaagaa ggcggccctc ataccccagatcaggaacag tttctaaaac 300 agcactttga gactctggcc aatgggactg ctccaggtgtggtctgtggg ccagccttca 360 gtcagccaca tctgcccttg tcccctagct gagagggagggtccagtagg cagtgcctta 420 ggttgctttg taggggctgc aaagacctcg ggcaagaactaaacttctga ctcagttcat 480 ggtttctgtg cctcctgcag ggggcccagc acgggtgctagagaggacag agtctcagag 540 catctcatca cgattccttc tgcaagtgca gacctccccactcaggtacg gaccacccca 600 catggctctg ctcacctggt gctcctgcac ctggcacagcatgtagcctt cctcatgtct 660 ctccagaagg ggacgttgta ctcctagatt tgaagcaggtggtctcacgc agactctgtc 720 ttgctttgtg cttgtcctct cctggtgcat ctctgtctgtgagggcatct ggccagctca 780 gggaggaaag cactgagcct tctctgggcc ttcttctgaacccattctcc ctgtagggaa 840 ccatccctat cctcctcagg cttggccctg acgtccagacctgaccaggt atcacaggtg 900 tctggtgagc agctgaaagg cagtggtgcc actcctccaggagcaccccc agaaatggaa 960 ccctcttctg gcaactctgg ccccaagcag gtggctcctgtgctgttgac acgacggcat 1020 aacaacttgg acaacagctg ggcctccaag aaaatggctgcaacccggcc tttagctgga 1080 ctcca 1085 116 1284 DNA Rattus sp. 116gtgtggtctg tgggccagcc ttcagtcagc cacatctgcc cttgtcccct agctgagagg 60gagggtccag taggcagtgc cttaggttgc tttgtagggg ctgcaaagac ctcgggcaag 120aactaaactt ctgactcagt tcatggtttc tgtgcctcct gcagggggcc cagcacgggt 180gctagagagg acagagtctc agagcatctc atcacgattc cttctgcaag tgcagacctc 240cccactcagg tacggaccac cccacatggc tctgctcacc tggtgctcct gcacctggca 300cagcatgtag ccttcctcat gtctctccag aaggggacgt tgtactccta gatttgaagc 360aggtggtctc acgcagactc tgtcttgctt tgtgcttgtc ctctcctggt gcatctctgt 420ctgtgagggc atctggccag ctcagggagg aaagcactga gccttctctg ggccttcttc 480tgaacccatt ctccctgtag ggaaccatcc ctatcctcct caggcttggc cctgacgtcc 540agacctgacc aggtatcaca ggtgtctggt gagcagctga aaggcagtgg tgccactcct 600ccaggagcac ccccagaaat ggaaccctct tctggcaact ctggccccaa gcaggtggct 660cctgtgctgt tgacacgacg gcataacaac ttggacaaca gctgggcctc caagaaaatg 720gctgcaaccc ggcctttagc tggactccag aaagcccagt ctgtgcatag tttggtacca 780cagggtaagg aaccttgatg agttcaacta caggttgtgg gggatgtgag acatatatgt 840gggcatgctg gaggaaggtg ggtctagtgt ggccctggca tgtcaccatg cttgccactg 900catgtccctt agtgattaca cacaggggag agtagcaact ggggactgag ccctagcatt 960tgcacacttt cctcaccacg cgacctgcat ctgtccctgt ccccaatgca gatgaggtgc 1020cttcatcacg tccactgctc ttccaggagg cagagaccca gggcagctta ggatccctgc 1080cacaagctgg tggctgctca tctcagcccc actcctacca gaaccacacc accagttcta 1140tggccaagct agcgcgtagt atttctgttg gcgagaatcc gggcctggca actgaacctc 1200aagctcctgt accgatccga atctcaccat tcaacaaact agctctgcct agcagggctc 1260accttgtcct ggacatcccc aaac 1284 117 1597 DNA Rattus sp. 117 tatcctcctcaggcttggcc ctgacgtcca gacctgacca ggtatcacag gtgtctggtg 60 agcagctgaaaggcagtggt gccactcctc caggagcacc cccagaaatg gaaccctctt 120 ctggcaactctggccccaag caggtggctc ctgtgctgtt gacacgacgg cataacaact 180 tggacaacagctgggcctcc aagaaaatgg ctgcaacccg gcctttagct ggactccaga 240 aagcccagtctgtgcatagt ttggtaccac agggtaagga accttgatga gttcaactac 300 aggttgtgggggatgtgaga catatatgtg ggcatgctgg aggaaggtgg gtctagtgtg 360 gccctggcatgtcaccatgc ttgccactgc atgtccctta gtgattacac acaggggaga 420 gtagcaactggggactgagc cctagcattt gcacactttc ctcaccacgc gacctgcatc 480 tgtccctgtccccaatgcag atgaggtgcc ttcatcacgt ccactgctct tccaggaggc 540 agagacccagggcagcttag gatccctgcc acaagctggt ggctgctcat ctcagcccca 600 ctcctaccagaaccacacca ccagttctat ggccaagcta gcgcgtagta tttctgttgg 660 cgagaatccgggcctggcaa ctgaacctca agctcctgta ccgatccgaa tctcaccatt 720 caacaaactagctctgccta gcagggctca ccttgtcctg gacatcccca aaccacttcc 780 tgaccgtcctactctgacca cattctcacc tgtatccaag ggcctggccc acaatgaaac 840 agaacaatcgggccccttgg tgagcctagg aaaggctcat actacagttg aaaagcactc 900 ctgtttaggggagggtacta ctcataaatc taggacagag tgccaggctt atcctggacc 960 caaccacccctgtgcccagc aactgccagt caacaacctt ctccaaggcc ctgagagctt 1020 gcagcccctgtcccctgaga agactcgtaa cccagtggaa agcagcaggc caggggtagc 1080 cctgagccaggactcaggtg tgcatggctc cccagtctca cctggcccat cctttctgtc 1140 tctgttggctactttctggc tctgtcccat ttctgtgtgc ctggcctttg gtgtttttgt 1200 cctgtctgctcctgtcttgg tccataagtc acacctctga tggtgagaca ctcttgccac 1260 ccttcataatctccctgtga cccagtgaac cctttagtct ggatactagg gctggctttt 1320 ccttctaaactttgtgtggt gttggggaag gtgttggaag aaggtgggac aagaggccag 1380 gattgtcggctggtagggat tatagctctg ctctgagagc cctgggttgg gatgcctgaa 1440 aaagcagcagggcctcactg gtgtttgtcc ttcagaactg gccttgagtc tgcaacagtg 1500 tgaacagctcgtggcagagc tccaggggaa tgtacgccag gcagtggagc tctaccgagc 1560 ggtgagtatggggcaaccac tgtaggcaac aacagag 1597 118 1086 DNA Rattus sp. 118ccagcaactg ccagtcaaca accttctcca aggccctgag agcttgcagc ccctgtcccc 60tgagaagact cgtaacccag tggaaagcag caggccaggg gtagccctga gccaggactc 120aggtgtgcat ggctccccag tctcacctgg cccatccttt ctgtctctgt tggctacttt 180ctggctctgt cccatttctg tgtgcctggc ctttggtgtt tttgtcctgt ctgctcctgt 240cttggtccat aagtcacacc tctgatggtg agacactctt gccacccttc ataatctccc 300tgtgacccag tgaacccttt agtctggata ctagggctgg cttttccttc taaactttgt 360gtggtgttgg ggaaggtgtt ggaagaaggt gggacaagag gccaggattg tcggctggta 420gggattatag ctctgctctg agagccctgg gttgggatgc ctgaaaaagc agcagggcct 480cactggtgtt tgtccttcag aactggcctt gagtctgcaa cagtgtgaac agctcgtggc 540agagctccag gggaatgtac gccaggcagt ggagctctac cgagcggtga gtatggggca 600accactgtag gcaacaacag agcttcttct acacactgga tggagaactc aagggtattc 660tgagcattgt aaaggggagg gtcagaagcc aggccaggcc tctcaacccc agaatctgtt 720ggttatttct aggcaagaaa cagggtcgta gcgtagaaca ccatattatt caagaaaatc 780ccaattcatg gctgttatct ttttttttta tatcccaaaa tggtttgggc actttagata 840gaagaaacaa tgtaactgtc acatttgaaa gagttgttgg gaaaagttgt caagaagtag 900atggttctaa tagtctggag ggatcctcat ctgggccacc catcagagtg actctggcca 960tcctgatctt gtgtgtagaa ctcctaggca gtcccttcta ctgggtgggc aaggcactgg 1020cagagcccct tttctatatt ccactgtcta ctgctctcca gctcactttc agtgttcctg 1080ttgcag 1086 119 1236 DNA Rattus sp. 119 gtgagtatgg ggcaaccact gtaggcaacaacagagcttc ttctacacac tggatggaga 60 actcaagggt attctgagca ttgtaaaggggagggtcaga agccaggcca ggcctctcaa 120 ccccagaatc tgttggttat ttctaggcaagaaacagggt cgtagcgtag aacaccatat 180 tattcaagaa aatcccaatt catggctgttatcttttttt tttatatccc aaaatggttt 240 gggcacttta gatagaagaa acaatgtaactgtcacattt gaaagagttg ttgggaaaag 300 ttgtcaagaa gtagatggtt ctaatagtctggagggatcc tcatctgggc cacccatcag 360 agtgactctg gccatcctga tcttgtgtgtagaactccta ggcagtccct tctactgggt 420 gggcaaggca ctggcagagc cccttttctatattccactg tctactgctc tccagctcac 480 tttcagtgtt cctgttgcag gtgaccagctataagacacc ttcggcagag caaagtcaca 540 tcacccgtct cctgagagac accttctcttcggtgcgaca ggagctcgag gttctggctg 600 gggcggtgct gtccagccca ggtggcagccctggggctgt gggggctgag cagacgcagg 660 ccctgttgga gcaatactcc gagctactgctaagagctgt ggagcggcgc atggagcgta 720 gactctgagt tcctgaagcc tgtcccaagagaaatgctct ccattccaaa ctgtatccct 780 gcttccactc aagaaaaggt gggaatgtctggagtggaca gcagtgatca gtgttgagag 840 gcaaagcagc cttcccagcc gccctcatggagcccctgta tttattaatt tatttccctg 900 actttgcctc acttccttgg gactcctgcctctaaagccc agcctggggc tcacagcagg 960 gcaagtcttg agtctacatc atcttggtgctgtgaggggt aggagggcag cctgcctccc 1020 ctggggacat cgggaagggc tggccttctcttcttagaag ccatttgaag tttctgcagg 1080 gatgagctcc ctggggcgga gcatccacagggtactctgg gatagagatg aaaggtaatg 1140 tggtatttag tgtcctaaag ccaactgtagacctttacct ctactcccac accagctgca 1200 ctcccctgcc tgccagagca ggggtagtttcccccc 1236 120 1065 DNA Unknown Organism Description of UnknownOrganism CPLA2-beta, EMBL No. q9ukv7 120 acgcatagtc aaactcctagcccaaagaac cgaagccact tgaggtgggc cccttggcag 60 tgtgggggtt agaagtcggcccactgccct gacctccacc aggttttaga ggtctttatg 120 ccagcctgcc cttctagagaaagcgccact accctgcatg ggtggggtct tgtggcctgt 180 ggcactttgt cctcttctgcatgtctgagg ccactggcaa ttgctgccca tgtccagatt 240 tgtcctatcc cagttttgaaagccccttat ttataacttt tatactgtgg cgcctgtctc 300 ctccccggct gtacggggtgggactgtttt aacgtttcgt ttgtacggat gtatgaaatt 360 gtcaataaac acaatcatttgttaacctgc tagcaaattc tgagaagagc gccgcttgtt 420 gcacctccta gagggcggaaacgggggcgg ggctgcgatc ctggagcgga aataggggcg 480 ggttcttgtc ccgcggccgtcatggcggag gcggctctgg aggcagttcg gagggcgttg 540 caagagttcc cggcggcggctcgcggtgag tgcactctca caggcagcag cgaccgcgcg 600 aggacagcgc ggagggagcctgggcaccct ggaactcagt gtgcatgagt gtccgaccgg 660 tggccacaca gttttgtgtgtacccttctt tagctggcgg acggctcctt agctcaggat 720 cgcacgcctg gctgccttcgtggggtgcag ttgtagtttt caagacccag cacagctctg 780 acggtagtca tggtgccattctcaaagcca gcggggtgct gagtccccgt gcgctgccat 840 gctatacttt cacctcaaacatctcggatg ctggtgggtt ctgaggagag aagcaggcga 900 cttccctcgt tcattcagactccaagcttt gaggattgta ggcagccgcc cagttgatct 960 tgtgtgtttc ctttcttcttcctctggtcc tcactacccc atcattaaac aagctggaga 1020 gatggctaag tgggtaggtaaagctcttaa gcacatgatg atctg 1065 121 1154 DNA Unknown OrganismDescription of Unknown Organism CPLA2-beta, EMBL No. q9ukv7 121ggcccggtgc tgggtccatt tcaggcgttc agtgaatatc accattggag gctgtcttag 60gattttactg ccgtgaagag acaccataat caccacaacc cttataaagg acaacattta 120actggggctg gcttacagct tcagtctgga ggccagctga gggttctaca tctggatcct 180caagaagaga ctgtcactgg ccagacttga gcttataaaa catcaaagcc cactcctagt 240gacacacttc ctctaacaag gccacaccgc ctgttagtgc tactccctgt tggtcaagga 300ttcacacaca tgaatctgtg gggtcatcca gagccagacc caccccagtt agcctgtggc 360caccagctca gtagtgcagg cctcctaggt cggaagcacc cttgcttagg atgtccgtca 420tagagggctt cttggtgcag tgtgatggaa gttgggtacc actgatttca cacctcctcc 480accaccattt ctttcttaag acctcaatgt acctcgtgtt gtgccctacc tggatgagcc 540cccaagccca ctctgcttct accgggattg ggtgtgcccc aacaggccct gcattatccg 600aaatgctctg cagcactggc cagccctcca gaagtggtcc ctgtcctact taaggtaagg 660tgttccttgg gaggttgggt ggaacagtga ccattagcag cagactacaa accaagtgtc 720tgtttcttca gagccacggt gggctccacg gaggtgagtg tggctgtgac tccagatggt 780tatgcggacg cggtgcgagg ggaccgcttt gtgatgcctg ctgaacgccg cctgcccata 840agccatgtac tggatgtgtt ggaaggtcgg gcccagcacc caggagtcct ctatgtgcag 900aaacagtgtt ccaacctgcc cactgagctg ccccagcttc tgtctgacat tgagtcccat 960gtgccctggg cctctgagtc actgggtgag tggtgggggt aagaggcggg gtatggacgt 1020gaagtgggga gataagagtt cagctagctt gttgattctc tgccttttgt gttgattctg 1080tgggggcagg tgctacctat ctgcccgctc cagggctgct gtctctgcca tcctgggatt 1140gtgttcccag tgtc 1154 122 1254 DNA Unknown Organism Description ofUnknown Organism CPLA2-beta, EMBL No. q9ukv7 122 actcctagtg acacacttcctctaacaagg ccacaccgcc tgttagtgct actccctgtt 60 ggtcaaggat tcacacacatgaatctgtgg ggtcatccag agccagaccc accccagtta 120 gcctgtggcc accagctcagtagtgcaggc ctcctaggtc ggaagcaccc ttgcttagga 180 tgtccgtcat agagggcttcttggtgcagt gtgatggaag ttgggtacca ctgatttcac 240 acctcctcca ccaccatttctttcttaaga cctcaatgta cctcgtgttg tgccctacct 300 ggatgagccc ccaagcccactctgcttcta ccgggattgg gtgtgcccca acaggccctg 360 cattatccga aatgctctgcagcactggcc agccctccag aagtggtccc tgtcctactt 420 aaggtaaggt gttccttgggaggttgggtg gaacagtgac cattagcagc agactacaaa 480 ccaagtgtct gtttcttcagagccacggtg ggctccacgg aggtgagtgt ggctgtgact 540 ccagatggtt atgcggacgcggtgcgaggg gaccgctttg tgatgcctgc tgaacgccgc 600 ctgcccataa gccatgtactggatgtgttg gaaggtcggg cccagcaccc aggagtcctc 660 tatgtgcaga aacagtgttccaacctgccc actgagctgc cccagcttct gtctgacatt 720 gagtcccatg tgccctgggcctctgagtca ctgggtgagt ggtgggggta agaggcgggg 780 tatggacgtg aagtggggagataagagttc agctagcttg ttgattctct gccttttgtg 840 ttgattctgt gggggcaggtgctacctatc tgcccgctcc agggctgctg tctctgccat 900 cctgggattg tgttcccagtgtcaccttcc cccagactcg gcactcttct ctctcaccca 960 tatttctgca tagctgccccccacacgggt ggttctcagc ctgatattaa ttcactgtgt 1020 cccacaggga agatgcctgatgccgtgaac ttctggctgg gtgatgcatc tgcagtgaca 1080 tcctgtaggt gtggagactcctcaagtggg gaggggcaga gggaagaaag gtgggcccca 1140 gaacgagtac ctcagatttcttttggtatt gtgggactag gagaccacag agtttctcct 1200 gatggcagga acactggggacagggaatac tgtacctttt aagtctctag aagc 1254 123 1057 DNA Unknown OrganismDescription of Unknown Organism CPLA2-beta, EMBL No. q9ukv7 123tgtggctgtg actccagatg gttatgcgga cgcggtgcga ggggaccgct ttgtgatgcc 60tgctgaacgc cgcctgccca taagccatgt actggatgtg ttggaaggtc gggcccagca 120cccaggagtc ctctatgtgc agaaacagtg ttccaacctg cccactgagc tgccccagct 180tctgtctgac attgagtccc atgtgccctg ggcctctgag tcactgggtg agtggtgggg 240gtaagaggcg gggtatggac gtgaagtggg gagataagag ttcagctagc ttgttgattc 300tctgcctttt gtgttgattc tgtgggggca ggtgctacct atctgcccgc tccagggctg 360ctgtctctgc catcctggga ttgtgttccc agtgtcacct tcccccagac tcggcactct 420tctctctcac ccatatttct gcatagctgc cccccacacg ggtggttctc agcctgatat 480taattcactg tgtcccacag ggaagatgcc tgatgccgtg aacttctggc tgggtgatgc 540atctgcagtg acatcctgta ggtgtggaga ctcctcaagt ggggaggggc agagggaaga 600aaggtgggcc ccagaacgag tacctcagat ttcttttggt attgtgggac taggagacca 660cagagtttct cctgatggca ggaacactgg ggacagggaa tactgtacct tttaagtctc 720tagaagcctc ttcagaagtc aggtagatct gagagcaggg gtcaggagat aacgcccgcc 780cattggtgat ccagatgaag gggagtccac atccagtttt tggtggccaa gttctgtgat 840tcttgcaaga accttggaat ctccacaagt ctgctaatcc tgtgtgggct tttcctttct 900ctgtaggctc tgctagggtg tggggtgtgg ggctgaggac agtgtggcct gcttccctcc 960acttaactcc aggccttcca tgtgtcaaca gtgcacaagg accactatga gaatctgtac 1020tgtgtagtct ctggcgagaa acacttcttg ttacatc 1057 124 1096 DNA UnknownOrganism Description of Unknown Organism CPLA2-beta, EMBL No. q9ukv7 124gtcccacagg gaagatgcct gatgccgtga acttctggct gggtgatgca tctgcagtga 60catcctgtag gtgtggagac tcctcaagtg gggaggggca gagggaagaa aggtgggccc 120cagaacgagt acctcagatt tcttttggta ttgtgggact aggagaccac agagtttctc 180ctgatggcag gaacactggg gacagggaat actgtacctt ttaagtctct agaagcctct 240tcagaagtca ggtagatctg agagcagggg tcaggagata acgcccgccc attggtgatc 300cagatgaagg ggagtccaca tccagttttt ggtggccaag ttctgtgatt cttgcaagaa 360ccttggaatc tccacaagtc tgctaatcct gtgtgggctt ttcctttctc tgtaggctct 420gctagggtgt ggggtgtggg gctgaggaca gtgtggcctg cttccctcca cttaactcca 480ggccttccat gtgtcaacag tgcacaagga ccactatgag aatctgtact gtgtagtctc 540tggcgagaaa cacttcttgt tacatccacc cagcgaccgg cccttcatcc cttacagtag 600gtgacatgaa ctaaaagaag ctagtagtca ctggtgaggg aagggcagca agaggtccct 660gccatgggcc ccagccctct ggtctctgta tgcagggaac gctgtgctgg tcatggtgag 720agtgcctgac aggctgttgg ccccttgtct ccctgacctt gccttcagat ctctacacac 780cagcaaccta ccagctgact gaagagggca cttttagggt ggtggacgag gaagccatgg 840agaaggtgtc tgtcctgttc ttgggctctg gggagtgggt agacctctgg ggaataggca 900caaagggcct ggggaggtgg catcccactc tgaaaatccc taggctgtga ttcttcaagc 960cgagaggaga ggggacagag ctggagatct tggggacctc agggcctgct ctcaggcagc 1020cgctgtgtct ctaggtaccc tggatcccac tggacccctt ggctccagac ctgacccagt 1080accccagtta cagcca 1096 125 1077 DNA Unknown Organism Description ofUnknown Organism CPLA2-beta, EMBL No. q9ukv7 125 ggtcaggaga taacgcccgcccattggtga tccagatgaa ggggagtcca catccagttt 60 ttggtggcca agttctgtgattcttgcaag aaccttggaa tctccacaag tctgctaatc 120 ctgtgtgggc ttttcctttctctgtaggct ctgctagggt gtggggtgtg gggctgagga 180 cagtgtggcc tgcttccctccacttaactc caggccttcc atgtgtcaac agtgcacaag 240 gaccactatg agaatctgtactgtgtagtc tctggcgaga aacacttctt gttacatcca 300 cccagcgacc ggcccttcatcccttacagt aggtgacatg aactaaaaga agctagtagt 360 cactggtgag ggaagggcagcaagaggtcc ctgccatggg ccccagccct ctggtctctg 420 tatgcaggga acgctgtgctggtcatggtg agagtgcctg acaggctgtt ggccccttgt 480 ctccctgacc ttgccttcagatctctacac accagcaacc taccagctga ctgaagaggg 540 cacttttagg gtggtggacgaggaagccat ggagaaggtg tctgtcctgt tcttgggctc 600 tggggagtgg gtagacctctggggaatagg cacaaagggc ctggggaggt ggcatcccac 660 tctgaaaatc cctaggctgtgattcttcaa gccgagagga gaggggacag agctggagat 720 cttggggacc tcagggcctgctctcaggca gccgctgtgt ctctaggtac cctggatccc 780 actggacccc ttggctccagacctgaccca gtaccccagt tacagccagg cacaggccct 840 tcactgcaca gtgcgggccggcgagatgct gtacctgcca gctctgtggt tccaccatgt 900 ccagcagtcc cacggctgtattgctggtaa gtagcacctg gagcatccag ggggtcaggc 960 cttgtcatgg cccaacaagggatcgggttg gggtggctct ggcttaaatc tcacatccgg 1020 gtccccctcc tctccacagtgaatttctgg tatgacatgg agtatgacct caagtac 1077 126 1073 DNA UnknownOrganism Description of Unknown Organism CPLA2-beta, EMBL No. q9ukv7 126tggcatgggt ttcagctcac tcacagtgcc taagccccaa tgtattcatt cctgtccctt 60gaaggctaat ctgacatctc agatcagccc taaagcctct tagtaggagt ggggtgggat 120ggtgaggcag ggggataaaa agacaaagga taccataccc agaaatggtg ggtgacacta 180actagcttgc ctgtgttctg agccaaacag aacctaggag agtggcctca gtttcctccc 240agggctggcc attgtcatag ctcccttcat aggatatgtg acaaataagt aaatgtatgg 300agctggcacg gtgttatata attatgggaa ggtgtcatgt agatgtatct tgtgtcactc 360tggcattctg atggctacag gtggacctgg tccttttggt agagaattaa gccttaagag 420tttgtccctg tcccctctcc tgtggccctg tcatatttga ccccgtctac ctatagcaaa 480cctgcccagt ctacatgcag gcaaaggtgc cagagacatg cctgctcact gtacgcgtcc 540tccgggccag tggcttgcct tccaaggacc taggtaagca cactgctttc ctgtccctta 600gctaagcagg cagtaggtgg gctgcttcag agtagttaag taccagtggg agggtctcca 660gggaaggccg ggctggtctt gcagatggct gccggaggga caatcccaaa agtggcagag 720ggctcagtcc tatggacatg aagtgtctgg gagaaggaag tggactctgg cagcctggga 780aatttcttga tcatacccga cacatgttcc tccttcctgc agtaacctcc tctgactgct 840atgtgactct gaacctgccc acggcttcca gccacacgct ccagacacgc acagtcaaga 900acagccgaaa ccctgtctgg aatcagaact tccacttccg gatccatagg cagctcaagg 960tagaccaggc atcaagtctg gccctgtcct tgtccctgtg ctccatcgtc acacgtgtct 1020cctagtctgc cattcccttc cccgttcacc tctcacccat ctcattcctg tag 1073 127 1137DNA Unknown Organism Description of Unknown Organism CPLA2-beta, EMBLNo. q9ukv7 127 tatgggaagg tgtcatgtag atgtatcttg tgtcactctg gcattctgatggctacaggt 60 ggacctggtc cttttggtag agaattaagc cttaagagtt tgtccctgtcccctctcctg 120 tggccctgtc atatttgacc ccgtctacct atagcaaacc tgcccagtctacatgcaggc 180 aaaggtgcca gagacatgcc tgctcactgt acgcgtcctc cgggccagtggcttgccttc 240 caaggaccta ggtaagcaca ctgctttcct gtcccttagc taagcaggcagtaggtgggc 300 tgcttcagag tagttaagta ccagtgggag ggtctccagg gaaggccgggctggtcttgc 360 agatggctgc cggagggaca atcccaaaag tggcagaggg ctcagtcctatggacatgaa 420 gtgtctggga gaaggaagtg gactctggca gcctgggaaa tttcttgatcatacccgaca 480 catgttcctc cttcctgcag taacctcctc tgactgctat gtgactctgaacctgcccac 540 ggcttccagc cacacgctcc agacacgcac agtcaagaac agccgaaaccctgtctggaa 600 tcagaacttc cacttccgga tccataggca gctcaaggta gaccaggcatcaagtctggc 660 cctgtccttg tccctgtgct ccatcgtcac acgtgtctcc tagtctgccattcccttccc 720 cgttcacctc tcacccatct cattcctgta gctgcttctc tttgtgcctcttccagaatg 780 ttatggaact gaaagtcttt gaccatgacc tggtgaccag agatgacccagtattgtcag 840 tgctgtttga cgtggggacc ctgcaaattg ggactcagcg ccagagcttctccttgggta 900 ctcaggtaaa gctcgggaaa gtaggggtcc ccagtgctgg ggctggagcttcggagcctc 960 ccctgctcca gggaggccca ggaatctcaa gtgacttcac caaggagcagtcctgtctct 1020 gactgctttc tcacgtggtc agaagtccag ggagtgtaga cagagtgacctggaaagaga 1080 cagttgcgct tccccactac gaaggcctcg gcagcctccc cgcccatctggtttgcc 1137 128 1129 DNA Unknown Organism Description of UnknownOrganism CPLA2-beta, EMBL No. q9ukv7 128 tagctaagca ggcagtaggtgggctgcttc agagtagtta agtaccagtg ggagggtctc 60 cagggaaggc cgggctggtcttgcagatgg ctgccggagg gacaatccca aaagtggcag 120 agggctcagt cctatggacatgaagtgtct gggagaagga agtggactct ggcagcctgg 180 gaaatttctt gatcatacccgacacatgtt cctccttcct gcagtaacct cctctgactg 240 ctatgtgact ctgaacctgcccacggcttc cagccacacg ctccagacac gcacagtcaa 300 gaacagccga aaccctgtctggaatcagaa cttccacttc cggatccata ggcagctcaa 360 ggtagaccag gcatcaagtctggccctgtc cttgtccctg tgctccatcg tcacacgtgt 420 ctcctagtct gccattcccttccccgttca cctctcaccc atctcattcc tgtagctgct 480 tctctttgtg cctcttccagaatgttatgg aactgaaagt ctttgaccat gacctggtga 540 ccagagatga cccagtattgtcagtgctgt ttgacgtggg gaccctgcaa attgggactc 600 agcgccagag cttctccttgggtactcagg taaagctcgg gaaagtaggg gtccccagtg 660 ctggggctgg agcttcggagcctcccctgc tccagggagg cccaggaatc tcaagtgact 720 tcaccaagga gcagtcctgtctctgactgc tttctcacgt ggtcagaagt ccagggagtg 780 tagacagagt gacctggaaagagacagttg cgcttcccca ctacgaaggc ctcggcagcc 840 tccccgccca tctggtttgccagtccctct gatttgcttc tcttcccagg agaaagggtg 900 cttagaagtt gagtttcggctacagactct gtaagttggt cttggagcag gggtgggggt 960 gggggtgggg atgggggtagggttggtgag tggcagtgga aagccccctt ctttggaggg 1020 acagtgccag ctcaccaaggctagcacctc tccctggtag aggaggagtg cctggcctct 1080 tgcagagagt cactggggcctctttccagg acagactgtg aggaacagc 1129 129 1041 DNA Unknown OrganismDescription of Unknown Organism CPLA2-beta, EMBL No. q9ukv7 129ccttgtccct gtgctccatc gtcacacgtg tctcctagtc tgccattccc ttccccgttc 60acctctcacc catctcattc ctgtagctgc ttctctttgt gcctcttcca gaatgttatg 120gaactgaaag tctttgacca tgacctggtg accagagatg acccagtatt gtcagtgctg 180tttgacgtgg ggaccctgca aattgggact cagcgccaga gcttctcctt gggtactcag 240gtaaagctcg ggaaagtagg ggtccccagt gctggggctg gagcttcgga gcctcccctg 300ctccagggag gcccaggaat ctcaagtgac ttcaccaagg agcagtcctg tctctgactg 360ctttctcacg tggtcagaag tccagggagt gtagacagag tgacctggaa agagacagtt 420gcgcttcccc actacgaagg cctcggcagc ctccccgccc atctggtttg ccagtccctc 480tgatttgctt ctcttcccag gagaaagggt gcttagaagt tgagtttcgg ctacagactc 540tgtaagttgg tcttggagca ggggtggggg tgggggtggg gatgggggta gggttggtga 600gtggcagtgg aaagccccct tctttggagg gacagtgcca gctcaccaag gctagcacct 660ctccctggta gaggaggagt gcctggcctc ttgcagagag tcactggggc ctctttccag 720gacagactgt gaggaacagc tcatcagcaa tggcatcgtg gtggtgagtg aggaacccag 780actcccctta gtagctcatc cctcgtgctg tctgctgctc tccaaggcct gatgcaggtc 840cacacagtct gtgtcatgta ggccgagttg gggaccttgg catgcatgtt cccaagagag 900tacatctcaa gtcaatgctt agtgactcag ggtgatgaaa gaatattctg ggaacaggga 960ccagaagccc acaatgtaca gcttgtgcct aagggggtct cttgtctgta ggcccgggaa 1020ctctcctgct tgcacgttga a 1041 130 1043 DNA Unknown Organism Descriptionof Unknown Organism CPLA2-beta, EMBL No. q9ukv7 130 gcttctccttgggtactcag gtaaagctcg ggaaagtagg ggtccccagt gctggggctg 60 gagcttcggagcctcccctg ctccagggag gcccaggaat ctcaagtgac ttcaccaagg 120 agcagtcctgtctctgactg ctttctcacg tggtcagaag tccagggagt gtagacagag 180 tgacctggaaagagacagtt gcgcttcccc actacgaagg cctcggcagc ctccccgccc 240 atctggtttgccagtccctc tgatttgctt ctcttcccag gagaaagggt gcttagaagt 300 tgagtttcggctacagactc tgtaagttgg tcttggagca ggggtggggg tgggggtggg 360 gatgggggtagggttggtga gtggcagtgg aaagccccct tctttggagg gacagtgcca 420 gctcaccaaggctagcacct ctccctggta gaggaggagt gcctggcctc ttgcagagag 480 tcactggggcctctttccag gacagactgt gaggaacagc tcatcagcaa tggcatcgtg 540 gtggtgagtgaggaacccag actcccctta gtagctcatc cctcgtgctg tctgctgctc 600 tccaaggcctgatgcaggtc cacacagtct gtgtcatgta ggccgagttg gggaccttgg 660 catgcatgttcccaagagag tacatctcaa gtcaatgctt agtgactcag ggtgatgaaa 720 gaatattctgggaacaggga ccagaagccc acaatgtaca gcttgtgcct aagggggtct 780 cttgtctgtaggcccgggaa ctctcctgct tgcacgttga actgaagagg acaggagatc 840 caaagagtgagttctgtcct ctgtaggcag cccttctgcc cttcttctcc tcttctgagg 900 gggtaaacttgttatactgg ctgctttagg tcccaaggtt gggaggtaag cccatgccgg 960 gcctcccctgggctccatct ctccggagat ctggaccatg tcagagacga tttccctgca 1020 gacttgataaggcattccgt gga 1043 131 1055 DNA Unknown Organism Description of UnknownOrganism CPLA2-beta, EMBL No. q9ukv7 131 cttagaagtt gagtttcggctacagactct gtaagttggt cttggagcag gggtgggggt 60 gggggtgggg atgggggtagggttggtgag tggcagtgga aagccccctt ctttggaggg 120 acagtgccag ctcaccaaggctagcacctc tccctggtag aggaggagtg cctggcctct 180 tgcagagagt cactggggcctctttccagg acagactgtg aggaacagct catcagcaat 240 ggcatcgtgg tggtgagtgaggaacccaga ctccccttag tagctcatcc ctcgtgctgt 300 ctgctgctct ccaaggcctgatgcaggtcc acacagtctg tgtcatgtag gccgagttgg 360 ggaccttggc atgcatgttcccaagagagt acatctcaag tcaatgctta gtgactcagg 420 gtgatgaaag aatattctgggaacagggac cagaagccca caatgtacag cttgtgccta 480 agggggtctc ttgtctgtaggcccgggaac tctcctgctt gcacgttgaa ctgaagagga 540 caggagatcc aaagagtgagttctgtcctc tgtaggcagc ccttctgccc ttcttctcct 600 cttctgaggg ggtaaacttgttatactggc tgctttaggt cccaaggttg ggaggtaagc 660 ccatgccggg cctcccctgggctccatctc tccggagatc tggaccatgt cagagacgat 720 ttccctgcag acttgataaggcattccgtg gacagatccc gtcctgagtt ttggttctgg 780 ttcctgtttt tagggtcagagcgcaaagtt caacttgtgg ttgctggggc ctgtgagggc 840 ccacaggatg cctctgcgggcactggatct ttccacttcc attatccagc ctgctgggag 900 caagagctga atgttcatctgcaggtgctt tgacttgctc ccaggaccct agggccacag 960 cctctcttgt ctcagcctgagctgttctcc ccccgccccg ccccctcata ctgctcctgt 1020 ctgtcaggtc acatgggcctttgttccttt ccctg 1055 132 1131 DNA Unknown Organism Description ofUnknown Organism CPLA2-beta, EMBL No. q9ukv7 132 gtgctgtctg ctgctctccaaggcctgatg caggtccaca cagtctgtgt catgtaggcc 60 gagttgggga ccttggcatgcatgttccca agagagtaca tctcaagtca atgcttagtg 120 actcagggtg atgaaagaatattctgggaa cagggaccag aagcccacaa tgtacagctt 180 gtgcctaagg gggtctcttgtctgtaggcc cgggaactct cctgcttgca cgttgaactg 240 aagaggacag gagatccaaagagtgagttc tgtcctctgt aggcagccct tctgcccttc 300 ttctcctctt ctgagggggtaaacttgtta tactggctgc tttaggtccc aaggttggga 360 ggtaagccca tgccgggcctcccctgggct ccatctctcc ggagatctgg accatgtcag 420 agacgatttc cctgcagacttgataaggca ttccgtggac agatcccgtc ctgagttttg 480 gttctggttc ctgtttttagggtcagagcg caaagttcaa cttgtggttg ctggggcctg 540 tgagggccca caggatgcctctgcgggcac tggatctttc cacttccatt atccagcctg 600 ctgggagcaa gagctgaatgttcatctgca ggtgctttga cttgctccca ggaccctagg 660 gccacagcct ctcttgtctcagcctgagct gttctccccc cgccccgccc cctcatactg 720 ctcctgtctg tcaggtcacatgggcctttg ttcctttccc tgccggtctt ctgtccttgc 780 cacagggagt tagttggtggggtcttagca aagaaaggag taatgactcg cagggtcctt 840 tctctccctg tccctaaggatgacccccat gagcagctga aggtgccact acgaactcta 900 ccctcctcgc agctggtgagacttgtcttc cccacgtccc aggtacatct ggtcatcgag 960 agaagctggg ttcatgcacagggctgctgc tggccctggt ctgcagtcag cctccttcag 1020 gtcatgcccg aggcgatcagtgggtgcaag ggtggaccct gtgaaagtgc ttggggccca 1080 agggttcatg gggatgttctggggtgcacc gaggccacag tggggtggag g 1131 133 1084 DNA Unknown OrganismDescription of Unknown Organism CPLA2-beta, EMBL No. q9ukv7 133gaggtaagcc catgccgggc ctcccctggg ctccatctct ccggagatct ggaccatgtc 60agagacgatt tccctgcaga cttgataagg cattccgtgg acagatcccg tcctgagttt 120tggttctggt tcctgttttt agggtcagag cgcaaagttc aacttgtggt tgctggggcc 180tgtgagggcc cacaggatgc ctctgcgggc actggatctt tccacttcca ttatccagcc 240tgctgggagc aagagctgaa tgttcatctg caggtgcttt gacttgctcc caggacccta 300gggccacagc ctctcttgtc tcagcctgag ctgttctccc cccgccccgc cccctcatac 360tgctcctgtc tgtcaggtca catgggcctt tgttcctttc cctgccggtc ttctgtcctt 420gccacaggga gttagttggt ggggtcttag caaagaaagg agtaatgact cgcagggtcc 480tttctctccc tgtccctaag gatgaccccc atgagcagct gaaggtgcca ctacgaactc 540taccctcctc gcagctggtg agacttgtct tccccacgtc ccaggtacat ctggtcatcg 600agagaagctg ggttcatgca cagggctgct gctggccctg gtctgcagtc agcctccttc 660aggtcatgcc cgaggcgatc agtgggtgca agggtggacc ctgtgaaagt gcttggggcc 720caagggttca tggggatgtt ctggggtgca ccgaggccac agtggggtgg aggtacccag 780cctttctcat taaggtactc atggtttcca ggagccactg atgaggctgg aactcaagaa 840ggaagaaggg taagagcctg tctggggaac gggagggcag gctagcaccc aggcagggtg 900gtctgtcagg ccaggaggat gagggggaga cggagatgca gcacctcctg agcgcatagg 960gctttgcatc aggggcttca gcatggacag gctgttctta gtgtccgcac ttggattggc 1020tacagtgtca tcctgcccag tacatcatcc tgggaaactg agggtcagtg tcttatctag 1080ataa 1084 134 1038 DNA Unknown Organism Description of Unknown OrganismCPLA2-beta, EMBL No. q9ukv7 134 tctcttgtct cagcctgagc tgttctccccccgccccgcc ccctcatact gctcctgtct 60 gtcaggtcac atgggccttt gttcctttccctgccggtct tctgtccttg ccacagggag 120 ttagttggtg gggtcttagc aaagaaaggagtaatgactc gcagggtcct ttctctccct 180 gtccctaagg atgaccccca tgagcagctgaaggtgccac tacgaactct accctcctcg 240 cagctggtga gacttgtctt ccccacgtcccaggtacatc tggtcatcga gagaagctgg 300 gttcatgcac agggctgctg ctggccctggtctgcagtca gcctccttca ggtcatgccc 360 gaggcgatca gtgggtgcaa gggtggaccctgtgaaagtg cttggggccc aagggttcat 420 ggggatgttc tggggtgcac cgaggccacagtggggtgga ggtacccagc ctttctcatt 480 aaggtactca tggtttccag gagccactgatgaggctgga actcaagaag gaagaagggt 540 aagagcctgt ctggggaacg ggagggcaggctagcaccca ggcagggtgg tctgtcaggc 600 caggaggatg agggggagac ggagatgcagcacctcctga gcgcataggg ctttgcatca 660 ggggcttcag catggacagg ctgttcttagtgtccgcact tggattggct acagtgtcat 720 cctgcccagt acatcatcct gggaaactgagggtcagtgt cttatctaga taagcagact 780 ggaggggagg accctgcccg aggctgaggcagagtgagca caccaagaag ggggagggat 840 gcctcttggc gtggatgctg ttgaggagttgccatcttgg gatagcggtt ctttgtcaca 900 aatccgtgga ggcagtggcc atctccgccctgtcgtcatc ttttggagat gtgggtaaag 960 gagagatttg acttggagat agagctcagccccggaccct gcacccagtc ccaacatctg 1020 ttttcccaca atcacgtg 1038 135 1136DNA Unknown Organism Description of Unknown Organism CPLA2-beta, EMBLNo. q9ukv7 135 ctgttcttag tgtccgcact tggattggct acagtgtcat cctgcccagtacatcatcct 60 gggaaactga gggtcagtgt cttatctaga taagcagact ggaggggaggaccctgcccg 120 aggctgaggc agagtgagca caccaagaag ggggagggat gcctcttggcgtggatgctg 180 ttgaggagtt gccatcttgg gatagcggtt ctttgtcaca aatccgtggaggcagtggcc 240 atctccgccc tgtcgtcatc ttttggagat gtgggtaaag gagagatttgacttggagat 300 agagctcagc cccggaccct gcacccagtc ccaacatctg ttttcccacaatcacgtggt 360 gcgcggttct gggttcccac tccttccaga gcaagtaatg gtgaggactgagaagggagt 420 agcgagagca aggaagggcc tggctggtga agccaaccag tttcctgtaacttgcttctg 480 ggtctcttcc ttctccccag accaaaggag ctggctgtgc ggctgggctgtgggccctgc 540 cctgaggaac aggccttcct aagcaagagg aagcaggtgg tggctgccgcgctgaaaaag 600 gccttacagc tggaccaaga cctgcacgag gatgaggtct gagggttgagcatggctggg 660 tggagtgttt gccaggcctg cttggtccca gggttcggtg ttgggacggttgtgcaagct 720 ctggtgccca ctcaggcttg tcactggcaa gccctgctgc tccgttcctcttcctcaatg 780 ttgtcagagt gatacgtgag gtgcctgctg ctcacagatg ggagtttccacataggctgc 840 cctgccttcc ctgtttcttg gtcccccacc tgactgatga gtaaggtagactcactagta 900 cgagggtctc ttggctcaga atagcctcag ctgtctccta gaaaataaattccagcactg 960 gcgagcagga cctttgggag acttttgaag gagccttggg gcttccagaaagtgatccca 1020 gactccttat gggctgccaa taggcaataa agcctggccc gtcaggctgttcttcctgga 1080 gccctgatgt ttgaaacagc aagacctttg gaaggctgct tctgactagattttta 1136 136 1146 DNA Unknown Organism Description of UnknownOrganism CPLA2-beta, EMBL No. q9ukv7 136 gctccgttcc tcttcctcaatgttgtcaga gtgatacgtg aggtgcctgc tgctcacaga 60 tgggagtttc cacataggctgccctgcctt ccctgtttct tggtccccca cctgactgat 120 gagtaaggta gactcactagtacgagggtc tcttggctca gaatagcctc agctgtctcc 180 tagaaaataa attccagcactggcgagcag gacctttggg agacttttga aggagccttg 240 gggcttccag aaagtgatcccagactcctt atgggctgcc aataggcaat aaagcctggc 300 ccgtcaggct gttcttcctggagccctgat gtttgaaaca gcaagacctt tggaaggctg 360 cttctgacta gatttttaacaggggtaact cagagttggt ccaagattca gtcacatgct 420 gaccaaccat catgccgtcttcccgtgtag ctttctccat ccctcaggcc ctggctttga 480 acctggcttt cctcttccagatccccgtga ttgccgtgat ggccactggt ggtgggatcc 540 gggccatgac gtctttgtatgggcagctgg ccggcctgca ggagctcggc cttctcgact 600 gcatctccta tatcacgggggcttcaggat ccacctggtg ggttggttgt gggcagagtg 660 ctggaggttg ccgttggctggtggggtcgg gaaagggaat gtagtgggaa ggaattccgc 720 ggatccttct atagtgtcacctaaatgtcg acggccaggc ggccgccagg cctacccact 780 agtcaattcg ggaggatcgaaacggcagat cgcaaaaaac agtacataca gaaggagaca 840 tgaacatgaa catcaaaaaaattgtaaaac aagccacagt tctgactttt acgactgcac 900 ttctggcagg aggagcgactcaagccttcg cgaaagaaaa taaccaaaaa gcatacaaag 960 aaacgtacgg cgtctctcatattacacgcc atgatatgct gcagatccct aaacagcagc 1020 aaaacgaaaa ataccaagtgcctcaattcg atcaatcaac gattaaaaat attgagtctg 1080 caaaaggact tgatgtgtgggacagctggc cgctgcaaaa cgctgacgga acagtagctg 1140 aataca 1146 137 1227DNA Homo sapiens 137 gattgtaaac aacctaaatc agcaatactt actttttggttgttgttttg ttttgtgttt 60 tgttcttttg agacagggtc tcactgtgta gcctcggctgtcctggaatt cactaggtac 120 accaggctgg ccttgaattc acagagatct acctgcctttgcctcccaag tgctgggatc 180 aaaggtgtgc gccaccatgc cccactcttg tttgttttttgacacagggt tttatgtact 240 tcaggctggc ttttaaactt accatatagc caagggtaacctggaacttt ctaccctctt 300 gctttttacc ccaagtgctg ggggttatag acaggtgcagccgccctcga gttggctgta 360 aataagttta ctagactgat ggccagagag ggctgatagagaaagaaatg ccagtgagct 420 cacatcaatg catggaaaag ataaagacca ccagggttcggttgtaaccg ctgctgtttt 480 gatgctttag gggtgaatga gagggagtac tggaaggagtcaaacaaagg gcacagctcc 540 agggccatga tgctgtccag accgaagcct ggagagtcagaggtggacct gctgcgcttc 600 cagagccagt tccttgaggc tggtgcagcc ccggcggtgcagctggtgaa ggggagtagg 660 aggcatggtg atgctcctcc agaccggctc ccaccgcaggaccatcggga tgtggtgatg 720 ctggacagtg agtgcttgcg agcatgggcg tgaggagagagggctcagcc tcagggaccc 780 tgcttccatc ctgaggtggc tgaatgctgc tccaactgtaacctctgttg ctgaaagttt 840 gttttatttt tattgctttc attcattcct ctgtgtgtgtgtgtgtgtgt gtgtgtgtgt 900 gtgtgtgtgt gtgtgtgtga gagagagaga gagagagagagtgtgagtgt gagtgtttgg 960 aactcactat tgagcacaag ctaactttca gtttgtgacaatcttcttgt aaatactgag 1020 ggaccagagg tgcaagccag cgctgcagct tcattatacagatgaagaaa ctgaggctca 1080 gagaggttaa atatcatacc caagataaca cagctgaagctagggcccag agcagctgtc 1140 ttttgttctt tgtttctgcc cccaatccat acttccttaggaacgtgtga atatacttaa 1200 tatctgcatt ccttttctct cagatct 1227 138 1149DNA Homo sapiens 138 gacagtgagt gcttgcgagc atgggcgtga ggagagagggctcagcctca gggaccctgc 60 ttccatcctg aggtggctga atgctgctcc aactgtaacctctgttgctg aaagtttgtt 120 ttatttttat tgctttcatt cattcctctg tgtgtgtgtgtgtgtgtgtg tgtgtgtgtg 180 tgtgtgtgtg tgtgtgagag agagagagag agagagagtgtgagtgtgag tgtttggaac 240 tcactattga gcacaagcta actttcagtt tgtgacaatcttcttgtaaa tactgaggga 300 ccagaggtgc aagccagcgc tgcagcttca ttatacagatgaagaaactg aggctcagag 360 aggttaaata tcatacccaa gataacacag ctgaagctagggcccagagc agctgtcttt 420 tgttctttgt ttctgccccc aatccatact tccttaggaacgtgtgaata tacttaatat 480 ctgcattcct tttctctcag atctcccaga tttgcccccagctctgcttc ccgctcctgc 540 aaaaagagca agaccgagcc ctggtcgccc cctgcctcacgatgaagacc ctgaagagag 600 gctgaacagg catgatcagc acatcactgc tgtcttgtctaagattgttg tacgtgtcag 660 cccggctggg tggggcaagg catcccattt gggcgagaaaagggtttata agtggagggt 720 gttgtagaaa ggtacacttt taacactcca cggtcaggttggaacatggt tagaaccacc 780 tagactagat ccaacatggg ttcctgaacc tagactagatccaacatggg ttcctgaacc 840 cctggaatga ggatcatggg ggccactggt atcgggttcagcctggagaa gcctgtagac 900 agtgcctatc catggcctct gcatctgctc ctgcctccaggttcctgccc tgtttggggt 960 cctgatgtgc attttcctta ctttgtgttg ccacaggaacgagatacaag ttcagtcact 1020 gtgactctgc ctgtgcccag tggtgttgct ttcccgcctgtgttccatcg ctctcaggag 1080 agacaggtaa gccagagttc ccttaggtgg actttcagttaggctttcta ttgctgcacc 1140 aaaacacca 1149 139 1090 DNA Homo sapiens 139tcagatctcc cagatttgcc cccagctctg cttcccgctc ctgcaaaaag agcaagaccg 60agccctggtc gccccctgcc tcacgatgaa gaccctgaag agaggctgaa caggcatgat 120cagcacatca ctgctgtctt gtctaagatt gttgtacgtg tcagcccggc tgggtggggc 180aaggcatccc atttgggcga gaaaagggtt tataagtgga gggtgttgta gaaaggtaca 240cttttaacac tccacggtca ggttggaaca tggttagaac cacctagact agatccaaca 300tgggttcctg aacctagact agatccaaca tgggttcctg aacccctgga atgaggatca 360tgggggccac tggtatcggg ttcagcctgg agaagcctgt agacagtgcc tatccatggc 420ctctgcatct gctcctgcct ccaggttcct gccctgtttg gggtcctgat gtgcattttc 480cttactttgt gttgccacag gaacgagata caagttcagt cactgtgact ctgcctgtgc 540ccagtggtgt tgctttcccg cctgtgttcc atcgctctca ggagagacag gtaagccaga 600gttcccttag gtggactttc agttaggctt tctattgctg caccaaaaca ccatgaccag 660aaacaacttg gggatgaaag gcattatttc aattacattt tcatcaggac cccaaacagg 720gcaggaacct ggaggcagga gcagatgcag aggccatgga taggcactgt ctactggctt 780gctcagcctg cttgtttata gaacccagga ccaccagctc aaggaagcac ccctcacaat 840gggctgggcc ctccccatca atcactagga aatgccttag agctggatct cctttctcat 900gactctagct tgtgtcacgt tgccgtaaaa ctatccagca caggcgatgc ttagggaatg 960agtggttctc agagcgcatc ttccctaggg agctctggac aatgataagc aagtcccttt 1020tattttccct taaagaaaac catatgtaag tatctatgtc tgggccaggc aggcagatct 1080ctgagtttga 1090 140 1121 DNA Homo sapiens 140 tttttgatgt tggtgtcttttttttttaat ttatttatta ttatatgtaa gtacactgta 60 gctatcttca gacacaccagaagagggtgt cagatctcat aacagatggt agtgagccac 120 catgtggttg ctgggatttgaactcaagac cttcagaaga gtagtcagtg ctcttaaccg 180 cttgagccat ctcaccagcaaacctgtttg ttttttcttt tctcttttct tttcttctct 240 tttcttttct tttttttagacaaggtctca tttctcatca ccatcttcaa gcttgctgtg 300 tagcagaggg tgtcttgaactcctcttatt tctgcctcta cctccagaat gctgatttta 360 gctgggtacc accatatcccagaagtccta ctttctctga gaaactttct tttctctttg 420 ttccagagcc ttggtttaaggagctaagaa agaatgggta atgaatattg acaacttggt 480 tttttctctt tgccctgtaggtgaaaccag cagcatctgg taaaaggagc atctttgccc 540 aagagattgc agcaagaagggtgtcaggaa acagggtgac atcagctgag caagttgtcc 600 ccagcttaga cacaccaaagggtgagtgct gccaggctga gggtgacagc gctcagtcat 660 gttggctcgt agaaatgtattctctctttg gtggtggtag agtggggcaa agtcaagatt 720 aatgtgtgcc agtctggcctcgaactcact gtgtaatgaa gggtgatttt aaaattgtga 780 ttctcctgct tccacctctggtctgctgga aatacagaca tgtgccacca tgccaggtta 840 tatggttatg ggatcaaaccccgggctttg tgtatcctag caaagatgca tgctagcaac 900 agagctacat ccctagcctctcaaatgtcc atccattttt cattctcata ttctctctct 960 ctcaaaactt tttgctgggcagtggtggcg tatgccttta atcccagcac ttgggaggca 1020 gaggcaggcg gatttctgagttcgaggcca gcctggtcta caaagtgagc tccaggacag 1080 ccagagctat acagagaaaccctgtctcga aaaaacaaaa a 1121 141 1222 DNA Homo sapiens 141 attagcaaccaaggcactgg ggctggagag atggccagtg gtgaagagtg aggattgctc 60 ttacagaaaaccctaacgtg attgctagct cctgtgtcaa gtacttacaa ctgcttgtaa 120 tcccaactctaggggagccg atgcctcatt tggaacacat gtgcacttgg catgtccaca 180 cacaacccatatatgtgtgc atgacacacc cacacagaca cagacccaca tacacacaca 240 taattaaaataaaactttta aaattaacct ctgagccatc tctccagctg tcccatgtaa 300 gtcttaagagaagaatgaat gagaagtggc catcttgcct cccccaaatg cctgaaatgc 360 tgtgtggtttcctttctgtg tccagggaag ccccggggcc atcgctggtc cctgggacta 420 gttgccttatttaagaggcc agagggtgta ggtagagcta ggagagtaga gcaataaaac 480 tgactgtctacttctttcag gtgctgtgcc ctgtgagaca ccctccgtca gggacagaag 540 caaccagcttcctgggagga gtcatggctt ccacagacca aatctagtca caggaaaggg 600 actcaggagcaaggtggctg agcaggaggt ccagacaatc catgaagaga atgtagcaag 660 actacaagccatggatcctg aggagatcct gaaggagcag caacagttac tggctcaact 720 cggtatggatgttaagtctt gcagttagct tgctggggcc acacgaagca ggggctgcca 780 cttgttggggaagacgtgtg tgtgtttgtg tgtgtgtggc tattcttcta ctcctgggag 840 agatatggtattaagttcat tttacgttca ttttactaat gaatgaatga atgaatgaat 900 gaatgaacgaacaaacgaac aaacaaacag agcaggctct gctacttgga gtggtacatg 960 cctttaatcccagcatgtgg aactacttcc aatcagacca gagttcgtgc tcagctacat 1020 ggctagtttgaggccagtct ggctctgaga cccttcctca aaaacaaagc ttgaagctga 1080 tggcatagctcagtggttaa ctaagcaagc ctttgaccat gtaaaggtgg gagagaactg 1140 actgcactaagttgtactca gacctgtaca tgtacacata ctacctccct gtgccccaat 1200 agtaactgaaaacaaaaaaa tc 1222 142 1185 DNA Homo sapiens 142 gctttatcac agctgtgctctgccctctct cctttaccct ctcctgtaac tacagtgaca 60 catacaggag tgtgctgtgccacacctttc ttctcagtca gtcttgttcc acattatatg 120 cggagcactt atgtgctgtatactcaattt ttagtaaatg tatttacaga ctgagaggaa 180 atgaagaagt ttggctgcgtgctgtccttc cggctctagt caacattcac ttgtttctca 240 gacatctgac ctggtagcacgcagaggttc cagcatagga acctctgcca gaggactgtg 300 gagggcaagg gccatgggggatagtcaggc tcaggggcta catgggtgtg ggctggcagg 360 gtcattacgg agccacaggtaggcctgagc caggacaggg aagtagtttg tctggacctt 420 agcacccaga ggtgggaatcttccagcagg tgtcccatga ggagtcaccc tagcctctta 480 ctctctgcct ctaccctcagaccccagctt ggttgccttc ttgagatctc atagccaggt 540 ccaggaacaa acaggaacaaaggccaccaa gaagcagagt ccagagagac cctcagttct 600 tgtcactaaa gaagagcctgtcacatcaac tcgtacaagg gagcctagga ctggggacaa 660 gctggaagaa aagccggaggccacggtgga ggacaaaatg gaagacaagc tgcagccaag 720 aaccccaggt atggagggcaggcaccatca tttcttcaga gaggaaaaaa tagccccgtg 780 tggtggcgca tgcttttaattccagcatcc ttgagaggca aagtctggcg gatctctgtg 840 agtttgaggc cagcctaatgtctgcatatc aagttccagg acagccaagg ctcagaaggg 900 gagtgtgcat gctaccaagccagacagcct gagttagatc cctggaatct acatgatgaa 960 agagaaaaac aacttgcacacgtacacaca cacacacaca cacactcaca cacatactcc 1020 tcatacacaa aataaataaatgttaaaaaa agaaaaaagg gtaggaaaag tgtcctttga 1080 cccagcctgc tgatggggaagatgctctct cgcccttgga catgggctgt tcatcttcat 1140 tagtgtcttt aaattggctcaatggtcctc atttgctagc gcaca 1185 143 1116 DNA Homo sapiens 143agggattaac aaaagaggaa atgtaattat gacagcccgg aacctcctgc tcctgaggga 60ctgagggact gctgggccag ccagggaggt tgagtggggg tgaggtgggg gtgaggacgc 120aggaggagat gatagaggtg ttctataccc tgccccactg gagcagcata gctgcctccc 180cttcttggtc tccattctct tgctccttca gagggttgta ccagagagtg gactcctata 240ctttccttga tgtatggtgt cctatcttct ttctctgtcc cttcttcctt ttcttctcct 300cttcttcaaa cacgtctttg aggtcagcat ggggctagag ccaggaccag ctatgtttgc 360tatagttgct atagttgaaa cattcatcca gttgctaggg gtgccagccc ccaagccgta 420ccatttagcc atagctgagg cagctgcttt ctgccagtgt gctgagcccc ttgaggaacg 480cagtgcttct gcctccctag cactgaaact gcccatgacc cccagcaaag actggctcca 540catggacacc gtagagctgg acaagctcca ctggacccag gacctgcccc cactccggag 600gcagcagaca caggaggtga ggacgaacag gtggggtggg gtggggttac tgctcttctg 660cccagacctg gggcctgaga aatagctctt atttgttctc agcttctctc ctgttaccct 720gcctggccct ataggcccca caagcctcgt ttccagtgag aggaagagcc cagagctaat 780cctaaaaggc ttgagattaa aggtgactga gtgtgaggaa ctgctgcagc acccaacaca 840gtccatttct tttgtcttag agaatgcagg ctcgattcag ccttcagggc gagctcctgg 900cgcctgatgt ggatcttccc acacatctgg gcctgcacca ccacggagaa gaggccgagg 960taagggatgg ggtcctagga ggactgggca actcttggca aacgtttagc aactgcaaaa 1020actgtgcaaa acttggagct ctggtcactt gcctttgacc tcctgtgtgt cccgccctag 1080ctcagggcct tgctgtcact cagtttctta gagtca 1116 144 1099 DNA Homo sapiens144 tatagttgct atagttgaaa cattcatcca gttgctaggg gtgccagccc ccaagccgta 60ccatttagcc atagctgagg cagctgcttt ctgccagtgt gctgagcccc ttgaggaacg 120cagtgcttct gcctccctag cactgaaact gcccatgacc cccagcaaag actggctcca 180catggacacc gtagagctgg acaagctcca ctggacccag gacctgcccc cactccggag 240gcagcagaca caggaggtga ggacgaacag gtggggtggg gtggggttac tgctcttctg 300cccagacctg gggcctgaga aatagctctt atttgttctc agcttctctc ctgttaccct 360gcctggccct ataggcccca caagcctcgt ttccagtgag aggaagagcc cagagctaat 420cctaaaaggc ttgagattaa aggtgactga gtgtgaggaa ctgctgcagc acccaacaca 480gtccatttct tttgtcttag agaatgcagg ctcgattcag ccttcagggc gagctcctgg 540cgcctgatgt ggatcttccc acacatctgg gcctgcacca ccacggagaa gaggccgagg 600taagggatgg ggtcctagga ggactgggca actcttggca aacgtttagc aactgcaaaa 660actgtgcaaa acttggagct ctggtcactt gcctttgacc tcctgtgtgt cccgccctag 720ctcagggcct tgctgtcact cagtttctta gagtcaagat gttgctcctt ctattgacat 780cctaccttcc tgtaactcaa gagccaggcc ttgcatgctt tccctcaggc tgttccctcc 840ctcacgagct gccatcctgg tttcctctgg cctaactcaa gctgtccttc accttggaaa 900gttccccagc cctcctttgc tcactgactg aggtcctagg ccttgcgctt ggccgggcag 960tccgtagacc cccaagctct gcctctccct cctctgacca ctctactgat gcttctacat 1020ggaatcccca ttttcacagc ctagcatggt tcactccaga gaatatctgt atccttagtc 1080catgctgggc cactgacgc 1099 145 1102 DNA Homo sapiens 145 tccctccctcacgagctgcc atcctggttt cctctggcct aactcaagct gtccttcacc 60 ttggaaagttccccagccct cctttgctca ctgactgagg tcctaggcct tgcgcttggc 120 cgggcagtccgtagaccccc aagctctgcc tctccctcct ctgaccactc tactgatgct 180 tctacatggaatccccattt tcacagccta gcatggttca ctccagagaa tatctgtatc 240 cttagtccatgctgggccac tgacgccata cccatccact gagaccagat tcactttcca 300 tggctgtcctctgattagaa attaaacagc tattacatcc ctgtttgctg tgtggtgcca 360 ttgctctgtgcatgacctat aatttttatt agcttgaggt tccaaggaga gccatgacta 420 gctgtcacttgtttatcttg cctttccctt gacaccttcc ctgtgtcttg attccttctg 480 actctctgtccctgcatcag cgagcagggt attctctaca ggagctgttc cacctgaccc 540 gtagccaggtgtcccagcag agagcactag ctttgcaagt gttgtcccgg atcgtcggca 600 gggtaagtgggctgctggcc tggtcctacc aagccacacc ccatccttca tcccttgatc 660 ttagccttttcctccttact gtgggtcaga ctaggaatgg agcaaatgta cagtaatggg 720 tcagcaaaggttctatccaa gttctgcatc ttgtacccaa ggcccaggct ggtgagtttg 780 gggaccgcctagtgggcagt gtcttgcgcc tcctcttgga tgctggtttc ctcttcctgc 840 tgcgcttctctctggatgac agggtggaca gtgtcatcgc agcagctgtc cgggctcttc 900 gtactctgctagtggctcct ggagatgagg tatgtcaggg tgacagggct ctgctctgcg 960 ttctgggcataccctttgcc aaggctttga ggcagactgg agaatagggt ggcaggtgta 1020 agccccttctgaagaccaca agccttgcct ccctgccgct gctgtgtgtt ggcgagggat 1080 aattttgctctgtcctggac ca 1102 146 1168 DNA Homo sapiens 146 gacgccatac ccatccactgagaccagatt cactttccat ggctgtcctc tgattagaaa 60 ttaaacagct attacatccctgtttgctgt gtggtgccat tgctctgtgc atgacctata 120 atttttatta gcttgaggttccaaggagag ccatgactag ctgtcacttg tttatcttgc 180 ctttcccttg acaccttccctgtgtcttga ttccttctga ctctctgtcc ctgcatcagc 240 gagcagggta ttctctacaggagctgttcc acctgacccg tagccaggtg tcccagcaga 300 gagcactagc tttgcaagtgttgtcccgga tcgtcggcag ggtaagtggg ctgctggcct 360 ggtcctacca agccacaccccatccttcat cccttgatct tagccttttc ctccttactg 420 tgggtcagac taggaatggagcaaatgtac agtaatgggt cagcaaaggt tctatccaag 480 ttctgcatct tgtacccaaggcccaggctg gtgagtttgg ggaccgccta gtgggcagtg 540 tcttgcgcct cctcttggatgctggtttcc tcttcctgct gcgcttctct ctggatgaca 600 gggtggacag tgtcatcgcagcagctgtcc gggctcttcg tactctgcta gtggctcctg 660 gagatgaggt atgtcagggtgacagggctc tgctctgcgt tctgggcata ccctttgcca 720 aggctttgag gcagactggagaatagggtg gcaggtgtaa gccccttctg aagaccacaa 780 gccttgcctc cctgccgctgctgtgtgttg gcgagggata attttgctct gtcctggacc 840 atgtcttctt tctgtctcttcccacctcta ccccatcctc tggcaggagc tcctggaccg 900 caccttctct tggtatcatggagcttcggt gttccctctg atgcccagcc aggacgataa 960 agaggatgaa gatgaagatgaggaactcac aacagaaaag gtgaagagaa agacacctga 1020 ggaaggaagc cgccctcccccggacctggc cagacatgat gtcatcaagg tagagggcac 1080 tctgcatttc cgtccttgacctacagggca ggctcgatga gcaggagagg tcaccaagac 1140 ctgggtgtcc cccttatgtggcaatggg 1168 147 1183 DNA Homo sapiens 147 tcatcccttg atcttagccttttcctcctt actgtgggtc agactaggaa tggagcaaat 60 gtacagtaat gggtcagcaaaggttctatc caagttctgc atcttgtacc caaggcccag 120 gctggtgagt ttggggaccgcctagtgggc agtgtcttgc gcctcctctt ggatgctggt 180 ttcctcttcc tgctgcgcttctctctggat gacagggtgg acagtgtcat cgcagcagct 240 gtccgggctc ttcgtactctgctagtggct cctggagatg aggtatgtca gggtgacagg 300 gctctgctct gcgttctgggcatacccttt gccaaggctt tgaggcagac tggagaatag 360 ggtggcaggt gtaagccccttctgaagacc acaagccttg cctccctgcc gctgctgtgt 420 gttggcgagg gataattttgctctgtcctg gaccatgtct tctttctgtc tcttcccacc 480 tctaccccat cctctggcaggagctcctgg accgcacctt ctcttggtat catggagctt 540 cggtgttccc tctgatgcccagccaggacg ataaagagga tgaagatgaa gatgaggaac 600 tcacaacaga aaaggtgaagagaaagacac ctgaggaagg aagccgccct cccccggacc 660 tggccagaca tgatgtcatcaaggtagagg gcactctgca tttccgtcct tgacctacag 720 ggcaggctcg atgagcaggagaggtcacca agacctgggt gtccccctta tgtggcaatg 780 ggtttctttc tgcatcctaggggctcctgg ctaccaacct gcttcctcgg ctccgctatg 840 tgctggaggt gacctgcccaggaccctctg tggtccttga catcctggct gtgcttatcc 900 gcctggcccg gcattccctggagtcggcca tgagggtgag aagggaagga gggcactgag 960 aatagacaaa aggtcccatgcactcttctt gttttatttt ttgggtcttt ttattggtgt 1020 ttttgttact gctcttgttttttttttttg tttttttttg ttttttttct gagacagggt 1080 ttctctgtgt agccctggctgccctggaac tcactttgta gaccaggctg gcctcgaact 1140 cagaaatttg cctgcctctgcctcccaagt actgggatta aag 1183 148 1135 DNA Homo sapiens 148 gctctgctctgcgttctggg catacccttt gccaaggctt tgaggcagac tggagaatag 60 ggtggcaggtgtaagcccct tctgaagacc acaagccttg cctccctgcc gctgctgtgt 120 gttggcgagggataattttg ctctgtcctg gaccatgtct tctttctgtc tcttcccacc 180 tctaccccatcctctggcag gagctcctgg accgcacctt ctcttggtat catggagctt 240 cggtgttccctctgatgccc agccaggacg ataaagagga tgaagatgaa gatgaggaac 300 tcacaacagaaaaggtgaag agaaagacac ctgaggaagg aagccgccct cccccggacc 360 tggccagacatgatgtcatc aaggtagagg gcactctgca tttccgtcct tgacctacag 420 ggcaggctcgatgagcagga gaggtcacca agacctgggt gtccccctta tgtggcaatg 480 ggtttctttctgcatcctag gggctcctgg ctaccaacct gcttcctcgg ctccgctatg 540 tgctggaggtgacctgccca ggaccctctg tggtccttga catcctggct gtgcttatcc 600 gcctggcccggcattccctg gagtcggcca tgagggtgag aagggaagga gggcactgag 660 aatagacaaaaggtcccatg cactcttctt gttttatttt ttgggtcttt ttattggtgt 720 ttttgttactgctcttgttt tttttttttg tttttttttg ttttttttct gagacagggt 780 ttctctgtgtagccctggct gccctggaac tcactttgta gaccaggctg gcctcgaact 840 cagaaatttgcctgcctctg cctcccaagt actgggatta aaggcgtgcg ccaccacgcc 900 cggctactgctcttgttttg agatagaatt tcattatgct caagcaggtc tagacctcac 960 tgcatcccttatgctggcct gaaacttgca gaaatccttc ctcagcttcc tgagtactga 1020 gattataggcataagcctgt ggtctatgac ctgagagatg atggacctca tcttgatctt 1080 ctttgcctccctttcccacc tatctcccac aggtcctgga gtgtcctcgg ctgat 1135 149 1171 DNA Homosapiens 149 attccctgga gtcggccatg agggtgagaa gggaaggagg gcactgagaatagacaaaag 60 gtcccatgca ctcttcttgt tttatttttt gggtcttttt attggtgtttttgttactgc 120 tcttgttttt tttttttgtt tttttttgtt ttttttctga gacagggtttctctgtgtag 180 ccctggctgc cctggaactc actttgtaga ccaggctggc ctcgaactcagaaatttgcc 240 tgcctctgcc tcccaagtac tgggattaaa ggcgtgcgcc accacgcccggctactgctc 300 ttgttttgag atagaatttc attatgctca agcaggtcta gacctcactgcatcccttat 360 gctggcctga aacttgcaga aatccttcct cagcttcctg agtactgagattataggcat 420 aagcctgtgg tctatgacct gagagatgat ggacctcatc ttgatcttctttgcctccct 480 ttcccaccta tctcccacag gtcctggagt gtcctcggct gatggagaccatagttcaag 540 agttcctgcc taccagttgg tcccctatag gggtggggcc tactcccagtctatataaag 600 tgccttgtgc ttctgccatg aaactgctta gagtcctggc ttcagctgggaggaatattg 660 ctgctcgact ggtaagctgg acacatggca agagatggag ggcataagacagggctgatt 720 tgagctggat ttactctgag tggtggatag ctacctcagt ccatcttcctcttcctctct 780 ggtctgtttg cttagaaatt caacagaaac cagcaggtgg gaccctggtcacctgggtct 840 gttggtattc tggtctcatg atatggggag ggttccctga ccccagcctgtccagagttg 900 ctgcatgcag acaggccttc atcacccata gctaagcaga aaaagtacctagcaaatact 960 aactaaaaag aagggaagac cactggctag ggagccactc agcaggtaaaggcacttgct 1020 gccaagctga tcacacaagt ttagcccctg gaactcacat ggaaggagaaggaaaagact 1080 cctcaaggtt tgtctgattt ccatatgcat tgtctgacag gtgagcgctgtggccccaga 1140 taaatgctaa ggaagaatgc tgaaggaggg g 1171 150 1158 DNAHomo sapiens 150 atcttcctct tcctctctgg tctgtttgct tagaaattca acagaaaccagcaggtggga 60 ccctggtcac ctgggtctgt tggtattctg gtctcatgat atggggagggttccctgacc 120 ccagcctgtc cagagttgct gcatgcagac aggccttcat cacccatagctaagcagaaa 180 aagtacctag caaatactaa ctaaaaagaa gggaagacca ctggctagggagccactcag 240 caggtaaagg cacttgctgc caagctgatc acacaagttt agcccctggaactcacatgg 300 aaggagaagg aaaagactcc tcaaggtttg tctgatttcc atatgcattgtctgacaggt 360 gagcgctgtg gccccagata aatgctaagg aagaatgctg aaggaggggaccagagactt 420 agaatagggc agcttgagcc tgtttccagg agagccagta ctagctggatgaccctgccg 480 ctgtaccttc tcatctctag ctaagcggct ttgatgtcag gagccgcctgtgccgattca 540 tagctgaagc gccacatgac ctggccttgc cccccgagga agcagagattctgaccactg 600 aggccttccg tctgtgggcc gtggctgcct cctatggcca gggtggtgacctttacaggt 660 gaggagaagc cggagatagg cttctcgcag ggccctgctg tcctgcactgttgagttctg 720 caatacatcc ttcagttttg ttgaaggccg tgaggaaggg aggccaaatacgatggggga 780 atctctgctg ggcatgaatt gctaggaaaa agcggaccaa ctgcattctttgacaaaagc 840 agaagtcaga tatcagttcc cagttgtggg gtaacctagg aggtttgtagccttcccagt 900 tttcagggcc tcgccttgca caagtgcctc tgtcctgggc tgtccccctccggctcctcg 960 agtttctctg ggttgaagct cctggcagaa ttgtgctctc ctcttgcctccctgtgtagt 1020 gaatgccagt tgtcttcccc agggagctgt acccagtgct gctgcgggccttgcagacac 1080 tgcctacaga gctcagcgct catcccctac agcccctggc catgcagcgggtggccgctc 1140 tgttcacact gcttaccc 1158 151 1159 DNA Homo sapiens 151gctgaagcgc cacatgacct ggccttgccc cccgaggaag cagagattct gaccactgag 60gccttccgtc tgtgggccgt ggctgcctcc tatggccagg gtggtgacct ttacaggtga 120ggagaagccg gagataggct tctcgcaggg ccctgctgtc ctgcactgtt gagttctgca 180atacatcctt cagttttgtt gaaggccgtg aggaagggag gccaaatacg atgggggaat 240ctctgctggg catgaattgc taggaaaaag cggaccaact gcattctttg acaaaagcag 300aagtcagata tcagttccca gttgtggggt aacctaggag gtttgtagcc ttcccagttt 360tcagggcctc gccttgcaca agtgcctctg tcctgggctg tccccctccg gctcctcgag 420tttctctggg ttgaagctcc tggcagaatt gtgctctcct cttgcctccc tgtgtagtga 480atgccagttg tcttccccag ggagctgtac ccagtgctgc tgcgggcctt gcagacactg 540cctacagagc tcagcgctca tcccctacag cccctggcca tgcagcgggt ggccgctctg 600ttcacactgc ttacccagct caccctggca gctagcagca tacctcctga gcccgccagg 660taggccagct ccaagcctgt cagcaggcat gcccatgtgg aatgctcctc cacagggagt 720aaggcggccc atgcttacct ttgccccttt ggcactcctg cagtggccct gctgagtcct 780gtgtgccggc catcccttcc tcagtcacct ggacacaggt gtctggactc aagccactgg 840tggagccatg tctaaagcag accctaaagt tcctgcccag gccggatgtg tggaatgccc 900tgggcccagt gcccagtgcc tgccttctgt tcttgggtgc ttactatcag gcctggagcc 960ggcaggtgag tgcagcctgc ctccctgcct gcctccagcc tacatacctc ttccattcct 1020tctcagttgg tcccttttct acctcttccc ccgcgtgtgg ttctgagtgt aaacatggct 1080gtgctgagtg gggccctcat aggccagaca gttacttttc tactgagaac caccctcacc 1140tttcgcttct acctgttcc 1159 152 1202 DNA Homo sapiens 152 gaaaaagcggaccaactgca ttctttgaca aaagcagaag tcagatatca gttcccagtt 60 gtggggtaacctaggaggtt tgtagccttc ccagttttca gggcctcgcc ttgcacaagt 120 gcctctgtcctgggctgtcc ccctccggct cctcgagttt ctctgggttg aagctcctgg 180 cagaattgtgctctcctctt gcctccctgt gtagtgaatg ccagttgtct tccccaggga 240 gctgtacccagtgctgctgc gggccttgca gacactgcct acagagctca gcgctcatcc 300 cctacagcccctggccatgc agcgggtggc cgctctgttc acactgctta cccagctcac 360 cctggcagctagcagcatac ctcctgagcc cgccaggtag gccagctcca agcctgtcag 420 caggcatgcccatgtggaat gctcctccac agggagtaag gcggcccatg cttacctttg 480 cccctttggcactcctgcag tggccctgct gagtcctgtg tgccggccat cccttcctca 540 gtcacctggacacaggtgtc tggactcaag ccactggtgg agccatgtct aaagcagacc 600 ctaaagttcctgcccaggcc ggatgtgtgg aatgccctgg gcccagtgcc cagtgcctgc 660 cttctgttcttgggtgctta ctatcaggcc tggagccggc aggtgagtgc agcctgcctc 720 cctgcctgcctccagcctac atacctcttc cattccttct cagttggtcc cttttctacc 780 tcttcccccgcgtgtggttc tgagtgtaaa catggctgtg ctgagtgggg ccctcatagg 840 ccagacagttacttttctac tgagaaccac cctcaccttt cgcttctacc tgttcctccc 900 tgctttgtttcccaggggag cctctgagag ccatgttgat gggaccaggg accccgagca 960 gcagctcagctttgtcagcc ctctcatgca cgctagatgt tatgtactag agcaagttca 1020 gggctgtctccccttcagaa agatcaggct gtggaagcct ccaaacagat tttttgagac 1080 cctcagtatgatggggctgg tctggatata tagggctagg gtcttctagt ccatcagctc 1140 agtgaaccccttggttctcc agtcacactt gtgcccagaa gattggcttc aggacatgga 1200 gc 1202 1531110 DNA Homo sapiens 153 tctgttcttg ggtgcttact atcaggcctg gagccggcaggtgagtgcag cctgcctccc 60 tgcctgcctc cagcctacat acctcttcca ttccttctcagttggtccct tttctacctc 120 ttcccccgcg tgtggttctg agtgtaaaca tggctgtgctgagtggggcc ctcataggcc 180 agacagttac ttttctactg agaaccaccc tcacctttcgcttctacctg ttcctccctg 240 ctttgtttcc caggggagcc tctgagagcc atgttgatgggaccagggac cccgagcagc 300 agctcagctt tgtcagccct ctcatgcacg ctagatgttatgtactagag caagttcagg 360 gctgtctccc cttcagaaag atcaggctgt ggaagcctccaaacagattt tttgagaccc 420 tcagtatgat ggggctggtc tggatatata gggctagggtcttctagtcc atcagctcag 480 tgaacccctt ggttctccag tcacacttgt gcccagaagattggcttcag gacatggagc 540 gcttgttgga tgagtccttg ctgccactgc tgagccagcctcctctgggc agtctgtggg 600 attccttaag gtacaatctg ggacggccgc tgggggagtgcgggatggag gcagttctcc 660 tgaagggccc ctgggtctgt ctccccagtc catcccaggacatggccctt taggggcctg 720 aggaaaccca aatttccagc aggagcaacc ctcagtactgtgaggaacat gaactctgat 780 ctgcacagcc atgcacggct tgcactcaca gcccagagtcccctcagcat gtctgttctc 840 cctgcaggga ctgctccccg ctctgcaatc cgctgtcctgtgcttccacc cctgaagccc 900 tccccagcct tgtgtcactg ggctgtgcag gaggctgtccccctctcagt gtggctggct 960 cagcctcacc cttcccgttc ctcactgccc tcctctccctcatcaacact ctggtccaga 1020 gccacaaggg gctctgtgga caggtgagcc tcgggtgcccatttggaggc caggcatggg 1080 gacaagatag caggggtagg aaagagggag 1110 1541196 DNA Homo sapiens 154 gagcaagttc agggctgtct ccccttcaga aagatcaggctgtggaagcc tccaaacaga 60 ttttttgaga ccctcagtat gatggggctg gtctggatatatagggctag ggtcttctag 120 tccatcagct cagtgaaccc cttggttctc cagtcacacttgtgcccaga agattggctt 180 caggacatgg agcgcttgtt ggatgagtcc ttgctgccactgctgagcca gcctcctctg 240 ggcagtctgt gggattcctt aaggtacaat ctgggacggccgctggggga gtgcgggatg 300 gaggcagttc tcctgaaggg cccctgggtc tgtctccccagtccatccca ggacatggcc 360 ctttaggggc ctgaggaaac ccaaatttcc agcaggagcaaccctcagta ctgtgaggaa 420 catgaactct gatctgcaca gccatgcacg gcttgcactcacagcccaga gtcccctcag 480 catgtctgtt ctccctgcag ggactgctcc ccgctctgcaatccgctgtc ctgtgcttcc 540 acccctgaag ccctccccag ccttgtgtca ctgggctgtgcaggaggctg tccccctctc 600 agtgtggctg gctcagcctc acccttcccg ttcctcactgccctcctctc cctcatcaac 660 actctggtcc agagccacaa ggggctctgt ggacaggtgagcctcgggtg cccatttgga 720 ggccaggcat ggggacaaga tagcaggggt aggaaagagggagagaagtg gctcgtaggg 780 ggcagcagtc tggggagtcc cagaacccat cagtgtttgtttctagatct gaacaaactt 840 gtttcctcag ctgtctgctg tgttgactgc cccaggactccagaagtact ttctccagtg 900 tgtggctcct gcgcctgccc cacagctcac acccttctctgcctgggccc tgcaccatga 960 gtaccaccta cagtatctgg tgctttccct cgcccacaaagcggtgggtc cctgtctgca 1020 gaatcagcct caccctgttg tctctcctgc ctctcagctgtagtccatat tccctggttc 1080 atatcctcca tctttctatc acttcctcac tctgtcacttcctcactccc tctgttctgt 1140 gtcctccatg ctgcctccct acactgacta gagccctgtctcctccctag gcaaca 1196 155 1153 DNA Homo sapiens 155 ggacatggccctttaggggc ctgaggaaac ccaaatttcc agcaggagca accctcagta 60 ctgtgaggaacatgaactct gatctgcaca gccatgcacg gcttgcactc acagcccaga 120 gtcccctcagcatgtctgtt ctccctgcag ggactgctcc ccgctctgca atccgctgtc 180 ctgtgcttccacccctgaag ccctccccag ccttgtgtca ctgggctgtg caggaggctg 240 tccccctctcagtgtggctg gctcagcctc acccttcccg ttcctcactg ccctcctctc 300 cctcatcaacactctggtcc agagccacaa ggggctctgt ggacaggtga gcctcgggtg 360 cccatttggaggccaggcat ggggacaaga tagcaggggt aggaaagagg gagagaagtg 420 gctcgtagggggcagcagtc tggggagtcc cagaacccat cagtgtttgt ttctagatct 480 gaacaaacttgtttcctcag ctgtctgctg tgttgactgc cccaggactc cagaagtact 540 ttctccagtgtgtggctcct gcgcctgccc cacagctcac acccttctct gcctgggccc 600 tgcaccatgagtaccaccta cagtatctgg tgctttccct cgcccacaaa gcggtgggtc 660 cctgtctgcagaatcagcct caccctgttg tctctcctgc ctctcagctg tagtccatat 720 tccctggttcatatcctcca tctttctatc acttcctcac tctgtcactt cctcactccc 780 tctgttctgtgtcctccatg ctgcctccct acactgacta gagccctgtc tcctccctag 840 gcaacactgcagccagaacc agctgccagc actgccctcc accatgctgt agccttggtc 900 ctactgagccggctattgcc tggaagcgaa taccttgccc aggagctgct gctgagctgt 960 gtgttccggctggagttcct gccgtaagtc caggggtttc aggattcagg ggtttggtac 1020 ttttggatgcccctgaactt tgttaacaaa acagcatctt ggagctggaa acctgggttt 1080 tagtctctatccttatactt aatttgttat tccctcagta aagtgaattg aggctattca 1140 tcttcaccccacc 1153 156 1143 DNA Homo sapiens 156 ggacaggtga gcctcgggtg cccatttggaggccaggcat ggggacaaga tagcaggggt 60 aggaaagagg gagagaagtg gctcgtagggggcagcagtc tggggagtcc cagaacccat 120 cagtgtttgt ttctagatct gaacaaacttgtttcctcag ctgtctgctg tgttgactgc 180 cccaggactc cagaagtact ttctccagtgtgtggctcct gcgcctgccc cacagctcac 240 acccttctct gcctgggccc tgcaccatgagtaccaccta cagtatctgg tgctttccct 300 cgcccacaaa gcggtgggtc cctgtctgcagaatcagcct caccctgttg tctctcctgc 360 ctctcagctg tagtccatat tccctggttcatatcctcca tctttctatc acttcctcac 420 tctgtcactt cctcactccc tctgttctgtgtcctccatg ctgcctccct acactgacta 480 gagccctgtc tcctccctag gcaacactgcagccagaacc agctgccagc actgccctcc 540 accatgctgt agccttggtc ctactgagccggctattgcc tggaagcgaa taccttgccc 600 aggagctgct gctgagctgt gtgttccggctggagttcct gccgtaagtc caggggtttc 660 aggattcagg ggtttggtac ttttggatgcccctgaactt tgttaacaaa acagcatctt 720 ggagctggaa acctgggttt tagtctctatccttatactt aatttgttat tccctcagta 780 aagtgaattg aggctattca tcttcaccccacctgagaat gataagactc cacagtatgt 840 caatggctaa aaaaatgtca cataagctaagctagggatg tagttgagca gtaaagcacc 900 tacttggcat gtgtgaggct ctgattcaaagtagggatct ggttcactga tgcacacctc 960 tcatcctagt actcgggagg tcagcctgggctacgtgaga gatagataga tagatagata 1020 gatagataga tagatagata gatagatagatagatagata gatagaggtc agcctgggct 1080 acatgataga tagatagata gatagatagatagatagata gatagataga tagatagata 1140 gat 1143 157 1921 DNA Homo sapiens157 tagatagata gatagataga tagatagata gatagataga tagatagagg tcagcctggg 60ctacatgaga gatagataga tggatggata gatagataga tagatagata gatagataga 120tagatagata gataggtagg taggtagata gatgtatata gatataggtg gataggtaga 180gatagatgat agataagtga tggatgcata gatagataga tgatagatta taagtaaata 240aataaataaa taaacaaaca aacaaataaa tagtaaagag ctgggtgaca ccttaacccc 300agcacagcta gaggtcaagc atggaagttt aagtaaactt tccctctgtt ccatctccta 360atgctatgca acattatggt gtgagaggct gtcaggggag cagagaggca caggactaaa 420cttagaaact ctagatctgg gacagctgtc tggatgctgt gattctagcc cttagttttg 480gcttttgtat catgtcacag ggaaagtgct tcagggggcc cagaggcagc tgacttctcc 540gatggactgt ccttagggag cagtggggac cctcagtgta gacgaggggc cctcctcgtt 600caagcttgcc aggatctccc cagcatccgc agctgctacc tggcccattg ttcaccagcc 660cgagccagtc tgctgagctc ccaagccttg taccgtggag agctactgcg agtctcaagt 720ctgctactgc ctgtacctaa ggagccactg ctggccactg actggccctt ccagccgttg 780atacatctct accaccgagc ttcagatact ccctctgggc cacctgctgc tgacactgta 840ggcgttgcca tgcgggtcct acaatgggtg ctagttctgg agagctggcg ccccgaggtc 900ctctgggctg tgccccctgc tgcccgccta gcacgtctca tgtgtgtgta cctggtggat 960agcgagctgt ttcgagagac tcccatacag cgactggtgg cagctctttt agctcggctc 1020tgtcggcccc aagtcttgcc aaacctcaag ctggactgcc ccctccctgg cctgacctct 1080tttcctgacc tttatgccag cttcttagac cattttgagg ctgtctcttt tggggaccac 1140ttgtttgggg ccctggtcct ccttcctctg cagcgtaggt tcagtgttac cttgcgcctc 1200gccctctttg gggagcacgt gggagtgttg cgagcacttg gcctgcctct gactcaggta 1260tgtcctacac tatcaaggcc ttcctaggac ccttcactag acactagggg cagtcttgag 1320cagtgtggca cttcggtggg caccattacc tcattacctc tttgaaagca tcaagctgta 1380ggaatagaag ggtttttatc atggcatctg gtagagagca ggtatacata ttattactat 1440tgggtttttt caagtcaggg tttgtctttg tagctatggc tgttctggaa cttgttctgg 1500agaccaggct ggcctgaaac tcacagagct gcctctgtct cctgagtgtt ggggttaaag 1560gtgtggatca ccactgtctg gcagggtttg tgttattaac aggtttggtt tctgcttgtg 1620aactcctaca gtttagaaga agatatgcta agatcaaaaa acaaaaacat acttgttaat 1680tactcagatc tttggtgtgt taagtcagaa ttcagagaat ttttaaaaga ctggagtggg 1740gctggtgaga tggctcagtg ggtaagaaca cctgactgct cttctgaagg tccagagttc 1800aaatcccagc aagagatctg actccctctt ctggagtgtc tgaagacagc tacagtatac 1860ttacatataa taaataaata aataaatctt tttttttttt tttttttttg gttttttgag 1920 a1921 158 1720 DNA Homo sapiens modified_base (697)..(895) a, t, c, g,other or unknown 158 tcagtgggta agaacacctg actgctcttc tgaaggtccagagttcaaat cccagcaaga 60 gatctgactc cctcttctgg agtgtctgaa gacagctacagtatacttac atataataaa 120 taaataaata aatctttttt tttttttttt tttttggttttttgagacag ggtttctctg 180 tatagccctg gctgtcctgg agctcacttt gtagaccaggctggcctcga actcagaaat 240 ccgcctgcct ctgcctcccg agtgctggga ttaaaggcgtgcgccaccac gcccggctta 300 aataaatctt taaaaaaaaa aaaaaagatt ggagtggactttaccttaag gaaaagatga 360 ggtgaaggag agaggttgtc ttagtgctga agtttgggaagaatttgact cttaagtgct 420 tactagaaaa aggctatgaa gcaaagccct aaagggtgatcagactaaag agtcagctca 480 caggttgtaa agagaaccag gcctggcaac acaggctctcgggagctgag tcaggaggat 540 tagaaggttt tgtttggttt ttagatttat ttatacatatgaatacactg tagttgtctt 600 tagataccag aaaatggtat cagatcccat tacagatggttgtgagccac catgtggttg 660 ctgggaattg aactcaggac ctctggaaga gcagtcnnnnnnnnnnnnnn nnnnnnnnnn 720 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnnnnnnnnnnnn nnnnnnnnnn 780 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnnnnnnnnnnnn nnnnnnnnnn 840 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnnnnnnnnnnnn nnnnnnccag 900 agaaaccctg tcttgaaccc ccacccaaaa atataaataaaaacaatact tactgagctg 960 ggagtgggag caggtgccta tcattcctgc acatacacagaaggccaggg caggggttac 1020 aaggctgagt ccagcctggg tcacatagga aggcactgtctcaaaacctt tattttccct 1080 tgaaacaggg tctctttatg aagctctggc tctgaacttctacataaacc aggctgtctt 1140 cagactcaca gagactcaac tgcctctgcg tcccaactgctgggattaaa ggtgtgcgcc 1200 actataccgg gctctaaaat gtttttaaat aaaaaaattactatgagtaa ctattaaatt 1260 tttaattttt ttatgtttta ataaatgtac atgtgtgtatgtgtatgtgt gtgtgtttta 1320 tgtacacgtg aatgcaggtg gacatgctca tgcaggcatgaacttgagga cactaggcat 1380 cctgttctgt ttctctgcct tactcctttg agacagtggagctaggagtg gctagcaagc 1440 tctctatcaa ctgagctaca atccttagca cgctgaagactgtctggact caccctagac 1500 tggactagaa ctctgtatat agcctaggct gtccttaaacttcttcttct tccttttttt 1560 tttttttttt tttttttttt ttttggtttt tttcaagacagggtttctct gtgtagtcct 1620 ggctgtcctg gaactcactc tgtagaccag gctggcctcgaactcaaaaa tctgcctgcc 1680 tctgcctccc aagtgctggg attaaaggtg tgcgccacca1720 159 1589 DNA Homo sapiens 159 tttctctgtg tagtcctggc tgtcctggaactcactctgt agaccaggct ggcctcgaac 60 tcaaaaatct gcctgcctct gcctcccaagtgctgggatt aaaggtgtgc gccaccatgc 120 cccgcgtatt tgtatatttt tataaaattggaattactgc ttaatgaatt tttcatttaa 180 ccttacatca tgagcagttg ccatcccttaaatactctta agaaatcaat acttaaaccg 240 ggagtggtgg cgcacgccaa taatcccagcacttgggagg tagaggcagg tggatttctg 300 agttcgaggc cagcctggtc tgcagagtgagtttcaggac agccagggct acacagagaa 360 accctgtctt gaaaaaaaca aaacaacaacaaaaaagaaa tctactttgt gtgtgtgtgt 420 ttacgtgtgt gtgtgtgtgt gtgtgtgtgtgtgtgtgtgt gtgtgtgtgt gtgtatgcgc 480 gcactagaaa tggaacacag ggcttcatgcatcctaggaa ggtgcgctca ggctgtaagc 540 tatgccctaa taccaaccag tctttgccctttagctttca ggcactaaag aagggaggtc 600 tttctaggac ctgatttctg ccctgtgatttgatggcatg tgaccaacag tcatccactg 660 ctgctactga tggacattcc cacttggccctcagcatatc atttccttct gtcacagctg 720 cctgtgcctc tggagtgcta cacagagcctgctgaagaca gcctgcctct ccttcagctc 780 tacttccggg ccttggttac tggctcactccgtgcacgtt ggtgccccat cctctacact 840 gtagccgtgg ctcatgtcaa cagtttcatcttctgccaag acccaaagag ctcagtaagt 900 cacctctctg tgttcagagg gaaggagggagctggtggac cagttgggga tgggctgagg 960 gttaagtgag tccatgggtg ggtaccagtcctcggctttg tgtcatatct ctcttccgtc 1020 cactcccagg atgaggtaaa gactgcccgaaggagtatgc tgcagagaac gtggctgctg 1080 acagatgagg tagtattgtg ggtgtcgggacagaaaagat acaggacgtt aaggtaccaa 1140 acctcaacaa actgaccacc cacttcatgggttttgtctt ctctgcaggg gctgcggcag 1200 catctcctcc actataagct tcccaactccagcctcccag agggctttga gctgtattcc 1260 cagttacctc gcctgaggca gcagtgccttcagacactgc ccacagaggg gctccagaat 1320 ggaggagtca agacataggg cacttgcccccagctaaaga tgactactct actctcctgg 1380 gactgagcag tgagcctccc gagagaaggcaacacaagac ttgccttcct gtgagcacat 1440 tgtttgagcc ttttttagaa cagaagagactcgtattaca tcatgatact ggagctcagg 1500 atctgggggc tgagggctgt gccaggcgtggaaggagggt ggcttcagtg tttaccctgc 1560 ggtgcccagg acagtctgag cacagctct1589 160 1158 DNA Homo sapiens 160 cctcagcata tcatttcctt ctgtcacagctgcctgtgcc tctggagtgc tacacagagc 60 ctgctgaaga cagcctgcct ctccttcagctctacttccg ggccttggtt actggctcac 120 tccgtgcacg ttggtgcccc atcctctacactgtagccgt ggctcatgtc aacagtttca 180 tcttctgcca agacccaaag agctcagtaagtcacctctc tgtgttcaga gggaaggagg 240 gagctggtgg accagttggg gatgggctgagggttaagtg agtccatggg tgggtaccag 300 tcctcggctt tgtgtcatat ctctcttccgtccactccca ggatgaggta aagactgccc 360 gaaggagtat gctgcagaga acgtggctgctgacagatga ggtagtattg tgggtgtcgg 420 gacagaaaag atacaggacg ttaaggtaccaaacctcaac aaactgacca cccacttcat 480 gggttttgtc ttctctgcag gggctgcggcagcatctcct ccactataag cttcccaact 540 ccagcctccc agagggcttt gagctgtattcccagttacc tcgcctgagg cagcagtgcc 600 ttcagacact gcccacagag gggctccagaatggaggagt caagacatag ggcacttgcc 660 cccagctaaa gatgactact ctactctcctgggactgagc agtgagcctc ccgagagaag 720 gcaacacaag acttgccttc ctgtgagcacattgtttgag ccttttttag aacagaagag 780 actcgtatta catcatgata ctggagctcaggatctgggg gctgagggct gtgccaggcg 840 tggaaggagg gtggcttcag tgtttaccctgcggtgccca ggacagtctg agcacagctc 900 tcctcactca cctccagtct tcaccagaccagggtgtgca attactgtgc tacactctga 960 aataaattct tttctagtct gactgatctggactgttttg tcacattcag agttggtagc 1020 aaggatggat tttcccgagg agagagatgggagaaaatgt cacaatggga ggtaaacaca 1080 ttaccatctg ggggtggcag aggtgtgtgtcctgggagtc agtgacagtg agcctggagt 1140 gggtgtggtc ctggagga 1158 161 1180DNA Unknown Organism Description of Unknown Organism Ltk 161 ttcaacaccttatccagtca tggcagtaag aaattgtcca caggaacagt gtgcaacaaa 60 ctcagaaagtcatgattctg aggtactggg atgtcctgcc tcatggtcag aaagggacac 120 agcaatggcaagcaataatg ccttacgggg gacagtttaa tcgccatcac ccaggaggca 180 gaggcaggtggatttttgga ggctctacat acttcccatg tgtgatcatg cacttaaact 240 aacactgacaccaataaagc cattcactat tgatgctatc ctgagaccca caaaagctac 300 tgccatgtactagggtgctg tccagcctgc tatcacaaag gtataatgta gagtcaactt 360 tttctcctaccaggaactca ctagtttgtt ggtgtgccat aggtggggac tagagccctt 420 cagctcagcaaggctcctcc cagaagcctg gggacctcgc tgtcctcatg ctccgccttt 480 tccttctatttcccgggtct gacgtgagtg tatacaggcc agttggaagt cggcagggta 540 gtggtgatagctctgagact gctgacacgc ctataaactg cagctaggga atcgagttct 600 caaccatcatcctttgctgg aaccaaggga tcgggcgatg ggctgctccc accggctgct 660 gctgtggctgggagctgctg gtaagtgctg tttggtggtc agggtaccag ccaaccagag 720 acaactagatttggggctgc attagcaaca gaccaggtct caatggttcc ttctaaggtg 780 gccttgtgcttttagagtac agcaagaaag gtgcggaaca cgtccaaatc taagaatcag 840 atggggccttggcactactt gggaggaagc tagagagagg agaggtggtg gggtgctgta 900 caacagagagcggtgcagcc cccaagtcac tccatgagag ctctggaata gaggtcatga 960 tatatgtagataccttgcaa ggcttgggaa acccggttgg gtggtaggtg tctagcttca 1020 gcctctgtatgcaccagctg ggcggcattc ggggtgtggc tggaagcagg gtactgctga 1080 gtggctatccatctcttatg tctcccctgt cacattctgc atcatctaac ccttcttcct 1140 gtcacctttcaggaactatt ctttgctcca actcggagtt 1180 162 1144 DNA Unknown OrganismDescription of Unknown Organism Ltk 162 cggctgctgc tgtggctggg agctgctggtaagtgctgtt tggtggtcag ggtaccagcc 60 aaccagagac aactagattt ggggctgcattagcaacaga ccaggtctca atggttcctt 120 ctaaggtggc cttgtgcttt tagagtacagcaagaaaggt gcggaacacg tccaaatcta 180 agaatcagat ggggccttgg cactacttgggaggaagcta gagagaggag aggtggtggg 240 gtgctgtaca acagagagcg gtgcagcccccaagtcactc catgagagct ctggaataga 300 ggtcatgata tatgtagata ccttgcaaggcttgggaaac ccggttgggt ggtaggtgtc 360 tagcttcagc ctctgtatgc accagctgggcggcattcgg ggtgtggctg gaagcagggt 420 actgctgagt ggctatccat ctcttatgtctcccctgtca cattctgcat catctaaccc 480 ttcttcctgt cacctttcag gaactattctttgctccaac tcggagttcc aggcaccttt 540 tctaacacct tcgcttttgc cggtgctggtactcaattcc caggagcaga aagtcacccc 600 cacacccagt aaattggagc cagcttccctcccaaatcct ctaggtgagt ttcaggctcc 660 tcccttttct tggttcacca tctccagatccctaggcctg gagaggaact ttttccttct 720 ccctttgtac ctaggcacac gggggccttgggtgtttaac acctgtggcg ccagcggcag 780 gagcggaccc acacaaacac agtgcgatggggcatacaca ggaagcagcg tgatggtgac 840 agtgggggct gccgggccgc tcaaaggcgtgcagctgtgg cgggcgccag acacaggcca 900 gtatctgtaa gtgctcagca ggaagagggtggcaatcacc tcttaggctg aggttttaca 960 gaccagggaa gttatcttaa aacattccgcagagaagtct agtgtcagtc acttcgattg 1020 tctgtcctcc taagttaacc atcgtcaggacggccgccca atcaacggtg gctgaagatg 1080 gggctggatg attccagcca tctccgttaacgctcttgaa atactcgtgg aacccaactg 1140 aaaa 1144 163 1172 DNA UnknownOrganism Description of Unknown Organism Ltk 163 ggtggggtgc tgtacaacagagagcggtgc agcccccaag tcactccatg agagctctgg 60 aatagaggtc atgatatatgtagatacctt gcaaggcttg ggaaacccgg ttgggtggta 120 ggtgtctagc ttcagcctctgtatgcacca gctgggcggc attcggggtg tggctggaag 180 cagggtactg ctgagtggctatccatctct tatgtctccc ctgtcacatt ctgcatcatc 240 taacccttct tcctgtcacctttcaggaac tattctttgc tccaactcgg agttccaggc 300 accttttcta acaccttcgcttttgccggt gctggtactc aattcccagg agcagaaagt 360 cacccccaca cccagtaaattggagccagc ttccctccca aatcctctag gtgagtttca 420 ggctcctccc ttttcttggttcaccatctc cagatcccta ggcctggaga ggaacttttt 480 ccttctccct ttgtacctaggcacacgggg gccttgggtg tttaacacct gtggcgccag 540 cggcaggagc ggacccacacaaacacagtg cgatggggca tacacaggaa gcagcgtgat 600 ggtgacagtg ggggctgccgggccgctcaa aggcgtgcag ctgtggcggg cgccagacac 660 aggccagtat ctgtaagtgctcagcaggaa gagggtggca atcacctctt aggctgaggt 720 tttacagacc agggaagttatcttaaaaca ttccgcagag aagtctagtg tcagtcactt 780 cgattgtctg tcctcctaagttaaccatcg tcaggacggc cgcccaatca acggtggctg 840 aagatggggc tggatgattccagccatctc cgttaacgct cttgaaatac tcgtggaacc 900 caactgaaaa ctcggttcttccccatccct tcacagtcca tctaagtccc ttaggaagaa 960 gctttccggc cgcgggttcccgaccgtgag ccgccgcctg gcccaggacc gaggcgccta 1020 ggactgagac gcggaccggtgctctctcct cctgcaggat ctccgcctac ggagcggcgg 1080 gcggcaaggg cgcccaaaaccacctgtcac gggcgcacgg catcttcctc tcagcagtct 1140 tcttcctccg tcgcggggagccggtgtaca tc 1172 164 1151 DNA Unknown Organism Description of UnknownOrganism Ltk 164 cacaaacaca gtgcgatggg gcatacacag gaagcagcgt gatggtgacagtgggggctg 60 ccgggccgct caaaggcgtg cagctgtggc gggcgccaga cacaggccagtatctgtaag 120 tgctcagcag gaagagggtg gcaatcacct cttaggctga ggttttacagaccagggaag 180 ttatcttaaa acattccgca gagaagtcta gtgtcagtca cttcgattgtctgtcctcct 240 aagttaacca tcgtcaggac ggccgcccaa tcaacggtgg ctgaagatggggctggatga 300 ttccagccat ctccgttaac gctcttgaaa tactcgtgga acccaactgaaaactcggtt 360 cttccccatc ccttcacagt ccatctaagt cccttaggaa gaagctttccggccgcgggt 420 tcccgaccgt gagccgccgc ctggcccagg accgaggcgc ctaggactgagacgcggacc 480 ggtgctctct cctcctgcag gatctccgcc tacggagcgg cgggcggcaagggcgcccaa 540 aaccacctgt cacgggcgca cggcatcttc ctctcagcag tcttcttcctccgtcgcggg 600 gagccggtgt acatccttgt ggggcagcag ggccaggacg cctgtcccggagtaagcggg 660 gcgagtggga caggggcgcc cggtccgaga gctggaggag gagagagtccctggtcacgc 720 agcatttcac cttggtgcca cccaggggag ccctgagagc caactcgtctgtctgggaga 780 gtctggggag catgcaacca cctatgggac cgaaaggatc ccaggctggagacgctgggc 840 cggcgggggc gggggtggcg gaggcgccac ctccatcttc cgggtaggtgcaccgggtgc 900 tgtcgcctcg acccccagct gggtagccca ggctccgctc tccctctgggttccccgggc 960 tcaggacccg ggtgcagccc ctgaccggcc actggcccca tagctgcgcgcgggggagcc 1020 agagccgctg ctggtggcgg cgggaggcgg cgggaggtcc taccggaggcgacctgaccg 1080 cggccggact caggccgtcc ccgagaggct ggagacccgc gcggcggcgccgggcagcgg 1140 cgggagagga g 1151 165 1138 DNA Unknown OrganismDescription of Unknown Organism Ltk 165 aaccatcgtc aggacggccg cccaatcaacggtggctgaa gatggggctg gatgattcca 60 gccatctccg ttaacgctct tgaaatactcgtggaaccca actgaaaact cggttcttcc 120 ccatcccttc acagtccatc taagtcccttaggaagaagc tttccggccg cgggttcccg 180 accgtgagcc gccgcctggc ccaggaccgaggcgcctagg actgagacgc ggaccggtgc 240 tctctcctcc tgcaggatct ccgcctacggagcggcgggc ggcaagggcg cccaaaacca 300 cctgtcacgg gcgcacggca tcttcctctcagcagtcttc ttcctccgtc gcggggagcc 360 ggtgtacatc cttgtggggc agcagggccaggacgcctgt cccggagtaa gcggggcgag 420 tgggacaggg gcgcccggtc cgagagctggaggaggagag agtccctggt cacgcagcat 480 ttcaccttgg tgccacccag gggagccctgagagccaact cgtctgtctg ggagagtctg 540 gggagcatgc aaccacctat gggaccgaaaggatcccagg ctggagacgc tgggccggcg 600 ggggcggggg tggcggaggc gccacctccatcttccgggt aggtgcaccg ggtgctgtcg 660 cctcgacccc cagctgggta gcccaggctccgctctccct ctgggttccc cgggctcagg 720 acccgggtgc agcccctgac cggccactggccccatagct gcgcgcgggg gagccagagc 780 cgctgctggt ggcggcggga ggcggcgggaggtcctaccg gaggcgacct gaccgcggcc 840 ggactcaggc cgtccccgag aggctggagacccgcgcggc ggcgccgggc agcggcggga 900 gaggaggcgc ggcaggtgag cgctccgcccggcggggaga ggcggggaga ggcgagcggc 960 tccgcaacgc cactgctcgt cgcttgctgtcgcttcgcag gtggagggag cggctggacg 1020 tcgcgagccc actctccgca ggccggacgctcgccgcggg aaggggccga gggcggcgag 1080 ggctgcgcgg aggcctgggc tgcgctccgctgggctgcgg cgggaggctt cgggggcg 1138 166 1157 DNA Unknown OrganismDescription of Unknown Organism Ltk 166 ctccgcctac ggagcggcgg gcggcaagggcgcccaaaac cacctgtcac gggcgcacgg 60 catcttcctc tcagcagtct tcttcctccgtcgcggggag ccggtgtaca tccttgtggg 120 gcagcagggc caggacgcct gtcccggagtaagcggggcg agtgggacag gggcgcccgg 180 tccgagagct ggaggaggag agagtccctggtcacgcagc atttcacctt ggtgccaccc 240 aggggagccc tgagagccaa ctcgtctgtctgggagagtc tggggagcat gcaaccacct 300 atgggaccga aaggatccca ggctggagacgctgggccgg cgggggcggg ggtggcggag 360 gcgccacctc catcttccgg gtaggtgcaccgggtgctgt cgcctcgacc cccagctggg 420 tagcccaggc tccgctctcc ctctgggttccccgggctca ggacccgggt gcagcccctg 480 accggccact ggccccatag ctgcgcgcgggggagccaga gccgctgctg gtggcggcgg 540 gaggcggcgg gaggtcctac cggaggcgacctgaccgcgg ccggactcag gccgtccccg 600 agaggctgga gacccgcgcg gcggcgccgggcagcggcgg gagaggaggc gcggcaggtg 660 agcgctccgc ccggcgggga gaggcggggagaggcgagcg gctccgcaac gccactgctc 720 gtcgcttgct gtcgcttcgc aggtggagggagcggctgga cgtcgcgagc ccactctccg 780 caggccggac gctcgccgcg ggaaggggccgagggcggcg agggctgcgc ggaggcctgg 840 gctgcgctcc gctgggctgc ggcgggaggcttcgggggcg gcggcggggc ctgcgcggct 900 ggcggcggtg gcggcggcta ccggggtaggtgcacccgtt gggagggtta gtcggacagc 960 ccgggtgatg tgacggtaga gcctaagaacctggcctgag ctttccagag gatagatggg 1020 gaatgcccca ctctccactg tgccaggccccagcaggtgc tcttacaaag gaggtctgac 1080 caggtcaggc ctgggcgggg tggcacactcgcctgcagcg cgtgctggag gcagaagtat 1140 tccaagctaa ataacta 1157 167 1183DNA Unknown Organism Description of Unknown Organism Ltk 167 gggagccctgagagccaact cgtctgtctg ggagagtctg gggagcatgc aaccacctat 60 gggaccgaaaggatcccagg ctggagacgc tgggccggcg ggggcggggg tggcggaggc 120 gccacctccatcttccgggt aggtgcaccg ggtgctgtcg cctcgacccc cagctgggta 180 gcccaggctccgctctccct ctgggttccc cgggctcagg acccgggtgc agcccctgac 240 cggccactggccccatagct gcgcgcgggg gagccagagc cgctgctggt ggcggcggga 300 ggcggcgggaggtcctaccg gaggcgacct gaccgcggcc ggactcaggc cgtccccgag 360 aggctggagacccgcgcggc ggcgccgggc agcggcggga gaggaggcgc ggcaggtgag 420 cgctccgcccggcggggaga ggcggggaga ggcgagcggc tccgcaacgc cactgctcgt 480 cgcttgctgtcgcttcgcag gtggagggag cggctggacg tcgcgagccc actctccgca 540 ggccggacgctcgccgcggg aaggggccga gggcggcgag ggctgcgcgg aggcctgggc 600 tgcgctccgctgggctgcgg cgggaggctt cgggggcggc ggcggggcct gcgcggctgg 660 cggcggtggcggcggctacc ggggtaggtg cacccgttgg gagggttagt cggacagccc 720 gggtgatgtgacggtagagc ctaagaacct ggcctgagct ttccagagga tagatgggga 780 atgccccactctccactgtg ccaggcccca gcaggtgctc ttacaaagga ggtctgacca 840 ggtcaggcctgggcggggtg gcacactcgc ctgcagcgcg tgctggaggc agaagtattc 900 caagctaaataactacggag tgaagccagg ctgggctaca gacttgtctg gttttgtttt 960 gttttaagactgggtttctt ttttgagaca ggctgacctg gaactccctc tgtaagccag 1020 gctggcctcgaactcacaga tacccacctg cctttgcctc ccaggagttg aaatgaaagg 1080 cttgcaccaccaccaagcag gctggtcttg ttttgtcttt tacaaagggc caaattaccc 1140 atgcttggtcgcacattcct ttaattctac tatcaggaaa cag 1183 168 1099 DNA Unknown OrganismDescription of Unknown Organism Ltk 168 caaggcagct gcatgctcct cctcaaccagtctccttttt gtagttaaac ctccatcagc 60 cgggcggtgg tggtacacgc cttaaatcccagcagaggat ttaagaggga ggcagaggca 120 ggtggatttc tgagtttgag gccagcctggtctacaaagt gagctccagg acagccaggg 180 ctacacagag aaaccctgtc tcaaaaaaacaaacaaacaa acaaacagac aaaaaaacaa 240 aaccaaaaca aacaaacaaa aaaaagatgctaagcacctt ttggggactg gagagatggc 300 tcaggggtta agagcaatga gtgctcttccgaaagtcctg agttcaaatc ccagcaacca 360 tatagtggct cacaaccatc tgtaatgagatctgatgccc tcttctgctg tgtctgaaaa 420 cagctacact gtacttacat gtaataataataaaaacaaa aaaacaaaaa acaaaaacct 480 ctatcactct ccatttcaag gcggtgatacttctgagtct gacctcctct gggctgatgg 540 ggaagatggc acatcctttg tccaccccagtggtgagctc tacctacagc ctctggcagg 600 tatttgtctg gaacccctga ttctcagcctggccagctcc tcctcaatct ggtaaaaccg 660 ttgcctctca agcttggtga cctgacaccatagtagaaga agaaaagaaa gtctgacttc 720 acaagcatgt gtgtgcgtgg cttggtctacctctgaatga aatcagtcaa cagaaattaa 780 gtccccgggg ctctgacatc accctttgtgttgctgtggt tgggaccact cctgactagg 840 agtagccata tgactggaaa gacctgtgtgtcccatcccc atccccaccc ccacttccca 900 ccccaccatg tctactcttt tactctgcagtcacagaggg ccatggggag gtggagatcc 960 gaaagcatcc caactgcagt cactgccctttcaaagactg ccagtggcag gcagagctct 1020 ggacggccga atgcacgtgc ccagagggcacggagctagc tgtggataat gtcacttgca 1080 tgggtatgtc ttcatagag 1099 169 1153DNA Unknown Organism Description of Unknown Organism Ltk 169 gtacttacatgtaataataa taaaaacaaa aaaacaaaaa acaaaaacct ctatcactct 60 ccatttcaaggcggtgatac ttctgagtct gacctcctct gggctgatgg ggaagatggc 120 acatcctttgtccaccccag tggtgagctc tacctacagc ctctggcagg tatttgtctg 180 gaacccctgattctcagcct ggccagctcc tcctcaatct ggtaaaaccg ttgcctctca 240 agcttggtgacctgacacca tagtagaaga agaaaagaaa gtctgacttc acaagcatgt 300 gtgtgcgtggcttggtctac ctctgaatga aatcagtcaa cagaaattaa gtccccgggg 360 ctctgacatcaccctttgtg ttgctgtggt tgggaccact cctgactagg agtagccata 420 tgactggaaagacctgtgtg tcccatcccc atccccaccc ccacttccca ccccaccatg 480 tctactcttttactctgcag tcacagaggg ccatggggag gtggagatcc gaaagcatcc 540 caactgcagtcactgccctt tcaaagactg ccagtggcag gcagagctct ggacggccga 600 atgcacgtgcccagagggca cggagctagc tgtggataat gtcacttgca tgggtatgtc 660 ttcatagagcattggaaatg gatcagggca cagtctcctg tcaagaacat gtaggccagt 720 gtgggaggcaagatagatat ttagatatag atatgtatct aaaaatggca gttgctatgg 780 aaggtatcaaatagttaagg ggctctcgag agggagagtt gcttttgtct ggggacaact 840 gtgggtggcactgtgggaaa gtaaacactg agatggggct tgaagcatgg ataagattta 900 agggtacccagtcatggtag catacacctc tcatcccagc agtgagtagg ctacagcaga 960 attgagagtctgagcccagc ctgggttatt gggagaccct atctcaaaaa caacaagaca 1020 aaacaaaacacaagacaaac gagaaaaata cttgagggta gcaggacaga ggaccctcct 1080 gctggaggtgacattgttct ttctccctag acctgccaac taccgcaagc cctctgatcc 1140 tgatgggagctgt 1153 170 1096 DNA Unknown Organism Description of Unknown OrganismLtk 170 ccagagggca cggagctagc tgtggataat gtcacttgca tgggtatgtcttcatagagc 60 attggaaatg gatcagggca cagtctcctg tcaagaacat gtaggccagtgtgggaggca 120 agatagatat ttagatatag atatgtatct aaaaatggca gttgctatggaaggtatcaa 180 atagttaagg ggctctcgag agggagagtt gcttttgtct ggggacaactgtgggtggca 240 ctgtgggaaa gtaaacactg agatggggct tgaagcatgg ataagatttaagggtaccca 300 gtcatggtag catacacctc tcatcccagc agtgagtagg ctacagcagaattgagagtc 360 tgagcccagc ctgggttatt gggagaccct atctcaaaaa caacaagacaaaacaaaaca 420 caagacaaac gagaaaaata cttgagggta gcaggacaga ggaccctcctgctggaggtg 480 acattgttct ttctccctag acctgccaac taccgcaagc cctctgatcctgatgggagc 540 tgtagtggca gccttggcac tgagtctcct aatgatgtgt gcagtcctgattctaggtat 600 gggcatctag catggctgat gcaggccgac ccttctctcc taggctgtgatgggcttctc 660 tgtggttcta ggctaaatgt ggctgacatc atggccctta ccccacagagcaatggtgga 720 gtcctctcag cttttaggag tagtgccagg gagtcctggg cctggggaagcagtgtgggc 780 ctgataaata cctctcttct cacccacagt gaaccagaag tgtcagggcctgtgggggac 840 caggctgcca ggccctgagc ttgagctaag caagcttcga tcctctgccatcaggacagc 900 acccaaccct tactattgtc aggtgggact cagtcctgcc cagccctggcctttgccccc 960 agggctcact gaggtttcac cagccaatgt cactctactc aggtgagtcctcaacctcct 1020 tctgcaatga tgtgcacttt gaagccctcc tccccattct tcctcctgtcatgatgcatt 1080 atgaatccca gagggc 1096 171 1193 DNA Unknown OrganismDescription of Unknown Organism Ltk 171 gcatacacct ctcatcccag cagtgagtaggctacagcag aattgagagt ctgagcccag 60 cctgggttat tgggagaccc tatctcaaaaacaacaagac aaaacaaaac acaagacaaa 120 cgagaaaaat acttgagggt agcaggacagaggaccctcc tgctggaggt gacattgttc 180 tttctcccta gacctgccaa ctaccgcaagccctctgatc ctgatgggag ctgtagtggc 240 agccttggca ctgagtctcc taatgatgtgtgcagtcctg attctaggta tgggcatcta 300 gcatggctga tgcaggccga cccttctctcctaggctgtg atgggcttct ctgtggttct 360 aggctaaatg tggctgacat catggcccttaccccacaga gcaatggtgg agtcctctca 420 gcttttagga gtagtgccag ggagtcctgggcctggggaa gcagtgtggg cctgataaat 480 acctctcttc tcacccacag tgaaccagaagtgtcagggc ctgtggggga ccaggctgcc 540 aggccctgag cttgagctaa gcaagcttcgatcctctgcc atcaggacag cacccaaccc 600 ttactattgt caggtgggac tcagtcctgcccagccctgg cctttgcccc cagggctcac 660 tgaggtttca ccagccaatg tcactctactcaggtgagtc ctcaacctcc ttctgcaatg 720 atgtgcactt tgaagccctc ctccccattcttcctcctgt catgatgcat tatgaatccc 780 agagggcatc taactcaaat cccttgtgcagaagaagttc caaaaggcaa agtagcatgg 840 gtagggtcag attttgcccc agttctggggtgcagagatc tgggaacatg actgttctgg 900 agcccacagc ttgcctttct cccagcagggtctgcattag cacaaggaga ggccttatcc 960 tacattatga ccctgactct ggccccagctctgtgtgtca gcattagctt gtgtctgaga 1020 gcacccatgg cccagagaga gctcagagaaggtcccctgg acctatgggg tgggagccaa 1080 agagataaag gggcattggc tcttctatagaccctgtttg cctatgccat cctcttcctt 1140 ccatcttgtc ttcttataga gcccttggccatggtgcctt tggggaagtg tac 1193 172 1091 DNA Unknown Organism Descriptionof Unknown Organism Ltk 172 ctgaggtttc accagccaat gtcactctac tcaggtgagtcctcaacctc cttctgcaat 60 gatgtgcact ttgaagccct cctccccatt cttcctcctgtcatgatgca ttatgaatcc 120 cagagggcat ctaactcaaa tcccttgtgc agaagaagttccaaaaggca aagtagcatg 180 ggtagggtca gattttgccc cagttctggg gtgcagagatctgggaacat gactgttctg 240 gagcccacag cttgcctttc tcccagcagg gtctgcattagcacaaggag aggccttatc 300 ctacattatg accctgactc tggccccagc tctgtgtgtcagcattagct tgtgtctgag 360 agcacccatg gcccagagag agctcagaga aggtcccctggacctatggg gtgggagcca 420 aagagataaa ggggcattgg ctcttctata gaccctgtttgcctatgcca tcctcttcct 480 tccatcttgt cttcttatag agcccttggc catggtgcctttggggaagt gtacgaggga 540 ctagtgactg gtcttcctgg ggactccagt cctcttccagtggctattaa ggtgagaagg 600 ggcagggctt gcggttggga taggcatatg gaaggaagggctgatgctag agcctttgtt 660 gttctccctc ctaaagcact caaagctcag gagtgctctgcgttccctcc ccagactctg 720 ccagagctct gctcccatca ggatgagctg gattttctcatggaggctct gatcatcagg 780 tgcagcccag ggcaggcagg agggtatggt gggaggcaggatctgcctac aggaatggcc 840 tctctgctct ttatggctga ggggcagcct tttagggcacagagattttt tgcactttaa 900 ttggatctag aatatgctta tctccccact ggtgatggggtctatgcgcc atttccactc 960 agcaagttca gccatcagaa cattgtacgc tgtgtggggctcagctttcg gtctgccccg 1020 cgcctcattc tgctggagct gatgtctggt ggggacatgaagagcttttt gaggcacagc 1080 agaccacacc c 1091 173 1065 DNA UnknownOrganism Description of Unknown Organism Ltk 173 agagatctgg gaacatgactgttctggagc ccacagcttg cctttctccc agcagggtct 60 gcattagcac aaggagaggccttatcctac attatgaccc tgactctggc cccagctctg 120 tgtgtcagca ttagcttgtgtctgagagca cccatggccc agagagagct cagagaaggt 180 cccctggacc tatggggtgggagccaaaga gataaagggg cattggctct tctatagacc 240 ctgtttgcct atgccatcctcttccttcca tcttgtcttc ttatagagcc cttggccatg 300 gtgcctttgg ggaagtgtacgagggactag tgactggtct tcctggggac tccagtcctc 360 ttccagtggc tattaaggtgagaaggggca gggcttgcgg ttgggatagg catatggaag 420 gaagggctga tgctagagcctttgttgttc tccctcctaa agcactcaaa gctcaggagt 480 gctctgcgtt ccctccccagactctgccag agctctgctc ccatcaggat gagctggatt 540 ttctcatgga ggctctgatcatcaggtgca gcccagggca ggcaggaggg tatggtggga 600 ggcaggatct gcctacaggaatggcctctc tgctctttat ggctgagggg cagcctttta 660 gggcacagag attttttgcactttaattgg atctagaata tgcttatctc cccactggtg 720 atggggtcta tgcgccatttccactcagca agttcagcca tcagaacatt gtacgctgtg 780 tggggctcag ctttcggtctgccccgcgcc tcattctgct ggagctgatg tctggtgggg 840 acatgaagag ctttttgaggcacagcagac cacacccagt aaggcccttt tctgggctcc 900 ccagaccctt ctaaaatcctatttgctcta cgatctggat gaaatgatgt accttctgcc 960 caactcaggg acaactggcacctctgacca tgcaggacct attgcagctg gcccaggata 1020 tagcccaggg ctgccactacctggaggaaa atcacttcat tcaca 1065 174 1130 DNA Unknown OrganismDescription of Unknown Organism Ltk 174 ctatgccatc ctcttccttc catcttgtcttcttatagag cccttggcca tggtgccttt 60 ggggaagtgt acgagggact agtgactggtcttcctgggg actccagtcc tcttccagtg 120 gctattaagg tgagaagggg cagggcttgcggttgggata ggcatatgga aggaagggct 180 gatgctagag cctttgttgt tctccctcctaaagcactca aagctcagga gtgctctgcg 240 ttccctcccc agactctgcc agagctctgctcccatcagg atgagctgga ttttctcatg 300 gaggctctga tcatcaggtg cagcccagggcaggcaggag ggtatggtgg gaggcaggat 360 ctgcctacag gaatggcctc tctgctctttatggctgagg ggcagccttt tagggcacag 420 agattttttg cactttaatt ggatctagaatatgcttatc tccccactgg tgatggggtc 480 tatgcgccat ttccactcag caagttcagccatcagaaca ttgtacgctg tgtggggctc 540 agctttcggt ctgccccgcg cctcattctgctggagctga tgtctggtgg ggacatgaag 600 agctttttga ggcacagcag accacacccagtaaggccct tttctgggct ccccagaccc 660 ttctaaaatc ctatttgctc tacgatctggatgaaatgat gtaccttctg cccaactcag 720 ggacaactgg cacctctgac catgcaggacctattgcagc tggcccagga tatagcccag 780 ggctgccact acctggagga aaatcacttcattcacaggt tggaagcaat caggagaccc 840 ttggcccact tctcccgtca gaacatccctctctatatat acaactttaa agaaatgtaa 900 cagaaagagc cagagtgcct atgctccgtctggcatgaac attttatgtt ttacagagac 960 attgctgccc gtaactgtct gcttagctgcagtggagcca gccgagtggc caagattgga 1020 gattttggaa tggcaagaga tatctaccagtaagcaggaa ctggagagct gggaaagctg 1080 ctgttccacg gaggttggct tgaccacactgggaaaactc tgcacttttt 1130 175 1098 DNA Unknown Organism Description ofUnknown Organism Ltk 175 aagctcagga gtgctctgcg ttccctcccc agactctgccagagctctgc tcccatcagg 60 atgagctgga ttttctcatg gaggctctga tcatcaggtgcagcccaggg caggcaggag 120 ggtatggtgg gaggcaggat ctgcctacag gaatggcctctctgctcttt atggctgagg 180 ggcagccttt tagggcacag agattttttg cactttaattggatctagaa tatgcttatc 240 tccccactgg tgatggggtc tatgcgccat ttccactcagcaagttcagc catcagaaca 300 ttgtacgctg tgtggggctc agctttcggt ctgccccgcgcctcattctg ctggagctga 360 tgtctggtgg ggacatgaag agctttttga ggcacagcagaccacaccca gtaaggccct 420 tttctgggct ccccagaccc ttctaaaatc ctatttgctctacgatctgg atgaaatgat 480 gtaccttctg cccaactcag ggacaactgg cacctctgaccatgcaggac ctattgcagc 540 tggcccagga tatagcccag ggctgccact acctggaggaaaatcacttc attcacaggt 600 tggaagcaat caggagaccc ttggcccact tctcccgtcagaacatccct ctctatatat 660 acaactttaa agaaatgtaa cagaaagagc cagagtgcctatgctccgtc tggcatgaac 720 attttatgtt ttacagagac attgctgccc gtaactgtctgcttagctgc agtggagcca 780 gccgagtggc caagattgga gattttggaa tggcaagagatatctaccag taagcaggaa 840 ctggagagct gggaaagctg ctgttccacg gaggttggcttgaccacact gggaaaactc 900 tgcacttttt ttctccttca tatagggcca gttattatcgcaagggtggc cggaccttgc 960 tcccagtcaa gtggatgccg ccagaagctc tcctggagggccttttcaca tccaagacag 1020 actcctggtg atagcatgtc ccccgctgtg ctcccctcactctgccctga agctggtcct 1080 atctcttcac cacctcat 1098 176 1093 DNA UnknownOrganism Description of Unknown Organism Ltk 176 tatctcccca ctggtgatggggtctatgcg ccatttccac tcagcaagtt cagccatcag 60 aacattgtac gctgtgtggggctcagcttt cggtctgccc cgcgcctcat tctgctggag 120 ctgatgtctg gtggggacatgaagagcttt ttgaggcaca gcagaccaca cccagtaagg 180 cccttttctg ggctccccagacccttctaa aatcctattt gctctacgat ctggatgaaa 240 tgatgtacct tctgcccaactcagggacaa ctggcacctc tgaccatgca ggacctattg 300 cagctggccc aggatatagcccagggctgc cactacctgg aggaaaatca cttcattcac 360 aggttggaag caatcaggagacccttggcc cacttctccc gtcagaacat ccctctctat 420 atatacaact ttaaagaaatgtaacagaaa gagccagagt gcctatgctc cgtctggcat 480 gaacatttta tgttttacagagacattgct gcccgtaact gtctgcttag ctgcagtgga 540 gccagccgag tggccaagattggagatttt ggaatggcaa gagatatcta ccagtaagca 600 ggaactggag agctgggaaagctgctgttc cacggaggtt ggcttgacca cactgggaaa 660 actctgcact ttttttctccttcatatagg gccagttatt atcgcaaggg tggccggacc 720 ttgctcccag tcaagtggatgccgccagaa gctctcctgg agggcctttt cacatccaag 780 acagactcct ggtgatagcatgtcccccgc tgtgctcccc tcactctgcc ctgaagctgg 840 tcctatctct tcaccacctcatatgacagc aggggacagt acacatgatg ggtcttgttt 900 gttccttcca cctctgacacaggtcttttg gggtcctgct ctgggagatc ttctcactgg 960 ggtatatgcc ctaccctggacataccaacc aggaggttct agacttcatt gccacaggga 1020 acaggatgga ccctcctaggaactgtcctg ggccagtgtg agctaacagt gctgcccagg 1080 gagggaggca tcc 1093 1771102 DNA Unknown Organism Description of Unknown Organism Ltk 177gggctcccca gacccttcta aaatcctatt tgctctacga tctggatgaa atgatgtacc 60ttctgcccaa ctcagggaca actggcacct ctgaccatgc aggacctatt gcagctggcc 120caggatatag cccagggctg ccactacctg gaggaaaatc acttcattca caggttggaa 180gcaatcagga gacccttggc ccacttctcc cgtcagaaca tccctctcta tatatacaac 240tttaaagaaa tgtaacagaa agagccagag tgcctatgct ccgtctggca tgaacatttt 300atgttttaca gagacattgc tgcccgtaac tgtctgctta gctgcagtgg agccagccga 360gtggccaaga ttggagattt tggaatggca agagatatct accagtaagc aggaactgga 420gagctgggaa agctgctgtt ccacggaggt tggcttgacc acactgggaa aactctgcac 480tttttttctc cttcatatag ggccagttat tatcgcaagg gtggccggac cttgctccca 540gtcaagtgga tgccgccaga agctctcctg gagggccttt tcacatccaa gacagactcc 600tggtgatagc atgtcccccg ctgtgctccc ctcactctgc cctgaagctg gtcctatctc 660ttcaccacct catatgacag caggggacag tacacatgat gggtcttgtt tgttccttcc 720acctctgaca caggtctttt ggggtcctgc tctgggagat cttctcactg gggtatatgc 780cctaccctgg acataccaac caggaggttc tagacttcat tgccacaggg aacaggatgg 840accctcctag gaactgtcct gggccagtgt gagctaacag tgctgcccag ggagggaggc 900atcccaaggt ttcaggaggc ataaactcct gcctctccct aggtaccgaa tcatgaccca 960gtgttggcag catcagccgg agctccgccc tgactttggc agcatcttgg aacggattca 1020gtactgcact caggtgtgcc ccccacccaa cccccagctc cctttcgacc ccctctaact 1080accctggttc tgcagggcag ga 1102 178 1135 DNA Unknown Organism Descriptionof Unknown Organism Ltk 178 atacaacttt aaagaaatgt aacagaaaga gccagagtgcctatgctccg tctggcatga 60 acattttatg ttttacagag acattgctgc ccgtaactgtctgcttagct gcagtggagc 120 cagccgagtg gccaagattg gagattttgg aatggcaagagatatctacc agtaagcagg 180 aactggagag ctgggaaagc tgctgttcca cggaggttggcttgaccaca ctgggaaaac 240 tctgcacttt ttttctcctt catatagggc cagttattatcgcaagggtg gccggacctt 300 gctcccagtc aagtggatgc cgccagaagc tctcctggagggccttttca catccaagac 360 agactcctgg tgatagcatg tcccccgctg tgctcccctcactctgccct gaagctggtc 420 ctatctcttc accacctcat atgacagcag gggacagtacacatgatggg tcttgtttgt 480 tccttccacc tctgacacag gtcttttggg gtcctgctctgggagatctt ctcactgggg 540 tatatgccct accctggaca taccaaccag gaggttctagacttcattgc cacagggaac 600 aggatggacc ctcctaggaa ctgtcctggg ccagtgtgagctaacagtgc tgcccaggga 660 gggaggcatc ccaaggtttc aggaggcata aactcctgcctctccctagg taccgaatca 720 tgacccagtg ttggcagcat cagccggagc tccgccctgactttggcagc atcttggaac 780 ggattcagta ctgcactcag gtgtgccccc cacccaacccccagctccct ttcgaccccc 840 tctaactacc ctggttctgc agggcaggaa gagagccataaaatagccat gtggttccct 900 cttccccaac tctcccatta caggaccctg atgtgctgaactcacccctg cccatggaac 960 ctgggcccat tctagaggag gaagaggcct ccaggctgggaaacaggtca ctggagggtc 1020 ttagatcccc aaagccccta gagctgagtt ctcagaacttgaagagctgg ggaggaggcc 1080 ttcttggctc ttggctgccc tctggcctca agaccctcaaacccaggtgc ctcca 1135 179 1091 DNA Unknown Organism Description ofUnknown Organism Ltk 179 acggaggttg gcttgaccac actgggaaaa ctctgcactttttttctcct tcatataggg 60 ccagttatta tcgcaagggt ggccggacct tgctcccagtcaagtggatg ccgccagaag 120 ctctcctgga gggccttttc acatccaaga cagactcctggtgatagcat gtcccccgct 180 gtgctcccct cactctgccc tgaagctggt cctatctcttcaccacctca tatgacagca 240 ggggacagta cacatgatgg gtcttgtttg ttccttccacctctgacaca ggtcttttgg 300 ggtcctgctc tgggagatct tctcactggg gtatatgccctaccctggac ataccaacca 360 ggaggttcta gacttcattg ccacagggaa caggatggaccctcctagga actgtcctgg 420 gccagtgtga gctaacagtg ctgcccaggg agggaggcatcccaaggttt caggaggcat 480 aaactcctgc ctctccctag gtaccgaatc atgacccagtgttggcagca tcagccggag 540 ctccgccctg actttggcag catcttggaa cggattcagtactgcactca ggtgtgcccc 600 ccacccaacc cccagctccc tttcgacccc ctctaactaccctggttctg cagggcagga 660 agagagccat aaaatagcca tgtggttccc tcttccccaactctcccatt acaggaccct 720 gatgtgctga actcacccct gcccatggaa cctgggcccattctagagga ggaagaggcc 780 tccaggctgg gaaacaggtc actggagggt cttagatccccaaagcccct agagctgagt 840 tctcagaact tgaagagctg gggaggaggc cttcttggctcttggctgcc ctctggcctc 900 aagaccctca aacccaggtg cctccaacct cagaacatttggaaccccac ctatggctcc 960 tggaccccaa ggggccccca gggtgaagat acaggcattgaacagtgcaa tggctcctcc 1020 tcaagttcca ttccaggcat ccagtaggct ctgcccctgccctgtgctgc atgttcaggc 1080 atgtttcagg g 1091 180 1606 DNA UnknownOrganism Description of Unknown Organism Ltk 180 tctcttcacc acctcatatgacagcagggg acagtacaca tgatgggtct tgtttgttcc 60 ttccacctct gacacaggtcttttggggtc ctgctctggg agatcttctc actggggtat 120 atgccctacc ctggacataccaaccaggag gttctagact tcattgccac agggaacagg 180 atggaccctc ctaggaactgtcctgggcca gtgtgagcta acagtgctgc ccagggaggg 240 aggcatccca aggtttcaggaggcataaac tcctgcctct ccctaggtac cgaatcatga 300 cccagtgttg gcagcatcagccggagctcc gccctgactt tggcagcatc ttggaacgga 360 ttcagtactg cactcaggtgtgccccccac ccaaccccca gctccctttc gaccccctct 420 aactaccctg gttctgcagggcaggaagag agccataaaa tagccatgtg gttccctctt 480 ccccaactct cccattacaggaccctgatg tgctgaactc acccctgccc atggaacctg 540 ggcccattct agaggaggaagaggcctcca ggctgggaaa caggtcactg gagggtctta 600 gatccccaaa gcccctagagctgagttctc agaacttgaa gagctgggga ggaggccttc 660 ttggctcttg gctgccctctggcctcaaga ccctcaaacc caggtgcctc caacctcaga 720 acatttggaa ccccacctatggctcctgga ccccaagggg cccccagggt gaagatacag 780 gcattgaaca gtgcaatggctcctcctcaa gttccattcc aggcatccag taggctctgc 840 ccctgccctg tgctgcatgttcaggcatgt ttcagggatg tgcgggcaac ctggcctccc 900 acactggaaa ctagcccagaccctcttggg gaaggtccta ggctactttc agtctttggt 960 ctttgaaacc agaggccatccacccactgc aggagtcagt tgggaaccct ggattgtcca 1020 ctcctcataa gtatcttttctctgctcatt ccagggctac aaatgtttta gtaataataa 1080 tggtaataaa aacaataaacccttctaatt cttcagttct ctgagtgaat gtggaagaga 1140 gaactggaag tgaaggggaggaggctggag tcacagaagc tgaatctttg agttttatta 1200 ggaagggtgt ccactgtagtgcaggagtta gaccaggaag tctatatacc tgtgaagtac 1260 aattatggat cgggaccctctggagaggtg caaagccact tgagaagagc tgggctgggg 1320 gagaagccca ttgtttctccccctccctat aaattagtgt cattcagctc tgggaaacag 1380 gcttgtgtgg taggcaactcctgatgtact acaccccctt agtggatggc acccggtcct 1440 gcaggaccat gtgaactgcccgcccagcgg ggttccagtc tcttgccggc atgcatggtg 1500 gggatgcagc cacaggtgcacatctgtctg accagccggc ccacgttgag ggaaaagggc 1560 tcagcctcat ctctcagccaggctggccaa gatgccaatg agattg 1606 181 728 DNA Unknown OrganismDescription of Unknown Organism lp3k 181 ggggggcgcg gccggggcggggcgcggccg ggcgggcgtt gccgaggctc cgccccgggg 60 cagtcccaag cccggggcgctgagcgtcta cagtccccgc cgcgccgcgg gctggtgggc 120 tcggctgcgg ctccggtgccgggagatgac cctgcccggg cgcccgacgg gcatggcgcg 180 gccacggggc gcggggccctgcagccccgg gctggagagg gctccgcgcc ggagcgtcgg 240 ggagctgcgc ctgctcttcgaagcgcgctg cgccgcagtc gccgctgcag cagccgcagg 300 ggagccccgg gcccgcggggccaagcggcg tgggggacaa gtgcccaacg ggctcccgcg 360 agctgcccct gccccggtgatccctcagct cactgtgaca agcgaggagg atgtgacccc 420 ggccagccca gggccgccagaccaggaggg gaactggctc ccagctgcgg ggtcgcacct 480 gcagcagcca cgccgcctctccacctcgtc cctctcctcc accggctcct cgtcgctgct 540 cgaggactcg gaggacgatctgctgagcga cagtgagagc aggagccgcg gcaacgtgca 600 gctggaaacc agcgaggacgtggggcaggt acgggccgcg ggggcggggc cagcgggggc 660 tgcgcgccgg ggactccgctctctgctctg ctctgaccgg cttgcgttcc ccgccgagag 720 cccaagcg 728 182 297 DNAUnknown Organism Description of Unknown Organism lp3k 182 gaccttaactgcttctagtg ggatgaaacc aagctgaaat cctgctctag agggacatta 60 ctgagacgctgacttgcaca cctggacctg ttgctttcag aaaagccact ggcagaagat 120 ccgtaccatggtcaatctgc ctgtcatgag tcctttcaga aagcgctact cctgggtgca 180 gttagcagggcacacaggtg agcatcattg caggtgggtg aggttgctgc cacaggaagg 240 cttgggcagttctaactggt gcccttgtgc agggagtttc aaagctgccg gcaccag 297 183 417 DNAUnknown Organism Description of Unknown Organism lp3k 183 tgggtgcagttagcagggca cacaggtgag catcattgca ggtgggtgag gttgctgcca 60 caggaaggcttgggcagttc taactggtgc ccttgtgcag ggagtttcaa agctgccggc 120 accagtggcctgatcctgaa acgcagctcg gagcctgaac actactgcct ggtgcggctg 180 atggctgacgtgctgcgtgg gtgtgtgccg gccttccatg gcatagtcga gcgggatggt 240 gaaagctacttgcagttaca ggacctgctc gatggcttcg atgggccttg tgtgcttgac 300 tgcaagatgggtgtcaggtt tgtgtcccct ctctttgtca ggcagaatca gtccggaacc 360 aaggactgggataaaagctc atatgccctg gcccctactt gcacttcaca gaactta 417 184 405 DNAUnknown Organism Description of Unknown Organism lp3k 184 tgtcaggtttgtgtcccctc tctttgtcag gcagaatcag tccggaacca aggactggga 60 taaaagctcatatgccctgg cccctacttg cacttcacag aacttacctg gaagaggagc 120 tgaccaaagcccgagaacgg cccaagctgc ggaaggacat gtataagaag atgctggcag 180 tggaccctgaggcacctact gaggaggagc atgcgcagcg cgccgtcacc aaaccacgct 240 acatgcaatggcgcgaaggc atcagctcca gcactacact cggctttcgc attgagggca 300 tcaaggtgggtcaggctccc ctcactttgc atggcctttc ttctatccca ccttcagtgc 360 tcctgacctcctgcctcaac catcaccaaa agacaccctc cggta 405 185 302 DNA Unknown OrganismDescription of Unknown Organism lp3k 185 cagaggttaa ggccccggggaggtaccact gccctttgca cgatcctctc tcccctcaga 60 tgggtcctgg gctctgacagtccttgccca cctccttcag aaagccgatg gatcttgcag 120 tactgatttc aaaactacacgaagccgaga gcaagtgacc cgtgtctttg aggagttcat 180 gcaaggagat gcagaagtgctggtgagagg aggttcccaa gccctggggt ctgggcacct 240 tgtttacaag ggcgcctcttgcctatgtcc tcctcgcctg tgctaccccc agtggtagca 300 ct 302 186 272 DNAUnknown Organism Description of Unknown Organism lp3k 186 cagtgtttgctaggcaagtt gaaataaatg catggtgctt ctaagagtca gtagagccgc 60 ccttggtgtgaaattaatct gtccactctg actcttccag aggaggtatc tgaaccgcct 120 acagcagatccgggataccc tggagatctc tgatttcttt agacggcacg aggtaagtaa 180 gaggtgggggggggggggct cagggtgtga gtttgggctt tatgagactc agaatgggaa 240 aggggggtgttttggggaaa agcaggtggc ct 272 187 789 DNA Unknown Organism Description ofUnknown Organism lp3k 187 gggggctcag ggtgtgagtt tgggctttat gagactcagaatgggaaagg ggggtgtttt 60 ggggaaaagc aggtggcctg actgccgtgg ggatcggcaggtgattggca gctcactcct 120 cttcgtgcat gaccattgcc atcgtgctgg tgtgtggctcatcgattttg gcaagaccac 180 gcctctcccc gatggccaga tcctggatca tcggaggccctgggaggagg gcaaccgtga 240 ggacggctat ttgctggggc tggacaatct cattggcatcttggccagcc tggctgagag 300 atgaggctga gcccttttcc ctcaacgtgg gccggctggtcagacagatg tgcacctgtg 360 gctgcatccc caccatgcat gccggcaaga gactggaaccccgctgggcg ggcagttcac 420 atggtcctgc aggaccgggt gccatccact aagggggtgtagtacatcag gagttgccta 480 ccacacaagc ctgtttccca gagctgaatg acactaatttatagggaggg ggagaaacaa 540 tgggcttctc ccccagccca gctcttctca agtggctttgcacctctcca gagggtcccg 600 atccataatt gtacttcaca ggtatataga cttcctggtctaactcctgc actacagtgg 660 acacccttcc taataaaact caaagattca gcttctgtgactccagcctc ctccccttca 720 cttccagttc tctcttccac attcactcag agaactgaagaattagaagg gtttattgtt 780 tttattacc 789 188 498 DNA Unknown OrganismDescription of Unknown Organism Tyro 3 188 ggagggggag ggcggcacgagctccgcgga gggcgggcgg gcgggccggg aggaggcggc 60 ggctcgcaga agaacatgaatcagcggcgg cggcggcggc tgtggaagga gcgcggtggc 120 ccagccgcag ccccggggactcctcgctgc tgacggcggt ggccgcggct ctaggcggcc 180 gcgggtccgg gacgccccggccgagcgccg ccccccgccc ctcccgcggg cctcccgccc 240 ctcctccgcc accctcctctcagcgctcgc gggccgggcc cggcatggtg cggcgtcgcc 300 gccgatggcg ctgaggcggagcatggggtg gccggggctc cggccgctgc tgctggcggg 360 actggcttct ctgctgctccccgggtctgc ggccgcaggt aggggtggcc cgggaggcgg 420 cgggaagcgg ggggctgctgagccgcacga ctgaggggcg cagcccgggg acggcagcgg 480 gcgagacccg ggcctggg 498189 384 DNA Unknown Organism Description of Unknown Organism Tyro 3 189agcatagaca actgttttcc agaagagaat gaagggggga tgttcccaga aatgagggct 60atttcagtcg tactgacaca tcccctttcc catcctgcag gcctgaagct catgggcgcc 120ccagtgaaga tgaccgtgtc tcaggggcag ccagtgaagc tcaactgcag cgtggagggg 180atggaggacc ctgacatcca ctggatgaag gatggcaccg tggtccagaa tgcaagccag 240gtgtccatct ccatcagcga gcacagctgg attggcttac tcaggtgcag gagtgcgggg 300agggagcggg aggactggcc tgtgcctgag gctttgctca tgtctagagg tctgtggtct 360taaaatttgg caaactgtgg aacc 384 190 301 DNA Unknown Organism Descriptionof Unknown Organism Tyro 3 190 ctgcctccca agtgctggaa ttaaaggcgtgcgccaccac gcctggctag gatctggctc 60 tcttgactct gaaaagtaag ctgctatcctgttttcacag cctaaagtca gtggagcggt 120 ctgatgctgg cctgtactgg tgccaggtgaaggatgggga ggaaaccaag atctctcagt 180 cagtatggct cactgtcgaa ggtgaggaggcagtactagc tgtatgggcc attgggcttg 240 gagctaagac ctataactct gcagaagagaacttaatgta agctggactg ccctaccgcc 300 t 301 191 371 DNA Unknown OrganismDescription of Unknown Organism Tyro 3 191 gcagctgacc caatcataagggtcctgtgg tgactgcctg ttacagagaa ctatagctaa 60 gaagcggcga ggctaactccccctcacttt ttctccctag gtgtgccatt cttcacagtg 120 gaaccaaaag atctggcggtgccacccaat gccccttttc agctgtcttg tgaggctgtg 180 ggtcctccag aacccgtaaccatttactgg tggagaggac tcactaaggt tgggggacct 240 gctccctctc cctctgttttaaatgtgaca ggtgagcagt ctcaggaggg ggctttgagc 300 caagagtgag ctgggtcaatgcctgtgggg agcactatag ggttgggatc tgcataaatc 360 tgagtttgtc g 371 192 287DNA Unknown Organism Description of Unknown Organism Tyro 3 192agatgctctg gcaagagcct gaattgaagt ccctccttcg taaactcaga ctcagtggga 60gttgctgctt aggggactga ctaaggtttt ctggccccag gagtgaccca gcgcacagag 120ttttcttgtg aagcccgcaa cataaaaggc ctggccactt cccgaccagc cattgttcgc 180cttcaaggta gggggacgca ggctaggttg ggaggggctg ggggtgttgg gaaaggacag 240aggcagcctc agccaactgt ctagcagcgg gattggctgg cttttca 287 193 316 DNAUnknown Organism Description of Unknown Organism Tyro 3 193 ctccaggccttaggaggaaa tcaagccttg actcccatgc ctccctccct ccctcccctc 60 ctattttcactcggtgctga cactaagtcc ctatccacag caccgcctgc agctcctttc 120 aacaccacagtaacaacgat ctccagctac aacgctagcg tggcctgggt gccaggtgct 180 gacggcctagctctgctgca ttcctgtact gtacaggtag gctgagctga gcacagcagg 240 gtctggctgactgactgtgc tggctttggc tgcactttgt cgcacttact aggcctgctt 300 gggaatctgcagctgc 316 194 378 DNA Unknown Organism Description of Unknown OrganismTyro 3 194 ctgccttcca tctcatctca gagacctgac tccttatctg agctcactgggtttgtcctt 60 ttctggtttt tgtcttttgc ttctgttttg ttttctgaag gtggcacacgccccaggaga 120 atgggaggcc cttgctgttg tggttcctgt gccacctttt acctgcctgcttcggaactt 180 ggcccctgcc accaactaca gccttagggt gcgctgtgcc aatgccttgggcccttctcc 240 ctacggcgac tgggtgccct ttcagacaaa gggcctaggt aagaaactcagcaggagggg 300 cagggctgga gagggaaggc atcactcatt cagtgagcgc ttattgagcacctactgcat 360 gctactgcgt accatgtt 378 195 346 DNA Unknown OrganismDescription of Unknown Organism Tyro 3 195 ctcaccctct gctttctgagctcttcagct cctggtatgt gtgggataat gatggtaggg 60 aaggcaggga ctcctaagagctttctttct ttgggtacag cgccagccag agctcctcag 120 aatttccatg ccattcgtaccgactcaggc cttatcctgg aatgggaaga agtgattcct 180 gaggaccctg gggaaggccccctaggacct tataagctgt cctgggtcca agaaaatgga 240 acccaggtaa gagagacagttccttctgct ccccctactg tgctggagag tctaccctgt 300 acttctgaga cttagaagagctttagaatg cttctggagg gtctgg 346 196 345 DNA Unknown OrganismDescription of Unknown Organism Tyro 3 196 aaggttccct aattccttagttgaactttc ttctggcctc ccagctcagc tggaggcttc 60 cccaggctgt gtgtaagggtggggcttttc ctggttacag gatgagctga tggtggaagg 120 gaccagggcc aatctgaccgactgggatcc ccagaaggac ctgattttgc gtgtgtgtgc 180 ctccaatgca attggtgatgggccctggag tcagccactg gtggtgtctt ctcatgacca 240 tgcaggtaag gcatgcagggcaggcgtagg gtgcaaggct ttcagggatt acaccgactg 300 ataggaggag gctggtctcacacacacaca cacacacaca cacac 345 197 330 DNA Unknown Organism Descriptionof Unknown Organism Tyro 3 197 aaatcttttg gctagattag gtaggtggccaccctaggac agttctaaaa ggacattttg 60 gtgtcagcct ggctcatgac aacgcctttccctctcccag ggaggcaggg ccctccccac 120 agccgcacat cctgggtgcc tgtggtcctgggcgtgctca ccgccctgat cacagctgct 180 gccttggccc tcatcctgct tcggaagagacgcaaggaga cgcgtttcgg gtaaggaagt 240 gggacagcgg ccagtgaaga aggtggtaacagggggcctt gtgatttacc tgatgtctgg 300 gtttctcttt aggcaagcct ttgacagtgt330 198 301 DNA Unknown Organism Description of Unknown Organism Tyro 3198 caaggagacg cgtttcgggt aaggaagtgg gacagcggcc agtgaagaag gtggtaacag 60ggggccttgt gatttacctg atgtctgggt ttctctttag gcaagccttt gacagtgtca 120tggcccgagg ggagccagct gtacacttcc gggcagcccg atctttcaat cgagaaaggc 180ctgaacgcat tgaggccaca tgtgagtgct ggagcatcac agaagggaag agacagacta 240tcttgtgttc ctacctctta ccaactcctt tatccagcta aagagcctga acctttctaa 300 g301 199 296 DNA Unknown Organism Description of Unknown Organism Tyro 3199 ggagatccag gctctgctga gggcagaaag ccgggtggag ctgtaggctg gagtgtggat 60ttgactgcag ccttgcttcc ctttcacctc ctccctgcag tggatagcct gggcatcagc 120gatgaattga aggaaaagct ggaggatgtc ctcattccag agcagcagtt caccctcggt 180cggatgttgg gcaaaggtgc gggggctgtg ggggactagc atgagtttgc cctctctgca 240tggcttgttc cagttgcttc cagggtatga atttgggtca gctcctataa acaaga 296 200281 DNA Unknown Organism Description of Unknown Organism Tyro 3 200gccttaattg atgattttat gaccatatga agagtcacct gagagggaag ggtgtgggga 60gcctgaggtg tctcacgctg tccattgatt tcttgcttag gagagtttgg atcagtgcgg 120gaagcccagc taaagcagga agatggctcc ttcgtgaaag tggcagtgaa gatgctgaaa 180ggtgagttag acagtagggt ttgttgccag gtagggaaga gggcaaaggg agggactgat 240ctggagcagg cgccactctg cctgagattt cccaagaagc t 281 201 293 DNA UnknownOrganism Description of Unknown Organism Tyro 3 201 gcccctgtgaagcccagggc ttctgtgagt cctaggagtc ctgggagggt ggcacgagtg 60 gtgagtcctgtttccattcc ttctccttcc tttctcccag ctgacatcat tgcctcaagc 120 gacatagaagagttcctccg ggaagcagct tgcatgaagg agtttgacca tccacacgtg 180 gccaagcttgttggtgagcc cgtttggagg aggcagatat agaatagggc taaaaatatg 240 ctccaccaacgtgacagggc agcctggagg agaaaagttt ggctacccag tga 293 202 322 DNA UnknownOrganism Description of Unknown Organism Tyro 3 202 gctagagatggaagccagca ggtagggagg cactgttgca gatacctagc tgtccttcgg 60 ccttcctgtgcccagttctt gacgctccct tgtctcctag gggtgagcct ccggagcagg 120 gctaaaggtcgtctccccat tcccatggtc atcctgccct tcatgaaaca tggagacttg 180 cacgcctttctgctcgcctc ccgaatcggg gagaaccctt ttgtgagtgc ctcaggtcgg 240 ggtgggagactggtgcctgg aaaagggaga gaacctgggg agaagaggct ttgttgggca 300 ggactcggggagctgatggg gt 322 203 310 DNA Unknown Organism Description of UnknownOrganism Tyro 3 203 cttacgatag tctttaggct ttctgaccag agaatttcattcattacgcc ccacacagag 60 tggggaggtt caacctgatt ttgccctgtc tgcctaccagaacctgcccc tgcagaccct 120 ggtccggttc atggtggaca ttgcctgtgg catggagtacctgagctccc ggaacttcat 180 ccaccgagac ctagcagctc ggaattgcat gtaggaatggattctggtgg cctgctgggt 240 gggagacagc tatcgcctcc taccttggat agaacctcctatgcacgggg atagcctcgc 300 ttttagtaag 310 204 360 DNA Unknown OrganismDescription of Unknown Organism Tyro 3 204 cctaccttgg atagaacctcctatgcacgg ggatagcctc gcttttagta aggctctggg 60 cctggggaag actgagtctgtctttcaaca cccctctcag gctggccgag gacatgacag 120 tgtgtgtggc tgattttggactctctcgga aaatctatag cggggactat tatcgtcagg 180 gctgtgcctc caaattgcccgtcaagtggc tggccctgga gagcttggct gacaacttgt 240 atactgtaca cagtgatgtggtgagcaggg tggcccagtg gggcttggta atgtgaatag 300 ggtgaattaa tgtgcgggtggatgtgcagg acccaaaaag gaccaccaaa gttctgttct 360 205 337 DNA UnknownOrganism Description of Unknown Organism Tyro 3 205 ttgagctttgtctattgacg agacccttga atcctgggat atggctctgc ttggctcagg 60 aaaccaataacattccccct caaccctgat tctataccag tgggccttcg gggtgaccat 120 gtgggagatcatgactcgtg ggcagacgcc atatgctggc attgaaaatg ctgagattta 180 caactacctcatcggcggga accgcctgaa gcagcctccg gagtgcatgg aggaagtgtg 240 agtatcctgggtcgtgggtt agggaaggag ctttggctcg aggctgctac catagcagct 300 cagaacctccacctgacttc tgtttgtcct tcttttg 337 206 1148 DNA Unknown OrganismDescription of Unknown Organism Tyro 3 206 agtactgtta aaagaatgagttattttccc atctcagcgt catatggtcg ggaggtcctc 60 tgctttgtgg ctactatgtccccgtattct tttacctcag gtatgatctc atgtaccagt 120 gctggagcgc cgaccccaagcagcgcccaa gcttcacgtg tctgcgaatg gaactggaga 180 acattctggg ccacctgtctgtgctgtcca ccagccagga ccccttgtac atcaacattg 240 agagagctga gcagcctactgagagtggca gccctgagct gcactgtgga gagcgatcca 300 gcagcgaggc aggggacggcagtggcgtgg gggcagtagg tggcatcccc agtgactctc 360 ggtacatctt cagccccggagggctatccg agtcaccagg gcagctggag cagcagccag 420 aaagccccct caatgagaaccagaggctgt tgttgctgca gcaagggcta ctgcctcaca 480 gtagctgtta accctcagccagaggaaagt tggggcccct ggctctgctg accactgtgc 540 tgcctgacta ggcccagtctgatcacagcc caggcagcaa ggtatggagg ctcctgtggt 600 agccctccca agctgtgctggcgcctggac ggaccaaatt gcccaatccc agttcttcct 660 gcagccgctc tggccagcctggcatcagtt caggccttgg cttagaggag gtgagccaga 720 gctggttgcc tgaatgcaggcagctggcag gaggggaggg tggctatgtt tccatgggta 780 ccatgggtgt ggatggcagtaagggagggt agcaacagcc ctgtgggccc ctaccctcct 840 ggctgagctg ctcctactttagtgcatgct tggagccgcc tgcagcctgg aactcagcac 900 tgcccaccac acttgggccgaaatgccagg tttgcccctc ttaagtcaca aagagatgtc 960 catgtattgt tcccttttaggtgatgatta ggaagggatt ggcacacttg ggtccctaag 1020 ccctatggca ggaaatggtgggatattctc aggtctgaat cctcatcatc ttcctgattc 1080 cccaccctgc aaaggcctggaactggctgt ggggctctga ggcatgctga aggacaaaag 1140 attacaga 1148

1. An isolated nucleic acid molecule comprising a nucleotide sequencederived from a vertebrate animal, said nucleotide sequence codes for apolypeptide that is capable of at least partially complementing thephenotype of an animal having the anx/anx genotype as described inMaltais et al., J. Hered., 1984, 75:468-472, or a similar genotype.
 2. Anucleic acid molecule according to claim 1 wherein the nucleotidesequence that codes for a polypeptide that is capable of complementingthe phenotype of an animal having the anx/anx genotype as described inMaltais et al., J. Hered., 1984, 75:468-472, or a similar genotype, isconstructed synthetically.
 3. A nucleic acid molecule according to claim1, further comprising a regulatory nucleotide sequence that regulatesthe expression of the nucleotide sequence coding for the phenotypecomplementing polypeptide, said regulatory nucleotide sequence is notnaturally associated with the nucleotide sequence coding for thephenotype complementing polypeptide.
 4. A nucleic acid moleculeaccording to claim 1, further comprising a nucleotide sequence thatencodes a secretion leader sequence that provides for secretion of thephenotype complementing polypeptide upon expression of the nucleotidesequence coding for the polypeptide.
 5. A nucleic acid moleculeaccording to claim 1 wherein the expression control sequence is oneselected from the group consisting of a prokaryotic cell promoter, aeukaryotic cell promoter and a viral promoter.
 6. A nucleic acidmolecule according to claim 1 wherein the nucleotide sequence coding fora polypeptide that is capable of at least partially complementing thephenotype of an animal having the anx/anx genotype as described inMaltais et al., J. Hered., 1984, 75:468-472, or a similar genotype, isderived from a vertebrate animal including an animal selected from thegroup consisting of a rodent and a human.
 7. A nucleic acid moleculeaccording to claim 6 wherein the nucleotide sequence coding for apolypeptide that is capable of at least partially complementing thephenotype of an animal having the anx/anx genotype as described inMaltais et al., J. Hered., 1984, 75:468-472, or a similar genotype, isderived from a mouse.
 8. A nucleic acid molecule according to claim 7wherein the nucleotide sequence coding for a polypeptide that is capableof at least partially complementing the phenotype of an animal havingthe anx/anx genotype as described in Maltais et al., J. Hered., 1984,75:468-472, or a similar genotype, is derived from a mouse having thegenotype anx/anx.
 9. A nucleic acid molecule according to claim 8 whichis derived from a fragment of Chromosome 2 that is delimited by D2Mit133and by D2Jojo5 as defined hereinbefore.
 10. A nucleic acid moleculeaccording to claim 1 comprising a nucleotide sequence selected from thegroup consisting of D2Dcr14, D2Mit104, D2Mit395, Tyro 3A, Tyro 3B andTyro 3, as defined hereinbefore.
 11. An expression vector comprising thenucleic acid molecule according to claim
 1. 12. An expression vectoraccording to claim 11 further comprising a regulatory nucleotidesequence that regulates the expression of the nucleotide sequence codingfor the phenotype complementing polypeptide.
 13. An expression vectoraccording to claim 12 wherein the regulatory nucleotide sequence is notnaturally associated with the nucleotide sequence coding for thephenotype complementing polypeptide.
 14. An expression vector accordingto claim 11, further comprising a nucleotide sequence that encodes asecretion leader sequence that provides for secretion of the phenotypecomplementing polypeptide upon expression of the nucleotide sequencecoding for the polypeptide.
 15. An expression vector according to claim12 wherein the expression control sequence is one selected from thegroup consisting of a prokaryotic cell promoter, a eukaryotic cellpromoter and a viral promoter.
 16. An expression vector according toclaim 11 wherein the nucleotide sequence coding for a polypeptide thatis capable of at least partially complementing the phenotype of ananimal having the anx/anx genotype as described in Maltais et al., J.Hered., 1984, 75:468-472, or a similar genotype, is derived from avertebrate animal including an animal selected from the group consistingof a rodent and a human.
 17. An expression vector according to claim 16wherein the nucleotide sequence coding for a polypeptide that is capableof at least partially complementing the phenotype of an animal havingthe anx/anx genotype as described in Maltais et al., J. Hered., 1984,75:468-472, or a similar genotype, is derived from a mouse.
 18. Anexpression vector according to claim 17 wherein the nucleotide sequencecoding for a polypeptide that is capable of at least partiallycomplementing the phenotype of an animal having the anx/anx genotype asdescribed in Maltais et al., J. Hered., 1984, 75:468-472, or a similargenotype, is derived from a mouse having the genotype anx/anx.
 19. Anexpression vector according to claim 18 wherein the nucleotide sequencecoding for a polypeptide that is capable of at least partiallycomplementing the phenotype of an animal having the anx/anx genotype asdescribed in Maltais et al., J. Hered., 1984, 75:468-472, or a similargenotype, is derived from a fragment of the murine chromosome 2 that isdelimited by D2Mit133 and by D2Jojo5 as defined hereinbefore.
 20. Anexpression vector according to claim 11 comprising a nucleotide sequenceselected from the group consisting of D2Dcr14, D2Mit104, D2Mit395, Tyro3A, Tyro 3B and Tyro 3, as defined hereinbefore.
 21. An expressionvector according to claim 11, further comprising a nucleotide sequencecoding for a selective marker.
 22. A host cell comprising the vector ofclaim
 11. 23. A host cell according to claim 22 wherein the vectorfurther comprises a selective marker.
 24. A host cell according to claim23 wherein the expression vector comprises a regulatory nucleotidesequence that regulates the expression of the nucleotide sequence codingfor the phenotype complementing polypeptide.
 25. A host cell accordingto claim 24 wherein the regulatory nucleotide sequence is not naturallyassociated with the nucleotide sequence coding for the phenotypecomplementing polypeptide.
 26. A host cell according to claim 22 whereinthe expression vector comprises a nucleotide sequence that encodes asecretion leader sequence that provides for secretion of the phenotypecomplementing polypeptide upon expression of the nucleotide sequencecoding for the polypeptide in the host cell.
 27. A host cell accordingto claim 22 which is selected from the group consisting of a prokaryoticcell and an eukaryotic cell.
 28. A host cell according to claim 27 whichis a prokaryotic cell selected from the group consisting of a gramnegative bacterium and a gram positive bacterium.
 29. A host cellaccording to claim 28 which is E. coli.
 30. A host cell according toclaim 28 which is an eukaryotic cell selected from the group consistingof a mammalian cell, an insect cell and a fungal cell.
 31. A host cellaccording to claim 30 which is a human cell.
 32. A method of producing apolypeptide that is capable of at least partially complementing thephenotype of an animal having the anx/anx genotype as described inMaltais et al., J. Hered., 1984, 75:468-472, or a similar genotype, themethod comprising the steps of: (i) providing a nucleic acid moleculeaccording to claim 1; (ii) introducing the nucleic acid molecule into ahost cell that is capable of expressing the nucleotide sequence codingfor the phenotype complementing polypeptide; (iii) culturing the hostcell under conditions permitting expression of the nucleotide sequencecoding for the phenotype complementing polypeptide: and (iv) harvestingthe polypeptide.
 33. A method according to claim 32 wherein the nucleicacid molecule is introduced into the host cell as the expression vectoraccording to claim
 11. 34. A method according to claim 32 wherein thehost cell cultured in step (iii) is the host cell of claim
 22. 35. Amethod of inducing, in a vertebrate animal, the production of apolypeptide that is capable of at least partially complementing thephenotype of an animal having the anx/anx genotype as described inMaltais et al., J. Hered., 1984, 75:468-472, or a similar genotype, themethod comprising administering to the animal the nucleic acid moleculeof claim
 1. 36. A method according to claim 35 wherein the nucleic acidmolecule is administered directly or by viral or non-viral means.
 37. Amethod according to claim 35 wherein the nucleic acid molecule isadministered as a vector according to claim
 11. 38. An isolatedpolypeptide that is capable of at least partially complementing thephenotype of an animal having the anx/anx genotype as described inMaltais et al., J. Heredity, 1984, 75:468-472, or a similar genotype,said polypeptide is obtainable by the method of claim
 32. 39. A methodof regulating food or feed intake in a vertebrate animal, the methodcomprising administering a food or feed intake regulating amount of thepolypeptide according to claim
 38. 40. A method of regulating weightgain in a vertebrate animal, the method comprising administering to theanimal a weight gain regulating amount of the polypeptide according toclaim
 38. 41. A method of regulating food or feed intake in a vertebrateanimal, the method comprising administering to the animal an effectiveamount of a molecule that blocks or inhibits or enhances the biologicalactivity of the polypeptide according to claim
 38. 42. A methodaccording to claim 41 wherein the molecule that blocks or inhibits thebiological activity of the polypeptide is a molecule selected from thegroup consisting of an antibody capable of binding to the polypeptide, areceptor capable of binding to the polypeptide, an antagonist thatprevents the polypeptide from binding to its receptor and any othermolecule that affects the activity of the polypeptide.
 43. A methodaccording to claim 41 wherein the molecule that enhances the biologicalactivity of the polypeptide is an agonist.
 44. A pharmaceuticalcomposition comprising a polypeptide that is capable of at leastpartially complementing the phenotype of an animal having the anx/anxgenotype as described in Maltais et al., J. Hered., 1984, 75:468-472, ora similar genotype, or a pharmaceutically active part thereof, and apharmaceutically acceptable carrier.
 45. A pharmaceutical compositioncomprising a molecule that blocks or inhibits the biological activity ofa polypeptide that is capable of at least partially complementing thephenotype of an animal having the anx/anx genotype as described inMaltais et al., J. Hered., 1984, 75:468-472, or a similar genotype, saidmolecule is selected from the group consisting of an antibody capable ofbinding to the polypeptide, a receptor capable of binding to thepolypeptide, an antagonist that prevents the polypeptide from binding toits receptor and any other molecule that is capable of binding to thepolypeptide and/or affecting the biological activity of the polypeptideor a pharmaceutically active part thereof, and a pharmaceuticallyacceptable carrier.
 46. A method of isolating a molecule that is capableof interacting with a polypeptide that is capable of at least partiallycomplementing the phenotype of an animal having the anx/anx genotype asdescribed in Maltais et al., J. Hered., 1984, 75:468-472, or a similargenotype, the method comprising the steps of: (i) providing thepolypeptide according to claim 38, (ii) permitting the polypeptide toreact with cells or fragments or extracts thereof to form a bindingpair, and (iii) separating from the binding pair a molecule that bindsto the polypeptide.
 47. An antibody comprising at least one binding sitethat is capable of binding to the polypeptide encoded by the nucleotidesequence according to claim
 1. 48. An antibody according to claim 47which is an antibody selected from the group consisting of a polyclonalantibody and a monoclonal antibody.
 49. An antibody according to claim47 which is one selected from an animal antibody and a humanisedantibody.
 50. A method of detecting the presence of a polypeptide thatis capable of at least partially complementing the phenotype of ananimal having the anx/anx genotype as described in Maltais et al., J.Hered., 1984, 75:468-472, or a similar genotype, or a homologue of saidpolypeptide, the method comprising contacting an antibody capable ofbinding to the polypeptide with a sample suspected of containing thepolypeptide or the homologue thereof to allow formation of apolypeptide/antibody complex and detecting the complex.
 51. A methodaccording to claim 50 wherein the sample is one selected from braintissue and pancreas tissue.
 52. A method according to claim 50 whereinthe antibody is a labelled antibody.
 53. An isolated molecule thatinteracts with a polypeptide that is capable of at least partiallycomplementing the phenotype of an animal having the anx/anx genotype asdescribed in Maltais et al., J. Hered., 1984, 75:468-472, or a similargenotype, that is provided by the method of claim
 46. 54. A moleculeaccording to claim 53 that is a receptor molecule.
 55. A method ofproducing an antibody to the molecule according to claim 53, the methodcomprising administering an immunologically effective amount of themolecule to an animal and collecting from the animals serum containingantibodies against the receptor or spleen cells for the production ofmonoclonal antibodies against the molecule.
 56. A method according toclaim 55 wherein the molecule is a receptor molecule.
 57. A method fordetection of a molecule that is capable of binding to a polypeptidecapable of at least partially complementing the phenotype of an animalhaving the anx/anx genotype as described in Maltais et al., J. Hered.,1984, 75:468-472, or a similar genotype, the method comprising the stepsof: (i) providing the antibody produced by the method of claim 55, (ii)reacting the antibody with cells or fragments or extracts thereof toform a binding pair, and (iii) detecting the presence of the bindingpair.
 58. A method according to claim 57 wherein the molecule is areceptor molecule.
 59. A method according to claim 57 wherein theantibody is a labelled antibody.
 60. A kit for detection of apolypeptide that is capable of at least partially complementing thephenotype of an animal having the anx/anx genotype as described inMaltais et al., J. Hered., 1984, 75:468-472, or a similar genotype, saidkit comprising an antibody according to claim
 47. 61. A kit fordetection of a receptor for a polypeptide that is capable of at leastpartially complementing the phenotype of an animal having the anx/anxgenotype as described in Maltais et al., J. Hered., 1984, 75:468-472, ora similar genotype, said kit comprising said polypeptide.
 62. A kitaccording to claim 61 wherein the polypeptide is in a labelled form. 63.A kit for detection of antibodies to a polypeptide that is capable of atleast partially complementing the phenotype of an animal having theanx/anx genotype as described in Maltais et al., J. Hered., 1984,75:468-472, or a similar genotype, said kit comprising the polypeptide.64. A kit according to claim 63 wherein the polypeptide is in a labelledform.
 65. A method of identifying in a sample a nucleotide sequence thatcodes for a putative polypeptide as defined in claim 1, the methodcomprising the steps of. (i) providing the coding nucleotide sequence ofclaim 1 or its complementary strand, or a part thereof, (ii) contactingthe sample with said sequence or part under hybridising conditions toform a binding pair; and (iii) detecting the presence of the bindingpair.
 66. A method according to claim 65 wherein the coding nucleotidesequence or its complementary strand, or part thereof is labelled.
 67. Amethod of controlling in an animal the expression of a nucleotidesequence coding for a polypeptide that is capable of at least partiallycomplementing the phenotype of an animal having the anx/anx genotype asdescribed in Maltais et al., J. Hered., 1984, 75:468-472, or a similargenotype, the method comprising the steps of: (i) providing a moleculethat inhibits the translation of a transcript of the coding sequence;and (ii) administering to the animal a translation inhibiting effectiveamount of said molecule.
 68. A method according to claim 67 wherein thetranslation inhibiting molecule is selected from the group consisting ofantisense RNA and PNA.